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1. 发明申请

WO2006106358A3 USE OF NK-3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NAUSEA AND VOMITING 审中-公开
标题翻译： NK-3受体拮抗剂在治疗恶性肿瘤和恶性肿瘤中的应用
公开(公告)号：WO2006106358A3
公开(公告)日：2006-12-28
申请号：PCT/GB2006050070
申请日：2006-03-31
申请人： MERCK SHARP & DOHME , RIGBY MICHAEL , TATTERSALL FREDERICK DAVID
发明人： RIGBY MICHAEL , TATTERSALL FREDERICK DAVID
IPC分类号： A61K31/47 , A61P1/08
CPC分类号： A61K31/47
摘要： This invention relates to the treatment or prevention of nausea and/or vomiting by the administration of a NK-3 receptor antagonist.
摘要翻译：本发明涉及通过施用NK-3受体拮抗剂治疗或预防恶心和/或呕吐。

2. 发明申请

WO2004008117A2 METHOD AND APPARATUS FOR MONITORING PARTICLES FLOWING IN A STACK 审中-公开
标题翻译：用于监测在堆栈中流动的颗粒的方法和装置
公开(公告)号：WO2004008117A2
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003073
申请日：2003-07-15
申请人： PCME LIMITED , RIGBY, Michael , WAKEFIELD, Michael , BLACKWELL, John, Michael , THOMAS, Victor, Frederick
发明人： RIGBY, Michael , WAKEFIELD, Michael , BLACKWELL, John, Michael , THOMAS, Victor, Frederick
IPC分类号： G01N21/53
CPC分类号： G01N21/532 , G01N21/274 , G01N2021/536
摘要： A particle monitor for monitoring particles flowing in a stack comprises: (i) a light source (90) for generating a measurement beam (60) on a first side of the particle flow (70); (ii) an optical system for directing the measurement beam (60) towards a second side of the particle flow (70) without the measurement beam (60) scattering from the particles, (iii) a reflector (210) arranged to reflect the measurement beam (60) back towards the first side of the particle flow (70), (iv) an optical system for directing the measurement beam (60) into the particle flow (70) such that light from the measurement beam (60) is scattered by the particles (70); and (v) a scattered-light detector (80) for detecting, on the first side of the particle flow (70), the scattered light.
摘要翻译：用于监测在堆叠中流动的颗粒的颗粒监测器包括：（i）用于在颗粒流（70）的第一侧上产生测量光束（60）的光源（90）; （ii）用于将测量光束（60）朝向颗粒流（70）的第二侧引导而不使测量光束（60）从颗粒散射的光学系统，（iii）布置成反射测量的反射器（210）（60）朝向所述颗粒流（70）的第一侧返回，（iv）用于将所述测量光束（60）引导到所述粒子流（70）中以使得来自所述测量光束（60）的光被散射的光学系统通过颗粒（70）和（v）散射光检测器（80），用于在所述粒子流（70）的第一侧上检测所述散射光。

3. 发明申请

WO2008075046A3 IMPROVEMENTS IN METHODS AND APPARATUS FOR MONITORING PARTICLES FLOWING IN A STACK 审中-公开
标题翻译：用于监测在堆叠中流动的颗粒的方法和设备的改进
公开(公告)号：WO2008075046A3
公开(公告)日：2008-10-02
申请号：PCT/GB2007004887
申请日：2007-12-19
申请人： PCME LTD , RIGBY MICHAEL , AVERDIECK WILLIAM JOHN
发明人： RIGBY MICHAEL , AVERDIECK WILLIAM JOHN
IPC分类号： G01N15/02 , G01N15/06
CPC分类号： G01N15/0656 , G01N15/0205 , G01N2015/0693
摘要： An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).
摘要翻译：一种用于监测在堆叠（6）中流动的颗粒的设备（7），包括：电互动监测器（1），其可操作以提供由颗粒与监测器（1）的电相互作用产生的信号（300）。可操作以提供由检测从粒子散射的光而产生的信号（310）的散射光监测器（10）;以及控制器（320），所述控制器（320）被配置为响应于所述电相互作用监测器1 电信号（信号300）和散射光信号（310）的相对大小。

