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1. 发明申请

WO2017112741A1 MESOTHELIN CHIMERIC ANTIGEN RECEPTOR (CAR) AND ANTIBODY AGAINST PD-L1 INHIBITOR FOR COMBINED USE IN ANTICANCER THERAPY 审中-公开
标题翻译：中间蛋白嵌合抗原受体（CAR）和抗PD-L1抑制剂联合应用于抗肿瘤治疗
公开(公告)号：WO2017112741A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067957
申请日：2016-12-21
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BROGDON, Jennifer , CHANG, Hwai, Wen , ENGELS, Boris , FREEMAN, Gordon, James , FREY, Gerhard, Johann , MATARAZA, Jennifer, Marie , SINGH, Reshma , SHARPE, Arlene, Helen
发明人： BROGDON, Jennifer , CHANG, Hwai, Wen , ENGELS, Boris , FREEMAN, Gordon, James , FREY, Gerhard, Johann , MATARAZA, Jennifer, Marie , SINGH, Reshma , SHARPE, Arlene, Helen
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/505 , A61K2039/5158 , A61K2039/545
摘要： Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.
摘要翻译：本发明提供用于治疗与间皮素表达相关的疾病的方法的组合物，其包括施用表达对间皮素特异性的嵌合抗原受体（CAR）的细胞与PD-L1抑制剂的组合。 p>

2. 发明申请

WO2017091729A1 COMPOSITIONS AND METHODS FOR MODULATING AN IMMUNE RESPONSE 审中-公开
标题翻译：调节免疫应答的组合物和方法
公开(公告)号：WO2017091729A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063604
申请日：2016-11-23
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SAGE, Peter, T. , SHARPE, Arlene, H.
发明人： SAGE, Peter, T. , SHARPE, Arlene, H.
IPC分类号： A61P37/00 , A61K39/395 , A61K39/00
CPC分类号： A61K39/395 , A61K2039/5158 , A61K2039/55522 , A61K2039/55527 , Y02A50/383 , Y02A50/386 , Y02A50/392 , Y02A50/41 , Y02A50/412
摘要： The invention provides methods of modulating follicular regulatory T (TFR) cell- mediated immune responses and the use of those methods in the treatment of diseases or conditions such as viral, bacterial, pathogenic, or fungal infections or cancer. Such methods provide for boosting of antibody production through the use of IL-21 to overcome TFR cell suppression of antibody production.
摘要翻译：本发明提供了调节滤泡调节T（TFR）细胞介导的免疫应答的方法以及这些方法在治疗疾病或病症如病毒，细菌，致病性或真菌感染或癌症。这些方法通过使用IL-21来克服TFR细胞对抗体产生的抑制，从而提高了抗体产量。

3. 发明申请

WO2015183885A9 METHODS AND COMPOSITIONS FOR PERTURBING GENE EXPRESSION IN HEMATOPOIETIC STEM CELL LINEAGES IN VIVO 审中-公开
标题翻译： VIVO中HEMATOPOIETIC STEM细胞系中表达基因表达的方法和组合
公开(公告)号：WO2015183885A9
公开(公告)日：2016-01-21
申请号：PCT/US2015032573
申请日：2015-05-27
申请人： DANA FARBER CANCER INST INC , HARVARD COLLEGE , HAINING WILLIAM N , SHARPE ARLENE H , GODEC JERNEJ
发明人： HAINING WILLIAM N , SHARPE ARLENE H , GODEC JERNEJ
IPC分类号： C12N5/00 , C12N5/10 , C12N15/86
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2227/105 , A01K2267/025 , A61K35/28 , A61K49/0008 , C12N5/0635 , C12N5/0636 , C12N15/11 , C12N15/86 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2740/15041 , C12N2740/15043 , C12N2840/002 , G01N33/505 , G01N33/5052 , G01N33/5088
摘要： The invention provides methods and compositions for perturbing gene expression in hematopoietic cell lineages in vivo.
摘要翻译：本发明提供用于扰乱体内造血细胞谱系中基因表达的方法和组合物。

