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1. 发明申请

WO02102985B1 PATE, A GENE EXPRESSED IN PROSTATE CANCER, PROSTATE AND TESTIS, AND USES THEREOF 审中-公开
标题翻译： PATE，在前列腺癌，前列腺癌和TESTIS中表达的基因及其用途
公开(公告)号：WO02102985B1
公开(公告)日：2004-05-27
申请号：PCT/US0219086
申请日：2002-06-14
申请人： US GOV HEALTH & HUMAN SERV , PASTAN IRA H , BERA TAPAN K , SALVATORE GUILIANA , VINCENT JAMES , LEE BYUNGKOOK
发明人： PASTAN IRA H , BERA TAPAN K , SALVATORE GUILIANA , VINCENT JAMES , LEE BYUNGKOOK
IPC分类号： C07K16/30 , C07K16/00 , G01N33/53
CPC分类号： C07K16/3069 , A61K2039/505
摘要： An antibody is disclosed that specifically binds a PATE polypeptide. A nucleic acid sequence is disclosed that includes a PATE promoter or a conservative variant thereof. Methods are also disclosed for detecting prostate cancer in a subject. In one embodiment, a method is disclosed for producing an immune response against a cell expressing a PATE polypeptide in a subject. In another embodiment, a method is disclosed for inhibiting the growth of a malignant cell expressing a PATE polypeptide. A method is also disclosed for reducing the number of prostate cancer cells in a subject that includes administering to the subject a therapeutically effective amount of the PATE polypeptide or a polynucleotide encoding the PATE polypeptide. Kits for detecting PATE polypeptides and PATE polynucleotides are disclosed. In one embodiment, these kits are ofuse to detect prostate cancer. A method is also disclosed for increasing the proliferation of a prostate cell. The method includes contacting the prostate cell with a PATE polypeptide or transfecting the prostate cell with a nucleic acid encoding the P ATE polypeptide, thereby increasing the proliferation of the prostate cell.
摘要翻译：公开了特异性结合PATE多肽的抗体。公开了包含PATE启动子或其保守变体的核酸序列。还公开了用于检测受试者中前列腺癌的方法。在一个实施方案中，公开了用于产生针对受试者中表达PATE多肽的细胞的免疫应答的方法。在另一个实施方案中，公开了抑制表达PATE多肽的恶性细胞生长的方法。还公开了一种减少受试者中前列腺癌细胞数量的方法，其包括向受试者施用治疗有效量的PATE多肽或编码PATE多肽的多核苷酸。公开了用于检测PATE多肽和PATE多核苷酸的试剂盒。在一个实施方案中，这些试剂盒可用于检测前列腺癌。还公开了用于增加前列腺细胞增殖的方法。该方法包括使前列腺细胞与PATE多肽接触或用编码P ATE多肽的核酸转染前列腺细胞，从而增加前列腺细胞的增殖。

2. 发明申请

WO2002102985A2 PATE, A GENE EXPRESSED IN PROSTATE CANCER, PROSTATE AND TESTIS, AND USES THEREOF 审中-公开
标题翻译： PATE，在前列腺癌，前列腺癌和TESTIS中表达的基因及其用途
公开(公告)号：WO2002102985A2
公开(公告)日：2002-12-27
申请号：PCT/US2002/019086
申请日：2002-06-14
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
IPC分类号： C12N
CPC分类号： C07K16/3069 , A61K2039/505
摘要： An antibody is disclosed that specifically binds a PATE polypeptide. A nucleic acid sequence is disclosed that includes a PATE promoter or a conservative variant thereof. Methods are also disclosed for detecting prostate cancer in a subject. In one embodiment, a method is disclosed for producing an immune response against a cell expressing a PATE polypeptide in a subject. In another embodiment, a method is disclosed for inhibiting the growth of a malignant cell expressing a PATE polypeptide. A method is also disclosed for reducing the number of prostate cancer cells in a subject that includes administering to the subject a therapeutically effective amount of the PATE polypeptide or a polynucleotide encoding the PATE polypeptide. Kits for detecting PATE polypeptides and PATE polynucleotides are disclosed. In one embodiment, these kits are ofuse to detect prostate cancer. A method is also disclosed for increasing the proliferation of a prostate cell. The method includes contacting the prostate cell with a PATE polypeptide or transfecting the prostate cell with a nucleic acid encoding the P ATE polypeptide, thereby increasing the proliferation of the prostate cell.
摘要翻译：公开了特异性结合PATE多肽的抗体。公开了包含PATE启动子或其保守变体的核酸序列。还公开了用于检测受试者中前列腺癌的方法。在一个实施方案中，公开了用于产生针对受试者中表达PATE多肽的细胞的免疫应答的方法。在另一个实施方案中，公开了抑制表达PATE多肽的恶性细胞生长的方法。还公开了一种减少受试者中前列腺癌细胞数量的方法，其包括向受试者施用治疗有效量的PATE多肽或编码PATE多肽的多核苷酸。公开了用于检测PATE多肽和PATE多核苷酸的试剂盒。在一个实施方案中，这些试剂盒可用于检测前列腺癌。还公开了用于增加前列腺细胞增殖的方法。该方法包括使前列腺细胞与PATE多肽接触或用编码P ATE多肽的核酸转染前列腺细胞，从而增加前列腺细胞的增殖。

3. 发明申请

WO2002102985A3 PATE, A GENE EXPRESSED IN PROSTATE CANCER, PROSTATE AND TESTIS, AND USES THEREOF 审中-公开
公开(公告)号：WO2002102985A3
公开(公告)日：2002-12-27
申请号：PCT/US2002/019086
申请日：2002-06-14
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
发明人： PASTAN, Ira, H. , BERA, Tapan, K. , SALVATORE, Guiliana , VINCENT, James , LEE, Byungkook
IPC分类号： C07K16/00
摘要： An antibody is disclosed that specifically binds a PATE polypeptide. A nucleic acid sequence is disclosed that includes a PATE promoter or a conservative variant thereof. Methods are also disclosed for detecting prostate cancer in a subject. In one embodiment, a method is disclosed for producing an immune response against a cell expressing a PATE polypeptide in a subject. In another embodiment, a method is disclosed for inhibiting the growth of a malignant cell expressing a PATE polypeptide. A method is also disclosed for reducing the number of prostate cancer cells in a subject that includes administering to the subject a therapeutically effective amount of the PATE polypeptide or a polynucleotide encoding the PATE polypeptide. Kits for detecting PATE polypeptides and PATE polynucleotides are disclosed. In one embodiment, these kits are ofuse to detect prostate cancer. A method is also disclosed for increasing the proliferation of a prostate cell. The method includes contacting the prostate cell with a PATE polypeptide or transfecting the prostate cell with a nucleic acid encoding the P ATE polypeptide, thereby increasing the proliferation of the prostate cell.

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