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1. 发明申请

WO2021164905A1 LOW COHERENCE INTERFEROMETRY ON COMPOSITIONS MANUFACTURED USING THERMAL MANUFACTURING PROCESSES 审中-公开
公开(公告)号：WO2021164905A1
公开(公告)日：2021-08-26
申请号：PCT/EP2020/080553
申请日：2020-10-30
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
发明人： WOLFGANG, Matthias , KHINAST, Johannes , STRANZINGER, Sandra
IPC分类号： G01B11/06 , G01N21/84
摘要： A method of determining information indicative of a material attribute of a composition, wherein the method comprises manufacturing the composition using a thermal manufacturing process, detecting detection data from the composition by low coherence interferometry during the manufacturing, in particular during said thermal manufacturing process, and determining the information based on the detected detection data.

2. 发明申请

WO2019002319A1 DEVICE AND METHOD FOR MEASURING A DENSITY OF PROVIDED GRANULAR MATTER 审中-公开
公开(公告)号：WO2019002319A1
公开(公告)日：2019-01-03
申请号：PCT/EP2018/067160
申请日：2018-06-26
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , TECHNISCHE UNIVERSITÄT GRAZ
发明人： KHINAST, Johannes , KLEIN, Thomas , BRESCIANI, Massimo , FAULHAMMER, Eva , STRANZINGER, Sandra , MARKL, Daniel , ZEITLER, Jochen Axel
IPC分类号： G01N21/3563 , G01N21/3581 , G01N21/59 , G01N21/85
摘要： A device and a method for providing granular matter is described, wherein the device comprises a receiving container (101) configured and adjusted for receiving the granular matter (103), wherein the receiving container (101) has an output (104) for providing the granular matter (103) to a further processing and the device comprises a measuring unit (102) configured for measuring a density of the granular matter (103) in the receiving container (101) using terahertz spectroscopy.

3. 发明申请

WO2015197830A1 APPARATUS, METHOD AND SYSTEM FOR MOULDING A THERMOPLASTIC MATERIAL BY VACUUM COMPRESSION MOULDING 审中-公开
标题翻译：用于通过真空压缩成型模制热塑性材料的装置，方法和系统
公开(公告)号：WO2015197830A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/064547
申请日：2015-06-26
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
发明人： TREFFER, Daniel , GRUBBAUER, Johann , KOSCHER, Gerold , KLEIN, Thomas , KHINAST, Johannes
IPC分类号： B29C33/68 , B29C43/14 , B29C43/56 , B29K105/00
CPC分类号： B29C43/14 , B29C33/68 , B29C43/027 , B29C43/361 , B29C43/52 , B29C43/56 , B29C43/58 , B29C2043/029 , B29C2043/3233 , B29C2043/3615 , B29C2043/563 , B29C2043/5816 , B29K2101/12 , B29K2105/0035 , B29L2031/40 , B29L2031/753
摘要： There is provided an apparatus for molding a thermoplastic material into a homogenous sample body having a predetermined shape, the apparatus comprising: (a) a main body (110) comprising a first opening (112), a second opening and a hollow bore (116) connecting the first opening (112) with the second opening, the hollow bore (116) being adapted to receive a separation foil shaped to cover at least a part of the hollow bore surface; (b) a piston (120) adapted to fit moveably into the hollow bore (116) containing the separation foil; (c) a base plate (130) comprising a protrusion, wherein the base plate (130) is adapted to be inserted into the first opening (112) in such a manner that the protrusion extends into a part of the hollow bore (116) containing the separation foil, and wherein the base plate (130) is adapted to transfer heat from a heating unit to a thermoplastic material (150) resting on the protrusion (132); (d) a vacuum connector (142) adapted to be connected to a vacuum source; (e) a lid (140) adapted to fit moveably into the second opening and adapted to apply a force to the piston (120) when the vacuum connector (142) is connected to the vacuum source such that the piston (120) applies a compressing force to the thermoplastic material (150) resting on the protrusion. There are further provided a method and a system for molding a thermoplastic material into a homogenous sample body having a predetermined shape.
摘要翻译：提供了一种用于将热塑性材料模制成具有预定形状的均匀样品体的装置，该装置包括：（a）主体（110），包括第一开口（112），第二开口和中空孔）将所述第一开口（112）与所述第二开口连接，所述中空孔（116）适于容纳形成为覆盖所述中空孔表面的至少一部分的分离箔; （b）适于可移动地装配到容纳分离箔的中空孔（116）中的活塞（120）; （c）包括突起的基板（130），其中所述基板（130）适于以突出部延伸到所述中空孔（116）的一部分中的方式插入所述第一开口（112），其中所述基板（130）适于将热量从加热单元传递到搁置在所述突起（132）上的热塑性材料（150）; （d）适于连接到真空源的真空连接器（142）; （e）适于可动地装配到所述第二开口中并且当所述真空连接器（142）连接到所述真空源时将力施加到所述活塞（120）的盖（140），使得所述活塞（120）施加压缩到搁置在突起上的热塑性材料（150）的力。还提供了一种用于将热塑性材料模制成具有预定形状的均匀样品体的方法和系统。

