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1. 发明申请

WO2007014338A3 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH SUSCEPTIBILITY TO CARDIOVASCULAR DISEASE 审中-公开
标题翻译：单核细胞多态性与心血管疾病不相关
公开(公告)号：WO2007014338A3
公开(公告)日：2010-05-20
申请号：PCT/US2006029449
申请日：2006-07-26
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , STOLL MONIKA , ASSMANN GERD , SCHULTE HELMUT , KROLL WERNER , SCHWERS STEPHEN , PETRY CHRISTOPH
发明人： STOLL MONIKA , ASSMANN GERD , SCHULTE HELMUT , KROLL WERNER , SCHWERS STEPHEN , PETRY CHRISTOPH
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention provides SNPs, polymorphic variants, and haplotypes associated with cardiovascular disease. The invention also provides methods for detecting the SNPs, polymorphic variants, and haplotypes. The invention also provides methods for determining an individual's genotype with respect to one or more polymorphisms and/or haplotypes associated with cardiovascular disease. The invention further provides methods of determining whether an individual has or is susceptible to development or occurrence of a cardiovascular disease or event. The methods are useful for providing diagnostic and/or prognostic information, selecting therapeutic regimens, etc. The invention further provides reagents and kits for practicing the methods.
摘要翻译：本发明提供了与心血管疾病相关的SNP，多态变体和单元型。本发明还提供了用于检测SNP，多态变体和单体型的方法。本发明还提供了关于与心血管疾病相关的一种或多种多态性和/或单倍型确定个体基因型的方法。本发明还提供了确定个体是否具有或易于发展或发生心血管疾病或事件的方法。该方法可用于提供诊断和/或预后信息，选择治疗方案等。本发明还提供用于实施该方法的试剂和试剂盒。

2. 发明申请

WO2007059423A3 PLANAR WAVEGUIDE DETECTION CHIPS AND CHAMBERS FOR PERFORMING MULTIPLEX PCR ASSAYS 审中-公开
标题翻译：用于执行多重PCR测定的平面波形检测器和检测器
公开(公告)号：WO2007059423A3
公开(公告)日：2007-11-29
申请号：PCT/US2006060754
申请日：2006-11-09
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , WARNER BRIAN , QUINN JOHN , DORN INGMAR
发明人： WARNER BRIAN , QUINN JOHN , DORN INGMAR
IPC分类号： G02B6/00 , G02B6/12
CPC分类号： G01N21/6428 , G01N21/648 , G01N21/7703
摘要： Provided are planar waveguide ("PWG") detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.
摘要翻译：提供了用于使用单个荧光染料进行多重PCR和动力学PCR测定的平面波导（“PWG”）检测芯片。 PWG检测芯片安装在容纳至少一个PWG芯片的PWG检测室中。 PWG检测室可以在单室或双室配置中。还提供了使用本发明的PWG检测室分析扩增产物的方法。

3. 发明申请

WO2008037700A3 METHODS FOR BREAST CANCER PROGNOSIS 审中-公开
标题翻译：乳腺癌预后的方法
公开(公告)号：WO2008037700A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007060143
申请日：2007-09-25
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , GEHRMANN MATHIAS , VON TOERNE CHRISTIAN
发明人： GEHRMANN MATHIAS , VON TOERNE CHRISTIAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118
摘要： The present invention relates to methods, kits and systems for the prognosis of the disease outcome of breast cancer in untreated breast cancer patients. More specific, the present invention relates to the prognosis of breast cancer based on measurements of the expression levels of marker genes in tumor samples of breast cancer patients. Marker genes are disclosed which allow for an accurate prognosis of breast cancer in patients having node negative, fast proliferating breast cancer.
摘要翻译：本发明涉及用于预测未治疗的乳腺癌患者乳腺癌疾病结果的方法，试剂盒和系统。更具体地说，本发明涉及基于乳腺癌患者肿瘤样品中标志物基因表达水平的测量的乳腺癌预后。公开了标记基因，其能够在患有淋巴结阴性，快速增殖的乳腺癌的患者中准确预测乳腺癌。

