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    • 1. 发明申请
    • BENZOPYRAN DERIVATIVES
    • BENZOPYRAN衍生物
    • WO1996034871A1
    • 1996-11-07
    • PCT/JP1996001180
    • 1996-04-30
    • NISSAN CHEMICAL INDUSTRIES, LTD.TANIKAWA, KeizoOHRAI, KazuhikoSATO, MasayukiHORIUCHI, TakashiYAMASHITA, Toru
    • NISSAN CHEMICAL INDUSTRIES, LTD.
    • C07D498/04
    • C07D498/04
    • Benzopyran derivatives of formula (I), wherein X and X are absent or represent an oxygen atom; X represents an oxygen atom, a sulfur atom, a nitrogen atom (said nitrogen atom is unsubstituted or substituted by a hydrogen atom or C1-C4 alkyl group), carbonyl or thiocarbonyl; A represents a hydroxyl group or may form a single bond together with B; B represents a hydrogen atom or may form a single bond together with A; Y represents 1-pyrrolyl group, 1-pyrazolyl group, 1-imidazolyl group, 1-(1,2,3-triazolyl) group or 1-(1,2,4-triazolyl) group which is unsubstituted or substituted by R ; R and R independently represent a hydrogen atom, a phenyl group or a C1-C4 alkyl group; R represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group and medicines for treating cardiac insufficiency containing said compound as an active ingredient. The compounds have a strong activity of reinforcing the contraction of cardiac muscles and a strong activity of reducing the heart rate. As the compounds are not toxic, they are useful medicines for treating cardiac insufficiency.
    • 式(I)的苯并吡喃衍生物,其中X 1和X 2不存在或表示氧原子; X表示氧原子,硫原子,氮原子(所述氮原子未被取代或被氢原子或C1-C4烷基取代),羰基或硫代羰基; A表示羟基或可与B一起形成单键; B代表氢原子或与A形成单键; Y表示未取代或被R 1取代的1-吡咯基,1-吡唑基,1-咪唑基,1-(1,2,3-三唑基)或1-(1,2,4-三唑基) 3>; R 1和R 2独立地表示氢原子,苯基或C 1 -C 4烷基; R 3表示氢原子,卤素原子,C 1 -C 6烷基和用于治疗含有所述化合物作为有效成分的心功能不全的药物。 这些化合物具有强化心肌收缩的活性和降低心率的强烈活性。 由于化合物没有毒性,它们是治疗心功能不全的有用药物。
    • 4. 发明申请
    • SEMICONDUCTOR INTEGRATED CIRCUIT
    • 半导体集成电路
    • WO2005008893A8
    • 2007-06-21
    • PCT/JP0309030
    • 2003-07-16
    • INNOTECH CORPSATO MASAYUKI
    • SATO MASAYUKI
    • H03K19/173G11C7/10H03K19/177
    • H03K19/1776G11C7/1075
    • A semiconductor integrated circuit is formed by a plurality of memory blocks (11). Each of the memory blocks (11) are surrounded by four sides (12a to 12d). Address input terminals (A0 to A11) and data I/O terminals (D0 to D11) are provided for each side. When two adjacent memory blocks (11) are a first and a second memory block (11), the address input terminals (A0 to A2) arranged on the side (12a) of the first memory block are respectively connected to the data I/O terminals (D8 to D6) of the opposing side of the second memory block (11). The data I/O terminals (D0 to D2) arranged on the side (12a) of the first memory block (11) are respectively connected to the address input terminals (A8 to A6) of the opposing side of the second memory block (11). Each memory block (11) constitutes a flexible variable logical cell. A desired logical circuit is formed by these variable logical cells.
    • 半导体集成电路由多个存储块(11)形成。 每个存储块(11)被四边(12a至12d)包围。 地址输入端子(A0至A11)和数据I / O端子(D0至D11)均为每侧提供。 当两个相邻的存储器块(11)是第一和第二存储器块(11)时,布置在第一存储器块的侧面(12a)上的地址输入端子(A0至A2)分别连接到数据I / O 第二存储块(11)的相对侧的端子(D8至D6)。 布置在第一存储块(11)的侧面(12a)上的数据I / O端子(D0至D2)分别连接到第二存储器块(11)的相对侧的地址输入端子(A8至A6) )。 每个存储器块(11)构成灵活的可变逻辑单元。 由这些可变逻辑单元形成期望的逻辑电路。
    • 5. 发明申请
    • CHROMAN DERIVATIVES
    • WO1998004542A1
    • 1998-02-05
    • PCT/JP1997002583
    • 1997-07-25
    • NISSAN CHEMICAL INDUSTRIES, LTD.TANIKAWA, KeizoOHRAI, KazuhikoSATO, MasayukiYAMASHITA, ToruYANAGIHARA, Kazufumi
    • NISSAN CHEMICAL INDUSTRIES, LTD.
