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1. 发明申请

WO2012109500A2 ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：核酸分析
公开(公告)号：WO2012109500A2
公开(公告)日：2012-08-16
申请号：PCT/US2012/024573
申请日：2012-02-09
申请人： BIO-RAD LABORATORIES, INC. , REGAN, John, Frederick , SAXONOV, Serge , LUCERO, Mike , HINDSON, Ben , BELGRADER, Phil , DUBE, Simant , SO, Austin , MELLEN, Jeffrey, Clark , HEREDIA, Nicholas, Jack , NESS, Kevin , COLSTON, Bill
发明人： REGAN, John, Frederick , SAXONOV, Serge , LUCERO, Mike , HINDSON, Ben , BELGRADER, Phil , DUBE, Simant , SO, Austin , MELLEN, Jeffrey, Clark , HEREDIA, Nicholas, Jack , NESS, Kevin , COLSTON, Bill
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以使得样品中核酸的拷贝数估计可以进行。本文还提供了用于确定样品中靶核酸的两个或多个拷贝（例如，两个或多个拷贝是位于同一染色体或不同染色体上）或用于定相等位基因的连接的方法，组合物和试剂盒。

2. 发明申请

WO2010005782A1 SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR 审中-公开
标题翻译：调节CB2受体的SULFONE化合物
公开(公告)号：WO2010005782A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/048392
申请日：2009-06-24
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , REGAN, John , RIETHER, Doris
发明人： REGAN, John , RIETHER, Doris
IPC分类号： C07D261/14 , C07D285/08 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/4025 , A61K31/433 , A61K31/42 , A61K31/4196 , A61P29/00
CPC分类号： C07D413/04 , C07D261/14 , C07D285/08 , C07D401/04 , C07D403/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
摘要翻译：公开了调节CB2受体的化合物。根据本发明的化合物与CB2受体结合并且是激动剂，并且可用于治疗炎症。作为激动剂的那些化合物另外可用于治疗疼痛。

3. 发明申请

WO2006071609A2 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：WO2006071609A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/045990
申请日：2005-12-16
申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. , BETAGERI, Raj , DISALVO, Darren , THOMSON, David, S. , KUZMICH, Daniel , REGAN, John , KOWALSKI, Jennifer
发明人： DISALVO, Darren , THOMSON, David, S. , KUZMICH, Daniel , REGAN, John , KOWALSKI, Jennifer
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4，R 4，R 4， R 5，R 6和R 7如本文所定义，或其互变异构体，前药，溶剂化物或盐物; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。

4. 发明申请

WO2002058546A3 METHODS FOR SCREENING FOR SUBSTANCES WHICH INHIBIT FP PROSTANOID RECEPTOR 审中-公开
公开(公告)号：WO2002058546A3
公开(公告)日：2002-08-01
申请号：PCT/US2002/000522
申请日：2002-01-24
申请人： THE ARIZONA BOARD OF REGENTS, on behalf of, THE UNIVERSITY OF ARIZONA , REGAN, John, W.
发明人： REGAN, John, W.
IPC分类号： C12Q1/00
摘要： The present invention provides mehtods for screening for substances which inhibit the interaction between a FP prostanoid receptor and a compoudn having PGF 2α activity, methods for inhibiting the interaction, methods of inhibiting signaling mediated by βbeta-catenin, and methods of treating cancer.

5. 发明申请

WO2002058546A2 METHODS FOR SCREENING FOR SUBSTANCES WHICH INHIBIT FP PROSTANOID RECEPTOR INTERACTION WITH A COMPOUND HAVING PGF2αalphaACTIVITY AND METHODS OF TREATING CANCER 审中-公开
标题翻译：用于筛选用于抑制FP前体受体与具有PGF>2αα活性的化合物相互作用的物质的方法和治疗癌症的方法
公开(公告)号：WO2002058546A2
公开(公告)日：2002-08-01
申请号：PCT/US2002/000522
申请日：2002-01-24
申请人： THE ARIZONA BOARD OF REGENTS, on behalf of, THE UNIVERSITY OF ARIZONA , REGAN, John, W.
发明人： REGAN, John, W.
IPC分类号： A61B
CPC分类号： C07K14/72 , A61K38/00
摘要： The present invention provides mehtods for screening for substances which inhibit the interaction between a FP prostanoid receptor and a compoudn having PGF 2αalpha activity, methods for inhibiting the interaction, methods of inhibiting signaling mediated by βbeta-catenin, and methods of treating cancer.
摘要翻译：本发明提供了用于筛选抑制FP前列腺素类受体和具有PGF>2αα活性的组合物的相互作用的物质的筛选方法，用于抑制相互作用的方法，抑制由β-β-连环蛋白介导的信号传导的方法治疗癌症。

