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1. 发明申请

WO2013014654A3 FORMULAS COMPRISING HIGHLY SOLUBLE ELEMENTS AND VITAMIN FOR THE PREVENTION AND AMELIORATION OF OSTEOPOROSIS 审中-公开
标题翻译：含有高度可溶性成分和维生素的配方，用于预防和改善骨质疏松症
公开(公告)号：WO2013014654A3
公开(公告)日：2013-03-21
申请号：PCT/IB2012053872
申请日：2012-07-27
申请人： SINOVEDA CANADA INC , TAM YUN KAU
发明人： TAM YUN KAU
IPC分类号： A61K33/06 , A61K9/20 , A61K9/48 , A61K31/593 , A61K33/30 , A61P3/02 , A61P19/08 , A61P19/10
CPC分类号： A61K31/593 , A61K9/2027 , A61K9/4875 , A61K33/06 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of producing dosage forms for formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D 3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.
摘要翻译：本发明提供了制备用于包含钙，镁和锌的乙酸盐以及维生素D 3的元素组合物的制剂的剂型的方法。乙酸盐可以从天然来源例如珍珠，珊瑚和牡蛎中提取或者使用合成物材料。使用体外和体内估计估计钙与镁的剂量和比率。促进骨骼健康和缓解骨质疏松症的剂量约为常规剂量的四分之一至三分之一。

2. 发明申请

WO2013050930A1 DEVELOPMENT OF A RED CLOVER PHYTOESTROGEN PRODUCT FOR THE PREVENTION OR TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：开发用于预防或治疗骨质疏松症的红色中性粒细胞产品
公开(公告)号：WO2013050930A1
公开(公告)日：2013-04-11
申请号：PCT/IB2012/055277
申请日：2012-10-02
申请人： SINOVEDA CANADA, INC, , TAM, Yun Kau , LIN, Yi-Chan, James , SLOLEY, Brian, Duff , TSENG, Chih-Yuan
发明人： TAM, Yun Kau , LIN, Yi-Chan, James , SLOLEY, Brian, Duff , TSENG, Chih-Yuan
IPC分类号： A61K31/352 , A61K36/48 , A61P19/10 , C12Q1/00 , C40B30/02 , G06F19/00 , A61K47/40
CPC分类号： A61K31/352 , A61K9/2027 , A61K9/2054 , A61K9/209 , A61K31/353 , A61K31/724 , A61K36/48 , G06F19/704 , A61K2300/00
摘要： Using computational modelling and entropic analysis (the Pharmaceutical Platform Technology), various pharmaceutical compositions derived from Red clover ( Trifolium pratense ) extracts comprising lsoflavones have been developed. Said compositions include an immediate release formulation comprising alpha-cyclodextrin, a sustained release formulation that comprises polyvinylpyrrolidone as an excipient, and a combined formulation comprising the aforementioned immediate release and sustained release compositions. The isoflavones of interest include biochanin A, formononetin, daidzein, equol, and genistein. The resulting pharmaceutical compositions are useful in the treatment and prevention of osteoporosis.
摘要翻译：使用计算建模和熵分析（药物平台技术），已经开发了衍生自包含黄素的红三叶草（Trifolium pratense）提取物的各种药物组合物。所述组合物包括立体释放制剂，其包含α-环糊精，包含聚乙烯吡咯烷酮作为赋形剂的缓释制剂和包含上述即释型和持续释放组合物的组合制剂。感兴趣的异黄酮包括鹰嘴豆素A，海参素，大豆黄素，雌马酚和染料木素。所得的药物组合物可用于治疗和预防骨质疏松症。

3. 发明申请

WO2013014654A4 FORMULAS COMPRISING HIGHLY SOLUBLE ELEMENTS AND VITAMIN FOR THE PREVENTION AND AMELIORATION OF OSTEOPOROSIS 审中-公开
标题翻译：包含高可溶性元素和维生素用于预防和改善骨质疏松症的配方
公开(公告)号：WO2013014654A4
公开(公告)日：2013-06-06
申请号：PCT/IB2012053872
申请日：2012-07-27
申请人： SINOVEDA CANADA INC , TAM YUN KAU
发明人： TAM YUN KAU
IPC分类号： A61K33/06 , A61K9/20 , A61K9/48 , A61K31/593 , A61K33/30 , A61P3/02 , A61P19/08 , A61P19/10
CPC分类号： A61K31/593 , A61K9/2027 , A61K9/4875 , A61K33/06 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of producing dosage forms for formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D 3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.
摘要翻译：本发明提供了生产包含钙，镁和锌的醋酸盐以及维生素D 3的元素组合物的剂型的方法。乙酸盐可以从天然来源如珍珠，珊瑚和牡蛎中提取，或者使用合成材料。使用体外和体内估计估计钙与镁的剂量和比例。用于促进骨骼健康和缓解骨质疏松症的剂量约为常规剂量的四分之一至三分之一。

