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1. 发明申请

WO2007012944A9 METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 审中-公开
标题翻译：疫苗管理方法，新疫苗药物和用于免疫动物疫苗的疫苗和疫苗病毒的治疗方法
公开(公告)号：WO2007012944A9
公开(公告)日：2008-10-16
申请号：PCT/IB2006002018
申请日：2006-07-17
申请人： PFIZER PROD INC , LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBY THOMAS JACK
发明人： LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBY THOMAS JACK
IPC分类号： A61K38/16 , A61K39/12 , A61K48/00 , C07K14/08 , C07K16/10 , C12N15/40
CPC分类号： C07K16/10 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K2317/76 , C12N7/00 , C12N2710/16734 , C12N2750/10034 , C12N2750/14334 , C12N2770/16021 , C12N2770/16022 , C12N2770/16034 , G01N33/56983 , G01N2469/10
摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.
摘要翻译：本发明涉及用于免疫猫对猫科动物病毒的疫苗。本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。还公开了免疫动物特别是猫的疾病，特别是针对猫杯状病毒（FCV）的方法。该方法包括给予猫治疗有效量的第一和第二FCV疫苗。第一种疫苗口服或肠胃外给药（例如皮下，肌肉内等）。第二种疫苗在第一种疫苗给药后N天口服或鼻道给药，其中N为3至120的整数，包括端值在内。也可以给予第三次疫苗管理。本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒的猫，其也被称为泛素减少或FPL，并且与另一种疾病FHV或猫疱疹病毒称为猫科鼻气管炎病毒。

2. 发明申请

WO2007012944A3 METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 审中-公开
公开(公告)号：WO2007012944A3
公开(公告)日：2007-02-01
申请号：PCT/IB2006/002018
申请日：2006-07-17
申请人： PFIZER PRODUCTS INC. , LOWERY, David, Earl , RONG, Sing , GUIMOND, Paul, Mark , CLARE, Paula, Munns , TUCKER, Cassius, McAllister , NEWBY, Thomas, Jack
发明人： LOWERY, David, Earl , RONG, Sing , GUIMOND, Paul, Mark , CLARE, Paula, Munns , TUCKER, Cassius, McAllister , NEWBY, Thomas, Jack
IPC分类号： A61K38/16 , A61K39/12 , A61K48/00 , C07K14/08 , C07K16/10 , C12N15/40
摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.

3. 发明申请

WO2004039307A3 METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING COMPANION ANIMAL CANCER 审中-公开
标题翻译：用于诊断和治疗公司动物癌症的方法和组合物
公开(公告)号：WO2004039307A3
公开(公告)日：2005-04-14
申请号：PCT/IB0304635
申请日：2003-10-21
申请人： PFIZER PROD INC , CAI JENNY HONG , RONG SING
发明人： CAI JENNY HONG , RONG SING
IPC分类号： C07H21/04 , C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/574 , C07K5/00
CPC分类号： G01N33/574 , C07K14/70575 , C07K16/2875 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2500/00
摘要： The present invention relates to polynucleotides associated with apoptosis-related disorders. The present invention also relates to canine and feline TRAIL genes, novel genes associated with apoptosis-related disorders, such as cancer. The invention encompasses TRAIL nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, TRAIL gene products and antibodies directed against such gene products, cloning vectors containing mammalian TRAIL gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of TRAIL genes and gene products and to the use of such compounds as therapeutic agents in the treatment of apoptosis-related disorders, e.g., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of apoptosis-related disorders, e.g., cancer, and to methods and compositions for the treatment these disorders.
摘要翻译：本发明涉及与凋亡相关病症相关的多核苷酸。本发明还涉及犬和猫TRAIL基因，与凋亡相关病症如癌症相关的新基因。本发明包括TRAIL核酸，重组DNA分子，克隆基因或其简并变体，针对此类基因产物的TRAIL基因产物和抗体，含有哺乳动物TRAIL基因分子的克隆载体，以及已被遗传工程化以表达该分子的宿主。本发明还涉及用于鉴定调节TRAIL基因和基因产物的表达的化合物的方法以及这些化合物作为治疗剂在治疗凋亡相关病症例如癌症中的用途。本发明还涉及用于诊断评估，基因测试和凋亡相关病症例如癌症的预后的方法以及用于治疗这些疾病的方法和组合物。

4. 发明申请

WO2004039307A2 METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING COMPANION ANIMAL CANCER 审中-公开
标题翻译：用于诊断和治疗公司动物癌症的方法和组合物
公开(公告)号：WO2004039307A2
公开(公告)日：2004-05-13
申请号：PCT/IB2003/004635
申请日：2003-10-21
申请人： PFIZER PRODUCTS INC. , CAI, Jenny, Hong , RONG, Sing
发明人： CAI, Jenny, Hong , RONG, Sing
IPC分类号： A61K
CPC分类号： G01N33/574 , C07K14/70575 , C07K16/2875 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2500/00
摘要： The present invention relates to polynucleotides associated with apoptosis-related disorders. The present invention also relates to canine and feline TRAIL genes, novel genes associated with apoptosis-related disorders, such as cancer. The invention encompasses TRAIL nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, TRAIL gene products and antibodies directed against such gene products, cloning vectors containing mammalian TRAIL gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of TRAIL genes and gene products and to the use of such compounds as therapeutic agents in the treatment of apoptosis-related disorders, e.g ., cancer. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of apoptosis-related disorders, e.g ., cancer, and to methods and compositions for the treatment these disorders.
摘要翻译：本发明涉及与凋亡相关病症相关的多核苷酸。本发明还涉及犬和猫TRAIL基因，与凋亡相关病症如癌症相关的新基因。本发明包括TRAIL核酸，重组DNA分子，克隆基因或其简并变体，针对此类基因产物的TRAIL基因产物和抗体，含有哺乳动物TRAIL基因分子的克隆载体，以及已被遗传工程化以表达该分子的宿主。本发明还涉及用于鉴定调节TRAIL基因和基因产物的表达的化合物的方法以及这些化合物作为治疗剂在治疗凋亡相关病症例如癌症中的用途。本发明还涉及用于诊断评估，基因测试和凋亡相关病症例如癌症的预后的方法以及用于治疗这些疾病的方法和组合物。

