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1. 发明申请

WO2008067044A3 DISPERSION DEVICES FOR AGGREGATES 审中-公开
标题翻译：用于聚合的分散装置
公开(公告)号：WO2008067044A3
公开(公告)日：2008-12-04
申请号：PCT/US2007080958
申请日：2007-10-10
申请人： MERIAL LTD , RIGAUT GUILLAUME
发明人： RIGAUT GUILLAUME
IPC分类号： A47J19/06 , B02C11/00 , B09B3/00 , C12N5/073
CPC分类号： C12M43/02 , C12M47/06 , C12N5/0603 , C12N2531/00
摘要： The present invention encompasses a flow-through dispersion device for the dispersion of cell aggregates, the device comprising a first or upstream inlet obstacle and a second or downstream outlet obstacle, each obstacle having at least one traversing hole wherein no two holes align. Between the two obstacles is a turbulence chamber, such that when a cell suspension is passed through the inlet holes, into the chamber and then exits the second obstacle, the turbulence within the chamber disrupts and disperses cell aggregates. The device optionally may have more than two obstacles and turbulence chambers and multiple units may be placed in series to increase the amount of turbulence and time applied to a volume of cells. The invention further encompasses methods of using the device to disperse cell aggregates, and methods of culturing cells that involve seeding cultures and maintaining dispersed individual cells.
摘要翻译：本发明包括用于细胞聚集体分散的流通分散装置，该装置包括第一或上游入口障碍物和第二或下游出口障碍物，每个障碍物具有至少一个不具有两个孔对准的横向孔。在两个障碍物之间是湍流室，使得当细胞悬浮液通过入口孔进入腔室然后离开第二个障碍物时，室内的湍流破坏并分散细胞聚集体。该设备可选地可以具有多于两个的障碍物和湍流室，并且可以串联放置多个单元以增加施加到一定体积的电池的湍流和时间量。本发明还包括使用该装置分散细胞聚集体的方法，以及培养涉及接种培养物并维持分散的个体细胞的细胞的方法。

2. 发明申请

WO2008067044A2 DISPERSION DEVICES FOR AGGREGATES 审中-公开
标题翻译：聚合物分散装置
公开(公告)号：WO2008067044A2
公开(公告)日：2008-06-05
申请号：PCT/US2007/080958
申请日：2007-10-10
申请人： MERIAL LIMITED , RIGAUT, Guillaume
发明人： RIGAUT, Guillaume
IPC分类号： C12M1/00 , C12N5/06
CPC分类号： C12M43/02 , C12M47/06 , C12N5/0603 , C12N2531/00
摘要： The present invention encompasses a flow-through dispersion device for the dispersion of cell aggregates, the device comprising a first or upstream inlet obstacle and a second or downstream outlet obstacle, each obstacle having at least one traversing hole wherein no two holes align. Between the two obstacles is a turbulence chamber, such that when a cell suspension is passed through the inlet holes, into the chamber and then exits the second obstacle, the turbulence within the chamber disrupts and disperses cell aggregates. The device optionally may have more than two obstacles and turbulence chambers and multiple units may be placed in series to increase the amount of turbulence and time applied to a volume of cells. The invention further encompasses methods of using the device to disperse cell aggregates, and methods of culturing cells that involve seeding cultures and maintaining dispersed individual cells.
摘要翻译：本发明包括用于细胞团聚体分散的流通式分散装置，该装置包括第一或上游进口障碍物和第二或下游出口障碍物，每个障碍物具有至少一个横向孔其中没有两个孔对齐。在两个障碍物之间是湍流室，使得当细胞悬液通过入口孔进入室并随后离开第二障碍物时，室内的湍流扰乱并分散细胞聚集体。该设备可选地可以具有多于两个的障碍物，并且湍流室和多个单元可以串联放置以增加施加到一定体积的细胞的湍流量和时间量。本发明还包括使用该装置分散细胞聚集体的方法，以及培养包括接种培养物和维持分散的单个细胞的细胞的方法。

