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1. 发明申请

WO2012131656A3 COMPOUNDS FOR USE AS THERAPEUTIC AGENTS AFFECTING P53 EXPRESSION AND/OR ACTIVITY 审中-公开
标题翻译：用作影响P53表达和/或活性的治疗剂的化合物
公开(公告)号：WO2012131656A3
公开(公告)日：2012-11-22
申请号：PCT/IB2012051603
申请日：2012-04-02
申请人： SPLICOS SOC , CENTRE NAT RECH SCIENT , INST CURIE , UNIV MONTPELLIER 2 , SCHERRER DIDIER , TAZI JAMAL , NAJMAN ROMAIN , MAHUTEAU FLORENCE , ROUX PIERRE
发明人： SCHERRER DIDIER , TAZI JAMAL , NAJMAN ROMAIN , MAHUTEAU FLORENCE , ROUX PIERRE
IPC分类号： A61K31/4164 , A61K31/4192 , A61K31/44 , A61P1/16 , A61P9/00 , A61P21/00 , A61P25/00 , A61P29/00 , A61P35/00 , C07D213/74 , C07D233/54 , C07D249/06 , C07D401/12
CPC分类号： C07C237/30 , A61K31/166 , A61K31/167 , A61K31/4164 , A61K31/417 , A61K31/4192 , A61K31/4409 , A61K31/4439 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/5377 , C07D213/36 , C07D213/38 , C07D233/61 , C07D233/64 , C07D249/06 , C07D401/12
摘要： The present invention relates to compound (I) wherein R1 and R2 independently represent a hydrogen atom, a (C1-C4)alkoxy group, a fluoro(C1-C4)alkoxy group, a hydroxyl group, a benzyloxy group, a di(C1-C4)alkylamino group, a pyridyl- vinyl group, a pyrimidinyl- vinyl group, a styryl group, or a -NHCOphenyl group; R3, R4 and R5 independently represent a hydrogen atom, a (C1-C4)alkyl group, a CONHR6 group, a -CONR7R8 group, a -SO2NHR6 group, or a heteroaryl group optionally substituted by a halogen atom, a -(CH2)nNR7R8 group or a hydroxy(C1-C4)alkyl group; R6 represents a hydrogen atom, a -(CHR9)m(CH2)nNR7R8 group or a (C1-C6)alkyl group optionally substituted by a hydroxyl group; or anyone of its pharmaceutically acceptable salt, for use in a method for preventing, inhibiting or treating a disease in a patient suffering thereof, said disease involving a deregulated p53. Some of said compounds are new and also form part of the invention.
摘要翻译：本发明涉及其中R 1和R 2独立地表示氢原子，（C 1 -C 4）烷氧基，氟（C 1 -C 4）烷氧基，羟基，苄氧基，二（C 1 -C 4） -C4）烷基氨基，吡啶基 - 乙烯基，嘧啶基 - 乙烯基，苯乙烯基或-NHCO苯基; R3，R4和R5独立地表示氢原子，（C1-C4）烷基，CONHR6基，-CONR7R8基，-SO2NHR6基或任选被卤素原子取代的杂芳基， - （CH2） nR 7 R 8基团或羟基（C 1 -C 4）烷基; R6表示氢原子， - （CHR9）m（CH2）nNR7R8基团或任选被羟基取代的（C1-C6）烷基; 或其任何药学上可接受的盐，用于在患有其的患者中预防，抑制或治疗疾病的方法中，所述疾病涉及失调的p53。一些所述化合物是新的并且也构成本发明的一部分。

