专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013082329A1 LAYERED SECURITY FOR AGE VERIFICATION AND TRANSACTION AUTHORIZATION 审中-公开
标题翻译：用于年龄验证和交易授权的分层安全
公开(公告)号：WO2013082329A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/067141
申请日：2012-11-29
申请人： ROSS, Bruce
发明人： ROSS, Bruce
IPC分类号： H04L29/06
CPC分类号： G06Q20/3674 , G06Q20/3821 , H04L63/0428 , H04L63/0853 , H04L63/0861 , H04L63/0869 , H04L63/166
摘要： A user may be willing to purchase item or participate in a pay-for service offered by a service provider. A service provider may wish to verify characteristics of the user prior to allowing transactions to take place, and may want to secure the transactions once the transactions are allowed. A credential issued to a user and a transaction application uploaded to a user device may be used to secure transactions between the user and a service provider interface, such as a webserver or a point-of-sale. The transaction application may capture real-time user data and comparing the real-time user data to prior user data stored on the credential, authenticate the service provider interface to the user and the user to the service provider interface; and establish an encrypted session between the service provider interface and the transaction application adapted to authenticate the transactions between the user and the service provider interface.
摘要翻译：用户可能愿意购买物品或参与由服务提供商提供的付费服务。服务提供商可能希望在允许交易发生之前验证用户的特征，并且可能希望在允许交易之后确保交易。发布给用户的证书和上传到用户设备的交易应用程序可用于保护用户与服务提供者接口之间的交易，例如网络服务器或销售点。交易应用可以捕获实时用户数据并将实时用户数据与存储在证书上的先前用户数据进行比较，将用户和用户的服务提供者接口认证到服务提供商接口; 并且在服务提供商接口和适于认证用户与服务提供者接口之间的事务的交易应用之间建立加密会话。

2. 发明申请

WO2010135569A1 N- [ (2 ' R) -2 ' -DEOXY-2 ' -FLUORO-2 ' -METHYL-P-PHENYL-5 ' -URIDYLYL] -L-ALANINE 1-METHYLETHYL ESTER AND PROCESS FOR ITS PRODUCTION 审中-公开
标题翻译： N- [（2'R）-2'-脱氧-2'-氟-2' - 甲基 - 对 - 苯基-5' - 脲] -L-阿兰碱1-甲基乙基酯及其生产方法
公开(公告)号：WO2010135569A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035641
申请日：2010-05-20
申请人： PHARMASSET, INC. , ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , RACHAKONDA, Suguna , ZHANG, Hai-ren , CHUN, Byoung-kwon , WANG, Peiyuan
发明人： ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , RACHAKONDA, Suguna , ZHANG, Hai-ren , CHUN, Byoung-kwon , WANG, Peiyuan
IPC分类号： C07H19/10 , C07H19/073 , A61K31/7072 , A61P31/14
CPC分类号： C07H19/10 , A61K31/7072 , A61K31/716 , A61K45/00 , C07F9/24 , C07F9/242 , C07F9/65586 , C07H1/00 , C07H17/02 , Y02A50/463 , Y02P20/55
摘要： Disclosed herein are nucleoside phosphoramidates of formula 4 and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent 5 RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals. Disclosed is also a process for preparing compound represented by formula 4: (Formula 4) wherein P* represents a chiral phosphorus atom, which comprises: a) reacting an isopropyl-alanate, (Formula A), a di-X'-phenylphosphate, (Formula B), 2'-deoxy-2f-fluoro-2'-C-methyluridine, (Formula 3), and a base to obtain a first mixture comprising 4; wherein X is a conjugate base of an acid, n is 0 or 1, and X' is a halogen, b) reacting the first mixture with a protecting compound to obtain a second mixture comprising 4; and c) optionally subjecting the second mixture to crystallization, chromatography or extraction in order to obtain 4.
摘要翻译：本文公开了式4的核苷氨基磷酸酯及其作为治疗病毒性疾病的试剂的用途。这些化合物是RNA依赖性5 RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。还公开了制备由式4表示的化合物的方法：（式4）其中P *表示手性磷原子，其包括：a）使异丙基 - 铝酸酯，（式A），二-X'-苯基磷酸酯，（式B），2'-脱氧-2f-fluor-2'-C-甲基尿苷，（式3）和碱，得到包含4的第一混合物; 其中X是酸的共轭碱，n是0或1，X'是卤素，b）使第一混合物与保护化合物反应，得到包含4的第二混合物; 和c）任选地使第二混合物进行结晶，色谱或提取，以获得4。

3. 发明申请

WO2009152095A3 NUCLEOSIDE CYCLICPHOSPHATES 审中-公开
标题翻译：核苷环状磷酸酯
公开(公告)号：WO2009152095A3
公开(公告)日：2010-11-04
申请号：PCT/US2009046619
申请日：2009-06-08
申请人： PHARMASSET INC , DU JINFA , NAGARATHNAM DHANAPALAN , PAMULAPATI GANAPATI REDDY , ROSS BRUCE S , SOFIA MICHAEL JOSEPH
发明人： DU JINFA , NAGARATHNAM DHANAPALAN , PAMULAPATI GANAPATI REDDY , ROSS BRUCE S , SOFIA MICHAEL JOSEPH
IPC分类号： C07H19/10 , C07D473/18 , C07H19/20
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure: Formula (I)
摘要翻译：用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：式（I）

