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1. 发明申请

WO2008094516A3 MULTI-TARGETING SHORT INTERFERING RNAS 审中-公开
标题翻译：多目标短暂干扰RNAS
公开(公告)号：WO2008094516A3
公开(公告)日：2008-11-13
申请号：PCT/US2008001111
申请日：2008-01-29
申请人： HOPE CITY , ROSSI JOHN J , SNOEVE OLA , SAETROM PAAL , EHSANI ALI , HOEHN BRITTA
发明人： ROSSI JOHN J , SNOEVE OLA , SAETROM PAAL , EHSANI ALI , HOEHN BRITTA
IPC分类号： C07H21/04 , A61K48/00
CPC分类号： G06F19/18 , C12N15/111 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N15/1138 , C12N2310/14 , C12N2310/51 , C12N2310/53 , C12N2320/30 , C40B30/02 , G06F19/22
摘要： The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.
摘要翻译：本发明涉及多靶向的新型短干扰RNA（siRNA）分子。更具体地，本发明涉及靶向两个或更多个序列的siRNA分子。在一个实施方案中，多靶向siRNA分子被设计为结合siRNA分子的特征和微RNA（miRNA）分子的特征。在另一个实施方案中，设计多靶向siRNA分子，使得每条链被引导到分离的靶。

2. 发明申请

WO2011161460A3 RNA MOLECULES AND USES THEREOF 审中-公开
标题翻译： RNA分子及其用途
公开(公告)号：WO2011161460A3
公开(公告)日：2012-02-16
申请号：PCT/GB2011051185
申请日：2011-06-23
申请人： MINA THERAPEUTICS LTD , SAETROM PAAL
发明人： SAETROM PAAL
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N15/111 , C12N15/67 , C12N2310/11 , C12N2310/111 , C12N2310/14 , C12N2330/10
摘要： The invention relates to a method of designing a short RNA molecule to increase the expression of a target gene in a cell through the down-regulation of a non-coding RNA transcript, said method comprising the steps of: a) obtaining the nucleotide sequence of the coding strand of the target gene, at least between 200 nucleotides upstream of the gene's transcription start site and 200 nucleotides downstream of the gene's transcription start site; b) determining the reverse complementary RNA sequence to the nucleotide sequence determined in step a); and c) designing a short RNA molecule which is the reverse complement or has at least 80% sequence identity with the reverse complement of a region of the sequence determined in step b); wherein said method does not include a step in which the existence of said non- coding RNA transcript is determined; as well as to such short RNA molecules and uses thereof.
摘要翻译：本发明涉及通过下调非编码RNA转录物来设计短RNA分子以增加细胞中靶基因表达的方法，所述方法包括以下步骤：a）获得目标基因的编码链，至少在基因的转录起始位点上游200个核苷酸和基因转录起始位点下游的200个核苷酸之间; b）确定在步骤a）中确定的核苷酸序列的反向互补RNA序列; 和c）设计作为反向互补序列或与步骤b）中确定的序列的区域的反向互补序列具有至少80％序列同一性的短RNA分子; 其中所述方法不包括确定所述非编码RNA转录物的存在的步骤; 以及这样的短RNA分子及其用途。

3. 发明申请

WO2008094516A8 MULTI-TARGETING SHORT INTERFERING RNAS 审中-公开
标题翻译：多目标短暂干扰RNAS
公开(公告)号：WO2008094516A8
公开(公告)日：2009-07-30
申请号：PCT/US2008001111
申请日：2008-01-29
申请人： HOPE CITY , ROSSI JOHN J , SNOEVE OLA , SAETROM PAAL , EHSANI ALI , HOEHN BRITTA
发明人： ROSSI JOHN J , SNOEVE OLA , SAETROM PAAL , EHSANI ALI , HOEHN BRITTA
IPC分类号： C07H21/04 , A61K48/00
CPC分类号： G06F19/18 , C12N15/111 , C12N15/113 , C12N15/1132 , C12N15/1135 , C12N15/1138 , C12N2310/14 , C12N2310/51 , C12N2310/53 , C12N2320/30 , C40B30/02 , G06F19/22
摘要： The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.
摘要翻译：本发明涉及多靶向的新型短干扰RNA（siRNA）分子。更具体地，本发明涉及靶向两个或更多个序列的siRNA分子。在一个实施方案中，多靶向siRNA分子被设计为结合siRNA分子的特征和微RNA（miRNA）分子的特征。在另一个实施方案中，设计多靶向siRNA分子，使得每条链被引导到分离的靶。

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