4. 发明申请

WO2007081613A3 A KINETIC PCR ASSAY FOR QUANTIFICATION OF GENE AMPLIFICATION ON CHROMOSOME 17 审中-公开
标题翻译：用于定量染色体上基因扩增的动力学PCR测定17
公开(公告)号：WO2007081613A3
公开(公告)日：2008-02-21
申请号：PCT/US2006061288
申请日：2006-11-28
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , SHEN LU PING , MUNNES MARC , WIRTZ RALPH MARKUS , KENNY DARYN , BUSH-DONOVAN CHARLENE E
发明人： SHEN LU PING , MUNNES MARC , WIRTZ RALPH MARKUS , KENNY DARYN , BUSH-DONOVAN CHARLENE E
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/16
摘要： Provided is a kinetic PCR ("kPCR") assay for determining gene copy number of a target gene located on chromosome 17. The kPCR assay uses the MMP-28 gene located at the 17q11.2-17q12 loci as a control and thus, is capable of detecting gene copy number of any gene on chromosome 17 in both singleplex and multiplex format without the need for a standard curve. The kPCR assay is useful for determining the gene copy number of the HER2/neu gene located at loci 17q12-17q21.32, which is a requirement for determining if a breast cancer patient is a candidate for anti-HER2/neu gene therapy.
摘要翻译：提供了用于确定位于染色体17上的靶基因的基因拷贝数的动力学PCR（“kPCR”）测定.kPCR测定使用位于17q11.2-17q12位点的MMP-28基因作为对照，因此是能够以单一和多重格式检测染色体17上的任何基因的基因拷贝数，而不需要标准曲线。 kPCR测定可用于确定位于位点17q12-17q21.32处的HER2 / neu基因的基因拷贝数，这是确定乳腺癌患者是否是抗HER2 / neu基因治疗的候选者的要求。

5. 发明申请

WO2008073691A2 SAMPLE PREPARATION DEVICE 审中-公开
标题翻译：样品制备装置
公开(公告)号：WO2008073691A2
公开(公告)日：2008-06-19
申请号：PCT/US2007085423
申请日：2007-11-21
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , DUMITRESCU NICOLAE
发明人： DUMITRESCU NICOLAE
IPC分类号： B01L3/00 , B01L3/14 , B65D47/00 , B67B7/00 , B67D3/00
CPC分类号： B01L3/5082 , B01L3/0272 , B01L2200/026 , B01L2300/046 , B01L2300/0851 , B01L2400/0638
摘要： The sample preparation device includes a vessel, such as a sample tube, having a bottom end with a bottom opening. A valve for control of the flow of any liquid outwardly of the vessel through the bottom opening is located at the bottom end of the vessel. The valve includes a deflectable membrane positioned against the bottom opening to close the bottom opening when the valve is in its normally closed condition. The membrane is deflectable away from the bottom opening when the valve is in an open condition to permit any liquid in the vessel to flow through the bottom opening to an outlet port of the valve for dispensation into a suitable collection vessel.
摘要翻译：样品制备装置包括具有底部开口的底端的容器，例如样品管。用于控制通过底部开口的容器外部的任何液体流动的阀位于容器的底端。阀门包括一个可偏转的膜片，当阀门处于常闭状态时，该膜片抵靠底部开口定位以关闭底部开口。当阀门处于打开状态时，膜片可偏离底部开口，以允许容器中的任何液体通过底部开口流动至阀门的出口端口以分配到合适的收集容器中。

