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1. 发明申请

WO2006123242A1 1, 2, 4 -TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译： 1,2,4-异噻唑衍生物作为VASOPRESSIN ANTAGONISTS
公开(公告)号：WO2006123242A1
公开(公告)日：2006-11-23
申请号：PCT/IB2006/001442
申请日：2006-05-08
申请人： PFIZER LIMITED , BRYANS, Justin, Stephen , JOHNSON, Patrick, Stephen , ROBERTS, Lee, Richard , RYCKMANS, Thomas
发明人： BRYANS, Justin, Stephen , JOHNSON, Patrick, Stephen , ROBERTS, Lee, Richard , RYCKMANS, Thomas
IPC分类号： C07D403/04 , C07D471/04 , C07D491/10 , C07D471/10 , C07D403/14 , C07D401/04 , C07D487/04 , C07D498/04 , A61K31/4196 , A61P15/00 , A61P9/00
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D403/14 , C07D471/10 , C07D487/04 , C07D491/10 , C07D498/04
摘要： Compounds of formula (I), or a pharmaceutically acceptable salt, solvate, ester or amide thereof, wherein R 1 represents [CH 2 ] n -R 2 ; R 2 represents H, C 1-6 alkyloxy or Het; n represents a number selected from 0 to 6; Het represents an unsaturated heterocycle of 5 or 6 atoms containing one or more heteroatoms selected from O, N, and S; R 3 represents halo; Ring A represents a 4 to 7 membered, saturated, partially saturated, or unsaturated heterocycle containing one or more heteroatoms selected from O, N, and S; Ring B represents a saturated, partially saturated, or unsaturated heterocycle of from 3 to 8 atoms containing one or more heteroatoms selected from O, N, and S, or Ring B represents a saturated or unsaturated carbocyclic ring of from 3 to 8 atoms; Ring B is optionally fused to an aryl ring and is optionally substituted with one or more groups independently selected from R 4 ; Ring A and Ring B share at least one atom; R 4 represents oxo, [CH 2 ] m -R 5 , or CH-R 6 R 7 ; R 5 represents H, OH, C 1-6 alkyloxy, COOH, or CONR 8 R 9 ; m represents a number selected from 0 or 1 ; and R 6 , R 7 , R 8 and R 9 independently represent H or C 1-6 alkyl; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物，酯或酰胺，其中R 1表示[CH 2 N] -R ^{2 ; R 2表示H，C 1-6烷氧基或Het; n表示选自0〜6的数; Het表示含有一个或多个选自O，N和S的杂原子的5或6个原子的不饱和杂环; R 3表示卤素; 环A表示含有一个或多个选自O，N和S的杂原子的4至7元饱和的，部分饱和的或不饱和的杂环; 环B表示含有一个或多个选自O，N和S的杂原子的3至8个原子的饱和，部分饱和或不饱和杂环，或环B表示3至8个原子的饱和或不饱和碳环; 环B任选地与芳环稠合并且任选地被一个或多个独立地选自R 4的基团取代; 环A和环B共享至少一个原子; R 4表示氧代，[CH 2 CH 2] m -R 5或CH-R 6 - [R ^{7 ; R 5表示H，OH，C 1-6烷氧基，COOH或CONR 8 R 9; m表示选自0或1的数字; 且R 6，R 7，R 8和R 9独立地表示H或C 1〜 6烷基; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。}}

2. 发明申请

WO2008117169A1 PYRIMIDO [4, 5-D] AZEPINE DERIVATIVES AS 5-HT2C AGONISTS 审中-公开
标题翻译： PYRIMIDO [4，5-D] AZEPINE衍生物作为5-HT2C激动剂
公开(公告)号：WO2008117169A1
公开(公告)日：2008-10-02
申请号：PCT/IB2008/000731
申请日：2008-03-14
申请人： PFIZER LIMITED , ANDREWS, Mark, David , BLAGG, Julian , BRENNAN, Paul, Edward , FISH, Paul, Vincent , ROBERTS, Lee, Richard , STORER, Robert, Ian , WHITLOCK, Gavin, Alistair
发明人： ANDREWS, Mark, David , BLAGG, Julian , BRENNAN, Paul, Edward , FISH, Paul, Vincent , ROBERTS, Lee, Richard , STORER, Robert, Ian , WHITLOCK, Gavin, Alistair
IPC分类号： C07D487/04 , A61K31/55 , A61P15/00 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I): wherein R 1 , R 2 , R 3a , R 3b , R 3c , R 3d and R 100 are as defined in the specification. These compounds act as 5-HT 2C agonists.
摘要翻译：本发明涉及式（I）的化合物：其中R 1，R 2，R 3a，R SUP， > 3b，R 3c，R 3d和R 100如说明书中所定义。这些化合物起5-HT 2C激动剂的作用。