4. 发明申请

WO2013014654A2 FORMULAS COMPRISING HIGHLY SOLUBLE ELEMENTS AND VITAMIN FOR THE PREVENTION AND AMELIORATION OF OSTEOPOROSIS 审中-公开
标题翻译：含有高度可溶性成分和维生素的配方，用于预防和改善骨质疏松症
公开(公告)号：WO2013014654A2
公开(公告)日：2013-01-31
申请号：PCT/IB2012/053872
申请日：2012-07-27
申请人： SINOVEDA CANADA, INC. , TAM, Yun Kau
发明人： TAM, Yun Kau
CPC分类号： A61K31/593 , A61K9/2027 , A61K9/4875 , A61K33/06 , A61K33/30 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods of producing dosage forms for formulas of elemental compositions encompassing acetate salts of calcium, magnesium and zinc along with vitamin D 3. The acetate salts could be extracted from natural sources such as pearls, coral, and oyster or compounded using synthetic materials. The dosage and ratio of calcium to magnesium was estimated using in vitro and in vivo estimations. The dosage for promoting bone health and alleviation of osteoporosis is about a quarter to a third of the conventional dose.
摘要翻译：本发明提供了制备用于包含钙，镁和锌的乙酸盐以及维生素D 3的元素组合物配方的剂型的方法。乙酸盐可以从天然来源提取，例如珍珠，珊瑚和牡蛎，或使用合成材料复合而成。使用体外和体内估计估计钙与镁的剂量和比率。促进骨骼健康和缓解骨质疏松症的剂量约为常规剂量的四分之一至三分之一。

5. 发明申请

WO2023021472A1 A PHARMACEUTICAL PLATFORM TECHNOLOGY FOR DRUG DISCOVERY AND CONSUMER HEALTH PRODUCT DEVELOPMENT 审中-公开
公开(公告)号：WO2023021472A1
公开(公告)日：2023-02-23
申请号：PCT/IB2022/057780
申请日：2022-08-19
申请人： TAM, Yun Kau , SINOVEDA CANADA INC.
发明人： TSENG, Chih-Yuan , BJORNDAHL, Trent
IPC分类号： A61K31/352 , A61K9/51 , A61K31/05 , A61P1/16 , A61P35/00 , C07C39/23 , C07D311/58 , C07D311/80 , G16C20/00 , G16C20/20 , G16C20/70 , G16H20/10 , G16C20/30
摘要： In one embodiment, the present invention describes a method for identifying an optimized natural medicine containing defined doses of active and contributing ingredients. In one embodiment, the method disclosed in the present invention develops compositions comprising cannabinoids for the treatment of hepatocellular carcinoma.

6. 发明申请

WO2015166468A1 FORMULAS COMPRISING HIGHLY SOLUBLE ELEMENTS AND VITAMIN D FOR THE PREVENTION AND TREATMENT OF BOWEL CONDITIONS DURING CALCIUM SUPPLEMENTATION 审中-公开
标题翻译：包含高可溶性元素和维生素D的配方用于在钙补充期间预防和治疗牙齿条件
公开(公告)号：WO2015166468A1
公开(公告)日：2015-11-05
申请号：PCT/IB2015/053201
申请日：2015-05-01
申请人： SINOVEDA CANADA, INC.
发明人： TAM, Yun Kau
IPC分类号： A61K33/06 , A61K31/593 , A61K33/30 , A61P1/10 , A61P19/10
CPC分类号： A61K31/593 , A61K33/06 , A61K33/30 , A61K2300/00
摘要： The present invention provides novel compositions that are effective in improving bowel function and additionally provides benefits to bone health. In one embodiment, the present invention provides uses of said compositions in the preparation of medicament for improving bowel function or constipation. In one embodiment, the present invention provides uses of said compositions in the preparation of medicament for maintaining or promoting bone health without worsening the bowel function in a subject. In one embodiment, the bowel issues or constipation are induced by calcium, supplementation. In another embodiment, the bowel issues or constipation are associated with other conditions or etiologies. In one embodiment, the composition described herein comprises acetate salts of calcium and magnesium. In another embodiment, the composition further comprises acetate salt of zinc and/or vitamin D 3 .
摘要翻译：本发明提供了有效改善肠功能并另外为骨骼健康提供益处的新型组合物。在一个实施方案中，本发明提供所述组合物在制备用于改善肠功能或便秘的药物中的用途。在一个实施方案中，本发明提供所述组合物在制备用于维持或促进骨骼健康而不恶化受试者的肠功能的药物中的用途。在一个实施方案中，肠道问题或便秘由钙补充引起。在另一个实施方案中，肠道问题或便秘与其他病症或病因相关。在一个实施方案中，本文所述的组合物包含钙和镁的乙酸盐。在另一个实施方案中，组合物还包含锌和/或维生素D3的乙酸盐。

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