4. 发明申请

WO2008075046A2 IMPROVEMENTS IN METHODS AND APPARATUS FOR MONITORING PARTICLES FLOWING IN A STACK 审中-公开
标题翻译：用于监测堆叠中流动的颗粒的方法和装置的改进
公开(公告)号：WO2008075046A2
公开(公告)日：2008-06-26
申请号：PCT/GB2007/004887
申请日：2007-12-19
申请人： PCME LIMITED , RIGBY, Michael , AVERDIECK, William, John
发明人： RIGBY, Michael , AVERDIECK, William, John
IPC分类号： G01N15/02 , G01N15/06
CPC分类号： G01N15/0656 , G01N15/0205 , G01N2015/0693
摘要： An apparatus (7) for monitoring particles flowing in a stack (6), comprises: an electrical-interaction monitor (1) operable to provide a signal (300) resulting from electrical interaction of the particles with the monitor (1). a scattered-light monitor (10) operable to provide a signal (310) resulting from detection of light scattered from the particles, and a controller (320) arranged to alter the calibration of the electrical-interaction monitor 1 in response to changes in the relative magnitude of the electrical-interaction (signal 300) and the scattered-light signal (310).
摘要翻译：一种用于监测在堆叠（6）中流动的颗粒的装置（7），包括：电相互作用监测器（1），可操作以提供由颗粒与监测器（1）的电相互作用产生的信号（300）。散射光监视器（10），其可操作以提供由从所述粒子散射的光的检测而产生的信号（310）;以及控制器（320），其被配置为响应于所述电动交互监视器1的变化而改变所述电动交互监视器1的校准电相互作用（信号300）和散射光信号（310）的相对大小。

5. 发明申请

WO2007113567A1 OPTICAL BEAM DUMP 审中-公开
标题翻译：光束灯
公开(公告)号：WO2007113567A1
公开(公告)日：2007-10-11
申请号：PCT/GB2007/001253
申请日：2007-04-04
申请人： PCME LTD. , ROGERS, John , RIGBY, Michael
发明人： ROGERS, John , RIGBY, Michael
IPC分类号： G01N21/53 , G01N15/02 , G02B5/00
CPC分类号： G01N15/0205 , G01N21/15 , G01N2021/151 , G01N2021/536 , G01N2201/0642
摘要： An optical beam dump (30), (51) having a passage defined by a passage wall and an optical filter (33), (55) located in an opening in that passage wall. The optical filter (33), (55) being arranged to direct light reflected from that filter (33), (55) along the passage away from an optical input (32), (65) to the beam dump. The passage may be formed as a tube (31), or may be cut within a block of material (52). The passage may have a plurality of bends. Provision for the flow of purging air through the beam dump is made by providing holes (36), (61) in the passage wall.
摘要翻译：具有由通道壁限定的通道和位于该通道壁的开口中的滤光器（33）的光束收集器（30），（51）。滤光器（33）（55）被布置成将从该滤光器（33），（55）反射的光沿着远离光输入（32），（65）的通道引导到光束转台。通道可以形成为管（31），或者可以在一块材料（52）内切割。通道可以具有多个弯曲部。通过在通道壁中设置孔（36），（61）来制造吹扫空气通过束流器的流动。

