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1. 发明申请

WO2014106117A3 ANALYTE PERMEABLE MEMBRANE SYSTEMS FOR OXIDATIVE AND OPTICAL STABILITY 审中-公开
标题翻译：分析渗透膜系统的氧化和光稳定性
公开(公告)号：WO2014106117A3
公开(公告)日：2015-07-16
申请号：PCT/US2013078103
申请日：2013-12-27
申请人： SENSEONICS INC
发明人： EMKEN JEREMY , HUFFSTETLER PHILIP , WHITEHURST TODD
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1459 , A61B2562/162
摘要： A sensor that may be used to detect the presence, amount, and/or concentration of an analyte in a medium within an animal. The sensor may include a sensor housing, an indicator element embedded within and/or covering at least a portion of the sensor housing, and a membrane over the indicator element. The membrane may reduce indicator element deterioration by preventing immune cells, such as white blood cells, from contacting the indicator element, substantially prevent transmission of light of at least a specified wavelength or range of wavelengths through the membrane, and/or permit the analyte to pass through to the indicator element. The membrane may be an opaque diffusion membrane. The sensor may include a foil. The foil may block light and/or reduce indicator element deterioration. The membrane may reduce oxidation of the indicator element.
摘要翻译：可用于检测动物中的介质中分析物的存在，量和/或浓度的传感器。传感器可以包括传感器壳体，嵌入在传感器壳体的至少一部分内和/或覆盖传感器壳体的至少一部分的指示器元件以及指示器元件上的膜。膜可以通过防止诸如白细胞的免疫细胞接触指示剂元件来减少指示剂元件的劣化，从而基本上防止透过膜的至少一定波长或波长范围的光的透过，和/或允许分析物传递到指示元素。膜可以是不透明扩散膜。传感器可以包括箔。箔可能阻挡光和/或降低指示元件的劣化。膜可以减少指示元件的氧化。

2. 发明申请

WO2014144514A3 IMPROVED IMPLANTATION AND ANTENNA ORIENTATION OF AN IMPLANTABLE SENSOR 审中-公开
标题翻译：改进的可植入传感器的植入和天线方位
公开(公告)号：WO2014144514A3
公开(公告)日：2014-11-27
申请号：PCT/US2014028956
申请日：2014-03-14
申请人： SENSEONICS INC
发明人： TANKIEWICZ SZYMON , WHITEHURST TODD
IPC分类号： H04B1/44
CPC分类号： A61B5/686 , A61B5/0015 , A61B5/0031 , A61B5/076 , A61B5/14532 , A61B5/14546 , A61B5/1459
摘要： A sensor system including an implantable sensor and an external transceiver. Aspects of the sensor system may provide improved implantation and antenna orientation of the implanted sensor. The sensor may include a sensor antenna, the transceiver may include a transceiver antenna. In some embodiments, the sensor antenna and/or transceiver antenna may include a first set of coils oriented in a first plane and a second set of coils oriented in a second plane that is different than the first plane. In some embodiments, the sensor may have a geometry that will prevent or reduce movement and/or rotation of the implanted sensor. For instance, in some embodiments, the sensor may be enclosed in silicon that contains antenna coils and/or include wings, a fluid filled sack, a swelling material, an expansion material, and/or arms.
摘要翻译：包括可植入传感器和外部收发器的传感器系统。传感器系统的方面可以提供植入式传感器的改进的植入和天线取向。传感器可以包括传感器天线，收发器可以包括收发器天线。在一些实施例中，传感器天线和/或收发器天线可以包括在第一平面中定向的第一组线圈和在与第一平面不同的第二平面中定向的第二组线圈。在一些实施例中，传感器可以具有将阻止或减少植入的传感器的移动和/或旋转的几何形状。例如，在一些实施例中，传感器可以封装在含有天线线圈和/或包括翼，流体填充的袋，膨胀材料，膨胀材料和/或臂的硅中。

