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1. 发明申请

WO1995024378A1 IODINATED AROYLOXY KETONES 审中-公开
标题翻译：碘化阿片糖
公开(公告)号：WO1995024378A1
公开(公告)日：1995-09-14
申请号：PCT/US1995002227
申请日：1995-02-24
申请人： EASTMAN KODAK COMPANY , SINGH, Baldev , BACON, Edward, R. , ROBINSON, Shaughnessy
发明人： EASTMAN KODAK COMPANY
IPC分类号： C07C233/54
CPC分类号： C07D307/33 , A61K49/0433 , C07C233/54 , C07C2603/74
摘要： Compounds having structure (Ia) or (Ib), wherein (Z-)-COO is the residue of an iodinated aromatic acid; n is an integer from 0 to 20; R , R , R and R are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, acetamidoaryl, -COO-alkyl, -COO-aryl, -COO-aralkyl, -CO-alkyl, -CO-aryl, -CO-heterocyclyl, cyano or heterocyclyl; R is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl, heterocyclyl, or a Z-CO2-CR R -(-CR R -)-n group, wherein Z, R , R , R , R and n are as defined above, m is an integer from 0 to 10, p is an integer from 0 to 10, and m + p >/= 1 are useful as contrast agents in x-ray imaging compositions and methods.
摘要翻译：具有结构（Ia）或（Ib）的化合物，其中（Z）-COO是碘化芳族酸的残基; n为0〜20的整数， R 1，R 2，R 3和R 4独立地是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基，芳氧基，卤素，羟基，酰氨基，乙酰氨基烷基，乙酰氨基芳基，烷基，-COO-芳基，-COO-芳烷基，-CO-烷基，-CO-芳基，-CO-杂环基，氰基或杂环基; R 5是H，烷基，氟代烷基，环烷基，芳基，芳烷基，烷氧基烷基，杂环基或Z-CO 2 -CR 1 R 2 - （ - CR 3 R 4 - ） - n 基团，其中Z，R 1，R 2，R 3，R 4和n如上所定义，m是0至10的整数，p是0至10的整数，以及 m + p> / = 1可用作x射线成像组合物和方法中的造影剂。

2. 发明申请

WO2008139288A3 SUBSTITUTED HETEROCYCLIC DERIVATIVES AND COMPOSITIONS AND THEIR PHARMACEUTICAL USE AS ANTIBACTERIALS 审中-公开
标题翻译：取代的杂环衍生物和组合物及其作为抗生素的药物使用
公开(公告)号：WO2008139288A3
公开(公告)日：2009-03-26
申请号：PCT/IB2008001076
申请日：2008-04-29
申请人： PFIZER , BRICKNER STEVEN JOSEPH , CHEN JINSHAN MICHAEL , LI ZHENGONG BRYAN , MARFAT ANTHONY , MITTON-FRY MARK JOSEPH , REILLY USA , PLOTKIN MICHAEL AARON , ROBINSON SHAUGHNESSY , SUBRAMANYAM CHAKRAPANI , ZHANG ZHIJUN
发明人： BRICKNER STEVEN JOSEPH , CHEN JINSHAN MICHAEL , LI ZHENGONG BRYAN , MARFAT ANTHONY , MITTON-FRY MARK JOSEPH , REILLY USA , PLOTKIN MICHAEL AARON , ROBINSON SHAUGHNESSY , SUBRAMANYAM CHAKRAPANI , ZHANG ZHIJUN
IPC分类号： C07D401/06 , A61K31/4709 , A61P31/04 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Compounds of the general Formula (I), wherein X1, X2, X3, X4, X5, X6, X7, R1, R2, R4, R5, R6, R7, R8, R9, R10, Y1, n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.
摘要翻译：通式（I）的化合物，其中X1，X2，X3，X4，X5，X6，X7，R1，R2，R4，R5，R6，R7，R8，R9，R10，Y1，n，m，p和 q如上所述，其制备及其作为抗微生物剂的用途。

3. 发明申请

WO2012097013A1 IRAK INHIBITORS AND USES THEREOF 审中-公开
标题翻译： IRAK抑制剂及其用途
公开(公告)号：WO2012097013A1
公开(公告)日：2012-07-19
申请号：PCT/US2012/020845
申请日：2012-01-10
申请人： NIMBUS IRIS, INC. , ROMERO, Donna L. , WESSEL, Matthew David , ROBINSON, Shaughnessy , GREENWOOD, Jeremy Robert , WATTS, Karl Shawn , FRYE, Leah Lynn , HARRIMAN, Geraldine C. , CORIN, Alan Franklin , MASSE, Craig
发明人： ROMERO, Donna L. , WESSEL, Matthew David , ROBINSON, Shaughnessy , GREENWOOD, Jeremy Robert , WATTS, Karl Shawn , FRYE, Leah Lynn , HARRIMAN, Geraldine C. , CORIN, Alan Franklin , MASSE, Craig
IPC分类号： A61K31/519 , C07D495/02
CPC分类号： A61K31/519 , A61K31/5377 , C07D495/04
摘要： The present invention relates to compounds and methods useful for inhibiting one or more interleukin-l receptor-associated kinases ("IRAK"). In some embodiments, a provided compound inhibits IRAK-1 and IRAK-4. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
摘要翻译：本发明涉及可用于抑制一种或多种白介素-1受体相关激酶（“IRAK”）的化合物和方法。在一些实施方案中，所提供的化合物抑制IRAK-1和IRAK-4。本发明还提供包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。

4. 发明申请

WO2008139288A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS 审中-公开
标题翻译：取代的杂环衍生物及其药物用途和组合物
公开(公告)号：WO2008139288A2
公开(公告)日：2008-11-20
申请号：PCT/IB2008/001076
申请日：2008-04-29
申请人： PFIZER INC. , BRICKNER, Steven, Joseph , CHEN, Jinshan, Michael , LI, Zhengong, Bryan , MARFAT, Anthony , MITTON-FRY, Mark, Joseph , REILLY, Usa , PLOTKIN, Michael, Aaron , ROBINSON, Shaughnessy , SUBRAMANYAM, Chakrapani , ZHANG, Zhijun
发明人： BRICKNER, Steven, Joseph , CHEN, Jinshan, Michael , LI, Zhengong, Bryan , MARFAT, Anthony , MITTON-FRY, Mark, Joseph , REILLY, Usa , PLOTKIN, Michael, Aaron , ROBINSON, Shaughnessy , SUBRAMANYAM, Chakrapani , ZHANG, Zhijun
IPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04 , A61K31/4709 , A61P31/04
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Compounds of the general Formula (I), wherein X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , X 7 , R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , Y 1 , n, m, p and q are defined as above, their preparation and their use as antimicrobial agents.
摘要翻译：通式（I）的化合物，其中X 1，X 2，X 3，X 4， X 5，X 6，X 7，R 1，R 2， R 4，R 5，R 6，R 7，R 8， R 9，R 10，Y 1，n，m，p和q如上所定义，它们的制备及其作为抗微生物剂的用途。

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