2. 发明申请

WO2008096009A3 POLYMORPHISM IN THE SLC30A8 GENE 审中-公开
标题翻译： SLC30A8基因多态性
公开(公告)号：WO2008096009A3
公开(公告)日：2009-03-19
申请号：PCT/EP2008051577
申请日：2008-02-08
申请人： MELLITECH , SEVE MICHEL , CHIMIENTI FABRICE , DE BOYSSON YANN , GIROD-ROUX PIERRE-MARIE , BARTH PHILIPPE
发明人： SEVE MICHEL , CHIMIENTI FABRICE , DE BOYSSON YANN , GIROD-ROUX PIERRE-MARIE , BARTH PHILIPPE
IPC分类号： A61K49/00 , C07K14/47
CPC分类号： C07K14/4713 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The present invention relates to a single nucleotide polymorphisme (SNP) identified in the slc30a8 gene, leading to a specific amino acid sequence of the coded protein, associated with susceptibility to diabetes. The invention is also relative to a transgenic mammalian model comprising a protein encoded bythe slc30a8 gene, having a specific polypeptidic sequence, which can be useful for elucidating the onset mechanism of diabetes, and for the screening of therapeutically active drugs for the treatment of diabetes, especially type II diabetes, and metabolic disorders, including syndrome X and obesity. The mammalian animal considered can be a mouse (preferably), a rat, a dog, a macaque, a chimp or a pig.
摘要翻译：本发明涉及在slc30a8基因中鉴定的单核苷酸多态性（SNP），导致与糖尿病易感性相关的编码蛋白的特定氨基酸序列。本发明还涉及包含由具有特异性多肽序列的slc30a8基因编码的蛋白质的转基因哺乳动物模型，其可用于阐明糖尿病的发病机制，以及用于筛选用于治疗糖尿病的治疗活性药物，特别是II型糖尿病，代谢紊乱，包括X综合症和肥胖症。所考虑的哺乳动物可以是小鼠（优选），大鼠，狗，猕猴，黑猩猩或猪。

3. 发明申请

WO2007149693A3 METHOD AND APPARATUS FOR SUPPORTING VOICE COMMUNICATIONS 审中-公开
标题翻译：支持语音通信的方法和装置
公开(公告)号：WO2007149693A3
公开(公告)日：2008-04-03
申请号：PCT/US2007070184
申请日：2007-06-01
申请人： MOTOROLA INC , ROUX PIERRE , FRATTI MARCO
发明人： ROUX PIERRE , FRATTI MARCO
IPC分类号： H04W36/14 , H04W76/04 , H04W88/16
CPC分类号： H04L12/66 , H04L29/06027 , H04L65/1069 , H04M7/0057 , H04W36/0022 , H04W76/04 , H04W88/16
摘要： An apparatus comprises two processors for supporting a remote terminal in a packet and circuit switched mode of operation respectively as well as two interfaces for interfacing to an external circuit and packet switched network respectively A first selector can select a remote terminal communication link as a packet switched mode communication link or a circuit switched mode communication link and a second selector can select an external voice communication link as a voice communication link of the external circuit switched network or a voice communication link of the external packet switched network in response to an identity of the other party involved in the call A conversion processor can support the voice communication by conveying voice data between the selected remote terminal communication link and the selected external voice communication link The apparatus may specifically be a home gateway facilitating operation in a combined packet and circuit switched environment
摘要翻译：一种装置包括两个处理器，用于分别支持分组中的远程终端和电路交换操作模式，以及分别用于与外部电路和分组交换网络对接的两个接口。第一选择器可以选择远程终端通信链路作为分组交换模式通信链路或电路交换模式通信链路，第二选择器可以选择外部语音通信链路作为外部电路交换网络的语音通信链路或外部分组交换网络的语音通信链路，参与呼叫的另一方A转换处理器可以通过在所选择的远程终端通信链路和所选择的外部语音通信链路之间传送语音数据来支持语音通信。该装置可以具体地是促进组合分组和电路交换环境中的操作的家庭网关

4. 发明申请

WO2007149693A2 METHOD AND APPARATUS FOR SUPPORTING VOICE COMMUNICATIONS 审中-公开
标题翻译：支持语音通信的方法和装置
公开(公告)号：WO2007149693A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/070184
申请日：2007-06-01
申请人： MOTOROLA, INC. , ROUX, Pierre , FRATTI, Marco,
发明人： ROUX, Pierre , FRATTI, Marco,
IPC分类号： H04J1/02
CPC分类号： H04L12/66 , H04L29/06027 , H04L65/1069 , H04M7/0057 , H04W36/0022 , H04W76/20 , H04W88/16
摘要： An apparatus comprises two processors (105, 107) for supporting a remote terminal in a packet and circuit switched mode of operation respectively as well as two interfaces (113, 117) for interfacing to an external circuit and packet switched network (111, 115) respectively. A first selector (109) can select a remote terminal communication link as a packet switched mode communication link or a circuit switched mode communication link and a second selector (119) can select an external voice communication link as a voice communication link of the external circuit switched network (111) or a voice communication link of the external packet switched network (115) in response to an identity of the other party involved in the call. A conversion processor (121) can support the voice communication by conveying voice data between the selected remote terminal communication link and the selected external voice communication link. The apparatus may specifically be a home gateway facilitating operation in a combined packet and circuit switched environment.
摘要翻译：一种装置包括分别支持分组和电路交换操作模式的远程终端的两个处理器（105,107）以及用于与外部电路和分组交换网络（111,115）进行接口的两个接口（113,117）分别。第一选择器（109）可以选择远程终端通信链路作为分组交换模式通信链路或电路交换模式通信链路，第二选择器（119）可以选择外部语音通信链路作为外部电路的语音通信链路交换网络（111）或外部分组交换网络（115）的语音通信链路，以响应该呼叫中涉及的另一方的身份。转换处理器（121）可以通过在所选择的远程终端通信链路和所选择的外部语音通信链路之间传送语音数据来支持语音通信。该装置可以具体地是便于在组合分组和电路交换环境中操作的家庭网关。