4. 发明申请

WO2021249708A1 PROCESSES FOR PREPARING NOR-OPIOID COMPOUNDS AND OPIOID ANTAGONISTS BY ELECTROCHEMICAL N-DEMETHYLATION 审中-公开
公开(公告)号：WO2021249708A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/062298
申请日：2021-05-10
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , KARL-FRANZENS-UNIVERSITÄT GRAZ
发明人： GLOTZ, Gabriel , CANTILLO NIEVES, David , KAPPE, Christian Oliver
IPC分类号： C25B3/05 , A61P25/00 , C25B3/25 , A61K31/00 , A61K31/385
摘要： The present invention relates to a process for preparing a nor-opioid compound wherein an opioid precursor compound is electrochemically N-demethylated. The present invention further relates to a process for preparing an opioid antagonist compound, wherein an opioid precursor compound is electrochemically N-demethylated and the thus obtained nor-opioid compound is alkylated again at its secondary amine functional group.

5. 发明申请

WO2019206779A1 MONITORING A PROPERTY OF A FLUID DURING A FLOW PROCESS 审中-公开
公开(公告)号：WO2019206779A1
公开(公告)日：2019-10-31
申请号：PCT/EP2019/060002
申请日：2019-04-17
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , KARL-FRANZENS-UNIVERSITÄT GRAZ
发明人： GLOTZ, Gabriel , KAPPE, Christian
IPC分类号： B01F15/00 , G01N21/85 , G01N21/84
摘要： A system for monitoring a property of a fluid during a flow process, the system comprising a flow apparatus, a supply apparatus configured to supply the fluid, and a monitoring apparatus configured for monitoring the property of the fluid during supplying the fluid by the supply apparatus. The flow apparatus comprises a flow unit which is movably arranged at a tube of the flow apparatus, wherein the fluid flows through the tube.

6. 发明申请

WO2019034569A1 PROCESS FOR GENERATING CYANOGEN BROMIDE (BRCN), BRCN GENERATOR, BROMINE GENERATOR AND PROCESS FOR SYNTHESIZING A NITROGEN-CONTAINING COMPOUND 审中-公开
公开(公告)号：WO2019034569A1
公开(公告)日：2019-02-21
申请号：PCT/EP2018/071820
申请日：2018-08-10
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , KARL-FRANZENS-UNIVERSITÄT GRAZ
发明人： GLOTZ, Gabriel , KAPPE, Christian Oliver , DALLINGER, Doris , LEBL, Rene
IPC分类号： C01C3/00 , C01B7/09 , C07D417/12
CPC分类号： C01C3/004 , C01B7/096
摘要： The present invention relates to a process for generating cyanogen bromide (BrCN) comprising the steps of: mixing a fluid containing a bromine source with a fluid containing a cyanide source, reacting the bromine source and the cyanide source with each other to give a reaction mixture containing cyanogen bromide, and purifying the reaction mixture by means of a membrane-based separation to give (purified) cyanogen bromide. The present invention further relates to an apparatus configured for continuously generating cyanogen bromide and an apparatus configured for continuously generating bromine, which both apparatuses may be combined, as well as a process for synthesizing a nitrogen-containing compound.

7. 发明申请

WO2011076912A3 METHODS AND COMPOSITIONS FOR BIOLOGICALLY CONTROLLING MICROBIAL GROWTH ON CLEAN ROOM EQUIPMENT 审中-公开
公开(公告)号：WO2011076912A3
公开(公告)日：2011-06-30
申请号：PCT/EP2010/070612
申请日：2010-12-22
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , BERG, Gabriele , HARTENBERGER, Kathrin , LIEBMINGER, Stefan
发明人： BERG, Gabriele , HARTENBERGER, Kathrin , LIEBMINGER, Stefan
IPC分类号： A01N25/34 , A01N63/00 , A01N63/02 , A01N63/04 , A01N65/00 , D06M16/00
摘要： The present invention relates to methods and compositions for controlling microbial growth on clean room equipment, preferably on clean room clothing. More particularly, the invention is directed to a corresponding method comprising contacting the clean room equipment to be treated with one or more antimicrobial agents; and incubating the clean room equipment for a pre-selected period of time, wherein the one or more antimicrobial agents are of organic origin. In a further aspect, the invention relates to a kit-of-parts, comprising one or more antimicrobial agents selected from the group consisting of microorganisms, preferably bacteria and fungi, and metabolites produced by said microorganisms for performing a method as defined herein.

