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    • 4. 发明申请
    • METHOD OF PREPARING N-PHOSPHONOMETHYLGLYCINE ESTERS
    • 用于生产N-膦酰基 - 甘氨酸酯
    • WO1997005147A1
    • 1997-02-13
    • PCT/EP1996003156
    • 1996-07-18
    • BAYER AKTIENGESELLSCHAFTRIEBEL, Hans-Jochem
    • BAYER AKTIENGESELLSCHAFT
    • C07F09/38
    • C07F9/3808
    • Disclosed is a technically simple method of preparing, in very good yields, highly pure N-phosphonomethylglycine esters, having a herbicidal action, of the formula (I) (HO)2P(O)-CH2-NH-CH2-CO-O-R, in which R is alkyl, by reacting N-phosphonomethylglycine of the formula (II) (HO)2P(O)-CH2-NH-CH2-COOH with alcohols of the general formula (III) HO-R at temperatures between 40 and 150 DEG C in the presence of an acid (1st stage) and then reacting, at temperatures between 0 and 60 DEG C, the acid adducts of the compounds of formula (I) - optionally after isolating them - with an acid binder selected from the group comprising dialkylamines, dicycloalkylamines, trialkylamines and N,N-dialkyl-N-cycloalkylamines, N,N-dicycloalkyl-N-alkylamines, N,N-dialkylamilines and (N,N)-dialkylbenzylamines plus pyridine, alkylpyridines, dialkylpyridines and trialkylpyridines, the acid binder being measured into the reaction mixture slowly with thorough mixing (2nd stage).
    • 式(I)(HO)的除草有效的N-膦酰基甲基甘氨酸酯2P(O)-CH2-NH-CH2-CO-OR,其中R代表烷基,在技术上简单的方式以非常良好的产率和以高得 纯度由式的N-膦酰基甲基甘氨酸(II)(HO)2 P(O)-CH 2 -NH-CH 2 -COOH与40°C之间的通式(III)HO-R在酸的温度存在的醇 和150℃(第一阶段),和式的化合物的酸加成物这样形成的(I) - 任选地在中间隔离 - 用酸从串联二烷基胺,dicycloalkylamines,三烷基胺,N,N-二烷基-N-环烷基的结合剂, N,N-二环烷基-N-烷基胺,N,N-二烷基 - 苯胺和N,N-二烷基苄基胺和吡啶,烷基吡啶,二烷基和Trialkylpyridine在0℃之间的温度并反应60℃,其特征在于,具有良好的酸结合剂 通过混合慢慢计量加入反应混合物(第二阶段)制备。