5. 发明申请

WO2007050235A2 METHOD AND APPARATUS FOR DELIVERY OF HIGH RATE DATA AS PART OF A MULTIMEDIA BROADCAST/MULTICAST SERVICE 审中-公开
标题翻译：作为多媒体广播/组播业务的一部分提供高速率数据的方法和设备
公开(公告)号：WO2007050235A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/038374
申请日：2006-09-30
申请人： MOTOROLA, INC. , FRATTI, Marco , MARTINEZ, Georges , ROUX, Pierre
发明人： FRATTI, Marco , MARTINEZ, Georges , ROUX, Pierre
IPC分类号： H04L7/02
CPC分类号： H04L12/1836 , H04H20/57 , H04H20/72 , H04H40/27 , H04H60/91 , H04L12/189 , H04W72/005
摘要： A communication system (100) is provided that comprises a Radio Access Network (110) having a Radio Network Controller (RNC) (114) coupled to each of a cellular Node B (112) and a Digital Broadcasting Video-Handhelds (DVB-H) Node B (120). When the communication system delivers low rate Multimedia Broadcast/Multicast Service (MBMS) user information, the user information is conveyed via the cellular Node B and a low data rate channel. When the communication system delivers high rate MBMS user information, the user information is conveyed via the DVB-H Node B and a high data rate channel. Thus the communication system provides high rate MBMS data services without imposing the system capacity constraints resulting from the employment of HSDPA by a cellular Node B.
摘要翻译：提供了一种通信系统（100），其包括具有耦合到蜂窝节点B（112）和数字蜂窝节点（112）中的每一个的无线电网络控制器（RNC）（114）的无线电接入网络广播视频手持设备（DVB-H）节点B（120）。当通信系统提供低速多媒体广播/多播服务（MBMS）用户信息时，用户信息通过蜂窝节点B和低数据速率信道传送。当通信系统提供高速率MBMS用户信息时，通过DVB-H节点B和高数据速率信道传送用户信息。因此，通信系统提供高速率的MBMS数据服务，而不会施加由蜂窝节点B使用HSDPA导致的系统容量限制。

6. 发明申请

WO0200456A3 AIRCRAFT TYRE WITH IMPROVED TYRE BEAD 审中-公开
标题翻译：具有改进的轮胎珠子的飞机轮胎
公开(公告)号：WO0200456A3
公开(公告)日：2002-05-10
申请号：PCT/EP0107223
申请日：2001-06-25
申请人： MICHELIN SOC TECH , MICHELIN RECH TECH , HERBELLEAU YVES , GUERINON BERNARD , ROUX PIERRE
发明人： HERBELLEAU YVES , GUERINON BERNARD , ROUX PIERRE
IPC分类号： B60C9/02 , B60C9/22 , B60C15/00 , B60C15/02 , B60C15/024 , B60C15/04 , B60C15/05 , B60C15/06 , B60C19/00
CPC分类号： B60C15/0018 , B60C9/023 , B60C15/024 , B60C15/04 , B60C15/05 , B60C15/06 , B60C2200/02 , Y10T152/10765 , Y10T152/10819 , Y10T152/10828 , Y10T152/10846
摘要： The invention concerns an aircraft tyre whereof the inflating pressure is higher than 12 bars, comprising a crown, two sidewalls and two beads, a carcass reinforcement anchored in the two beads and a crown reinforcement, wherein the carcass reinforcement comprises at least two circumferential alignments of first reinforcing elements with high modulus of elasticity and wherein the anchoring means of the first reinforcing elements in each bead comprise second circumferentially oriented reinforcing elements axially bordering the circumferential alignments of the first reinforcing elements, the first and second reinforcing elements being separated by a layer of a mixture with very high modulus of elasticity.
摘要翻译：本发明涉及一种飞机轮胎，其中膨胀压力高于12巴，包括冠部，两个侧壁和两个珠粒，锚固在两个珠粒中的胎体增强件和冠部加强件，其中胎体增强件包括至少两个圆周对准具有高弹性模量的第一增强元件，并且其中每个胎圈中的第一增强元件的锚定装置包括与第一增强元件的圆周对准轴向接合的第二周向取向的增强元件，第一和第二增强元件被一层具有非常高的弹性模量的混合物。

