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1. 发明申请

WO2008097967A2 SELF-ORIENTATING SUTURE WOUND CLOSURE DEVICE 审中-公开
标题翻译：自立式闭合闭合装置
公开(公告)号：WO2008097967A2
公开(公告)日：2008-08-14
申请号：PCT/US2008/053046
申请日：2008-02-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
发明人： DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
IPC分类号： A61B17/00 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/047 , A61B2017/0472 , A61B2017/3484 , A61B2090/067 , A61B2090/0811
摘要： A device is disclosed foi providing an indication as to the relative position of a vessel or aiteiy opening thereby facilitating the choice of which suturing or plugging technique to thereafter use. A disclosed device includes an outei tube and a collapsible foot slidably disposed within a distal end of the outei tube The foot is connected to a shaft that passes through the tube and exits a proximal end thereof The device may further include one or more threaded suture needles, a biodegradable plug or1 other wound closing device that is connected to another shaft The collapsed or1 folded foot is pushed distally out of the tube and through the opening in the vessel whereupon the foot expands Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out The shaft connected to the foot is preferably connected to an indicator that indicates to the operator or physician that the vessel opening is in one of three positions on the vessel - left, top or right As an alternative, the indicator bar may indicate a relative position in degrees, mm ot μm in deviation from a top stick (or1 top position)
摘要翻译：公开了一种提供关于容器的相对位置或有利开口的指示的装置，从而便于选择其后使用哪种缝合或堵塞技术。所公开的装置包括外壳管和可滑动地设置在外管的远端内的可折叠的脚。脚连接到穿过管并离开其近端的轴。该装置还可包括一个或多个螺纹缝合针，可生物降解的塞子或其他伤口闭合装置，其连接到另一个轴。折叠的或折叠的脚被向远侧推出管并通过容器中的开口，由此足部膨胀。沿近侧方向拉伸扩张的脚，提供指示有助于确定要执行的关闭程序的类型。连接到脚的轴优选地连接到指示器，该指示器向操作者或医师指示血管开口处于船上的三个位置 - 左侧，右侧或右侧。另外，指示杆可能表示相对位置，以mm为单位偏离顶杆（或顶部位置）

2. 发明申请

WO2008097967A3 SELF-ORIENTATING SUTURE WOUND CLOSURE DEVICE 审中-公开
标题翻译：自立式闭合闭合装置
公开(公告)号：WO2008097967A3
公开(公告)日：2008-12-31
申请号：PCT/US2008053046
申请日：2008-02-05
申请人： BOSTON SCIENT SCIMED INC , DRASLER WILLIAM J , EIDENSCHINK TRACEE , THIELEN JOESEPH M , JENSON MARK L , SADISIVA ANU
发明人： DRASLER WILLIAM J , EIDENSCHINK TRACEE , THIELEN JOESEPH M , JENSON MARK L , SADISIVA ANU
IPC分类号： A61B17/00 , A61B17/34 , A61B19/00
CPC分类号： A61B17/0057 , A61B17/0469 , A61B2017/00641 , A61B2017/00663 , A61B2017/00867 , A61B2017/047 , A61B2017/0472 , A61B2017/3484 , A61B2090/067 , A61B2090/0811
摘要： A device is disclosed for providing an indication as to the relative position of a vessel or artery opening thereby facilitating the choice of which suturing or plugging technique to thereafter use. A disclosed device includes an outer tube (41) and a collapsible foot (31) slidably disposed within a distal end of the outer tube. The foot is connected to a shaft (32) that passes through the tube and exits a proximal end thereof. The collapsed or folded foot is pushed distalIy out of the tube and through the opening in the vessel whereupon the foot expands Pulling the expanded foot in the proximal direction provides an indication as to the orientation of the opening in the vessel, which assists in determining the type of closing procedure to be carried out.
摘要翻译：公开了一种用于提供关于血管或动脉开口的相对位置的指示的装置，从而便于选择其后使用哪种缝合或堵塞技术。所公开的装置包括可滑动地设置在外管的远端内的外管（41）和可折叠的脚（31）。脚连接到穿过管并离开其近端的轴（32）。折叠或折叠的脚被远离推出管并穿过容器中的开口，由此足部膨胀沿着近端方向拉伸扩张的脚部，提供关于容器中的开口的取向的指示，这有助于确定要执行的关闭程序的类型。

