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1. 发明申请

WO03066131A3 AGENT DELIVERY AND ASPIRATION DEVICE 审中-公开
标题翻译：代理交付和吸引装置
公开(公告)号：WO03066131A3
公开(公告)日：2003-09-12
申请号：PCT/US0303361
申请日：2003-02-03
申请人： NDT , DRINAN DARREL , EDMAN CARL , ROSATI ROBERT J
发明人： DRINAN DARREL , EDMAN CARL , ROSATI ROBERT J
IPC分类号： A61B5/00 , A61M1/00 , A61M3/02 , A61M11/04 , A61M15/00
CPC分类号： A61B5/411 , A61B5/145 , A61M1/0003 , A61M1/0062 , A61M1/0072 , A61M3/0262 , A61M11/007 , A61M11/008 , A61M11/042 , A61M15/00 , A61M15/025 , A61M2205/075 , A61M2205/36 , A61M2210/0618 , A61M2230/005
摘要： The methods and devices disclosed provide for the delivery of agents to an orifice cavity and subsequent aspiration of the agent and the orifice contents from the orifice cavity and related areas. In one form, the delivery and aspiration system (5) comprises an agent delivery sub-assembly (10), and aspiration sub-assembly (20) and a device tip sub-assembly (30). The subassemblies operate to first deliver an agent contained within the device to an orifice cavity and after an optional time delay,subsequently aspirate the delivered agent and orifice contents from the orifice cavity and related areas. In another form, a removable reservoir is provided whereby the aspirated agent and orifice contents from the orifice are assayed either independent of or within the device itself.
摘要翻译：所公开的方法和装置提供了将试剂递送到孔腔并随后从孔腔和相关区域吸取试剂和孔口内容物。在一种形式中，输送和抽吸系统（5）包括药剂输送子组件（10）和抽吸子组件（20）和装置尖端子组件（30）。子组件操作以首先将包含在装置内的试剂输送到孔腔中，并且在任选的时间延迟之后，随后从孔腔和相关区域抽吸输送的试剂和孔口内容物。在另一种形式中，提供可移除的储存器，其中来自孔的吸出剂和孔口内容物独立于装置或其内部进行测定。

2. 发明申请

WO1995010513A1 BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS 审中-公开
标题翻译：苯并噻唑和相关化合物作为雌激素激动剂
公开(公告)号：WO1995010513A1
公开(公告)日：1995-04-20
申请号：PCT/IB1994000282
申请日：1994-09-19
申请人： PFIZER INC. , CAMERON, Kimberly, O. , DA SILVA-JARDINE, Paul , LARSON, Eric, R. , HAUSKE, James, R. , ROSATI, Robert, L.
发明人： PFIZER INC.
IPC分类号： C07D333/56
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D409/04 , C07D409/06 , C07D409/12 , C07D417/04
摘要： Benzothiophenes and related compounds of formula (1), wherein A, B, Z are independently -CH=, -CR4= or =N-; X is -S-, -O-, -NH-, -NR2, -CH2-CH2-, -CH2-CH2-CH2-, -CH2-O-; -OCH2-, -CH2-S-, -CO-, -SCH2-, -N=CR2- or -R2C=N-; Y is optionally substituted phenyl, alkyl, cycloalkyl, cycloalkenyl, heterocycle or bicyclic ring system; D is -CO-, -CR2R3-, -CONH-, -NHCO-, -CR2(OH)-, -CONR2, NOR1 CH-NO2 N-CN -NR2-CO-, -C-, -C-, -C-; E is a single bond, optionally substituted phenyl, heterocycle; Z is -(CH2)p W(CH2)q-, -O(CH2)p CR5R6- or -O(CH2)p W(CH2)q; G is -NR7R8, (a), (b), (c), a 5- or 6-membered saturated, unsaturated or partially unsaturated and optionally substituted heterocycle or a bicyclic amine containing 5 to 12 carbon atoms either bridged or fused and optionally substituted and R is halogen, -NR2R3, -NHCOR2, -NHSO2R2, -CR2R3OH, -CONR2R3, -SO2NR2R3, OH, -OR1, -O-COR1; are estrogen agonists which are useful for treating syndromes and diseases caused by estrogen deficiency.
摘要翻译：苯并噻吩和式（1）的相关化合物，其中A，B，Z独立地是-CH =，-CR 4 =或= N-; X是-S-，-O-，-NH-，-NR2，-CH2-CH2-，-CH2-CH2-CH2-，-CH2-O-; -OCH 2 - ， - CH 2 -S-，-CO-，-SCH 2 - ， - N = CR 2 - 或-R 2 C = N-; Y是任选取代的苯基，烷基，环烷基，环烯基，杂环或双环系统; D是-CO - ， - CR 2 R 3 - ， - CONH - ， - NHCO-， - CR 2（OH） - ， - CONR 2，NOR 1 CH-NO 2 N-CN -NR 2 -CO-， - C - ， - C-; E是单键，任选取代的苯基，杂环; Z 1是 - （CH 2）p W（CH 2）q - ， - O（CH 2）p CR 5 R 6 - 或-O（CH 2）p W（CH 2）q; G是-NR 7 R 8，（a），（b），（c），5或6元饱和，不饱和或部分不饱和和任选取代的杂环或含有5至12个碳原子的双环胺，其桥接或稠合，取代的，R是卤素，-NR2R3，-NHCOR2，-NHSO2R2，-CR2R3OH，-CONR2R3，-SO2NR2R3，OH，-OR1，-O-COR1; 是雌激素激动剂，其可用于治疗由雌激素缺乏引起的综合征和疾病。

