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1. 发明申请

WO2017143162A8 CRYOPROTECTION COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2017143162A8
公开(公告)日：2017-08-24
申请号：PCT/US2017/018331
申请日：2017-02-17
申请人： REGENTS OF UNIVERSITY OF MINNESOTA , MANUCHEHRABADI, Navid , SHI, Meng , XU, Feng , LU, TJ , BISCHOF, John
发明人： MANUCHEHRABADI, Navid , SHI, Meng , XU, Feng , LU, TJ , BISCHOF, John
IPC分类号： A01N1/02 , A01N1/00 , C12N13/00
摘要： Compositions and methods for cryoprotecting a biological tissue can involve a cryoprotective agent and a metal component that includes a metal foam, a metal foil, or a metal seed. The method allows the biological tissue to be rewarmed at a rate of at least 100°C/min.

2. 发明申请

WO2012000081A1 REMOVAL OF ETHANE FROM NATURAL GAS AT HIGH PRESSURE 审中-公开
标题翻译：从高压天然气中去除乙醚
公开(公告)号：WO2012000081A1
公开(公告)日：2012-01-05
申请号：PCT/CA2011/000728
申请日：2011-06-23
申请人： THE GOVERNORS OF THE UNIVERSITY OF ALBERTA , KUZNICKI, Steven M. , AVILA, Adolfo Maria , SHI, Meng , STROM, Vernon Lindsay , HERRERA, Patricio S.
发明人： KUZNICKI, Steven M. , AVILA, Adolfo Maria , SHI, Meng , STROM, Vernon Lindsay , HERRERA, Patricio S.
IPC分类号： B01D53/02 , B01D53/047 , B01J20/10
CPC分类号： B01D53/04 , B01D2253/108 , B01D2256/245 , B01D2257/7022 , C10L3/101 , C10L3/12
摘要： ETS-10 type materials preferentially adsorb ethane and, if present, C 3+ paraffins from mixtures comprising methane, ethane and optionally C 3+ paraffins at pressures above 200 psia. A process in which ETS-10 type materials are used to separate ethane and C 3+ paraffins from natural gas streams at over 200 psia is provided.
摘要翻译： ETS-10型材料优先吸附乙烷，如果有的话，C3 +石蜡从包含甲烷，乙烷和任选的C3 +石蜡的混合物中，压力高于200 psia。提供了使用ETS-10型材料从天然气流中分离出乙烷和C3 +链烷烃超过200psia的方法。

3. 发明申请

WO2007003054A1 METHOD OF BIOMOLECULE IMMOBILIZATION ON POLYMERS USING CLICK-TYPE CHEMISTRY 审中-公开
标题翻译：使用点击式化学的聚合物生物分子固定化方法
公开(公告)号：WO2007003054A1
公开(公告)日：2007-01-11
申请号：PCT/CA2006/001100
申请日：2006-07-06
申请人： SHOICHET, Molly, S. , YUAN, Yumin , SHI, Meng , WOSNICK, Jordan
发明人： SHOICHET, Molly, S. , YUAN, Yumin , SHI, Meng , WOSNICK, Jordan
IPC分类号： C08G64/02 , A61K35/76 , A61K31/7088 , A61K38/00 , A61K47/30
CPC分类号： C08G63/912 , A61K47/48907 , A61K47/6935 , C08G63/64 , C08G64/0241 , C08G64/42
摘要： The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloadditon between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.
摘要翻译：本发明提供了生物分子共价固定在聚合物上用于递送生物分子的方法，其具有相对于传统固定技术简单，高效，环保且无副产物的优点。本发明提供了一种修饰的微/纳米颗粒体系，其使用形成微米或纳米颗粒的官能化聚合物，以使用易于使用的化学成分将二氧化物和亲二烯体之间的狄尔斯 - 阿尔德环加成物与聚合物进行官能化的分子和另一个分子，或者在末端炔烃和叠氮化物之间的Huisgen 1,3-偶极环加成以将分子结合到颗粒。分子和/或其它治疗剂可以包封在聚合物颗粒内用于静脉内治疗递送。本发明还提供了一种新型的合成可生物降解聚合物，呋喃/炔官能化的聚（碳酸亚丙基酯）（PTMC）（PTMC））聚合物，其组合物可以被设计成满足规定的物理和化学性质要求。在一个实例中，颗粒系统自聚集于含有聚（乙二醇）（PEG）链段的官能化的基于PTMC的共聚物。共聚物的组成可以设计成满足各种颗粒系统的要求，包括尺寸，热力学稳定性，表面PEG密度，药物包封能力和生物分子固定能力。