3. 发明申请

WO2012125814A3 INTEGRATED CATALYTIC PROTECTION OF OXIDATION SENSITIVE MATERIALS 审中-公开
标题翻译：氧化敏感材料的综合催化保护
公开(公告)号：WO2012125814A3
公开(公告)日：2013-12-27
申请号：PCT/US2012029209
申请日：2012-03-15
申请人： SENSEONICS INC , COLVIN ARTHUR E JR , JIANG HUI
发明人： COLVIN ARTHUR E JR , JIANG HUI
IPC分类号： A61B5/1459
CPC分类号： A61B5/076 , A61B5/145 , A61B5/14532 , A61B5/1459 , A61B2562/028 , A61B2562/162 , A61B2562/18
摘要： An implantable device with in vivo functionality, where the functionality of the device is negatively affected by ROS typically associated with inflammation reaction as well as chronic foreign body response as a result of tissue injury, is at least partially surrounded by a protective material, structure, and/or a coating that prevents damage to the device from any inflammation reactions. The protective material, structure, and/or coating is a biocompatible metal, preferably silver, platinum, palladium, gold, manganese, or alloys or oxides thereof that decomposes reactive oxygen species (ROS), such as hydrogen peroxide, and prevents ROS from oxidizing molecules on the surface of or within the device. The protective material, structure, and/or coating thereby prevents ROS from degrading the in vivo functionality of the implantable device.
摘要翻译：具有体内功能性的可植入装置，其中器官的功能受到通常与炎症反应相关的ROS以及由于组织损伤导致的慢性异物反应的不利影响，至少部分被保护材料，结构，和/或防止装置受到任何炎症反应的损伤的涂层。保护材料，结构和/或涂层是分解活性氧（ROS）（例如过氧化氢）并防止ROS氧化的生物相容性金属，优选银，铂，钯，金，锰或其合金或氧化物器件表面或器件内的分子。保护材料，结构和/或涂层从而防止ROS降解可植入装置的体内功能。

4. 发明申请

WO2013119951A3 DIGITAL ASIC SENSOR PLATFORM 审中-公开
标题翻译：数字ASIC传感器平台
公开(公告)号：WO2013119951A3
公开(公告)日：2015-06-18
申请号：PCT/US2013025346
申请日：2013-02-08
申请人： SENSEONICS INC
发明人： DEHENNIS ANDREW , COLVIN ARTHUR E
IPC分类号： A61B5/145
CPC分类号： A61B5/1455 , A61B5/0031 , A61B5/076 , A61B5/1451 , A61B5/14532 , A61B5/14551 , A61B5/14552 , A61B5/14556 , A61B5/1459 , A61B5/6861 , A61B5/7225
摘要： The present invention relates to an optical sensor that may be implanted within a living animal (e.g., a human) and may be used to measure the concentration of an analyte in a medium within the animal. The optical sensor may wirelessly receive and may be capable of bi-directional data communication. The optical sensor may include a semiconductor substrate in which various circuit components, one or more photodectors and/or a light source may be fabricated. The circuit components fabricated in the semiconductor substrate may include a comparator, an analog to digital converter, a temperature transducer, a measurement controller, a rectifier and/or a nonvolatile storage medium. The comparator may output a signal indicative of the difference between the outputs of first and second photodetectors. The measurement controller may receive digitized temperature, photodetector and/or comparator measurements and generate measurement information, which may be wirelessly transmitted from the optical sensor.
摘要翻译：本发明涉及一种可以植入活体动物（例如人）中的光学传感器，并可用于测量动物中介质中分析物的浓度。光学传感器可以无线地接收并且可能能够进行双向数据通信。光学传感器可以包括其中可以制造各种电路部件，一个或多个光电探测器和/或光源的半导体衬底。制造在半导体衬底中的电路部件可以包括比较器，模数转换器，温度传感器，测量控制器，整流器和/或非易失性存储介质。比较器可以输出指示第一和第二光电检测器的输出之间的差的信号。测量控制器可以接收数字化的温度，光电检测器和/或比较器测量并产生可以从光学传感器无线传输的测量信息。

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