4. 发明申请

WO2009152095A2 NUCLEOSIDE CYCLICPHOSPHATES 审中-公开
标题翻译：核苷环状磷酸酯
公开(公告)号：WO2009152095A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/046619
申请日：2009-06-08
申请人： PHARMASSET, INC. , DU, Jinfa , NAGARATHNAM, Dhanapalan , PAMULAPATI, Ganapati, Reddy , ROSS, Bruce, S. , SOFIA, Michael, Joseph
发明人： DU, Jinfa , NAGARATHNAM, Dhanapalan , PAMULAPATI, Ganapati, Reddy , ROSS, Bruce, S. , SOFIA, Michael, Joseph
IPC分类号： A61K31/712
CPC分类号： C07D473/18 , C07H19/10 , C07H19/20
摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure: Formula (I)
摘要翻译：用于治疗哺乳动物中的病毒感染的核苷衍生物的环磷酸酯，其为化合物，其立体异构体，由以下结构表示的盐（酸或碱加成盐），水合物，溶剂化物或其结晶形式：式（I）

5. 发明申请

WO2005077473A1 PHYSICAL TRAINING APPARATUS 审中-公开
标题翻译：物理训练装置
公开(公告)号：WO2005077473A1
公开(公告)日：2005-08-25
申请号：PCT/AU2005/000212
申请日：2005-02-18
申请人： ROSS, Bruce, William
发明人： ROSS, Bruce, William
IPC分类号： A63B69/34
CPC分类号： A63B21/151 , A63B21/0615 , A63B21/08 , A63B21/4045 , A63B23/0405 , A63B23/047 , A63B69/345 , A63B2023/0411
摘要： A physical training apparatus (10) has a main frame (11) having a front portion (15) and a back portion (16), an upright portion (17) spaced from the front portion (15) and moveable carriage (12) slidable with respect to the front portion (15) of the main frame (11). A cable (14) is connected by one of its ends to the carriage (12) and extends from the front portion (15) to the upright portion (17). A weight (13) is pivotally mounted on the upright portion (17) and is connected to the other end of the cable (14) and is positioned above the base of the main frame rearward of the front portion (17), so that a driving force on the carriage (12) causes the weight (14) to rise thereby providing resistance to the driving force on the carriage (12).
摘要翻译：体育训练装置（10）具有主框架（11），其具有前部（15）和后部（16），与前部（15）间隔开的直立部分（17）和可滑动的滑架相对于主框架（11）的前部（15）。电缆（14）通过其一端连接到滑架（12）并从前部（15）延伸到直立部分（17）。重物（13）枢转地安装在直立部分（17）上，并连接到电缆（14）的另一端，并且位于主框架的基部之上，位于前部（17）的后方，使得滑架（12）上的驱动力使重物（14）升高，从而对滑架（12）上的驱动力提供阻力。

6. 发明申请

WO2003087130A3 PROCESS FOR MANUFACTURING PURIFIED PHOSPHORODIAMIDITE 审中-公开
公开(公告)号：WO2003087130A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/011016
申请日：2003-04-11
申请人： ISIS PHARMACEUTICALS, INC. , SONG, Quanlai , ROSS, Bruce
发明人： SONG, Quanlai , ROSS, Bruce
IPC分类号： C07F09/28
摘要： A scalable process for purification of phosphorodiamidite includes steps of solubilizing a crude phosphorodiamidite in an apolar organic solvent, contacting the non-polar organic solvent with a polar phase comprising a polar organic solvent to remove impurities from the solubilized phosphorodiamidite, and removing the non-polar organic solvent from the phosphorodiamidite.

7. 发明申请

WO2011123668A2 STEREOSELECTIVE SYNTHESIS OF PHOSPHORUS CONTAINING ACTIVES 审中-公开
标题翻译：含磷活性物的选择性合成
公开(公告)号：WO2011123668A2
公开(公告)日：2011-10-06
申请号：PCT/US2011030762
申请日：2011-03-31
申请人： PHARMASSET INC , ROSS BRUCE S , SOFIA MICHAEL JOSEPH , PAMULAPATI GANAPATI REDDY , RACHAKONDA SUGUNA , ZHANG HAI-REN
发明人： ROSS BRUCE S , SOFIA MICHAEL JOSEPH , PAMULAPATI GANAPATI REDDY , RACHAKONDA SUGUNA , ZHANG HAI-REN
IPC分类号： C07H19/10
CPC分类号： C07H19/10 , C07F7/1856 , C07F9/242 , C07F9/2458 , C07F9/65517 , C07F9/65586 , C07F9/65616 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/06 , C07H19/20 , C07H19/207 , C07H19/24
摘要： Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.
摘要翻译：本文公开了含磷活性物质，它们作为治疗疾病的活性物质的用途和用于制备它们的立体选择性方法。本文还公开了有用的合成中间体及其制备方法。