7. 发明申请

WO2011007013A1 ZNF217 A NEW PROGNOSTIC AND PREDICTIVE BIOMARKER OF RECURRENT, INVASIVE AND METASTATIC PHENOTYPES IN BREAST CANCER 审中-公开
标题翻译： ZNF217乳腺癌中新陈代谢和预后的生物标志物
公开(公告)号：WO2011007013A1
公开(公告)日：2011-01-20
申请号：PCT/EP2010/060381
申请日：2010-07-19
申请人： CENTRE LEON BERARD , UNIVERSITE CLAUDE BERNARD LYON 1 , COHEN, Pascale , VENDRELL, Julie , ROUX, Pierre
发明人： COHEN, Pascale , VENDRELL, Julie , ROUX, Pierre
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57484
摘要： The present invention relates to methods for determining the prognosis of a cancer. The methods involve determining the level of expression of the ZNF217 gene in a cancer cell sample or in a tumor sample wherein over-expression of ZNF217 is correlated with likelihood of metastasis and with likelihood of relapse/recurrence of the cancer.
摘要翻译：本发明涉及确定癌症预后的方法。该方法涉及确定癌细胞样品或肿瘤样品中ZNF217基因表达水平，其中ZNF217的过度表达与转移的可能性和癌症复发/复发的可能性相关。

8. 发明申请

WO2011000891A1 METHOD FOR TESTING A SUBJECT THOUGHT TO BE PREDISPOSED TO HAVING METASTATIC CANCER USING DELTA133P53BETA 审中-公开
标题翻译：用于测试使用DELTA133P53BETA预测具有特发性癌症的主体的方法
公开(公告)号：WO2011000891A1
公开(公告)日：2011-01-06
申请号：PCT/EP2010/059321
申请日：2010-06-30
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
发明人： ROUX, Pierre , GADEA, Gilles , VINOT, Stéphanie , ANGUILLE, Christelle , BOURDON, Jean-Christophe , FERNANDES, Kenneth
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： G01N33/57484 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , G01N2333/4748 , G01N2500/10 , G01N2800/52 , G01N2800/56
摘要： The present invention concerns a method of testing a subject thought to be predisposed to having a metastatic cancer which comprises the step of i) analyzing a biological sample from said subject for detecting the presence of a p53 isoform selected in the group consisting in Δ133p53, Δ133p53γ and Δ133p53β, the presence of said p53 isoform being indicative of a metastatic cancer.
摘要翻译：本发明涉及一种测试被认为具有转移性癌症的受试者的方法，该方法包括以下步骤：i）分析来自所述受试者的生物样品，以检测选自下组的p53同种型的存在：133b53，？133p53？和〜133p53β，所述p53同种型的存在表示转移性癌症。