4. 发明申请

WO2011082400A3 MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF 审中-公开
标题翻译：免疫抑制剂PD-1的调节剂及其使用方法
公开(公告)号：WO2011082400A3
公开(公告)日：2011-11-03
申请号：PCT/US2011020046
申请日：2011-01-03
申请人： HARVARD COLLEGE , SHARPE ARLENE H , BUTTE MANISH J , OYAMA SHINJI
发明人： SHARPE ARLENE H , BUTTE MANISH J , OYAMA SHINJI
IPC分类号： C07D285/135 , A61K31/433 , A61K31/4412 , A61P31/12 , A61P35/00 , A61P37/00 , C07D213/72 , C07D417/12
CPC分类号： C07D239/42 , C07D213/76
摘要： Disclosed are an assay to identify modulators of the PD-1 :PD-L pathway and PD-1 :PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1 :PD-L pathway such as, for example, autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, immune deficiency, and other immune system-related disorders, are also disclosed.
摘要翻译：公开了用于鉴定PD-1：PD-L途径和PD-1：PD-L途径调节剂（例如其化合物及其药物组合物）的调节剂的测定法。还公开了用于治疗受PD-1：PD-L途径调节影响的疾病的方法，例如自身免疫疾病，炎症性疾病，过敏反应，移植排斥反应，癌症，免疫缺陷和其他免疫系统相关疾病。

5. 发明申请

WO2008060449A2 MICROFLUIDIC DETECTOR 审中-公开
标题翻译：微流体检测器
公开(公告)号：WO2008060449A2
公开(公告)日：2008-05-22
申请号：PCT/US2007023595
申请日：2007-11-09
申请人： HARVARD COLLEGE , BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
发明人： BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/54373 , G01N2333/16 , G01N2333/70503 , G01N2800/24
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.
摘要翻译：提供了用于确定指示疾病状况的分析物的文章和方法。在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

6. 发明申请

WO2006133396A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY 审中-公开
标题翻译：通过抑制编程性细胞死亡1（PD-1）途径治疗不间断感染和癌症的方法和组合物
公开(公告)号：WO2006133396A3
公开(公告)日：2007-08-09
申请号：PCT/US2006022423
申请日：2006-06-08
申请人： DANA FARBER CANCER INST INC , BRIGHAM & WOMENS HOSPITAL , UNIV EMORY , FREEMAN GORDAN , SHARPE ARLENE , DORFMAN DAVID M , AHMED RAFI , BARBER DANIEL , WHERRY E JOHN
发明人： FREEMAN GORDAN , SHARPE ARLENE , DORFMAN DAVID M , AHMED RAFI , BARBER DANIEL , WHERRY E JOHN
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2803 , A61K31/713 , A61K38/1709 , A61K39/39 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K16/2818 , C07K16/2827 , C07K2317/70 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/505 , G01N33/57484 , G01N33/57492 , G01N2800/26
摘要： The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
摘要翻译：本发明提供用于治疗，预防或减少持续感染例如慢性感染，潜伏感染，慢感染和癌症的方法和组合物。本发明的方法和组合物还可用于缓解与这种感染和癌症相关的一种或多种症状。