3. 发明申请

WO2009099437A1 APPARATUS AND METHOD FOR CLOSING AN OPENING IN A BLOOD VESSEL USING MEMORY METAL AND COLLAGEN 审中-公开
标题翻译：使用记忆金属和胶原封闭在血管中开放的装置和方法
公开(公告)号：WO2009099437A1
公开(公告)日：2009-08-13
申请号：PCT/US2008/053020
申请日：2008-02-05
申请人： BOSTON SCIENTIFIC LIMITED , DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M , JENSON, Mark, L. , SADISIVA, Anu
发明人： DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M , JENSON, Mark, L. , SADISIVA, Anu
IPC分类号： A61B17/03
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00654
摘要： An apparatus and method for closing an arteriotomy site are disclosed The apparatus and method employ the use of a delivery shea within which is provided an anchoring device formed of memory metal The delivery sheath can be inserted through a tissue tract extending from an epidermal layer to the blood vessel wall, whereupon the anchoring device can be extended from the delivery sheat into the blood vessel itself. The memory metal, once freed from the delivery sheath, obtains a nonlinear or coiled configuration which can then be pulled back against the inner surface of the blood vessel to form a backstop A biodegradable plug is then introduced into the tissue tract until it engages the backstop formed by the anchoring device thereby ensuring proper positioning of the biodegradable plug. The anchoring device is then retracted through the biodegradable plug leaving the arteriotomy site substantially closed with hemostasis formed therearound. The various biodegradable plugs disclosed provide for improved retention of the biodegradable plug and proper positioning of the plug within the tissue tract.
摘要翻译：公开了一种用于闭合动脉切开术部位的装置和方法。装置和方法采用输送片材，其中提供由记忆金属形成的锚定装置。输送鞘可以插入通过从表皮层延伸到组织管道血管壁，因此锚固装置可以从输送鞘延伸到血管本身。记忆金属一旦从输送鞘中释放出来就获得非线性或盘绕的构型，然后可以将其拉回血管的内表面以形成反作用力然后将可生物降解的塞子引入组织管，直到其接合止回由锚定装置形成，从而确保生物可降解塞的适当定位。然后将锚定装置缩回通过可生物降解的塞子，离开动脉切开术部位基本封闭，并在其周围形成止血。所公开的各种可生物降解的栓塞提供了可生物降解的塞子的改进的保持和塞子在组织道内的适当定位。

4. 发明申请

WO2008097956A1 VASCULAR SEALING DEVICE AND METHOD USING CLOT ENHANCING BALLOON AND ELECTRIC FIELD GENERATION 审中-公开
标题翻译：油封密封装置和使用加强气球和电场产生的方法
公开(公告)号：WO2008097956A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053034
申请日：2008-02-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
发明人： DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
IPC分类号： A61B17/00 , A61B18/00
CPC分类号： A61B18/14 , A61B17/0057 , A61B2017/00654 , A61N1/18 , A61N1/32
摘要： An apparatus and method for closing an opening in a blood vessel wall is disclosed. The apparatus includes at least one member which is extended through a tissue tract formed though the epidermis and subcutaneous layer of skin and through the opening in the blood vessel. The member includes a proximal end and a distal end with the distal end being positionable proximate to the opening in the blood vessel wall. A positive electrode is positioned next to the distal end with a negative electrode being positioned next to the proximal end When the electrodes are energized an electric field is created therebetween, blood cells are attracted to the positive electrode, and a thrombus is formed at the opening in the blood vessel wall. The member may include a balloon at the distal end to temporarily occlude blood flow from the blood vessel to the tissue tract to facilitate formation of the thrombus. In addition, the shape of the balloon may be tailored to facilitate the formation of the thrombus including, but not limited to, the creation of pockets and self-supporting balloons.
摘要翻译：公开了一种用于封闭血管壁中的开口的装置和方法。该装置包括至少一个构件，其延伸穿过通过皮肤的表皮和皮下层形成并通过血管中的开口形成的组织通道。该构件包括近端和远端，远端可靠近血管壁中的开口定位。正电极位于远端附近，负极位于近端的旁边。当电极通电时，电极之间产生电场，血细胞被吸引到正电极，并且在开口处形成血栓在血管壁。该构件可以包括在远端处的气囊，以暂时阻断从血管到组织道的血流，以促进血栓的形成。此外，气囊的形状可以被调整以促进血栓的形成，包括但不限于口袋和自支撑气囊的产生。

5. 发明申请

WO2008097955A1 APPARATUS AND METHOD FOR CLOSING AN OPENING IN A BLOOD VESSEL USING A PERMANENT IMPLANT 审中-公开
标题翻译：使用永久植入物在血管中闭合开放装置和方法
公开(公告)号：WO2008097955A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053033
申请日：2008-02-05
申请人： BOSTON SCIENTIFIC SCIMED, INC. , DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
发明人： DRASLER, William, J. , EIDENSCHINK, Tracee , THIELEN, Joeseph, M. , JENSON, Mark, L. , SADISIVA, Anu
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00654 , A61B2017/00659 , A61B2017/0069 , A61B2017/00862 , A61B2017/00867 , A61B2017/00884
摘要： An apparatus (28) and method for closing an arteriotomy site (20) is disclosed The apparatus includes inner (32) and outer flames (34) adapted to sandwich a blood vessel wall (26) therebetween. The inner and outer frames may be manufactured from memory metals such that they can be compressed during the insertion into the tissue tract proximate the arteriotomy site, and then deployed into an expanded configuration larger than the dimensions of the arteriotomy opening itself. A universal joint (36) connects the inner and outer frames to ensure proper pivoting therebetween. In addition, polymeric coverings (54) can be provided on the inner and outer frames to ensure closure, while a collagen plug (52) can also be provided between inner and outer frames to facilitate closure as well.
摘要翻译：公开了一种用于闭合动脉切开术部位（20）的装置（28）和方法。该装置包括适于将血管壁（26）夹在其间的内部（32）和外部火焰（34）。内框架和外框架可以由记忆金属制成，使得它们可以在插入到接近动脉切开部位的组织道中被压缩，然后展开成比动脉切开术本身的尺寸更大的扩张构型。万向接头（36）连接内框架和外框架，以确保其间的正确枢转。此外，聚合物覆盖物（54）可以设置在内框架和外框架上以确保封闭，而也可以在内框架和外框架之间提供胶原塞（52）以便于封闭。

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