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1. 发明申请

WO2004000361A1 METASTABLE PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：可食用药物组合物
公开(公告)号：WO2004000361A1
公开(公告)日：2003-12-31
申请号：PCT/AU2003/000785
申请日：2003-06-24
申请人： ACRUX DDS PTY LTD , WILKINS, Nina, Frances , KLOSE, Kathryn, Traci-Jane , MORGAN, Timothy, Matthias , REED, Barry, Leonard , FINNIN, Barrie, Charles
发明人： WILKINS, Nina, Frances , KLOSE, Kathryn, Traci-Jane , MORGAN, Timothy, Matthias , REED, Barry, Leonard , FINNIN, Barrie, Charles
IPC分类号： A61K47/10
CPC分类号： A61K31/568 , A61K9/0014 , A61K9/7015 , A61K31/435 , A61K31/496 , A61K31/565 , A61K31/567 , A61K47/10 , A61K47/32 , A61K47/38
摘要： The present invention provides a pharmaceutical composition for transdermal delivery comprising; one or more physiologically active agents; and a volatile pharmaceutically acceptable solvent; and wherein the physiological active agent forms a metastable deposit upon evaporation of the volatile solvent.
摘要翻译：本发明提供了一种用于透皮递送的药物组合物，一种或多种生理活性剂; 和挥发性药学上可接受的溶剂; 并且其中所述生理活性剂蒸发挥发性溶剂时形成亚稳沉积物。

2. 发明申请

WO2004000242A1 TOPICAL COSMETIC COMPOSITIONS 审中-公开
标题翻译：主题化妆品组合物
公开(公告)号：WO2004000242A1
公开(公告)日：2003-12-31
申请号：PCT/AU2003/000786
申请日：2003-06-24
申请人： COSMECEUTIC SOLUTIONS PTY LTD , GERVASIO-NUGENT, Carla , MORGAN, Timothy, Matthias , FINNIN, Barrie, Charles , REED, Barry, Leonard
发明人： GERVASIO-NUGENT, Carla , MORGAN, Timothy, Matthias , FINNIN, Barrie, Charles , REED, Barry, Leonard
IPC分类号： A61K7/00
CPC分类号： A61Q19/02 , A61K8/0208 , A61K8/0212 , A61K8/355 , A61K8/365 , A61K8/37 , A61K8/492 , A61K8/498 , A61K8/671 , A61Q1/04 , A61Q5/12 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61Q19/10
摘要： A topical cosmetic composition including: at least one water-soluble cosmetic agent; at least one oil-soluble cosmetic agent; and a dermal penetration enhancer; wherein topical application of the composition results in the delivery of the water-soluble and oil-soluble cosmetic agents into the stratum corneum as well as delivery of the oil-soluble cosmetic agent into the epidermis and dermis.
摘要翻译：一种局部化妆品组合物，其包含：至少一种水溶性化妆品; 至少一种油溶性化妆品; 和皮肤渗透增强剂; 其中组合物的局部施用导致将水溶性和油溶性化妆品递送到角质层中，以及将油溶性化妆品递送到表皮和真皮中。

3. 发明申请

WO2004000263A1 TRANSDERMAL DELIVERY RATE CONTROL USING AMORPHOUS PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：使用非晶态药物组合物的超导递送速率控制
公开(公告)号：WO2004000263A1
公开(公告)日：2003-12-31
申请号：PCT/AU2003/000787
申请日：2003-06-24
申请人： ACRUX DDS PTY LTD , MORGAN, Timothy, Matthias , WILKINS, Nina, Frances , KLOSE, Kathryn, Traci-Jane , FINNIN, Barrie, Charles , REED, Barry, Leonard
发明人： MORGAN, Timothy, Matthias , WILKINS, Nina, Frances , KLOSE, Kathryn, Traci-Jane , FINNIN, Barrie, Charles , REED, Barry, Leonard
IPC分类号： A61K9/00
CPC分类号： A61K31/568 , A61K9/0014 , A61K9/12 , A61K9/7015 , A61K47/14 , A61K47/18 , Y10S514/872 , Y10S514/874 , Y10S514/946 , Y10S514/947
摘要： A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (C max ) to the average concentration (C avg ) for the physiologically active agent over the dosage interval within the range of 1 to 10.
摘要翻译：一种用于透皮递送的药物组合物，其包含一种或多种生理活性剂; 一种或多种皮肤渗透增强剂; 和包含挥发性溶剂的挥发性药学上可接受的载体; 并且其中所述生理活性剂和皮肤渗透增强剂在挥发性载体蒸发时形成无定形沉积物，所述无定形沉积物在角质层内形成储存器; 和（A）其中所述组合物具有生理活性剂的释放速率曲线，以便提供在1范围内的剂量间隔内生理活性剂的最大浓度（C max）与平均浓度（Cavg）之比到10。

4. 发明申请

WO1997029735A1 DERMAL PENETRATION ENHANCERS AND DRUG DELIVERY SYSTEMS INVOLVING SAME 审中-公开
标题翻译：涉及其的透气增强剂和药物递送系统
公开(公告)号：WO1997029735A1
公开(公告)日：1997-08-21
申请号：PCT/AU1997000091
申请日：1997-02-19
申请人： MONASH UNIVERSITY , REED, Barry, Leonard , MORGAN, Timothy, Matthias , FINNIN, Barrie, Charles
发明人： MONASH UNIVERSITY
IPC分类号： A61K07/42
CPC分类号： A61Q17/04 , A61K8/046 , A61K8/37 , A61K8/445 , A61K9/0014 , A61K9/12 , A61K9/122 , A61K47/14 , A61M35/003 , Y02A50/411 , Y10S514/947 , Y10S514/974
摘要： A transdermal drug delivery system which comprises at least one physiologically active agent or prodrug thereof and at least one dermal penetration enhancer; characterised in that the dermal penetration enhancer is a safe skin-tolerant ester sunscreen. A non-occlusive, percutaneous or transdermal drug delivery system which comprises: (i) an effective amount of at least one physiologically active agent or prodrug thereof; (ii) at least one non-volatile dermal penetration enhancer; and (iii) at least one volatile liquid; characterised in that the dermal penetration enhancer is adapted to transport the physiologically active agent across a dermal surface or mucosal membrane of an animal, including a human, when the volatile liquid evaporates, to form a reservoir or depot of a mixture comprising the penetration enhancer and the physiologically active agent or prodrug within said surface or membrane; and the dermal penetration enhancer is of low toxicity to, and is tolerated by, the dermal surface or mucosal membrane of the animal.
摘要翻译：一种透皮药物递送系统，其包含至少一种生理活性剂或其前药和至少一种皮肤渗透促进剂; 其特征在于，皮肤渗透增强剂是安全的耐受皮肤的酯类防晒剂。非闭塞性，经皮或透皮药物递送系统，其包括：（i）有效量的至少一种生理活性剂或其前药; （ii）至少一种非挥发性皮肤渗透增强剂; 和（iii）至少一种挥发性液体; 其特征在于，当挥发性液体蒸发时，皮肤渗透增强剂适于将生理活性剂转运到包括人的动物的皮肤表面或粘膜上，以形成包含渗透增强剂和所述表面或膜内的生理活性剂或前药; 并且皮肤渗透增强剂对动物的真皮表面或粘膜具有低毒性并且被其耐受。

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