3. 发明申请

WO2006060282A2 MIXING DEVICES FOR CHEMICAL LYSIS OF CELLS 审中-公开
标题翻译：化学物质的混合装置
公开(公告)号：WO2006060282A2
公开(公告)日：2006-06-08
申请号：PCT/US2005042797
申请日：2005-11-28
申请人： MERIAL LTD , DETRAZ NOEL JOSEPH FRANCOIS , RIGAUT GUILLAUME
发明人： DETRAZ NOEL JOSEPH FRANCOIS , RIGAUT GUILLAUME
IPC分类号： C12P1/00 , C12N1/06
CPC分类号： C12N1/06 , B01F5/0268 , B01F5/0451 , B01F5/0682 , B01F5/0688 , B01F2005/0034 , C12M47/06
摘要： The invention relates to flow-through devices for mixing fluids and uses thereof for mixing and for lysing cells to release biological compounds of interest. The invention particularly encompasses flow-through methods for mixing and chemical methods for the isolation and purification of plasmid DNA from cell culture.
摘要翻译：本发明涉及用于混合流体的流通装置及其用于混合和裂解细胞以释放感兴趣的生物化合物的用途。本发明特别包括用于混合的流通方法和用于从细胞培养物分离和纯化质粒DNA的化学方法。

4. 发明申请

WO2011031850A1 NEW VACCINE FORMULATIONS COMPRISING SAPONIN-CONTAINING ADJUVANTS 审中-公开
标题翻译：包含蕴含SAPONIN ADJUVANTS的新型酒精配方
公开(公告)号：WO2011031850A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048256
申请日：2010-09-09
申请人： MERIAL LIMITED , DETRAZ, Noel Joseph, Francois , RIGAUT, Guillaume
发明人： DETRAZ, Noel Joseph, Francois , RIGAUT, Guillaume
IPC分类号： A61K39/135 , A61K39/39 , A61K39/02 , A61K39/12 , A61K39/295 , A61P31/00
CPC分类号： A61K39/00 , A61K9/0019 , A61K9/107 , A61K39/0241 , A61K39/12 , A61K39/125 , A61K39/135 , A61K39/39 , A61K45/06 , A61K47/06 , A61K47/26 , A61K2039/52 , A61K2039/525 , A61K2039/5252 , A61K2039/54 , A61K2039/552 , A61K2039/55505 , A61K2039/55566 , A61K2039/55577 , C12N7/00 , C12N2750/00022 , C12N2750/00034 , C12N2750/10034 , C12N2770/32022 , C12N2770/32134
摘要： The present invention provides for a novel oil-in-water (O/W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.
摘要翻译：本发明提供了一种新型的水包油（O / W）乳液，其在细菌或病毒悬浮液，特别是浓缩和非纯化（粗提取物）或最低限纯化的存在下具有增加的稳定性。本发明的乳液可用作递送包含至少一种免疫原的药物组合物，特别是选自灭活病原体，减毒病原体，亚单位，重组表达载体的免疫原的载体，以及质粒或其组合。

5. 发明申请

WO2006060282A3 MIXING DEVICES FOR CHEMICAL LYSIS OF CELLS 审中-公开
公开(公告)号：WO2006060282A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/042797
申请日：2005-11-28
申请人： MERIAL LIMITED , DETRAZ, Noël, Joseph, François , RIGAUT, Guillaume
发明人： DETRAZ, Noël, Joseph, François , RIGAUT, Guillaume
IPC分类号： C12M1/33 , C12N1/06 , C12N1/08 , C12P1/00 , C12M1/34 , C12M1/36 , C12M1/38
摘要： The invention relates to flow-through devices for mixing fluids and uses thereof for mixing and for lysing cells to release biological compounds of interest. The invention particularly encompasses flow-through methods for mixing and chemical methods for the isolation and purification of plasmid DNA from cell culture.

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