4. 发明申请

WO2017143162A1 CRYOPROTECTION COMPOSITIONS AND METHODS 审中-公开
标题翻译：冷冻组合物和方法
公开(公告)号：WO2017143162A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018331
申请日：2017-02-17
申请人： REGENTS OF UNIVERSITY OF MINNESOTA , MANUCHEHRABADI, Navid , SHI, Meng , XU, Feng , LU, Tj , BISCHOF, John
发明人： MANUCHEHRABADI, Navid , SHI, Meng , XU, Feng , LU, Tj , BISCHOF, John
IPC分类号： A01N1/02 , A01N1/00 , C12N13/00
CPC分类号： A01N1/0284 , A01N1/0268 , C12N13/00
摘要： Compositions and methods for cryoprotecting a biological tissue can involve a cryoprotective agent and a metal component that includes a metal foam, a metal foil, or a metal seed. The method allows the biological tissue to be rewarmed at a rate of at least 100°C/min.
摘要翻译：用于冷冻保护生物组织的组合物和方法可涉及低温保护剂和包含金属泡沫，金属箔或金属种子的金属组分。该方法允许生物组织以至少100℃/分钟的速率复温

5. 发明申请

WO2020068132A1 INTERACTIVE ENVIRONMENTS USING VISUAL COMPUTING AND IMMERSIVE REALITY 审中-公开
公开(公告)号：WO2020068132A1
公开(公告)日：2020-04-02
申请号：PCT/US2018/053644
申请日：2018-09-28
申请人： YANG, Shao-Wen , SANJAY, Addicam V. , VEERAMANI, Karthik , SILVA, Gabriel L. , DA SILVA, Marcos P. , AVALOS, Jose A. , PALERMO, Stephen T. , ANDERSON, Glen J. , SHI, Meng , BAIR, Benjamin W. , DENMAN, Pete A. , BOWES, Reese L. , CHIERICHETTI, Rebecca A. , AGRAWAL, Ankur , MRUTUNJAYYA, Mrutunjayya , ROGERS, Gerald A. , CHIEN, Shih-Wei Roger , DURHAM, Lenitra M. , RAFFA, Giuseppe , LIEW, Irene , VERPLANKE, Edwin
发明人： YANG, Shao-Wen , SANJAY, Addicam V. , VEERAMANI, Karthik , SILVA, Gabriel L. , DA SILVA, Marcos P. , AVALOS, Jose A. , PALERMO, Stephen T. , ANDERSON, Glen J. , SHI, Meng , BAIR, Benjamin W. , DENMAN, Pete A. , BOWES, Reese L. , CHIERICHETTI, Rebecca A. , AGRAWAL, Ankur , MRUTUNJAYYA, Mrutunjayya , ROGERS, Gerald A. , CHIEN, Shih-Wei Roger , DURHAM, Lenitra M. , RAFFA, Giuseppe , LIEW, Irene , VERPLANKE, Edwin
IPC分类号： G06Q50/20 , G06F3/00 , G06F3/01 , G06F3/16
摘要： In one embodiment, an apparatus comprises a memory and a processor. The memory is to store sensor data, wherein the sensor data is captured by a plurality of sensors within an educational environment. The processor is to: access the sensor data captured by the plurality of sensors; identify a student within the educational environment based on the sensor data; detect a plurality of events associated with the student based on the sensor data, wherein each event is indicative of an attention level of the student within the educational environment; generate a report based on the plurality of events associated with the student; and send the report to a third party associated with the student.

6. 发明申请

WO2011088296A1 COMBINED SPACE MAINTENANCE AND BONE REGENERATION SYSTEM FOR THE RECONSTRUCTION OF LARGE OSSEOUS DEFECTS 审中-公开
标题翻译：用于重建大型OSSEOUS缺陷的组合空间维护和骨再生系统
公开(公告)号：WO2011088296A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/021266
申请日：2011-01-14
申请人： WILLIAM MARSH RICE UNIVERSITY , MIKOS, Antonios, G. , WONG, Mark, E. , YOUNG, Simon, W. , KRETLOW, James, D. , SHI, Meng , KASPER, F., Kurtis , SPICER, Patrick
发明人： MIKOS, Antonios, G. , WONG, Mark, E. , YOUNG, Simon, W. , KRETLOW, James, D. , SHI, Meng , KASPER, F., Kurtis , SPICER, Patrick
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/2803 , A61F2210/0085 , A61L27/16 , A61L27/3608 , A61L27/56 , A61L2430/02 , C08L33/12
摘要： Systems, methods and compositions useful for treatment of traumatic bone injuries are provided. In one embodiment, a bone reconstruction system comprising a space maintaining composition comprising porous polymethylmethacrylate; and an osseous generating construct comprising a polymethylmethacrylate chamber that comprises one or more osseous generating materials is provided. Associated compositions and methods are also provided.
摘要翻译：提供了可用于治疗创伤性骨损伤的系统，方法和组合物。在一个实施方案中，一种骨重建系统，包括空间维持组合物，其包含多孔聚甲基丙烯酸甲酯; 并且提供了包含包含一种或多种骨发生材料的聚甲基丙烯酸甲酯室的骨骼产生构建体。还提供了相关的组合物和方法。

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