3. 发明申请

WO2005060749A1 SUBSTITUTED ARYLPYRAZOLES AS PARASITICIDAL AGENTS 审中-公开
标题翻译：取代的芳基作为芳族化合物
公开(公告)号：WO2005060749A1
公开(公告)日：2005-07-07
申请号：PCT/IB2004/004193
申请日：2004-12-15
申请人： PFIZER LIMITED , PFIZER, INC. , BILLEN, Denis , CHUBB, Nathan, Anthony, Logan , GETHIN, David, Morris , HALL, Kim, Thomas , ROBERTS, Lee, Richard , WALSHE, Nigel, Derek, Arthur
发明人： BILLEN, Denis , CHUBB, Nathan, Anthony, Logan , GETHIN, David, Morris , HALL, Kim, Thomas , ROBERTS, Lee, Richard , WALSHE, Nigel, Derek, Arthur
IPC分类号： A01N43/56
CPC分类号： A01N43/56 , A61K31/415 , A61K31/416 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D413/04
摘要： This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, to compositions comprising such compounds, processes to their synthesis and their use as parasticides.
摘要翻译：本发明涉及其中存在至少一个与环丙基环连接的氟的1-芳基-4-环丙基吡唑的范围，包含这些化合物的组合物，其合成方法及其作为残留物的用途。

4. 发明申请

WO2013068708A1 A PROTECTIVE INSERT FOR AN ITEM OF HEADWEAR 审中-公开
标题翻译：一个项目的保护插件
公开(公告)号：WO2013068708A1
公开(公告)日：2013-05-16
申请号：PCT/GB2012/000767
申请日：2012-10-09
申请人： ROBERTS, Lee Richard
发明人： ROBERTS, Lee Richard
IPC分类号： A42B1/08
CPC分类号： A42B3/12 , A42B1/08
摘要： In any number of head positions a golf ball has potential to do great damage. According to the present invention there is provided a protective insert for an item of golfing headwear with integral rigid peak.
摘要翻译：在任何数量的头部位置，高尔夫球都有潜在的巨大伤害。根据本发明，提供了一种用于具有整体刚性顶点的高尔夫球头件的保护插入件。

5. 发明申请

WO2010067286A2 IgE CH3 PEPTIDE VACCINE 审中-公开
公开(公告)号：WO2010067286A2
公开(公告)日：2010-06-17
申请号：PCT/IB2009/055508
申请日：2009-12-04
申请人： PFIZER VACCINES LLC , BROWN, Alan Daniel , CHAMPION, Brian Robert , CHRISTY, Clare , GERVAIS, David Paul , JONES, Lyn Howard , KJERRSTROM, Anne Maria Kristina , PRYDE, David Cameron , ROBERTS, Lee Richard , WYATT, David Michael
发明人： BROWN, Alan Daniel , CHAMPION, Brian Robert , CHRISTY, Clare , GERVAIS, David Paul , JONES, Lyn Howard , KJERRSTROM, Anne Maria Kristina , PRYDE, David Cameron , ROBERTS, Lee Richard , WYATT, David Michael
IPC分类号： A61K39/00 , C07K16/00 , A61P37/08
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供新型免疫原，其包含抗原性IgE肽，优选与免疫原性载体连接以预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在医药中的应用。

6. 发明申请

WO2006114706A1 TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译：三唑衍生物作为VASOPRESSIN拮抗剂
公开(公告)号：WO2006114706A1
公开(公告)日：2006-11-02
申请号：PCT/IB2006/001071
申请日：2006-04-18
申请人： PFIZER LIMITED , BRYANS, Justin, Stephen , BUNNAGE, Mark, Edward , JOHNSON, Patrick, Stephen , MASON, Helen, Janet , ROBERTS, Lee, Richard , RYCKMANS, Thomas , STOBIE, Alan , UNDERWOOD, Toby, James
发明人： BRYANS, Justin, Stephen , BUNNAGE, Mark, Edward , JOHNSON, Patrick, Stephen , MASON, Helen, Janet , ROBERTS, Lee, Richard , RYCKMANS, Thomas , STOBIE, Alan , UNDERWOOD, Toby, James
IPC分类号： C07D401/14 , C07D498/04 , C07D413/14 , C07D487/04 , C07D471/04 , C07D417/14 , C07D513/04 , A61K31/4196 , A61P25/00
CPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: R 1 represents a group selected from H, CF 3 , and C 1-6 alkyl (optionally substituted by C 1-6 alkyloxy or triazolyl); R 2 represents halo; Ring A represents a 5- or 6-membered heterocyclic ring containing at least one N atom (the ring being optionally bridged with two or more carbon atoms); R 3 represents a 5- or 6-membered heterocyclic ring containing at least one atom selected from N, O or S, the heterocyclic ring being optionally substituted by one or more groups selected from C 1-6 alkyl, oxo or NH 2 , the heterocyclic ring being further optionally fused to a 5- or 6-membered aryl or heterocyclic ring containing at least one atom selected from N, O or S, the fused aryl or heterocyclic ring being substituted by one or more halo atoms; are useful for treating a disorder for which a V1a antagonist is indicated, in particular, dysmenorrhoea.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：R 1表示选自H，CF 3 N和C 1-6的基团，（任选被C 1-6烷氧基或三唑基取代）; R 2表示卤素; 环A表示含有至少一个N原子（该环任选地与两个或多个碳原子桥连）的5-或6-元杂环; R 3表示含有至少一个选自N，O或S的原子的5或6元杂环，该杂环任选被一个或多个选自C 1 -6个烷基，氧代或NH 2，杂环进一步任选地与含有至少一个选自N，O或者O的原子的5-或6-元芳基或杂环稠合 S，稠合的芳基或杂环被一个或多个卤素原子取代; 可用于治疗指示V1a拮抗剂的疾病，特别是痛经。

