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1. 发明申请

WO2007065128A3 HUMAN ALPHA-DEFENSINS INHIBIT INTERLEUKIN-1BETA RELEASE 审中-公开
标题翻译：人类免疫缺陷抑制白细胞介素-1BETA释放
公开(公告)号：WO2007065128A3
公开(公告)日：2007-09-13
申请号：PCT/US2006061404
申请日：2006-11-30
申请人： UNIV AUBURN , SHI JISHU , AONO SHELLY , LU WUYUAN
发明人： SHI JISHU , AONO SHELLY , LU WUYUAN
IPC分类号： A61K38/17 , A61P29/00
CPC分类号： A61K38/1709
摘要： Human a-defensins are inhibitors of interleukin-lß post transitional processing and release. Interleukin-lß is a key cytokine involved in the initiation and amplification of the 5 inflammatory process, including the inflammation of diseases such as Crohn's Disease and Ulcerative Colitis. Particularly, human neutrophil defensin-1 (HNP-I) produced mainly by neutrophils, and human a-defensin 5(HD-5) produced by Paneth cells has been found to block interleukin-lß post transitional processing and release. Thus, a pharmaceutical composition and method for treating inflammation in the mammalian tissues is herein disclosed. The pharmaceutical composition is a therapeutic supplementation of a metabolic pathway to reduce inflammation comprising a human a-defensins in a therapeutically effective amount or an amide, ester or salt thereof and a pharmaceutically effective carrier. The method for treating inflammation in mammalian tissues includes administering a human a-defensins to a mammal in an amount effective to inhibit the post translational processing and release of interleukin-lß.
摘要翻译：人类防御素是过渡性加工和释放后白介素-1β的抑制剂。白细胞介素-Iβ是涉及5种炎症过程的引发和扩增的关键细胞因子，包括诸如克罗恩病和溃疡性结肠炎等疾病的炎症。特别是主要由嗜中性粒细胞产生的人嗜中性粒细胞防御素-1（HNP-1），Paneth细胞产生的人α-防御素5（HD-5）已经被发现阻断了过渡性加工和释放后的白细胞介素-β。因此，本文公开了用于治疗哺乳动物组织中的炎症的药物组合物和方法。药物组合物是治疗性补充代谢途径以减少炎症，其包含治疗有效量的人α-防御素或其酰胺，酯或其盐和药学上有效的载体。用于治疗哺乳动物组织炎症的方法包括以有效抑制翻译后加工和释放白细胞介素-β的量向哺乳动物施用人α-防御素。

2. 发明申请

WO2012162637A2 VACCINE ADJUVANTS FROM SELF-ASSEMBLING PEPTIDES 审中-公开
标题翻译：来自自组装肽的疫苗佐剂
公开(公告)号：WO2012162637A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/039642
申请日：2012-05-25
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , SUN, Xiuzhi Susan , SHI, Jishu
发明人： SUN, Xiuzhi Susan , SHI, Jishu
IPC分类号： A61K39/39 , A61K38/17 , A61K38/16 , A61P37/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N2760/16134 , C12N2770/10034
摘要： Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based adjuvants are provided. The peptide adjuvants comprise a peptide having a hydrophobic region, a turning region, and a hydrophilic region. The turning region comprises amino acid residues GSII (SEQ ID NO: 10). The peptide adjuvants can be used to immunopotentiate active agents by improving the immune response to the active agent.
摘要翻译：提供了使用基于肽的佐剂来治疗或保护受试者的病症的药物或兽医组合物，疫苗系统，方法和试剂盒。肽佐剂包含具有疏水区，转转区和亲水区的肽。转向区包含氨基酸残基GSII（SEQ ID NO：10）。肽佐剂可用于通过改善对活性剂的免疫应答来免疫增强活性剂。

