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1. 发明申请

WO2002059132A1 INTERMEDIATE COMPOUNDS USEFUL FOR MAKING ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：用于制备抗病毒化合物的中间体化合物
公开(公告)号：WO2002059132A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/002338
申请日：2002-01-28
申请人： VIROPHARMA INCORPORATED , RYS, David, J. , NITZ, Theodore, J.
发明人： RYS, David, J. , NITZ, Theodore, J.
IPC分类号： C07F7/02
CPC分类号： C07F7/1856 , C07C45/59 , C07C45/60 , C07C45/71 , C07C47/575 , C07D317/22 , C07D319/06
摘要： Novel compounds of Formula I and Formula II (below): formula (I) wherein R a is selected from the group consisting of -CH 2 -OCH 3 , -CH 2 -OCH 2 CH 3 , -CH(CH 3 )OCH 2 CH 3 , -CH 2 -OCH 2 CH 2 -OCH 3 , -CH 2 OCH 2 CH 2 -Si(CH 3 ) 3 , and formula (II); R 1 is a radical selected from the group consisting of hydrogen, halogen, perfluoroalkyl, nitro, carbalkoxy, carboxamide, carboxamidoalkyl, alkyl, cycloalkyl, alkoxy, alkoxyalkyl, alkoxy-C 2 -C 6 -alkoxy, alkylsulfinyl, alkylsulfonyl, sulfonamide, cyano, amido, dialkylamino, OR a , or a heterocyclic radical selected from the group consisting of morpholinyl, piperadinyl, pyrrolidinyl, or an N-substituted piperazinyl, said piperazinyl substituents selected from an alkyl group, the point of attachment of said heterocyclic radical is at a nitrogen atom; P is a protected formaldehyde group such as: formula (III) or formula (IV) wherein R 2 , R 3 , R 4 and R 5 are independently selected from the group consisting of hydrogen or alkyl. The compounds are useful for making antiviral agents.
摘要翻译：式I和式II的新型化合物（下文）：其中R a选自-CH 2 -OCH 3，-CH 2 -OCH 2 CH 3，-CH（CH 3）OCH 2 CH 3，-CH 2 -OCH 2 CH 2 -OCH 3， - CH 2 OCH 2 CH 2 -Si（CH 3）3和式（II）; R 1是选自氢，卤素，全氟烷基，硝基，烷氧基，羧酰胺，甲酰氨基烷基，烷基，环烷基，烷氧基，烷氧基烷基，烷氧基-C 2 -C 6 - 烷氧基，烷基亚磺酰基，烷基磺酰基，磺酰胺，氰基，酰胺基，二烷基氨基，ORa或选自吗啉基，哌啶基，吡咯烷基或N-取代的哌嗪基的杂环基，所述哌嗪基取代基选自烷基，所述杂环基的连接点在氮原子上; P是受保护的甲醛基团，例如：式（III）或式（IV）其中R2，R3，R4和R5独立地选自氢或烷基。该化合物可用于制备抗病毒剂。

2. 发明申请

WO2004041201A3 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES 审中-公开
标题翻译：苯唑嘌呤化合物，组合物和方法治疗和预防乙型肝炎病毒感染和相关疾病
公开(公告)号：WO2004041201A3
公开(公告)日：2004-08-19
申请号：PCT/US0334962
申请日：2003-10-31
申请人： VIROPHARMA INC , WYETH CORP , BURNS CHRISTOPHER J , DEL VECCHIO ALFRED M , BAILEY THOMAS R , KULKARNI BHEEMASHANKAR A , FAITG THOMAS H , SHERK SUSAN R , BLACKLEDGE CHARLES W , RYS DAVID J , LESSEN THOMAS A , SWESTOCK JOHN , DENG YIJUN , NITZ THEODORE J , REINHARDT JASON A , FENG HAO , SAHA ASHIS K
发明人： BURNS CHRISTOPHER J , DEL VECCHIO ALFRED M , BAILEY THOMAS R , KULKARNI BHEEMASHANKAR A , FAITG THOMAS H , SHERK SUSAN R , BLACKLEDGE CHARLES W , RYS DAVID J , LESSEN THOMAS A , SWESTOCK JOHN , DENG YIJUN , NITZ THEODORE J , REINHARDT JASON A , FENG HAO , SAHA ASHIS K
IPC分类号： A61K31/34 , A61K31/4025 , A61K31/4433 , A61P31/12 , C07D307/84 , C07D317/44 , C07D323/02 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及苯并呋喃衍生物和类似物，以及含有它们的组合物及其用于治疗或预防与其相关的病毒感染和疾病的用途，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病。