6. 发明申请

WO1993000357A1 THERAPEUTIC POLYPEPTIDES BASED ON VON WILLEBRAND FACTOR 审中-公开
标题翻译：基于VON WILLEBRAND因子的治疗性多糖
公开(公告)号：WO1993000357A1
公开(公告)日：1993-01-07
申请号：PCT/US1992005472
申请日：1992-06-29
申请人： RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. , THE SCRIPPS RESEARCH INSTITUTE , CHANG, Michael, N. , MCGARRY, Daniel, G. , REGAN, John, R. , RUGGERI, Zaverio, M. , WARE, Jerry, L.
发明人： RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. , THE SCRIPPS RESEARCH INSTITUTE
IPC分类号： C07K03/08
CPC分类号： C07K14/755 , A61K38/00
摘要： A polypeptide patterned on a fragment of wild type mature von Willebrand factor (vWF) subunit having one or more binding sites of predetermined affinity for one or more of the ligands selected from the group consisting of collagen, glycosaminoglycans, proteoglycans, platelet glycoprotein Ib alpha , platelet glycoprotein IIb/IIIa, or coagulation factor VIII, said polypeptide having a modified amino acid sequence relative to that of said fragment and an increased binding affinity, relative to said predetermined affinity, for one or more of said ligands, including also such a polypeptide prepared by mutagenesis of a DNA sequence and patterned on wild type mature vWF subunit, and also a polypeptide in purified form patterned upon a parent polypeptide which comprises the wild type amino acid sequence of mature von Willebrand factor subunit, or a fragment thereof, and including also purified DNA sequences encoding such polypeptides, expression plasmids and viral expression vectors containing the DNA sequences, and therapeutic compositions comprising such polypeptides effective in the treatment of thrombosis, and methods for the use thereof, and also preparation of such polypeptides by mutagenesis of an encoding DNA sequence or covalent modification of wild type vWF.
摘要翻译：在野生型成熟血管性血友病因子（vWF）亚基的片段上图案化的多肽，其具有一种或多种预定亲和力的结合位点，所述结合位点选自胶原，糖胺聚糖，蛋白聚糖，血小板糖蛋白Ibα，血小板糖蛋白IIb / IIIa或凝血因子VIII，所述多肽相对于所述片段具有修饰的氨基酸序列，相对于所述预定亲和力，对于一种或多种所述配体，包括此类多肽通过DNA序列的诱变制备并在野生型成熟vWF亚基上图案化的多肽，以及在包含成熟血管性血友病因子亚基的野生型氨基酸序列或其片段的母体多肽图案化的纯化形式的多肽，并且包括还纯化编码这种多肽的DNA序列，表达质粒和含有的病毒表达载体 DNA序列和包含有效治疗血栓形成的这些多肽的治疗组合物，及其使用方法，以及通过编码DNA序列的突变或野生型vWF的共价修饰来制备这些多肽。

7. 发明申请

WO2012109500A3 ANALYSIS OF NUCLEIC ACIDS 审中-公开
标题翻译：核酸分析
公开(公告)号：WO2012109500A3
公开(公告)日：2012-10-11
申请号：PCT/US2012024573
申请日：2012-02-09
申请人： BIO RAD LABORATORIES , REGAN JOHN FREDERICK , SAXONOV SERGE , LUCERO MIKE , HINDSON BEN , BELGRADER PHIL , DUBE SIMANT , SO AUSTIN , MELLEN JEFFREY CLARK , HEREDIA NICHOLAS JACK , NESS KEVIN , COLSTON BILL
发明人： REGAN JOHN FREDERICK , SAXONOV SERGE , LUCERO MIKE , HINDSON BEN , BELGRADER PHIL , DUBE SIMANT , SO AUSTIN , MELLEN JEFFREY CLARK , HEREDIA NICHOLAS JACK , NESS KEVIN , COLSTON BILL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q1/6858 , C12Q2600/158 , C12Q2600/172 , C12Q2537/16 , C12Q2563/159 , C12Q2537/165
摘要： Provided herein are improved methods, compositions, and kits for analysis of nucleic acids. The improved methods, compositions, and kits can enable copy number estimation of a nucleic acid in a sample. Also provided herein are methods, compositions, and kits for determining the linkage of two or more copies of a target nucleic acid in a sample (e.g., whether the two or more copies are on the same chromosome or different chromosomes) or for phasing alleles.
摘要翻译：本文提供了用于分析核酸的改进的方法，组合物和试剂盒。改进的方法，组合物和试剂盒可以实现样品中核酸的拷贝数估计。本文还提供了用于确定样品中两个或更多个拷贝的靶核酸的连接（例如，两个或更多个拷贝是在相同染色体上还是不同染色体上）或用于定相等位基因的方法，组合物和试剂盒。