8. 发明申请

WO2021164904A1 LOW COHERENCE INTERFEROMETRY ANALYSIS OF PHARMACEUTICAL COMPOSITIONS USING MACHINE LEARNING 审中-公开
公开(公告)号：WO2021164904A1
公开(公告)日：2021-08-26
申请号：PCT/EP2020/080552
申请日：2020-10-30
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
发明人： WOLFGANG, Matthias , WEISSENSTEINER, Michael , PÖLLITSCH, Simon , KHINAST, Johannes
IPC分类号： G01N15/14 , G06K9/00
摘要： A method of determining information indicative of a material attribute of a pharmaceutical composition (100), wherein the method comprises detecting detection data from the composition (100) by low coherence interferometry, and determining the information indicative of the material attribute based on the detection data and using machine learning.

9. 发明申请

WO2021204889A1 VERFAHREN ZUM HERSTELLEN EINES PORÖSEN WIRKSTOFFTRÄGERS MITTELS HEIßSCHMELZEXTRUSION 审中-公开
公开(公告)号：WO2021204889A1
公开(公告)日：2021-10-14
申请号：PCT/EP2021/059085
申请日：2021-04-07
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH , KARL-FRANZENS-UNIVERSITÄT GRAZ , TECHNISCHE UNIVERSITÄT GRAZ
发明人： EDER, Simone , KOUTSAMANIS, Ioannis , KLEIN, Thomas , ROBLEGG, Eva , KHINAST, Johannes
IPC分类号： A61K9/00 , A61K9/14
摘要： Beschrieben wird ein Verfahren zum Herstellen eines Wirkstoffträgers, wobei das Verfahren aufweist: i) Bereitstellen eines Polymers (112) an eine Heißschmelzextrusion (150), iii) Bereitstellen eines Treibmittels (113) an das Polymer (112), und iii) Extrudieren des Polymers (112) mittels der Heißschmelzextrusion (150) derart, dass das Treibmittel (113) mittels einer Reaktion Wirkstofftransport-geeignete Poren (121) in dem Polymer (112) erzeugt, um den Wirkstoffträger (120) bereitzustellen. Hierbei sind die Wirkstofftransport-geeigneten Poren (121) eingerichtet sind zum Aufnehmen eines Wirkstoffs (111) und/oder Freigeben des Wirkstoffs (111).

10. 发明申请

WO2018065616A1 A SYSTEM AND A METHOD FOR CONSTANT MICRO DOSING AND FEEDING OF POWDER MATERIAL 审中-公开
标题翻译：一种用于粉末材料的恒定微计量和给料的系统和方法
公开(公告)号：WO2018065616A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/075578
申请日：2017-10-06
申请人： RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH
发明人： KHINAST, Johannes , SLAMA, Eyke , FATHOLLAHI, Sara , KLEIN, Thomas , BESENHARD, Maximilian
IPC分类号： G01F11/02 , G01F11/00
摘要： A system and a method for a constant micro dosing of powder material, comprising a control device,a cylinder comprising a first opening and a piston movably arranged inside the cylinder and controllable by the control device, wherein the piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder is configured for storing the powder material between the piston and the first opening. The piston is configured for pushing the powder material through the first opening by moving along the piston stroke direction. Further the system and the method comprise a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device is configured for controlling the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.
摘要翻译：一种用于粉末材料的恒定微量配量的系统和方法，包括控制装置，包括第一开口和活塞可移动地布置在所述汽缸内并且可由所述控制装置控制的活塞的汽缸，其中，活塞可沿着活塞行程方向朝向或远离第一开口的方向移动。气缸构造成用于将粉末材料储存在活塞与第一开口之间。活塞构造成用于通过沿着活塞行程方向移动来推动粉末材料通过第一开口。此外，该系统和方法包括用于移除从气缸的第一开口推出的粉末材料的移除装置。控制装置构造成用于以同步方式控制活塞和移除装置，使得通过移除装置移除通过第一开口推动的预定量的粉末材料。

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