7. 发明申请

WO2010067286A3 IgE CH3 PEPTIDE VACCINE 审中-公开
公开(公告)号：WO2010067286A3
公开(公告)日：2010-08-05
申请号：PCT/IB2009055508
申请日：2009-12-04
申请人： PFIZER VACCINES LLC , BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
发明人： BROWN ALAN DANIEL , CHAMPION BRIAN ROBERT , CHRISTY CLARE , GERVAIS DAVID PAUL , JONES LYN HOWARD , KJERRSTROM ANNE MARIA KRISTINA , PRYDE DAVID CAMERON , ROBERTS LEE RICHARD , WYATT DAVID MICHAEL
IPC分类号： A61K39/00 , A61P37/08 , C07K16/00
CPC分类号： A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要： The present invention relates to the provision of immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译：本发明涉及提供免疫原，其包含优选与免疫原性载体连接的抗原性IgE肽，用于预防，治疗或减轻IgE介导的病症。本发明还涉及这些药物的生产方法，免疫原性组合物及其药物合成及其在医药中的应用。

8. 发明申请

WO2006134466A1 SUBSTITUTED ARYLPYRAZOLES AS PARASITICIDAL AGENTS 审中-公开
标题翻译：取代的芳基作为芳族化合物
公开(公告)号：WO2006134466A1
公开(公告)日：2006-12-21
申请号：PCT/IB2006/001579
申请日：2006-06-06
申请人： PFIZER LIMITED , BILLEN, Denis , CHUBB, Nathan, Antony, Logan , GETHIN, David, Morris , HALL, Kim, Thomas , ROBERTS, Lee, Richard , WALSHE, Nigel, Derek, Arthur
发明人： BILLEN, Denis , CHUBB, Nathan, Antony, Logan , GETHIN, David, Morris , HALL, Kim, Thomas , ROBERTS, Lee, Richard , WALSHE, Nigel, Derek, Arthur
IPC分类号： A01N43/56 , C07D401/04 , C07D413/04 , C07D401/12 , C07D403/12
CPC分类号： C07D401/04 , A61K31/415 , A61K31/4439 , C07D231/38 , C07D231/40 , C07D401/12 , C07D403/12 , C07D413/04 , A61K2300/00
摘要： This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further therapeutic agents, particularly anti-parasitic agents.
摘要翻译：本发明涉及包含一系列1-芳基-4-环丙基吡唑的组合产品，其中至少一个氟连接到环丙基环上，另外还有一种还有更多的治疗剂，特别是抗寄生虫剂。

9. 发明申请

WO2005063754A1 TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译：三唑衍生物作为VASOPRESSIN拮抗剂
公开(公告)号：WO2005063754A1
公开(公告)日：2005-07-14
申请号：PCT/IB2004/004059
申请日：2004-12-09
申请人： PFIZER LIMITED , PFIZER INC. , BRYANS, Justin, Stephen , JOHNSON, Patrick, Stephen , ROBERTS, Lee, Richard , RYCKMANS, Thomas
发明人： BRYANS, Justin, Stephen , JOHNSON, Patrick, Stephen , ROBERTS, Lee, Richard , RYCKMANS, Thomas
IPC分类号： C07D487/04
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D413/14 , C07D471/04
摘要： Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: V represents a direct link or -O-; Ring A represents an optionally substituted 5- to 7-membered saturated heterocyclic ring, or a phenylene group.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中：V表示直链或-O-; 环A表示任选取代的5至7元饱和杂环或亚苯基。

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