6. 发明申请

WO2006106358A2 USE OF NK-3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NAUSEA AND VOMITING 审中-公开
标题翻译：使用NK-3受体拮抗剂治疗鼻炎和感冒
公开(公告)号：WO2006106358A2
公开(公告)日：2006-10-12
申请号：PCT/GB2006/050070
申请日：2006-03-31
申请人： MERCK SHARP & DOHME LIMITED , RIGBY, Michael , TATTERSALL, Frederick, David
发明人： RIGBY, Michael , TATTERSALL, Frederick, David
IPC分类号： A61K31/47 , A61P1/08
CPC分类号： A61K31/47
摘要： This invention relates to the treatment or prevention of nausea and/or vomiting by the administration of a NK-3 receptor antagonist.
摘要翻译：本发明涉及通过施用NK-3受体拮抗剂治疗或预防恶心和/或呕吐。

7. 发明申请

WO2004008117A3 METHOD AND APPARATUS FOR MONITORING PARTICLES FLOWING IN A STACK 审中-公开
标题翻译：用于监测堆栈中流动的颗粒的方法和装置
公开(公告)号：WO2004008117A3
公开(公告)日：2004-03-18
申请号：PCT/GB0303073
申请日：2003-07-15
申请人： PCME LTD , RIGBY MICHAEL , WAKEFIELD MICHAEL , BLACKWELL JOHN MICHAEL , THOMAS VICTOR FREDERICK
发明人： RIGBY MICHAEL , WAKEFIELD MICHAEL , BLACKWELL JOHN MICHAEL , THOMAS VICTOR FREDERICK
IPC分类号： G01N21/27 , G01N21/53
CPC分类号： G01N21/532 , G01N21/274 , G01N2021/536
摘要： A particle monitor for monitoring particles flowing in a stack comprises: (i) a light source (90) for generating a measurement beam (60) on a first side of the particle flow (70); (ii) an optical system and a tube connected thereto for directing the measurement beam (60) through said tube towards a second side of the particle flow (70) without the measurement beam (60) scattering from the particles, (iii) a reflector (210) arranged to reflect the measurement beam (60) back towards the first side of the particle flow (70), (iv) an optical system for directing the measurement beam (60) into the particle flow (70) such that light from the measurement beam (60) is scattered by the particles (70); and (v) a scattered-light detector (80) for detecting, on the first side of the particle flow (70), the scattered light.
摘要翻译：用于监测在堆叠中流动的颗粒的颗粒监测器包括：（i）用于在颗粒流（70）的第一侧上产生测量光束（60）的光源（90）; （ii）光学系统和连接到其上的管，用于将测量光束（60）引导通过所述管朝向颗粒流（70）的第二侧，而测量光束（60）不与颗粒散射，（iii）反射器（210），被布置成将所述测量光束（60）反射回所述粒子流（70）的第一侧;（iv）用于将所述测量光束（60）引导到所述粒子流（70）中的光学系统，测量光束（60）被颗粒（70）散射; 和（v）散射光检测器（80），用于在所述粒子流（70）的第一侧检测所述散射光。

