会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 4. 发明申请
    • IDENTIFICATION OF ANTIGEN EPITOPES
    • IDENTIFYING抗原位
    • WO2004078909A2
    • 2004-09-16
    • PCT/EP2004002170
    • 2004-03-03
    • FRAUNHOFER GES FORSCHUNGBRUNNER HERWIGTOVAR GUENTERSCHIESTEL THOMASMUELLER CLAUDIA AFLAD THOMAS
    • BRUNNER HERWIGTOVAR GUENTERSCHIESTEL THOMASMUELLER CLAUDIA AFLAD THOMAS
    • A61K39/00B82B1/00C07K16/18C12N20060101C12N5/00C12N15/63G01N33/50G01N33/53G01N33/543G01N33/68C12N
    • G01N33/543G01N33/6893
    • The invention relates to methods for the identification and/or for detection of T-cell-epitopes of a protein antigen, methods for the production of peptide vaccines against a protein antigen, methods for the quality control of receptor ligand complexes and/or components thereof, methods for the production of nanoparticles comprising at least one immobilised receptor unit or an immobilised receptor, methods for the production of nanoparticles comprising immobilised receptor ligand complexes, especially MHC molecules comprising a peptide, methods for the enrichment of and/or isolation of specific CD4 -T- or CD8 -T-lymphocytes from peripheral mononuclear blood cells, methods for the priming a CD8 -T-lymphocyte reaction in vitro, nanoparticle having an immobilised receptor unit, especially an immobilised chain of an MHC-molecule, nanoparticles having an immobilised receptor, especially an immobilised MHC-molecule, nanoparticles having an immobilised receptor ligand complex, especially an MHC molecule comprising a peptide, a peptide vaccine, a kit for the identification and/or detection of T-cell epitopes of a protein antigen, and the use of nanoparticles in the identification and/or detection of T-cell epitopes, for the production of peptide vaccines in order to enrich and/or isolate specific T-lymphocytes and for priming a CD8 -T-lymphocyte reaction in vitro.
    • 本发明涉及用于鉴定和/或检测蛋白质抗原的T细胞表位,方法用于制备针对蛋白质抗原肽疫苗,对于受体 - 配体复合物和/或它们的组件的质量控制方法的 用于制备纳米颗粒与至少一个固定的受体单元或固定化受体的方法,制备纳米颗粒的方法具有固定化受体 - 配体复合物,在特定的肽呈递MHC分子,特异性CD4的富集和/或分离<+处理 > -T-或CD8 <+> - 从外周血单核细胞的T淋巴细胞,用于引发方法的CD8 <+> - 体外T-淋巴细胞反应,与固定化的受体单元的纳米粒子,特别是固定在MHC的链 分子,纳米颗粒有固定受体,特别是固定化的MHC分子 ,纳米颗粒有固定受体 - 配体复合物,特别是肽提呈MHC分子,肽疫苗,用于鉴定和/或检测蛋白质抗原的T细胞表位的试剂盒,以及使用纳米颗粒的 用于鉴定和/或检测T细胞表位,用于生产肽疫苗的,对于特定的T淋巴细胞的富集和/或分离,以及用于灌注CD8 <+> - 体外T-淋巴细胞反应。