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1. 发明申请

WO2009108689A1 SUGAR GLASSIFIED VIRUS LIKE PARTICLES (VLPS) 审中-公开
标题翻译：糖果玻璃样颗粒（VLPS）
公开(公告)号：WO2009108689A1
公开(公告)日：2009-09-03
申请号：PCT/US2009/035122
申请日：2009-02-25
申请人： NOVAVAX, INC. , SHENOY, Dinesh , ROBINSON, James
发明人： SHENOY, Dinesh , ROBINSON, James
IPC分类号： A61K9/14 , C12N15/00
CPC分类号： A61K9/1623 , A61K9/19 , A61K39/12 , A61K39/39 , A61K47/26 , A61K2039/5258 , A61K2039/55511 , C12N7/00 , C12N2760/16023
摘要： The present invention discloses and claims Virus Like Particles (VLPs) associated with sugar glass for enhancing overall stability of VLPs. These VLPs formulations will reduce the cost and increase the distribution and delivery of VLP based vaccines worldwide. The invention also claims methods of making and delivering said formulation to a patient.
摘要翻译：本发明公开并要求与糖玻璃相关的病毒样颗粒（VLPs），以提高VLP的整体稳定性。这些VLP制剂将降低成本并增加全世界基于VLP的疫苗的分布和递送。本发明还要求将所述制剂制备和递送给患者的方法。

2. 发明申请

WO2009033131A2 MULTI-PHASIC, NANO-STRUCTURED COMPOSITIONS CONTAINING A COMBINATION OF A FIBRATE AND A STATIN 审中-公开
标题翻译：多相组合物，纳米结构组合物包含纤维素和鞣质素的组合
公开(公告)号：WO2009033131A2
公开(公告)日：2009-03-12
申请号：PCT/US2008/075544
申请日：2008-09-08
申请人： NOVAVAX, INC. , SHENOY, Dinesh , LEE, Robert
发明人： SHENOY, Dinesh , LEE, Robert
IPC分类号： A61K31/401
CPC分类号： A61K9/107 , A61K9/0056 , A61K9/0095 , A61K9/10 , A61K9/4866 , A61K31/00 , A61K31/401 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The present invention discloses a pharmaceutical formulation containing a multi-phasic pharmaceutical composition in an oral dosage form. The multi-phasic pharmaceutical composition contains: (a) a fibrate, or a pharmaceutically acceptable salt, ester, hydrate, or prodrug thereof; (b) a statin, or a pharmaceutically acceptable salt, ester, hydrate, or prodrug thereof; (c) a solvent; (d) a non-miscible liquid; (e) a stabilizer; and (f) water. The fibrate or the statin or both is in a particulate state and/or a solubilized state. Such pharmaceutical formulations are capable of reducing the fed/fast variability and improving oral bioavailability to which a number of active pharmaceutical ingredients are susceptible. The pharmaceutical formulations of the invention, therefore are bioequivalent in fed and fasted states and have improved oral bioavailability.
摘要翻译：本发明公开了含有口服剂型的多相药物组合物的药物制剂。多相药物组合物包含：（a）贝特类或其药学上可接受的盐，酯，水合物或前药; （b）他汀类或其药学上可接受的盐，酯，水合物或前药; （c）溶剂; （d）不混溶液体; （e）稳定剂; 和（f）水。贝特类或他汀类或二者均处于颗粒状态和/或溶解状态。这样的药物制剂能够降低进食/快速变异性并改善许多活性药物成分敏感的口服生物利用度。因此，本发明的药物制剂在进食和禁食状态下是生物等效的并且具有改善的口服生物利用度。

3. 发明申请

WO2009033131A3 MULTI-PHASIC, NANO-STRUCTURED COMPOSITIONS CONTAINING A COMBINATION OF A FIBRATE AND A STATIN 审中-公开
标题翻译：含有一种纤维素和一种抗坏血酸的组合的多相纳米结构组合物
公开(公告)号：WO2009033131A3
公开(公告)日：2009-12-30
申请号：PCT/US2008075544
申请日：2008-09-08
申请人： NOVAVAX INC , SHENOY DINESH , LEE ROBERT
发明人： SHENOY DINESH , LEE ROBERT
IPC分类号： A61K9/00
CPC分类号： A61K9/107 , A61K9/0056 , A61K9/0095 , A61K9/10 , A61K9/4866 , A61K31/00 , A61K31/401 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The present invention discloses a pharmaceutical formulation containing a multi-phasic pharmaceutical composition in an oral dosage form. The multi-phasic pharmaceutical composition contains: (a) a fibrate, or a pharmaceutically acceptable salt, ester, hydrate, or prodrug thereof; (b) a statin, or a pharmaceutically acceptable salt, ester, hydrate, or prodrug thereof; (c) a solvent; (d) a non-miscible liquid; (e) a stabilizer; and (f) water. The fibrate or the statin or both is in a particulate state and/or a solubilized state. Such pharmaceutical formulations are capable of reducing the fed/fast variability and improving oral bioavailability to which a number of active pharmaceutical ingredients are susceptible. The pharmaceutical formulations of the invention, therefore are bioequivalent in fed and fasted states and have improved oral bioavailability.
摘要翻译：本发明公开了含有口服剂型的多相药物组合物的药物制剂。多相药物组合物含有：（a）贝特类或其药学上可接受的盐，酯，水合物或前药; （b）他汀或其药学上可接受的盐，酯，水合物或前药; （c）溶剂; （d）不混溶液体; （e）稳定剂; 和（f）水。贝特类药物或他汀类药物或二者均处于颗粒状态和/或溶解状态。这样的药物制剂能够降低喂食/快速变异性并改善许多活性药物成分易感的口服生物利用度。因此，本发明的药物制剂在进食和禁食状态下是生物等效的并具有改善的口服生物利用度。