3. 发明申请

WO2007065128A2 HUMAN ALPHA-DEFENSINS INHIBIT INTERLEUKIN-1BETA RELEASE 审中-公开
标题翻译：人类α-防御素抑制白细胞介素-1β释放
公开(公告)号：WO2007065128A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/061404
申请日：2006-11-30
申请人： AUBURN UNIVERSITY , SHI, Jishu , AONO, Shelly , LU, Wuyuan
发明人： SHI, Jishu , AONO, Shelly , LU, Wuyuan
IPC分类号： A61K38/17 , A61P29/00
CPC分类号： A61K38/1709
摘要： Human α-defensins are inhibitors of interleukin-lβ post transitional processing and release. Interleukin-lβ is a key cytokine involved in the initiation and amplification of the 5 inflammatory process, including the inflammation of diseases such as Crohn's Disease and Ulcerative Colitis. Particularly, human neutrophil defensin-1 (HNP-I) produced mainly by neutrophils, and human α-defensin 5(HD-5) produced by Paneth cells has been found to block interleukin-lβ post transitional processing and release. Thus, a pharmaceutical composition and method for treating inflammation in the mammalian tissues is herein disclosed. The pharmaceutical composition is a therapeutic supplementation of a metabolic pathway to reduce inflammation comprising a human α-defensins in a therapeutically effective amount or an amide, ester or salt thereof and a pharmaceutically effective carrier. The method for treating inflammation in mammalian tissues includes administering a human α-defensins to a mammal in an amount effective to inhibit the post translational processing and release of interleukin-lβ.
摘要翻译：人α-防御素是白细胞介素-1β过渡后加工和释放的抑制剂。白细胞介素-1β是参与启动和扩增炎性过程的关键细胞因子，包括克罗恩氏病和溃疡性结肠炎等疾病的炎症。特别是，已经发现主要由嗜中性粒细胞产生的人嗜中性粒细胞防御素-1（HNP-1）和由潘氏细胞产生的人α-防御素5（HD-5）阻断白细胞介素-1β在过渡后处理和释放。因此，本文公开了用于治疗哺乳动物组织中的炎症的药物组合物和方法。所述药物组合物是治疗性补充代谢途径以减轻炎症，所述炎症包含治疗有效量的人α-防御素或其酰胺，酯或盐以及药学上有效的载体。用于治疗哺乳动物组织炎症的方法包括以有效抑制白介素-1β的翻译后加工和释放的量向哺乳动物施用人α-防御素。

4. 发明申请

WO2012162637A3 VACCINE ADJUVANTS FROM SELF-ASSEMBLING PEPTIDES 审中-公开
标题翻译：来自自组装肽的疫苗佐剂
公开(公告)号：WO2012162637A3
公开(公告)日：2013-02-28
申请号：PCT/US2012039642
申请日：2012-05-25
申请人： UNIV KANSAS STATE , SUN XIUZHI SUSAN , SHI JISHU
发明人： SUN XIUZHI SUSAN , SHI JISHU
IPC分类号： A61K39/39 , A61K38/16 , A61K38/17 , A61P37/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55516 , A61K2039/55555 , A61K2039/55566 , C12N2760/16134 , C12N2770/10034
摘要： Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based adjuvants are provided. The peptide adjuvants comprise a peptide having a hydrophobic region, a turning region, and a hydrophilic region. The turning region comprises amino acid residues GSII (SEQ ID NO: 10). The peptide adjuvants can be used to immunopotentiate active agents by improving the immune response to the active agent.
摘要翻译：提供了使用基于肽的佐剂来治疗或保护受试者的病症的药物或兽医组合物，疫苗系统，方法和试剂盒。肽佐剂包含具有疏水区，转转区和亲水区的肽。转向区包含氨基酸残基GSII（SEQ ID NO：10）。肽佐剂可用于通过改善对活性剂的免疫应答来免疫增强活性剂。

5. 发明申请

WO1996032129A1 SYNTHETIC PEPTIDES THAT INHIBIT LEUKOCYTE SUPEROXIDE ANION PRODUCTION AND/OR ATTRACT LEUKOCYTES 审中-公开
标题翻译：抑制超氧化物超氧化物阴离子生成和/或诱导白细胞介素的合成肽
公开(公告)号：WO1996032129A1
公开(公告)日：1996-10-17
申请号：PCT/US1996004674
申请日：1996-04-10
申请人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , BLECHA, Frank , SHI, Jishu
发明人： KANSAS STATE UNIVERSITY RESEARCH FOUNDATION
IPC分类号： A61K38/16
CPC分类号： C07K14/4705 , A61K38/00
摘要： Methods of inhibiting leukocyte O2 production and attracting leukocytes using specific peptides are disclosed. These peptides include the proline-arginine (PR)-rich antimicrobial peptide known as PR-39 and truncated analogs thereof. These peptides can be used as medicaments that fight infection by attracting leukocytes to a wound site, yet restrict tissue damage at the wound site caused by excessive oxygen radicals produced by these leukocytes.
摘要翻译：公开了使用特定肽抑制白细胞O 2 - 产生和吸引白细胞的方法。这些肽包括称为PR-39的脯氨酸 - 精氨酸（PR） - 抗菌肽及其截短的类似物。这些肽可以用作通过将白细胞吸引到伤口部位来抵抗感染的药物，但是限制由由这些白细胞产生的过量氧自由基引起的伤口部位的组织损伤。

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