3. 发明申请

WO2004033434A1 PYRAZOLE COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译：用于治疗神经损伤性疾病的吡咯化合物
公开(公告)号：WO2004033434A1
公开(公告)日：2004-04-22
申请号：PCT/IB2003/004252
申请日：2003-09-26
申请人： PFIZER PRODUCTS INC. , ALLEN, Martin, Patrick , CHEN, Yuhpyng, L. , LIRAS, Spiros , ROSATI, Robert, L.
发明人： ALLEN, Martin, Patrick , CHEN, Yuhpyng, L. , LIRAS, Spiros , ROSATI, Robert, L.
IPC分类号： C07D231/40
CPC分类号： C07D401/06 , C07D231/40 , C07D401/12 , C07D403/06 , C07D405/04 , C07D409/04 , C07D409/12 , C07D413/14 , C07D471/04 , C07D487/04
摘要： The invention provides compounds of Formula (I): wherein R 1 ,R 2 ,R 3 , R 4 ,R 6 ,R 7 , R 8 and A are as defined. Compounds of formula (I) have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula (I).
摘要翻译：本发明提供了式（I）化合物：其中R 1，R 2，R 3，R 4，R 6，R 7，R 8和A如上定义。式（I）化合物具有抑制Abeta肽生产的活性。本发明还提供用于治疗包括式（I）化合物的哺乳动物疾病例如阿尔茨海默病的药物组合物和方法。

4. 发明申请

WO1998028264A1 PREVENTION OF LOSS AND RESTORATION OF BONE MASS BY CERTAIN PROSTAGLANDIN AGONISTS 审中-公开
标题翻译：通过某些PROSTAGLANDIN AGONISTS预防骨质疏松的损失和恢复
公开(公告)号：WO1998028264A1
公开(公告)日：1998-07-02
申请号：PCT/IB1997001417
申请日：1997-11-10
申请人： PFIZER INC. , CAMERON, Kimberly, O'Keefe , KE, Hua, Zhu , LEFKER, Bruce, Allen , ROSATI, Robert, Louis , THOMPSON, David, Duane
发明人： PFIZER INC.
IPC分类号： C07C311/06
CPC分类号： C07D207/263 , A61K45/06 , C07C235/34 , C07C311/04 , C07C311/06 , C07C323/49 , C07C2601/14 , C07C2602/08 , C07D209/14 , C07D213/42 , C07D215/18 , C07D239/26 , C07D241/12 , C07D249/06 , C07D257/04 , C07D271/12 , C07D277/28 , C07D277/56 , C07D307/24 , C07D307/52 , C07D307/68 , C07D307/81 , C07D317/58 , C07D319/18 , C07D333/20 , C07D333/24 , C07D333/34 , C07D333/38 , C07D409/12
摘要： Prostaglandin agonists of formula (I), in which, for example, A is a sulphonyl or acyl group, B is N or CH, M contains a ring and K and Q are linking groups, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits useful for the treatment of bone disorders including osteoporosis.
摘要翻译：式（I）的前列腺素激动剂，其中例如A是磺酰基或酰基，B是N或CH，M包含环，K和Q是连接基团，使用这种前列腺素激动剂的方法，含有这种前列腺素激动剂和用于治疗包括骨质疏松症在内的骨疾病的试剂盒。