4. 发明申请

WO2009091894A1 OPHTHALMIC PREPARATIONS 审中-公开
标题翻译：眼科准备
公开(公告)号：WO2009091894A1
公开(公告)日：2009-07-23
申请号：PCT/US2009/031111
申请日：2009-01-15
申请人： NOVAVAX, INC. , LEE, Robert , SHENOY, Dinesh
发明人： LEE, Robert , SHENOY, Dinesh
IPC分类号： A61K9/00 , A61K9/107 , A61P27/02 , A61K38/13 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/44
CPC分类号： A61K9/0048 , A61K9/1075 , A61K38/13 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/44
摘要： The present invention provides ophthalmic formulations containing cyclosporine, methods for preparing the formulation, and methods for using the formulation.
摘要翻译：本发明提供含有环孢菌素的眼用制剂，制备制剂的方法和使用该制剂的方法。

5. 发明申请

WO2007103294A2 NANO-STRUCTURED COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：纳米结构组合物及其制备和使用方法
公开(公告)号：WO2007103294A2
公开(公告)日：2007-09-13
申请号：PCT/US2007005562
申请日：2007-03-06
申请人： NOVAVAX INC , LEE ROBERT , SHENOY DINESH , WRIGHT D CRAIG
发明人： LEE ROBERT , SHENOY DINESH , WRIGHT D CRAIG
IPC分类号： A61K9/107
CPC分类号： A61K9/1075
摘要： The present invention provides a new tri-phasic method for making nanoparticles of poorly soluble active pharmaceutical ingredients
摘要翻译：本发明提供了用于制备难溶性活性药物成分的纳米颗粒的新三相方法

6. 发明申请

WO2008063910A2 METHOD OF PREPARING SOLID DOSAGE FORMS OF MULTI-PHASIC PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：制备多相药物组合物固体剂型的方法
公开(公告)号：WO2008063910A2
公开(公告)日：2008-05-29
申请号：PCT/US2007084141
申请日：2007-11-08
申请人： NOVAVAX INC , SHENOY DINESH , LEE ROBERT , SOPPIMATH KUMARESH , BETAGERI GURU
发明人： SHENOY DINESH , LEE ROBERT , SOPPIMATH KUMARESH , BETAGERI GURU
CPC分类号： A61K9/2077 , A61K9/1075 , A61K9/143 , A61K9/1611
摘要： Pharmaceutical formulations comprising a multi-phasic pharmaceutical composition, and an adsorbent carrier, where the pharmaceutical formulation is a solid dosage form. Methods for preparing such pharmaceutical compositions are described.
摘要翻译：包含多相药物组合物和吸附剂载体的药物制剂，其中药物制剂是固体剂型。描述了制备这种药物组合物的方法。

7. 发明申请

WO2007103294A3 NANOEMULSIONS OF POORLY SOLUBLE PHARMACEUTICAL ACTIVE INGREDIENTS AND METHODS OF MAKING THE SAME 审中-公开
公开(公告)号：WO2007103294A3
公开(公告)日：2007-09-13
申请号：PCT/US2007/005562
申请日：2007-03-06
申请人： NOVAVAX, INC. , LEE, Robert , SHENOY, Dinesh , WRIGHT, D., Craig
发明人： LEE, Robert , SHENOY, Dinesh , WRIGHT, D., Craig
IPC分类号： A61K9/107
摘要： The present invention provides a new tri-phasic method for making nanoparticles of poorly soluble active pharmaceutical ingredients