8. 发明申请

WO2011123645A2 NUCLEOSIDE PHOSPHORAMIDATES 审中-公开
标题翻译：核苷酸磷酸酯
公开(公告)号：WO2011123645A2
公开(公告)日：2011-10-06
申请号：PCT/US2011/030725
申请日：2011-03-31
申请人： PHARMASSET, INC. , ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , RACHAKONDA, Suguna , ZHANG, Hai-Ren , CHUN, Byoung-Kwon , WANG, Peiyuan
发明人： ROSS, Bruce, S. , SOFIA, Michael, Joseph , PAMULAPATI, Ganapati, Reddy , RACHAKONDA, Suguna , ZHANG, Hai-Ren , CHUN, Byoung-Kwon , WANG, Peiyuan
IPC分类号： C07H19/06 , C07H19/207 , A61K31/7072 , C07F9/26 , A61P31/14
CPC分类号： C07H19/10 , C07F7/1856 , C07F9/242 , C07F9/2458 , C07F9/65517 , C07F9/65586 , C07F9/65616 , C07H19/04 , C07H19/044 , C07H19/052 , C07H19/06 , C07H19/20 , C07H19/207 , C07H19/24
摘要： Disclosed herein are nucleoside phosphoramidates and their use as agents for treating viral diseases. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.
摘要翻译：本文公开了核苷氨基磷酸酯及其作为治疗病毒性疾病的药剂的用途。这些化合物是RNA依赖性RNA病毒复制的抑制剂，可用作HCV NS5B聚合酶的抑制剂，作为HCV复制的抑制剂和用于治疗哺乳动物的丙型肝炎感染。

9. 发明申请

WO2009029985A1 PHYSICAL TRAINING APPARATUS SUITABLE FOR SCRUM TRAINING 审中-公开
标题翻译：物理训练装置适用于螺杆培训
公开(公告)号：WO2009029985A1
公开(公告)日：2009-03-12
申请号：PCT/AU2008/001311
申请日：2008-09-04
申请人： ROSS, Bruce William
发明人： ROSS, Bruce William
IPC分类号： A63B21/06 , A63B69/34
CPC分类号： A63B23/03525 , A63B21/0617 , A63B23/0405 , A63B69/345 , A63B2208/0247 , A63B2243/0066
摘要： A physical training apparatus (10) has a main frame (11), a moveable carriage (12) connected to the main frame (11), and an arm assembly (14, 15) having an end connected to the moveable carriage (12), and another end connected to a weight (13). The weight (13) is pivotally connected to a fixed pivot point (50). In use, a force exerted by a user on the carriage (12) causes the weight (13) to rise about the pivot point (5O), the force being transmitted through the arm assembly (14, 15), and whereby continued rising of the weight (13) requires a variation in the force to at least compensate for a variation in the resistance to movement of the weight (13) as it rises about the pivot point (50).
摘要翻译：体育训练装置（10）具有主框架（11），连接到主框架（11）的可移动滑架（12）和具有连接到可移动滑架（12）的端部的臂组件（14,15），另一端连接到重物（13）。重物（13）枢转地连接到固定枢轴点（50）。在使用中，由使用者施加在滑架（12）上的力使得重物（13）围绕枢轴点（50）升高，该力通过臂组件（14,15）传递，并且由此持续上升重量（13）需要力的变化，以至少补偿当重物（13）绕枢转点（50）上升时抵抗运动的阻力的变化。

10. 发明申请

WO2005108411A2 AMIDITES AND METHODS OF RNA SYNTHESIS 审中-公开
标题翻译： RNA合成的氨基酸和方法
公开(公告)号：WO2005108411A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/015240
申请日：2005-05-03
申请人： ISIS PHARMACEUTICALS, INC. , GRIFFEY, Richard, H. , ROSS, Bruce, S. , QUANLAI, Song
发明人： GRIFFEY, Richard, H. , ROSS, Bruce, S. , QUANLAI, Song
IPC分类号： C07H
CPC分类号： C07H19/06 , C07H21/00 , Y02P20/55
摘要： The present invention is directed to amidites useful in the synthesis of oligonucleotides comprising at least one RN moiety, and to methods of using such amidites in the synthesis of such oligonucleotides. The inventive amidites possess surprising coupling efficiency as compared to prior art amidites, while providing convenient intermediates in the synthesis of oligonucleotides possessing at least one free 2'-OH moiety.
摘要翻译：本发明涉及可用于合成包含至少一个RN部分的寡核苷酸的脒基，以及在合成这些寡核苷酸时使用这种脒基的方法。与现有技术的脒基相比，本发明的脒基具有惊人的偶联效率，同时在合成具有至少一个游离2'-OH部分的寡核苷酸的合成中提供方便的中间体。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式