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1. 发明申请

WO2008013797A2 COMPOSITIONS AND METHODS FOR MACULAR DEGENERATION 审中-公开
标题翻译：黄斑变性的组合物和方法
公开(公告)号：WO2008013797A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016619
申请日：2007-07-23
申请人： THE CLEVELAND CLINIC FOUNDATION , CRABB, John, W. , SALOMON, Robert, G. , ANAND-APTE, Bela , EBRAHEM, Quteba , REGANATHAN, Kutralanathan
发明人： CRABB, John, W. , SALOMON, Robert, G. , ANAND-APTE, Bela , EBRAHEM, Quteba , REGANATHAN, Kutralanathan
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/76
摘要： The present invention pertains to methods of inhibiting angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits one or more CEP protein adducts wherein the angiogenesis is the result of oxidative peptide modification of polyunsaturated fatty acids (PUFA) in the individual, and administration of the agent inhibits angiogenesis in the individual. In one embodiment, the invention is directed to methods of inhibiting ocular angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the.agent inhibits ocular angiogenesis in the individual. In another embodiment, the invention is directed to methods of inhibiting choroidal neovascularization in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the agent inhibits choroidal neovascularization in the individual.
摘要翻译：本发明涉及抑制有需要的个体的血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的试剂，其中血管生成是多不饱和的氧化肽修饰的结果个体中的脂肪酸（PUFA），并且所述药剂的施用抑制个体中的血管生成。在一个实施方案中，本发明涉及抑制有需要的个体的眼血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的试剂，其中所述试剂的施用抑制个人。在另一个实施方案中，本发明涉及抑制有需要的个体的脉络膜新血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的试剂，其中所述试剂的施用抑制个体中的脉络膜新血管生成

2. 发明申请

WO2008013797A8 COMPOSITIONS AND METHODS FOR MACULAR DEGENERATION 审中-公开
标题翻译：麦芽糖变性的组合物和方法
公开(公告)号：WO2008013797A8
公开(公告)日：2008-05-02
申请号：PCT/US2007016619
申请日：2007-07-23
申请人： CLEVELAND CLINIC FOUNDATION , UNIV CASE WESTERN RESERVE , CRABB JOHN W , SALOMON ROBERT G , ANAND-APTE BELA , EBRAHEM QUTEBA , REGANATHAN KUTRALANATHAN
发明人： CRABB JOHN W , SALOMON ROBERT G , ANAND-APTE BELA , EBRAHEM QUTEBA , REGANATHAN KUTRALANATHAN
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/76
摘要： The present invention pertains to methods of inhibiting angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits one or more CEP protein adducts wherein the angiogenesis is the result of oxidative peptide modification of polyunsaturated fatty acids (PUFA) in the individual, and administration of the agent inhibits angiogenesis in the individual. In one embodiment, the invention is directed to methods of inhibiting ocular angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the.agent inhibits ocular angiogenesis in the individual. In another embodiment, the invention is directed to methods of inhibiting choroidal neovascularization in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the agent inhibits choroidal neovascularization in the individual.
摘要翻译：本发明涉及在有需要的个体中抑制血管发生的方法，包括向个体施用抑制一种或多种CEP蛋白加合物的药剂，其中血管生成是个体中多不饱和脂肪酸（PUFA）的氧化肽修饰的结果，并且该药剂的给药抑制个体的血管发生。在一个实施方案中，本发明涉及在有需要的个体中抑制眼血管发生的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的药剂，其中所述药物的给药在个人。在另一个实施方案中，本发明涉及在有需要的个体中抑制脉络膜新生血管形成的方法，包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的试剂，其中所述试剂的施用抑制个体中的脉络膜新生血管形成。

3. 发明申请

WO2008013797A3 COMPOSITIONS AND METHODS FOR MACULAR DEGENERATION 审中-公开
标题翻译：黄斑变性的组合物和方法
公开(公告)号：WO2008013797A3
公开(公告)日：2008-03-13
申请号：PCT/US2007016619
申请日：2007-07-23
申请人： CLEVELAND CLINIC FOUNDATION , CRABB JOHN W , SALOMON ROBERT G , ANAND-APTE BELA , EBRAHEM QUTEBA , REGANATHAN KUTRALANATHAN
发明人： CRABB JOHN W , SALOMON ROBERT G , ANAND-APTE BELA , EBRAHEM QUTEBA , REGANATHAN KUTRALANATHAN
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/76
摘要： The present invention pertains to methods of inhibiting angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits one or more CEP protein adducts wherein the angiogenesis is the result of oxidative peptide modification of polyunsaturated fatty acids (PUFA) in the individual, and administration of the agent inhibits angiogenesis in the individual. In one embodiment, the invention is directed to methods of inhibiting ocular angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the.agent inhibits ocular angiogenesis in the individual. In another embodiment, the invention is directed to methods of inhibiting choroidal neovascularization in an individual in need thereof comprising administering to the individual an agent that inhibits the angiogenic activity of one or more CEP protein adducts wherein administration of the agent inhibits choroidal neovascularization in the individual.
摘要翻译：本发明涉及抑制有需要的个体血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的试剂，其中血管生成是个体中多不饱和脂肪酸（PUFA）的氧化肽修饰的结果并且该药剂的施用抑制个体中的血管生成。在一个实施方案中，本发明涉及抑制有需要的个体的眼血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的试剂，其中所述试剂的施用抑制个人。在另一个实施方案中，本发明涉及抑制有需要的个体的脉络膜新血管生成的方法，其包括向个体施用抑制一种或多种CEP蛋白加合物的血管生成活性的试剂，其中所述试剂的施用抑制个体中的脉络膜新血管生成。

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