8. 发明申请

WO2012035480A3 PHARMACEUTICAL COMPOSITIONS OF CURCUMIN 审中-公开
标题翻译：曲霉素的药物组合物
公开(公告)号：WO2012035480A3
公开(公告)日：2012-07-05
申请号：PCT/IB2011053974
申请日：2011-09-12
申请人： CADILA PHARMACEUTICALS LTD , KHAMAR BAKULESH MAFATLAL , GOGIA ASHISH PREMKUMAR , GODA CHIRAG CHANDRAKANT , SHENOY DINESH BALKUNJE , SHRIVASTAVA RAJNEESH RAMESH , PATRAVALE VANDANA BHARAT , MODI INDRAVADAN AMBALAL , LADDHA RITU NITIN , KHAN IMRAN AHMAD
发明人： KHAMAR BAKULESH MAFATLAL , GOGIA ASHISH PREMKUMAR , GODA CHIRAG CHANDRAKANT , SHENOY DINESH BALKUNJE , SHRIVASTAVA RAJNEESH RAMESH , PATRAVALE VANDANA BHARAT , MODI INDRAVADAN AMBALAL , LADDHA RITU NITIN , KHAN IMRAN AHMAD
IPC分类号： A61K31/05 , A61K31/121
CPC分类号： A61K31/12 , A61K9/1075 , A61K31/121 , A61K47/14 , A61K47/44
摘要： The present invention relates to stable liquid pharmaceutical compositions of curcumin or its pharmaceutically acceptable salts or its derivatives with higher curcumin concentration and improved bioavailability without the use of buffer and/or molecular aggregation inhibitor(s). In accordance with present invention the curcumin is in the solubilized form to make a stable liquid pharmaceutical composition.
摘要翻译：本发明涉及姜黄素或其药学上可接受的盐或其衍生物的稳定液体药物组合物，其具有较高的姜黄素浓度和改进的生物利用度，而不使用缓冲剂和/或分子聚集抑制剂。根据本发明，姜黄素是溶解形式，以制备稳定的液体药物组合物。

9. 发明申请

WO2005013035A3 METHOD, SYSTEM, AND PROGRAM PRODUCT FOR AUTOMATICALLY FORMATTING ELECTRONIC MAIL 审中-公开
标题翻译：用于自动格式化电子邮件的方法，系统和程序产品
公开(公告)号：WO2005013035A3
公开(公告)日：2007-01-25
申请号：PCT/US2004021726
申请日：2004-07-08
申请人： ESTATIONER LLC , CURRY JAMES T , SHENOY DINESH A
发明人： CURRY JAMES T , SHENOY DINESH A
IPC分类号： G06F15/16 , G06F20060101 , G06Q10/00
CPC分类号： G06Q10/107
摘要： The concepts discussed herein address a system, method, and computer product by which an e-mail is automatically formatted. An e-mail is sent by an e-mail client (112) and received by a server (114) for processing outbound and inbound e-mail including a SMTP server, POP3/IMAP server, or another server in communication with the SMTP server, POP3/IMAP server, or both. The server receives the e-mail message from the e-mail client and text-parses the received e-mail for identifying an e-mail attribute. Next, the system formats the received e-mail message in accordance with a predetermined format corresponding to the identified e-mail attribute, which is sent to intended recipient(s).
摘要翻译：本文讨论的概念解决了自动格式化电子邮件的系统，方法和计算机产品。电子邮件由电子邮件客户端（112）发送并由服务器（114）接收，用于处理出站和入站电子邮件，包括SMTP服务器，POP3 / IMAP服务器或与SMTP服务器通信的其他服务器，POP3 / IMAP服务器或两者兼容。服务器从电子邮件客户端接收电子邮件，并对接收的电子邮件进行文本解析，以识别电子邮件属性。接下来，系统根据与所识别的电子邮件属性相对应的预定格式来格式化所接收的电子邮件消息，该邮件属性被发送给预定的接收者。

10. 发明申请

WO2005013035A2 METHOD, SYSTEM, AND PROGRAM PRODUCT FOR AUTOMATICALLY FORMATTING ELECTRONIC MAIL 审中-公开
标题翻译：用于自动格式化电子邮件的方法，系统和程序产品
公开(公告)号：WO2005013035A2
公开(公告)日：2005-02-10
申请号：PCT/US2004/021726
申请日：2004-07-08
申请人： CURRY, James, T. , SHENOY, Dinesh, A.
发明人： CURRY, James, T. , SHENOY, Dinesh, A.
IPC分类号： G06F
CPC分类号： G06Q10/107
摘要： The concepts discussed herein address a system, method, and computer product by which gin e-mail is automatically formatted. An e-mail is sent by an e-mail client and received by a server for processing outbound and inbound e-mail including a SMTP server, POP3/IMAP server, or another server in communication with the SMTP server, POP3/IMAP server, or both. The server receives the e-mail message from the e-mail client and text-parses the received e-mail for identifying an e-mail attribute. Next, the system formats the received e-mail message in accordance with a predetermined format corresponding to the identified e-mail attribute, which is sent to intended recipient(s).
摘要翻译：本文讨论的概念解决了自动格式化通用电子邮件的系统，方法和计算机产品。电子邮件由电子邮件客户端发送并由服务器接收，用于处理出站和入站电子邮件，包括SMTP服务器，POP3 / IMAP服务器或与SMTP服务器POP3 / IMAP服务器通信的其他服务器，或两者。服务器从电子邮件客户端接收电子邮件，并对接收的电子邮件进行文本解析，以识别电子邮件属性。接下来，系统根据与所识别的电子邮件属性相对应的预定格式来格式化所接收的电子邮件消息，该邮件属性被发送给预期的接收者。

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