6. 发明申请

WO2006104616A3 CAROUSEL SYSTEM FOR AUTOMATED CHEMICAL OR BIOLOGICAL ANALYZERS EMPLOYING LINEAR RACKS 审中-公开
标题翻译：用于自动化学或生物分析仪的CAROUSEL系统使用线性架
公开(公告)号：WO2006104616A3
公开(公告)日：2007-12-13
申请号：PCT/US2006006714
申请日：2006-02-27
申请人： SIEMENS MEDICAL SOLUTIONS DIAG
发明人： BABSON ARTHUR
IPC分类号： B65G1/00
CPC分类号： G01N35/025 , G01N35/00693 , G01N35/0095 , G01N35/026 , G01N2035/00574 , G01N2035/00752 , G01N2035/00782 , G01N2035/0444 , G01N2035/0465 , Y10T436/113332
摘要： ABSTRACT OF THE DISCLOSURE A collet and lock nut assembly (10) includes a collet (12) for receiving a cutting tool shank (16) and a lock nut (14) for creating a gripping force between the collet (12) and the shank (16). The collet (12) has a nose portion (24) and a body portion (26) separated by an annular groove (28). The lock nut (14) has a concentricbore (48) with a plurality of retention tabs (72) and a corresponding number of clearportions (74). The collet and lock nut assembly (10) can be easily assembled by inserting at least one retention tab (72) within the groove (28) of the collet (12), and then applying pressure to the collet (12) such that the remaining retention tabs (72) of the lock nut (14) are received within the groove (28) of the collet (12) to place the assembly (10) in a locked position. The collet (12) and cutting tool shank (16) can be drawn from the tool holder (18) by applying rotational torque to the lock nut (14). The collet (12) is easily removed from the lock nut (14) by applying pressure in any circumferential, lateral direction against the collet (12).
摘要翻译：发明内容一种夹头和锁紧螺母组件（10）包括用于容纳切割工具柄（16）的夹头（12）和用于在夹头（12）和柄部（12）之间产生夹紧力的锁紧螺母（14） 16）。夹头（12）具有鼻部（24）和由环形凹槽（28）分开的本体部分（26）。锁紧螺母（14）具有带有多个保持突片（72）和相应数量的清理部分（74）的同心圆孔（48）。通过在夹头（12）的凹槽（28）内插入至少一个保持凸片（72），然后向夹头（12）施加压力，使得夹头和锁紧螺母组件（10）能够容易地组装，锁定螺母（14）的保持突片（72）被容纳在夹头（12）的凹槽（28）内，以将组件（10）放置在锁定位置。通过向锁紧螺母（14）施加旋转扭矩，夹头（12）和切割工具柄（16）可以从工具夹具（18）中拉出。通过在任何圆周方向上向压头（12）施加压力，容易地将夹头（12）从锁紧螺母（14）移除。

7. 发明申请

WO2007120311A2 DETECTION OF SOLUBLE ADIPONECTIN RECEPTOR PEPTIDES AND USE IN DIAGNOSTICS AND THERAPEUTICS 审中-公开
标题翻译：检测可溶性ADIPONECTIN受体肽并用于诊断和治疗
公开(公告)号：WO2007120311A2
公开(公告)日：2007-10-25
申请号：PCT/US2006061555
申请日：2006-12-04
申请人： SIEMENS MEDICAL SOLUTIONS DIAG
发明人： PUGIA MICHAEL J
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/042 , G01N2800/32 , G01N2800/52
摘要： The present invention relates to soluble C-terminal fragments of the adiponectin receptor and their use in the diagnosis and management of disorders.
摘要翻译：本发明涉及脂联素受体的可溶性C末端片段及其在病症诊断和治疗中的用途。

8. 发明申请

WO2007106690A2 DEGENERATE NUCLEOBASE ANALOGS 审中-公开
标题翻译：变性核苷酸类似物
公开(公告)号：WO2007106690A2
公开(公告)日：2007-09-20
申请号：PCT/US2007063483
申请日：2007-03-07
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , BATTERSBY THOMAS R
发明人： BATTERSBY THOMAS R
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q1/6876 , Y10T436/143333
摘要： The present invention relates to novel degenerate nucleobase analogs and degenerate nucleobase oligomers derived therefrom, and methods of using such degenerate nucleobase oligomers.
摘要翻译：本发明涉及新型简并核碱基类似物和衍生自其的简并核碱基寡聚体，以及使用这种简并核碱基寡聚物的方法。

