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1. 发明申请

WO2005020933A3 NANOPARTICLES FOR DRUG-DELIVERY 审中-公开
标题翻译：用于药物递送的纳米颗粒
公开(公告)号：WO2005020933A3
公开(公告)日：2005-06-09
申请号：PCT/US2004028995
申请日：2004-09-02
申请人： UNIV SOUTH FLORIDA , TUROS EDWARD , SHIM JEUNG-YEOP
发明人： TUROS EDWARD , SHIM JEUNG-YEOP
IPC分类号： A61K20060101 , A61K9/14 , A61K9/51
CPC分类号： A61K9/5138 , A61K9/5192
摘要： This invention relates to a unique process for the preparation of polymeric nanoparticles with target molecules bonded to the surface of the particles and having sizes of up to 1000nm, preferably Inm to 400nm, more preferably Inm to 200nm, that are dispersed homogeneously in aqueous solution. To accomplish the above objective, the polymeric nanoparticles of the subject invention are prepared using a novel technique of microemulsion polymerization. The resulting aqueous solution of polymeric nanoparticles is comprised of about 1 to 100 parts per weight of water or buffer, about 1 to 80 parts per weight of polymeric nanoparticles, which the bio-active molecules are conjugated, about 0.001 to 10 parts per weight of emulsifier, and about 0.00001 to 5 parts per weight of radical initiator based on the weight of the solution. In the method of this invention, the target drug/target substance is covalently bonded to the polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell.
摘要翻译：本发明涉及一种制备聚合物纳米颗粒的独特方法，其中目标分子与颗粒表面结合并具有最高达1000nm，优选Inm至400nm，更优选Inm至200nm的尺寸，其均匀分散于水溶液中。为了实现上述目的，本发明的聚合物纳米颗粒使用微乳液聚合的新技术制备。所得到的聚合物纳米粒子的水溶液由约1至100重量份的水或缓冲剂，约1至80重量份的生物活性分子缀合的聚合物纳米粒子，约0.001至10重量份的乳化剂和约0.00001-5重量份的基于溶液重量的自由基引发剂。在本发明的方法中，目标药物/目标物质共价结合到聚合物纳米粒子上，以确保它们免于体外外部干预或体外细胞培养，直到它们暴露于细胞内的靶位点。

2. 发明申请

WO2005020933A2 NANOPARTICLES FOR DRUG-DELIVERY 审中-公开
标题翻译：药物输送纳米脂
公开(公告)号：WO2005020933A2
公开(公告)日：2005-03-10
申请号：PCT/US2004/028995
申请日：2004-09-02
申请人： UNIVERSITY OF SOUTH FLORIDA , TUROS, Edward , SHIM, Jeung-Yeop
发明人： TUROS, Edward , SHIM, Jeung-Yeop
IPC分类号： A61K
CPC分类号： A61K9/5138 , A61K9/5192
摘要： This invention relates to a unique process for the preparation of polymeric nanoparticles with target molecules bonded to the surface of the particles and having sizes of up to 1000nm, preferably Inm to 400nm, more preferably Inm to 200nm, that are dispersed homogeneously in aqueous solution. To accomplish the above objective, the polymeric nanoparticles of the subject invention are prepared using a novel technique of microemulsion polymerization. The resulting aqueous solution of polymeric nanoparticles is comprised of about 1 to 100 parts per weight of water or buffer, about 1 to 80 parts per weight of polymeric nanoparticles, which the bio-active molecules are conjugated, about 0.001 to 10 parts per weight of emulsifier, and about 0.00001 to 5 parts per weight of radical initiator based on the weight of the solution. In the method of this invention, the target drug/target substance is covalently bonded to the polymeric nanoparticles to secure them from outer intervention in vivo or cell culture in vitro until they are exposed at the target site within the cell.
摘要翻译：本发明涉及用于制备聚合物纳米颗粒的独特方法，其中靶分子键合到颗粒的表面，并且具有均匀分散在水溶液中的高达1000nm，优选Inm至400nm，更优选Inm至200nm的尺寸。为了实现上述目的，使用微乳液聚合的新技术制备本发明的聚合物纳米颗粒。所得到的聚合物纳米颗粒水溶液由约1至100份/重量的水或缓冲剂组成，约1至80份/重量的聚合物纳米颗粒，生物活性分子共轭，约0.001至10份/ 乳化剂和基于溶液重量的约0.00001至5重量份的自由基引发剂。在本发明的方法中，目标药物/靶物质共价键合到聚合物纳米颗粒上以确保它们在体内不受外部介入或体外细胞培养，直到它们暴露于细胞内的靶位点为止。

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