3. 发明申请

WO2004041201A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES 审中-公开
标题翻译：苯佐芬化合物，组合物和方法治疗和预防乙型肝炎病毒感染和相关疾病
公开(公告)号：WO2004041201A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/034962
申请日：2003-10-31
申请人： VIROPHARMA INCORPORATED , WYETH , BURNS, Christopher, J. , DEL VECCHIO, Alfred, M. , BAILEY, Thomas, R. , KULKARNI, Bheemashankar, A. , FAITG, Thomas, H. , SHERK, Susan, R. , BLACKLEDGE, Charles, W. , RYS, David, J. , LESSEN, Thomas, A. , SWESTOCK, John , DENG, Yijun , NITZ, Theodore, J. , REINHARDT, Jason, A. , FENG, Hao , SAHA, Ashis, K.
发明人： BURNS, Christopher, J. , DEL VECCHIO, Alfred, M. , BAILEY, Thomas, R. , KULKARNI, Bheemashankar, A. , FAITG, Thomas, H. , SHERK, Susan, R. , BLACKLEDGE, Charles, W. , RYS, David, J. , LESSEN, Thomas, A. , SWESTOCK, John , DENG, Yijun , NITZ, Theodore, J. , REINHARDT, Jason, A. , FENG, Hao , SAHA, Ashis, K.
IPC分类号： A61K
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

4. 发明申请

WO2004014317A3 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗或预防肺炎链球菌感染和相关疾病的化合物，组合物和方法
公开(公告)号：WO2004014317A3
公开(公告)日：2004-04-15
申请号：PCT/US0325166
申请日：2003-08-11
申请人： VIROPHARMA INC , RYS DAVID J , NITZ THEODORE J , GABOURY JANET A , BURNS CHRISTOPHER J , PEVEAR DANIEL C , LESSEN THOMAS A , HERBERTZ TORSTEN
发明人： RYS DAVID J , NITZ THEODORE J , GABOURY JANET A , BURNS CHRISTOPHER J , PEVEAR DANIEL C , LESSEN THOMAS A , HERBERTZ TORSTEN
IPC分类号： A61K31/41 , C07D257/04 , C07D207/30 , A61K31/33
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

5. 发明申请

WO2004014316A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES 审中-公开
标题翻译：用于治疗或预防肺炎链球菌感染和相关疾病的化合物，组合物和方法
公开(公告)号：WO2004014316A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025165
申请日：2003-08-11
申请人： VIROPHARMA INCORPORATED , NITZ, Theodore, J. , GABOURY, Janet, A. , BURNS, Christopher, J. , LAQUERRE, Sylvie , PEVEAR, Daniel, C. , LESSEN, Thomas, A. , RYS, David, J.
发明人： NITZ, Theodore, J. , GABOURY, Janet, A. , BURNS, Christopher, J. , LAQUERRE, Sylvie , PEVEAR, Daniel, C. , LESSEN, Thomas, A. , RYS, David, J.
IPC分类号： A61K
CPC分类号： C07D275/02 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/357 , A61K31/41 , A61K31/425 , A61K31/427 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C47/565 , C07C69/18 , C07C223/06 , C07C235/16 , C07C235/68 , C07C311/29 , C07D211/32 , C07D257/04 , C07D401/14 , C07D407/10 , C07D417/14
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

6. 发明申请

WO2004014316A3 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES 审中-公开
标题翻译：治疗或预防肺部感染和相关疾病的化合物，组合物和方法
公开(公告)号：WO2004014316A3
公开(公告)日：2004-06-17
申请号：PCT/US0325165
申请日：2003-08-11
申请人： VIROPHARMA INC , NITZ THEODORE J , GABOURY JANET A , BURNS CHRISTOPHER J , LAQUERRE SYLVIE , PEVEAR DANIEL C , LESSEN THOMAS A , RYS DAVID J
发明人： NITZ THEODORE J , GABOURY JANET A , BURNS CHRISTOPHER J , LAQUERRE SYLVIE , PEVEAR DANIEL C , LESSEN THOMAS A , RYS DAVID J
IPC分类号： A61K31/41 , A61P25/00 , C07D257/04 , C07D401/14 , C07D417/14 , A61K31/335 , C07D317/44
CPC分类号： C07D275/02 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/357 , A61K31/41 , A61K31/425 , A61K31/427 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C47/565 , C07C69/18 , C07C223/06 , C07C235/16 , C07C235/68 , C07C311/29 , C07D211/32 , C07D257/04 , C07D401/14 , C07D407/10 , C07D417/14
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
摘要翻译：提供了用于预防和治疗由副粘病毒科肺病毒亚科病毒引起的感染和与这种感染相关的疾病的化合物，组合物和方法。

7. 发明申请

WO2004014317A2 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PNEUMOVIRUS INFECTION AND ASSOCIATED DISEASES 审中-公开
标题翻译：治疗或预防肺部感染和相关疾病的化合物，组合物和方法
公开(公告)号：WO2004014317A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/025166
申请日：2003-08-11
申请人： VIROPHARMA INCORPORATED , RYS, David, J. , NITZ, Theodore, J. , GABOURY, Janet, A. , BURNS, Christopher, J. , PEVEAR, Daniel, C. , LESSEN, Thomas, A. , HERBERTZ, Torsten
发明人： RYS, David, J. , NITZ, Theodore, J. , GABOURY, Janet, A. , BURNS, Christopher, J. , PEVEAR, Daniel, C. , LESSEN, Thomas, A. , HERBERTZ, Torsten
IPC分类号： A61K
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要翻译：提供了用于预防和治疗由副粘病毒科肺病毒亚科病毒引起的感染和与此类感染相关的疾病的化合物，组合物和方法。

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