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    • 7. 发明申请
    • METHODS AND COMPOSITIONS FOR UPREGULATION OF PEROXIREDOXIN ACTIVITY
    • 过氧化物酶活性升高的方法和组合物
    • WO2008036835A2
    • 2008-03-27
    • PCT/US2007079068
    • 2007-09-20
    • REDDY US THERAPEUTICSKHANNA ISHPILLARISETTI RAMSAXENA UDAY
    • KHANNA ISHPILLARISETTI RAMSAXENA UDAY
    • A61K31/47
    • C12Q1/28G01N33/92G01N2500/10G01N2800/044
    • A novel method of identifying compounds capable of upregulating Peroxiredoxin activity is disclosed. The method includes providing a sample of cells that express Peroxiredoxin, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of Peroxiredoxin activity within the cell sample after the contacting step. Peroxiredoxin inducers identified by the method and uses therefore to upregulate Peroxiredoxin activity in subjects and to reduce LDL and/or VLDL levels and to prevent or treat atherosclerosis and inflammatory disorders such as arthritis in subjects are also described. The invention also provides a method of treatment of inflammatory and cardiovascular diseases which comprises providing a patient in need of treatment with an effective amount of a composition that increases Peroxiredoxin protein or activity.
    • 公开了鉴定能够上调过氧化还原毒素活性的化合物的新方法。 该方法包括提供表达过氧化还原毒素的细胞样品,提供候选化合物样品,接触细胞样品和化合物样品,以及在接触步骤后测量细胞样品内过氧化还原毒素活性的定量指标。 本文还描述了通过该方法和用途鉴定的过氧化还原毒素诱导剂,以上调受试者中的过氧化还原毒素活性并降低LDL和/或VLDL水平,并预防或治疗动脉粥样硬化和炎症性疾病如受试者中的关节炎。 本发明还提供了一种治疗炎性和心血管疾病的方法,其包括提供需要治疗的患者,所述治疗有效量的增加过氧化还原蛋白或活性的组合物。