9. 发明申请

WO2006102612A3 EXTRACTING REAGENT FOR HYDROPHOBIC ANALYTE IN WHOLE BLOOD 审中-公开
标题翻译：在全血中提取血液分析试剂
公开(公告)号：WO2006102612A3
公开(公告)日：2009-04-16
申请号：PCT/US2006010885
申请日：2006-03-24
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , BELENKY ALEXANDER , LIVSHIN LAURIE ANN , BARBARAKIS MINAS
发明人： BELENKY ALEXANDER , LIVSHIN LAURIE ANN , BARBARAKIS MINAS
IPC分类号： A61K38/13 , G01N33/53 , G01N33/566
CPC分类号： G01N33/9493
摘要： The present invention utilizes an extracting reagent to achieve quantitative detection of hydrophobic analytes from a biological test sample. The hydrophobic analytes can include steroids, hydrophobic peptides, and drugs. The biological test sample can include serum, plasma, whole blood, urine and spinal fluid. The hydrophobic analyte is preferably the drug cyclosporine, which is used primarily as an immunosuppressant. The biological test sample is preferably whole blood. The extracting reagent comprises a zwitterionic detergent and saponin, and optionally, a viscosity additive such as sucrose or glycerin. The detection and analysis of the hydrophobic analyte is preferably performed in an automated immunoanalyzer.
摘要翻译：本发明利用提取试剂来实现来自生物测试样品的疏水性分析物的定量检测。疏水性分析物可以包括类固醇，疏水肽和药物。生物测试样品可以包括血清，血浆，全血，尿液和脊髓液。疏水性分析物优选为药物环孢菌素，其主要用作免疫抑制剂。生物测试样品优选是全血。提取试剂包括两性离子洗涤剂和皂苷，以及任选的粘度添加剂如蔗糖或甘油。疏水性分析物的检测和分析优选在自动化免疫分析仪中进行。

10. 发明申请

WO2008028926A3 METHODS AND COMPOSITIONS FOR THE PREDICTION OF RESPONSE TO TRASTUZUMAB CONTAINING CHEMOTHERAPY REGIMEN IN MALIGNANT NEOPLASIA 审中-公开
标题翻译：用于预测恶性肿瘤化疗方案对含有TRASTUZUMAB的化疗方案的反应的方法和组合物
公开(公告)号：WO2008028926A3
公开(公告)日：2008-07-10
申请号：PCT/EP2007059283
申请日：2007-09-05
申请人： SIEMENS MEDICAL SOLUTIONS DIAG , WIRTZ RALPH MARKUS , MUNNES MARC
发明人： WIRTZ RALPH MARKUS , MUNNES MARC
IPC分类号： C12Q1/68
CPC分类号： G01N33/57449 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , G01N33/57407 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446
摘要： The invention relates to methods and compositions for the prediction, diagnosis, prognosis, prevention and treatment of neoplastic disease. Neoplastic disease is often caused by chromosomal rearrangements which lead to over- or underexpression of the rearranged genes. The invention discloses genes which are overexpressed in neoplastic tissue and are useful as diagnostic markers and targets for treatment. Methods are disclosed for predicting, diagnosing and prognosing as well as preventing and treating neoplastic disease.
摘要翻译：本发明涉及用于肿瘤疾病的预测，诊断，预后，预防和治疗的方法和组合物。肿瘤疾病通常是由染色体重排引起的，这会导致重排基因过度或过度表达。本发明公开了在肿瘤组织中过度表达并且可用作治疗的诊断标记和靶标的基因。公开了用于预测，诊断和预后以及预防和治疗肿瘤疾病的方法。

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