9. 发明申请

WO2010143168A2 COMPOUNDS USEFUL FOR TREATING CANCER 审中-公开
标题翻译：化合物可用于治疗癌症
公开(公告)号：WO2010143168A2
公开(公告)日：2010-12-16
申请号：PCT/IB2010/052650
申请日：2010-06-14
申请人： SOCIÉTÉ SPLICOS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE MONTPELLIER 2 , ROUX, Pierre , MAHUTEAU, Florence , NAJMAN, Romain , TAZI, Jamal , GADEA, Gilles
发明人： ROUX, Pierre , MAHUTEAU, Florence , NAJMAN, Romain , TAZI, Jamal , GADEA, Gilles
IPC分类号： C07D215/38 , C07D401/12 , A61K31/33 , A61P43/00 , A61K31/444
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/4985 , C07D213/74 , C07D215/38 , C07D215/42 , C07D215/46 , C07D241/44 , C07D401/12
摘要： The present invention relates to compound (I) wherein: means a pyridazine, a pyrimidine or a pyrazine group, R independently represent a hydrogen atom, a halogen atom or a group chosen among a CN group, a hydroxyl group, a COOR 1 group, a (C 1 -C 3 )fluoroalkyl group, a (C 1 -C 3 )fluoroalkoxy group, a NO 2 group, a NR 1 R 2 group, a (C 1 -C 4 )alkoxy group, a phenoxy group and a (C 1 -C 3 )alkyl group, said alkyl being optionally mono-substituted by a hydroxyl group, n is 1, 2 or 3, n is 1 or 2, R is a hydrogen atom, a halogen atom or a group chosen among a (C 1 -C 3 )alkyl group,, a hydroxyl group, a COOR 1 group, a NO 2 group, a NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C 1 -C 3 )fluoroalkyl group, a (C1-C4)alkoxy group and a CN group, Z is N or C, Y is N or C, X is N or C, W is N or C, T is N or C, U is N or C, for use as an agent for preventing, inhibiting or treating cancer. Some of said compounds are new and also form part of the invention.
摘要翻译：本发明涉及化合物（I），其中：表示哒嗪，嘧啶或吡嗪基，R独立地表示氢原子，卤原子或选自CN基，羟基，COOR1基，（C1-C3）氟代烷基，（C1-C3）氟烷氧基，NO2基，NR1R2基，（C1-C4）烷氧基，苯氧基和（C1-C3）烷基）任选被羟基单取代，n为1,2或3，n为1或2，R为氢原子，卤素原子或选自（C1-C3）烷基，羟基中的基团，COOR1基团，NO2基团，NR1R2基团，吗啉基或吗啉基，N-甲基哌嗪基，（C1-C3）氟烷基，（C1-C4）烷氧基和CN基，Z为 N或C，Y是N或C，X是N或C，W是N或C，T是N或C，U是N或C，用作预防，抑制或治疗癌症的药剂。一些所述化合物是新的并且也构成本发明的一部分。

10. 发明申请

WO2008096009A2 MAMMALIAN ANIMAL MODEL COMPRISING A POLYMORPHISM IN THE SLC30A8 GENE 审中-公开
标题翻译：在SLC30A8基因中包含多态性的MAMMALIAN动物模型
公开(公告)号：WO2008096009A2
公开(公告)日：2008-08-14
申请号：PCT/EP2008/051577
申请日：2008-02-08
申请人： MELLITECH , SEVE, Michel , CHIMIENTI, Fabrice , DE BOYSSON, Yann , GIROD-ROUX, Pierre-Marie , BARTH, Philippe
发明人： SEVE, Michel , CHIMIENTI, Fabrice , DE BOYSSON, Yann , GIROD-ROUX, Pierre-Marie , BARTH, Philippe
IPC分类号： C12Q1/68
CPC分类号： C07K14/4713 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： The present invention relates to a single nucleotide polymorphisme (SNP) identified in the slc30a8 gene, leading to a specific amino acid sequence of the coded protein, associated with susceptibility to diabetes. The invention is also relative to a transgenic mammalian model comprising a protein encoded bythe slc30a8 gene, having a specific polypeptidic sequence, which can be useful for elucidating the onset mechanism of diabetes, and for the screening of therapeutically active drugs for the treatment of diabetes, especially type II diabetes, and metabolic disorders, including syndrome X and obesity. The mammalian animal considered can be a mouse (preferably), a rat, a dog, a macaque, a chimp or a pig.
摘要翻译：本发明涉及在slc30a8基因中鉴定的单核苷酸多态性（SNP），导致与糖尿病易感性相关的编码蛋白的特定氨基酸序列。本发明还涉及包含由具有特异性多肽序列的slc30a8基因编码的蛋白质的转基因哺乳动物模型，其可用于阐明糖尿病的发病机制，以及用于筛选用于治疗糖尿病的治疗活性药物，特别是II型糖尿病，代谢紊乱，包括X综合症和肥胖症。所考虑的哺乳动物可以是小鼠（优选），大鼠，狗，猕猴，黑猩猩或猪。

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