5. 发明申请

WO2011011824A1 PRINTING SYSTEM WITH FIXED PRINTHEADS AND MOVABLE VACUUM PLATEN 审中-公开
标题翻译：具有固定打印头和可移动真空板的打印系统
公开(公告)号：WO2011011824A1
公开(公告)日：2011-02-03
申请号：PCT/AU2010/000954
申请日：2010-07-29
申请人： SILVERBROOK RESEARCH PTY LTD , ROSATI, Robert , PETCH, David , BURNEY, David , SYKORA, Jim , REGAS, Kenneth A. , BOUND, Andy , DOHERTY, Neil , DENNIS, Scott , JONES, Ben , BUYDA, Oksana , TONTHAT, Locson , BUYDA, Andrew , KIRK, Patrick , HUNT, Loren , DEWEY, Jason , TRINCHERA, Jim , CRESSMAN, Bill , ZECH, Ron
发明人： ROSATI, Robert , PETCH, David , BURNEY, David , SYKORA, Jim , REGAS, Kenneth A. , BOUND, Andy , DOHERTY, Neil , DENNIS, Scott , JONES, Ben , BUYDA, Oksana , TONTHAT, Locson , BUYDA, Andrew , KIRK, Patrick , HUNT, Loren , DEWEY, Jason , TRINCHERA, Jim , CRESSMAN, Bill , ZECH, Ron
IPC分类号： B41J11/02 , B41J13/08 , B41J29/10 , B41J29/377
CPC分类号： B41J11/0085 , B41J2/165 , B41J2/16547 , B41J2/16585 , B41J2/175 , B41J2/1752 , B41J3/543 , B41J11/001 , B41J11/007 , B41J15/04 , B41J29/02
摘要： A printing system that has a printhead assembly, a drive roller for feeding media along a media path and a vacuum platen assembly configured for movement relative to the fixed printhead assembly.
摘要翻译：一种打印系统，其具有打印头组件，用于沿着介质路径供给介质的驱动辊和被配置为相对于固定打印头组件移动的真空压板组件。

6. 发明申请

WO2003066131A2 AGENT DELIVERY AND ASPIRATION DEVICE 审中-公开
标题翻译：代理交付和吸取装置
公开(公告)号：WO2003066131A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003361
申请日：2003-02-03
申请人： NDT , DRINAN, Darrel , EDMAN, Carl , ROSATI, Robert, J.
发明人： DRINAN, Darrel , EDMAN, Carl , ROSATI, Robert, J.
IPC分类号： A61M1/00
CPC分类号： A61B5/411 , A61B5/145 , A61M1/0003 , A61M1/0062 , A61M1/0072 , A61M3/0262 , A61M11/007 , A61M11/008 , A61M11/042 , A61M15/00 , A61M15/025 , A61M2205/075 , A61M2205/36 , A61M2210/0618 , A61M2230/005
摘要： The methods and devices disclosed provides for the delivery of agents to an orifice cavity and subsequent aspiration of the agent and orifice contents from the orifice cavity and related areas. In one form, the delivery and aspiration system comprises an agent delivery sub-assembly, an aspiration sub-assembly and a device tip sub-assembly. The subassemblies operate to first deliver an agent contained within the device to an orifice cavity and after an optional time delay,subsequently aspirate the delivered agent and orifice contents from the orifice cavity and related areas. In another form, a removable reservoir is provided whereby the aspirated agent and orifice contents from the orifice are assayed either independent of or within the device itself.
摘要翻译：所公开的方法和装置提供了将试剂输送到孔腔并且随后从孔腔和相关区域抽吸试剂和孔内容物。在一种形式中，递送和抽吸系统包括药剂递送子组件，抽吸子组件和装置尖端子组件。这些子组件用于首先将包含在该设备内的试剂递送到孔腔并且在可选的时间延迟之后，随后从孔腔和相关区域抽吸递送的试剂和孔内容物。在另一种形式中，提供可移除的储存器，由此从孔口抽吸的试剂和孔内容物被独立或在装置本身内进行分析。