8. 发明申请

WO1993024405A1 TOOL FOR OPENING A CONTAINER 审中-公开
标题翻译：打开集装箱的工具
公开(公告)号：WO1993024405A1
公开(公告)日：1993-12-09
申请号：PCT/GB1993000850
申请日：1993-04-23
申请人： RIGBY, Michael, Edward , FAIRMAN, Michael, Terence
IPC分类号： B67B07/52
CPC分类号： B67B7/44 , B67B7/30
摘要： A tool for opening a container comprises a cylindrical housing (2) with a radially extending inwardly directed annular flange (4). Extending from around the inner circumferential surfaces of the annular flange and directed axially downwardly is an array (6) of eight teeth (8). The radially inner side of each tooth (8) has a radially outwardly directed step (8A). The steps (8A) of all eight teeth define an interrupted land which will support a severed membrane. In operation the cylindrical member (2) is lowered onto the screw threaded neck of a container. The neck is closed by a rupturable membrane. When the teeth (8) engage the membrane they will pierce the membrane at eight separate locations until the flange (4) rests on the neck. In this position the step (8A) in each tooth (8) will underlie the membrane. The cylindrical housing (2) is then rotated to produce a complete circular cut out of the membrane. The circular cut-out upon being disconnected from the rest of the membrane will now rest on the interrupted land formed by the teeth. The cylindrical housing (2) can now be withdrawn and will take with it the circular cut-out.
摘要翻译：用于打开容器的工具包括具有径向延伸的向内指向的环形凸缘（4）的圆柱形壳体（2）。从环形凸缘的内圆周表面周围延伸并且轴向向下延伸的是具有八个齿（8）的阵列（6）。每个齿（8）的径向内侧具有径向向外指向的台阶（8A）。所有八个齿的步骤（8A）限定了将支撑切断的膜的中断的平台。在操作中，圆柱形构件（2）下降到容器的螺纹颈部上。颈部由可破裂的膜封闭。当齿（8）接合膜时，它们将在八个不同的位置刺穿膜，直到凸缘（4）搁在颈部上。在该位置，每个牙齿（8）中的台阶（8A）将位于膜的下面。然后旋转圆柱形壳体（2）以从膜产生完整的圆形切口。与膜的其余部分断开的圆形切口现在将搁置在由牙齿形成的中断的地面上。圆柱形外壳（2）现在可以撤回，并带有圆形切口。

9. 发明申请

WO1993022653A1 DETECTING PARTICLES IN A GAS FLOW 审中-公开
标题翻译：检测气体流中的颗粒
公开(公告)号：WO1993022653A1
公开(公告)日：1993-11-11
申请号：PCT/GB1992000816
申请日：1992-05-05
申请人： POLLUTION CONTROL & MEASUREMENT (EUROPE) LTD. , RIGBY, Michael
发明人： POLLUTION CONTROL & MEASUREMENT (EUROPE) LTD.
IPC分类号： G01N15/06
CPC分类号： G01F1/64 , G01N15/0656
摘要： In a method for detecting particles in a gas flow, a probe (8) is charged triboelectrically by particles (10) in the flow and the quantities of electrical charges transferred to the probe are evaluated to provide an indication of the particle flow in the gas flow. In order to reduce the effect of variations in 'gas flow related variables' other than those relating to particle flow, an alternating component in the signal caused by the triboelectrical charging of the probe is monitored.

10. 发明申请

WO1994023281A1 METHOD AND APPARATUS FOR DETECTING PARTICLES IN A FLOW 审中-公开
标题翻译：在流程中检测颗粒的方法和装置
公开(公告)号：WO1994023281A1
公开(公告)日：1994-10-13
申请号：PCT/GB1994000711
申请日：1994-03-31
申请人： POLLUTION CONTROL AND MEASUREMENT (EUROPE) LTD. , RIGBY, Michael , THOMAS, Victor, Frederick
发明人： POLLUTION CONTROL AND MEASUREMENT (EUROPE) LTD.
IPC分类号： G01N15/06
CPC分类号： G01N15/06 , G01F1/64 , G01F1/74 , G01N27/60
摘要： An apparatus for detecting particles in a flow comprises a probe (1) positioned so that it projects into the flow and is charged triboelectrically by the particles in the flow. An electric circuit is coupled to the probe (1) and includes evaluating means for monitoring a signal from the probe (1) and for providing an output in dependence on the signal generated by the triboelectric charging of the probe (1). The part of the probe (1) that projects into the particle flow comprises an electrically conducting core covered with an insulating layer (2) which insulates the core from the particle flow.
摘要翻译：用于检测流体中的颗粒的装置包括定位成使得其突出到流中并由流中的颗粒摩擦电荷的探针（1）。电路耦合到探头（1），并且包括用于监测来自探针（1）的信号并根据由探针（1）的摩擦带电产生的信号提供输出的评估装置。投影到颗粒流中的探针（1）的部分包括覆盖有绝缘层（2）的导电芯，该绝缘层使芯与颗粒流绝缘。

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