7. 发明申请

WO2018231339A3 ANTI-PHOSPHOTYROSINYLATED PD-1 ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2018231339A3
公开(公告)日：2018-12-20
申请号：PCT/US2018/028581
申请日：2018-04-20
申请人： DANA-FARBER CANCER INSTITUTE, INC. , BETH ISRAEL DEACONESS MEDICAL CENTER , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , FREEMAN, Gordon J. , BOUSSIOTIS, Vassiliki A. , BU, Xia , JUNEJA, Vikram R. , SHARPE, Arlene H. , PATSOUKIS, Nikolaos , WEAVER, Jessica , STRAUS, Laura
发明人： FREEMAN, Gordon J. , BOUSSIOTIS, Vassiliki A. , BU, Xia , JUNEJA, Vikram R. , SHARPE, Arlene H. , PATSOUKIS, Nikolaos , WEAVER, Jessica , STRAUS, Laura
IPC分类号： C07K16/30 , G01N33/53
摘要： The present invention is based, in part, on the discovery of monoclonal and polyclonal antibodies that specifically bind to phosphorylated PD-1, as well as immunoglobulins, polypeptides, nucleic acids thereof, and methods of using such antibodies for diagnostic, prognostic, and therapeutic purposes.

8. 发明申请

WO2010102278A1 METHODS AND COMPOSITIONS FOR THE GENERATION AND MAINTENANCE OF REGULATORY T CELLS 审中-公开
标题翻译：用于产生和维持调节性T细胞的方法和组合物
公开(公告)号：WO2010102278A1
公开(公告)日：2010-09-10
申请号：PCT/US2010/026498
申请日：2010-03-08
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , SHARPE, Arlene , FRANCISCO, Loise, M. , KUCHROO, Vijay
发明人： SHARPE, Arlene , FRANCISCO, Loise, M. , KUCHROO, Vijay
IPC分类号： A01N65/00
CPC分类号： A61K38/1774 , A61K35/17 , A61K2035/122 , C07K16/2827 , C07K2317/75 , C12N5/0636 , C12N5/0637 , C12N2501/15 , C12N2501/48 , C12N2501/51 , C12N2501/515
摘要： Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.
摘要翻译：提供了用于产生和维持诱导的调节性T细胞（iTreg）的方法和组合物。还提供了用于治疗自身免疫性疾病，器官移植排斥，移植物抗宿主病或过敏性或过敏性和炎症的方法和组合物。

9. 发明申请

WO2008060449A3 MICROFLUIDIC DETECTOR 审中-公开
公开(公告)号：WO2008060449A3
公开(公告)日：2008-05-22
申请号：PCT/US2007/023595
申请日：2007-11-09
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , BUTTE, Manish, J. , WONG, Amy, P. , SHARPE, Arlene, H. , WHITESIDES, George, M.
发明人： BUTTE, Manish, J. , WONG, Amy, P. , SHARPE, Arlene, H. , WHITESIDES, George, M.
IPC分类号： G01N33/543 , G01N33/569
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.

10. 发明申请

WO2006133396A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS 审中-公开
标题翻译：治疗不间断感染的方法和组合
公开(公告)号：WO2006133396A2
公开(公告)日：2006-12-14
申请号：PCT/US2006/022423
申请日：2006-06-08
申请人： DANA-FARBER CANCER INSTITUTE , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , EMORY UNIVERSITY , FREEMON, Gordon , SHARPE, Arlene , DORFMAN, David, M. , AHMED, Rafi , BARBER, Daniel , WHERRY, E., John
发明人： FREEMON, Gordon , SHARPE, Arlene , DORFMAN, David, M. , AHMED, Rafi , BARBER, Daniel , WHERRY, E., John
CPC分类号： C07K16/2803 , A61K31/713 , A61K38/1709 , A61K39/39 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , A61K2039/55566 , A61K2039/572 , C07K16/2818 , C07K16/2827 , C07K2317/70 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , G01N33/5011 , G01N33/505 , G01N33/57484 , G01N33/57492 , G01N2800/26 , Y02A50/412 , Y02A50/467 , Y02A50/58
摘要： The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and cancer. The methods and compositions of the invention are also useful for the alleviation of one or more symptoms associated with such infections and cancer.
摘要翻译：本发明提供用于治疗，预防或减少持续感染例如慢性感染，潜伏感染，慢感染和癌症的方法和组合物。本发明的方法和组合物还可用于缓解与这种感染和癌症相关的一种或多种症状。

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