7. 发明申请

WO1988003022A1 RELATIVELY LOW MOLECULAR WEIGHT POLYPEPTIDES AS RENIN INHIBITORS 审中-公开
标题翻译：相对低分子量多肽作为RININ抑制剂
公开(公告)号：WO1988003022A1
公开(公告)日：1988-05-05
申请号：PCT/US1986002348
申请日：1986-10-31
申请人： PFIZER INC. , ROSATI, Robert, L.
发明人： PFIZER INC.
IPC分类号： A61K31/335
CPC分类号： C07D403/12 , C07D209/42 , C07D403/14 , C07D405/12 , C07D405/14 , C07K5/0227 , C07K5/06139
摘要： Renin inhibitory polypeptides of relatively low molecular weight and small size; namely, derivatives of 4-amino-3-hydroxy-4-substituted-butanoic acids and 5-amino-2,5-disubstituted-4-hydroxypentanoic acids.
摘要翻译：相对低分子量和小尺寸的肾素抑制性多肽; 即4-氨基-3-羟基-4-取代 - 丁酸和5-氨基-2,5-二取代-4-羟基戊酸的衍生物。

8. 发明申请

WO2011143700A1 FLUID DISTRIBUTION SYSTEM FOR PRESSURE CONTROL AT PRINTHEAD 审中-公开
标题翻译：用于压力控制的流体分配系统
公开(公告)号：WO2011143700A1
公开(公告)日：2011-11-24
申请号：PCT/AU2011/000574
申请日：2011-05-16
申请人： SILVERBROOK RESEARCH PTY LTD , HIBBARD, Christopher , KWAN, Kent Benjamen , DYER, Geoffrey Philip , ESDAILE-WATTS, Edward Ellis , BORRA, Jeff , ROOT, Ryan , LUCAS, Jon , GUICHARD, Ray , ALESI, Tom , CEKALSKI, Neal , MALLORY, Bob , ROSATI, Robert , ECKARD, Mike
发明人： HIBBARD, Christopher , KWAN, Kent Benjamen , DYER, Geoffrey Philip , ESDAILE-WATTS, Edward Ellis , BORRA, Jeff , ROOT, Ryan , LUCAS, Jon , GUICHARD, Ray , ALESI, Tom , CEKALSKI, Neal , MALLORY, Bob , ROSATI, Robert , ECKARD, Mike
IPC分类号： B41J2/17
CPC分类号： B41J2/17596 , B41J2/175 , B41J2/17506 , B41J2/17556 , B41J2/17566 , B41J2/17593 , B41J2/18 , Y10T29/49826 , Y10T29/49865 , Y10T137/86863 , Y10T137/87338
摘要： A fluid distribution system for a printhead. The system having a first fluid container a fluid connector for connection to a fluid input of the printhead; and a second fluid container connected between the first container and the connector for delivering fluid from the first container to the connector, wherein the second container is located relative to the first container and the connector so that a fluid pressure difference between fluid contained within the second container and fluid at the connector is independent of the amount of fluid contained within the first container.
摘要翻译：用于打印头的流体分配系统。该系统具有第一流体容器，用于连接到打印头的流体输入端的流体连接器; 以及第二流体容器，其连接在所述第一容器和所述连接器之间，用于将流体从所述第一容器输送到所述连接器，其中所述第二容器相对于所述第一容器和所述连接器定位，使得包含在所述第二容器内的流体之间的流体压力差连接器处的容器和流体与包含在第一容器内的流体的量无关。

9. 发明申请

WO1998027976A1 PREVENTION AND TREATMENT OF SKELETAL DISORDER WITH EP2 RECEPTOR SUBTYPE SELECTIVE PROSTAGLANDIN E2 AGONISTS 审中-公开
标题翻译： EP2受体亚型选择性PROSTAGLANDIN E2 AGONISTS预防和治疗脊髓障碍
公开(公告)号：WO1998027976A1
公开(公告)日：1998-07-02
申请号：PCT/IB1997001483
申请日：1997-11-27
申请人： PFIZER INC. , CAMERON, Kimberly, O'Keefe , KE, Hua, Zhu , LEFKER, Bruce, Allen , ROSATI, Robert, Louis , THOMPSON, David, Duane
发明人： PFIZER INC.
IPC分类号： A61K31/18
CPC分类号： A61K31/195 , A61K31/00 , A61K31/18 , A61K31/192 , A61K31/197 , A61K31/20 , A61K31/381 , A61K31/41
摘要： Methods for treating (e.g. preventing bone loss) a mammal having a condition which presents with low bone mass or other skeletal disorders for promoting fracture healing comprising inhibiting the EP2 receptor subtype by administering to a mammal a therapeutically effective amount of an EP2 receptor subtype agonist.
摘要翻译：用于治疗（例如预防骨丢失）具有低骨量的疾病的哺乳动物或用于促进骨折愈合的其它骨骼疾病的方法包括通过向哺乳动物施用治疗有效量的EP2受体亚型激动剂来抑制EP2受体亚型。

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