    • C07D311/70
    • C07D405/04C07D311/70C07D405/12C07D407/12C07D409/12C07F7/1804
    • The present invention relates to chroman derivatives of formula (I): wherein R represents a hydrogen atom, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, a C3-6 alkoxymethyl group, etc.; R and R each independently represent a hydrogen atom, a C1-6 alkyl group, etc.; R represents a hydroxyl group or a C1-6 alkylcarbonyloxyl group or forms a bond together with R ; R represents a hydrogen atom or forms a bond together with R ; R and R each independently represent a hydrogen atom, a C1-6 alkyl group, a C3-6 cycloalkyl group, a phenyl group, etc.; n is 0 or an integer of 1, 2, 3, or 4; W represents a phenyl group, etc.; X represents C=O, CH2, SO2, etc.; Y represents NR (in which R represents a hydrogen atom, a C1-4 alkyl group, a phenyl group, etc.), etc.; Z does not exist or represents CH2 or NR (R represents a hydrogen atom, a C1-4 alkyl group, or a phenyl group, etc.) or their salts.
    • 本发明涉及式(I)的苯并二氢吡喃衍生物:其中R 1表示氢原子,卤素原子,C 1-6烷基,C 1-6烷氧基,C 3-6烷氧基甲基等。 ; R 3和R 4各自独立地表示氢原子,C 1-6烷基等; R 5代表羟基或C 1-6烷基羰基氧基或与R 5一起形成键; R 6表示氢原子或与R 5一起形成键; R 7和R 8各自独立地表示氢原子,C 1-6烷基,C 3-6环烷基,苯基等; n为0或1,2,3或4的整数; W表示苯基等; X表示C = O,CH 2,SO 2等; Y表示NR 17(其中R 17表示氢原子,C 1-4烷基,苯基等)等; Z不存在或表示CH 2或NR 18(R 18表示氢原子,C 1-4烷基或苯基等)或其盐。
    • 10. 发明申请
    • THERAPEUTIC AGENT FOR CARDIAC FAILURE
    • 治疗失败的治疗剂
    • WO1997023209A1
    • 1997-07-03
    • PCT/JP1996003761
    • 1996-12-24
    • NISSAN CHEMICAL INDUSTRIES, LTD.TANIKAWA, KeizoOHRAI, KazuhikoSATO, MasayukiYAMASHITA, Toru
    • NISSAN CHEMICAL INDUSTRIES, LTD.
    • A61K31/35
    • C07D311/68A61K31/353A61K31/397A61K31/4025A61K31/453A61K31/55
    • A therapeutic agent for cardiac failure comprising as the active ingredient either a benzopyran derivative represented by general formula (I) or a pharmacologically acceptable salt thereof, wherein R and R each independently represent hydrogen, halogeno, nitro, cyano, amino, C1-6 alkylcarbonylamino, etc.; R and R each independently represents hydrogen, C1-6 alkyl, or phenyl, or R and R are bonded together to form C3-6 cycloalkyl in cooperation with the carbon atom bonded thereto; R represents hydroxy, C1-6 alkoxy, or C1-6 alkylcarbonyloxy, or R is bonded to R to form a bond; R represents hydrogen, or R is bonded to R to form a bond; and R and R each independently represent hydrogen or C1-6 alkyl, or R and R are bonded together to form pyrrolidinyl, imidazolidinyl, pyrazolidinyl, piperidyl, piperazinyl, etc. in cooperation with the nitrogen atom bonded thereto, or R and R are bonded together to form, in cooperation with the nitrogen atom bonded thereto, pyrrole ring optionally substituted with R (where R has the same meaning as R ).
    • 一种用于心力衰竭的治疗剂,其包含作为活性成分的通式(I)表示的苯并吡喃衍生物或其药理学上可接受的盐,其中R 1和R 2各自独立地表示氢,卤素,硝基,氰基, 氨基,C 1-6烷基羰基氨基等; R 3和R 4各自独立地表示氢,C 1-6烷基或苯基,或者R 3和R 4与键合的碳原子一起形成C 3-6环烷基; R 5表示羟基,C 1-6烷氧基或C 1-6烷基羰基氧基,或R 5与R 6结合形成键; R 6表示氢,或R 6与R 5键合形成键; R 7和R 8各自独立地表示氢或C 1-6烷基,或者R 7和R 8结合在一起形成吡咯烷基,咪唑烷基,吡唑烷基,哌啶基,哌嗪基等,与 与其键合的氮原子或R 7和R 8键合在一起,以与其键合的氮原子一起形成任选被R 9取代的吡咯环(其中R 9具有相同的含义 作为R 1)。