8. 发明申请

WO2009015067A3 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：糖皮质激素模拟物，其制备方法，药物组合物及其用途
公开(公告)号：WO2009015067A3
公开(公告)日：2009-09-11
申请号：PCT/US2008070596
申请日：2008-07-21
申请人： BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , KUZMICH DANIEL , REGAN JOHN R
发明人： KUZMICH DANIEL , REGAN JOHN R
IPC分类号： C07D209/10 , C07D209/42 , C07D211/04 , C07D215/06 , C07D215/227 , C07D215/233 , C07D217/04 , C07D217/24 , C07D231/12 , C07D235/06 , C07D295/13 , C07D307/79 , C07D471/04
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/42 , C07D215/06 , C07D215/18 , C07D215/48
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：其中R1，R2，R3，R4，R5，R6和R7如本文所定义的式（I）化合物或其互变异构体，前药，溶剂化物或盐; 含有这些化合物的药物组合物以及调节糖皮质激素受体功能的方法以及使用这些化合物治疗患者的糖皮质激素受体功能介导的疾病状态或病症或以炎症，变应原或增殖过程为特征的方法。

9. 发明申请

WO2008127791A1 AUTOMATED HIGH-THROUGHPUT FLOW-THROUGH REAL-TIME DIAGNOSTIC SYSTEM 审中-公开
标题翻译：自动高通量流量实时诊断系统
公开(公告)号：WO2008127791A1
公开(公告)日：2008-10-23
申请号：PCT/US2008/055219
申请日：2008-02-28
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , REGAN, John, Frederick
发明人： REGAN, John, Frederick
IPC分类号： G01N35/08 , G01N35/10 , B01J19/00 , B01L7/00
CPC分类号： G01N35/08 , B01L3/5023 , B01L9/50 , B01L2200/04 , B01L2200/0631 , B01L2300/0681 , G01N35/1097
摘要： An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, and decontamination. The system is able to hold and access an unlimited number of fluorescent reagents that may be used to screen samples for the presence of specific sequences. The apparatus works by associating extracted and purified sample with a series of reagent plugs that have been formed in a flow channel and delivered to a flow-through real-time amplification detector that has a multiplicity of optical windows, to which the sample-reagent plugs are placed in an operative position. The diagnostic apparatus includes sample multi-position valves, a master sample multi-position valve, a master reagent multi-position valve, reagent multi-position valves, and an optical amplification/detection system.
摘要翻译：一种自动化实时流通系统，能够以异步，同步和并行方式处理多个样品用于核酸提取和纯化，随后进行测定装配，遗传扩增，多重检测，分析和去污。该系统能够容纳和访问无限数量的可用于筛选样品以存在特定序列的荧光试剂。该装置通过将提取的和纯化的样品与在流动通道中形成的一系列试剂塞相关联并将其输送到具有多个光学窗口的流通实时放大检测器来工作，样品试剂插入被放置在操作位置。诊断装置包括样本多位置阀，主样本多位置阀，主试剂多位置阀，试剂多位置阀以及光学放大/检测系统。

10. 发明申请

WO2008124745A1 GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF 审中-公开
标题翻译：葡萄糖酸化物质，其制备方法，药物组合物及其用途
公开(公告)号：WO2008124745A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/059694
申请日：2008-04-09
申请人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , KUZMICH, Daniel , DISALVO, Darren , REGAN, John Robinson
发明人： KUZMICH, Daniel , DISALVO, Darren , REGAN, John Robinson
IPC分类号： A61K31/535
CPC分类号： C07C323/49 , C07C311/17 , C07C311/18 , C07C311/41 , C07C2602/08 , C07C2602/10
摘要： Compounds of Formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, R 7 , and R 8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译：式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， R 5，R 6，R 6，R 7和R 8如本文所定义，或互变异构体，前药，溶剂化物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

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