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1. 发明申请

WO2009010240A1 ANALYSIS OF DOPING COMPOUNDS 审中-公开
标题翻译：分析化合物
公开(公告)号：WO2009010240A1
公开(公告)日：2009-01-22
申请号：PCT/EP2008/005684
申请日：2008-07-11
申请人： DSM IP ASSETS B.V. , DEBOER, Douwe , KIP, Bert , MENGERINK, Ynze , MOMMERS, John , PETERS, Roland , REUMKENS, Nicolle
发明人： DEBOER, Douwe , KIP, Bert , MENGERINK, Ynze , MOMMERS, John , PETERS, Roland , REUMKENS, Nicolle
IPC分类号： G01N33/50 , G01N1/34 , G01N30/06
CPC分类号： G01N30/06 , G01N1/405 , G01N2030/062 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845 , Y10T436/174614 , Y10T436/200833 , G01N30/463
摘要： Process for determination of a drug or medicament or their metabolites in a (body) fluid or an extract of (body)tissue or (body)sample comprising the steps: (i) optionally treatment of the fluid or sample extract with at least one enzyme, (ii) contacting at least a first part of the fluid or extract with at least one first solid phase able to adsorb or absorb organic compounds out of the fluid or extract, and/or (iii) contacting at least a second part of the fluid or extract with at least one second phase, able to extract or adsorb organic compounds out of the fluid or extract, and/or (iv) optionally contacting at least a third part of the fluid or extract with a liquid phase able to extract organic compounds out of the fluid or extract, and/or (v) desorbing the compound(s) bound to the first solid phase by applying heat to the solid phase and/or by solvent extraction, optionally followed by evaporating the solvent at least partially, (vi) optionally extracting or desorbing the compound(s) contained in or bound to the second phase by applying heat and/or by solvent extraction, optionally followed by evaporation of the solvent at least partially and (vii) analyzing the desorbed compounds of steps (v) and (vi) and optionally the compounds extracted in step (iv) by multi-dimensional gas chromatography (GC), preferably by comprehensive multi-dimensional GC (GC*GC) coupled preferably to a mass spectrometry.
摘要翻译：（体）流体或（身体）组织或（身体）样品提取物中药物或药物或其代谢物的测定方法，包括以下步骤：（i）任选地处理流体（ii）使流体或提取物的至少第一部分与至少一个能够从流体或提取物中吸附或吸收有机化合物的第一固相接触，和/或（iii）使流体或提取物的至少第二部分与至少一个第二相接触，所述第二相能够从所述流体或提取物中提取或吸附有机化合物，和/或（iv）任选地使至少第三部分流体或提取物具有能够从流体或提取物中提取有机化合物的液相和/或（v）通过对固相和/或通过溶剂提取施加热量来解吸与第一固相结合的化合物，任选随后通过至少部分地蒸发溶剂，（vi）任选地萃取或解吸通过加热和/或通过溶剂萃取，任选地接着至少部分地蒸发溶剂，和（vii）分析步骤（v）和（vi）中解吸的化合物）和任选地通过多维气相色谱（GC），优选通过综合多维GC（GC * GC）在步骤（iv）中提取的化合物，优选与质谱法偶联。

2. 发明申请

WO2009010240A9 ANALYSIS OF DOPING COMPOUNDS 审中-公开
标题翻译：掺杂化合物的分析
公开(公告)号：WO2009010240A9
公开(公告)日：2009-04-16
申请号：PCT/EP2008005684
申请日：2008-07-11
申请人： DSM IP ASSETS BV , DE BOER DOUWE , KIP BERT , MENGERINK YNZE , MOMMERS JOHN , PETERS ROLAND , REUMKENS NICOLLE
发明人： DE BOER DOUWE , KIP BERT , MENGERINK YNZE , MOMMERS JOHN , PETERS ROLAND , REUMKENS NICOLLE
IPC分类号： G01N33/50 , G01N1/34 , G01N30/06
CPC分类号： G01N30/06 , G01N1/405 , G01N2030/062 , Y10T436/141111 , Y10T436/142222 , Y10T436/145555 , Y10T436/147777 , Y10T436/173845 , Y10T436/174614 , Y10T436/200833 , G01N30/463
摘要： Process for determination of a drug or medicament or their metabolites in a (body) fluid or an extract of (body)tissue or (body)sample comprising the steps: (i) optionally treatment of the fluid or sample extract with at least one enzyme, (ii) contacting at least a first part of the fluid or extract with at least one first solid phase able to adsorb or absorb organic compounds out of the fluid or extract, and/or (iii) contacting at least a second part of the fluid or extract with at least one second phase, able to extract or adsorb organic compounds out of the fluid or extract, and/or (iv) optionally contacting at least a third part of the fluid or extract with a liquid phase able to extract organic compounds out of the fluid or extract, and/or (v) desorbing the compound(s) bound to the first solid phase by applying heat to the solid phase and/or by solvent extraction, optionally followed by evaporating the solvent at least partially, (vi) optionally extracting or desorbing the compound(s) contained in or bound to the second phase by applying heat and/or by solvent extraction, optionally followed by evaporation of the solvent at least partially and (vii) analyzing the desorbed compounds of steps (v) and (vi) and optionally the compounds extracted in step (iv) by multi-dimensional gas chromatography (GC), preferably by comprehensive multi-dimensional GC (GC*GC) coupled preferably to a mass spectrometry.
摘要翻译：用于测定（体）液体或（体）组织或（体）样品的（体）液或提取物中的药物或其药物或其代谢物的方法，包括以下步骤：（i）任选用至少一种酶处理流体或样品提取物，（ii）使流体或提取物的至少第一部分与至少一个能够从流体或萃取物中吸附或吸收有机化合物的第一固相接触，和/或（iii）使至少第二部分的具有至少一个第二相的流体或提取物，其能够从有机化合物中提取或吸收流体或提取物，和/或（iv）任选地将至少第三部分流体或提取物与能够提取有机物质的液相接触化合物离开流体或提取物，和/或（v）通过向固相施加热量和/或通过溶剂萃取来解吸与第一固相结合的化合物，任选地至少部分蒸发溶剂，（vi）任选地提取或解吸组合物 d）通过施加热量和/或通过溶剂萃取来包含或结合到第二相中，任选地至少部分蒸发溶剂，和（vii）分析步骤（v）和（vi）的解吸附化合物和任选地，通过多维气相色谱（GC）在步骤（iv）中提取的化合物，优选通过优选与质谱耦合的综合多维GC（GC * GC）。

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