5. 发明申请

WO2005080416A1 FELINE CALICIVIRUS VACCINES 审中-公开
公开(公告)号：WO2005080416A1
公开(公告)日：2005-09-01
申请号：PCT/IB2005/000069
申请日：2005-01-10
申请人： PHARMACIA & UPJOHN COMPANY LLC , RONG, Sing , SLADE, David, Ewell , ANKENBAUER, Robert, Gerard , WHEELER, David, Walter
发明人： RONG, Sing , SLADE, David, Ewell , ANKENBAUER, Robert, Gerard , WHEELER, David, Walter
IPC分类号： C07K14/08
CPC分类号： C07K14/005 , A61K2039/5252 , A61K2039/5254 , C12N7/00 , C12N2770/16034 , C12N2770/16043 , C12N2770/16061
摘要： The present invention relates to a vaccine for immunizing a cat against feline calicivirus. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus.
摘要翻译：本发明涉及用于免疫猫对猫杯状病毒的疫苗。本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。本发明还涉及用于鉴定可用于产生疫苗组合物的猫杯状病毒病的方法和用于诊断感染猫杯状病毒的猫的测定方法。

6. 发明申请

WO2007012944A2 METHODS OF VACCINE ADMINISTRATION, NEW FELINE CALICIVIRUSES, AND TREATMENTS FOR IMMUNIZING ANIMALS AGAINST FELINE PARAOVIRUS AND FELINE HERPES VIRUS 审中-公开
标题翻译：疫苗施用方法，新的恶性疟原虫以及用于免疫动物对抗细小病毒和细毛虫疱疹病毒的治疗
公开(公告)号：WO2007012944A2
公开(公告)日：2007-02-01
申请号：PCT/IB2006002018
申请日：2006-07-17
申请人： PFIZER PROD INC , LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBUY THOMAS JACK
发明人： LOWERY DAVID EARL , RONG SING , GUIMOND PAUL MARK , CLARE PAULA MUNNS , TUCKER CASSIUS MCALLISTER , NEWBUY THOMAS JACK
IPC分类号： A61K38/16 , A61K39/12 , A61K48/00 , C07K14/08 , C07K16/10 , C12N15/40
CPC分类号： C07K16/10 , A61K39/00 , A61K39/12 , A61K39/245 , A61K2039/5252 , A61K2039/5254 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C07K14/005 , C07K2317/76 , C12N7/00 , C12N2710/16734 , C12N2750/10034 , C12N2750/14334 , C12N2770/16021 , C12N2770/16022 , C12N2770/16034 , G01N33/56983 , G01N2469/10
摘要： The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or killed vaccine comprising the isolated feline calicivirus, a subunit vaccine comprising the capsid protein of the isolated feline calicivirus, a nucleic acid vaccine comprising a nucleic acid clone of the isolated feline calicivirus, and a recombinant virus vector vaccine comprising nucleic acid encoding the capsid protein of the isolated feline calicivirus. The present invention also relates to a method for identifying a feline calicivirus useful for producing a vaccine composition and for assays for diagnosing cats infected with feline calicivirus. Also disclosed is a method of immunizing animals, especially cats, against disease, in particular against feline calicivirus (FCV). The method includes administering to a cat therapeutically effective amounts of first and second FCV vaccines. The first vaccine is administered orally or parenterally (e.g., subcutaneously, intramuscularly, and the like). The second vaccine is administered orally or oronasally N days following administration of the first vaccine, wherein N is an integer from 3 to 120, inclusive. A third vaccine administration may also be given. The present invention also describes methods and materials for treating and immunizing animals with vaccine, and in particular cats against both FPV or Feline Parvovirus, which has also been called Panleukopenia or FPL and against another disease, FHV or Feline Herpes Virus, which has also been called Feline Rhinotracheitis Virus.
摘要翻译：本发明涉及使猫免疫猫病毒的疫苗。本发明还涉及编码分离的猫杯状病毒的衣壳蛋白的核酸克隆。本发明还涉及包含分离的猫杯状病毒的活的或杀死的疫苗，包含分离的猫杯状病毒的衣壳蛋白的亚单位疫苗，包含分离的猫杯状病毒的核酸克隆的核酸疫苗和重组病毒载体包含编码分离的猫杯状病毒的衣壳蛋白的核酸的疫苗。本发明还涉及用于鉴定可用于生产疫苗组合物的猫杯状病毒的方法和用于诊断猫猫杯状病毒感染的猫的测定方法。还公开了免疫动物，特别是猫免疫疾病，特别是对猫猫杯状病毒（FCV）的免疫方法。该方法包括向猫施用治疗有效量的第一和第二FCV疫苗。第一种疫苗经口服或胃肠外给药（例如皮下，肌肉内等）。第二次疫苗在第一次疫苗给药后口服或口服给药N天，其中N是3至120的整数，包括3和120。还可以给予第三次疫苗施用。本发明还描述了用疫苗治疗和免疫动物的方法和材料，特别是针对FPV或猫细小病毒（也称为泛白细胞减少症或FPL）以及针对另一种疾病的FVV或猫疱疹病毒的猫，其也已被称为猫鼻气管炎病毒。

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