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1. 发明申请

WO2006036288A3 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：用于监测早期治疗反应的方法
公开(公告)号：WO2006036288A3
公开(公告)日：2007-04-19
申请号：PCT/US2005027060
申请日：2005-07-29
申请人： RECEPTOMON LLC , NORFRAY JOSEPH F
发明人： NORFRAY JOSEPH F
IPC分类号： A61B5/05 , A61K51/00
CPC分类号： A61B5/055 , A61B5/4833 , G01N24/08 , G01R33/465 , G06F19/3456 , G06F19/3481
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the cancerous tissue before and after treatment; the treatment comprises administration of a cell surface receptor inhibitor, for example, an EGFR inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cell surface receptor inhibitor in the treatment of cancer. Further, the present invention provides for a method for monitoring protein translation in an animal having a cancerous tissue by MRS.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括通过磁共振光谱（MRS）测量例如质子MRS，治疗前后癌组织中存在的胆碱的量; 治疗包括施用细胞表面受体抑制剂例如EGFR抑制剂，由此治疗后胆碱量的减少表示阳性反应。由于细胞器及其分泌颗粒及其运输囊泡的下调，胆碱的量的减少代表内细胞膜的减少。还公开了一种确定细胞表面受体抑制剂治疗癌症的有效性的方法。此外，本发明提供了通过MRS具有癌组织的动物监测蛋白质翻译的方法。

2. 发明申请

WO2006107950A3 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：用于监测早期治疗反应的方法
公开(公告)号：WO2006107950A3
公开(公告)日：2007-06-14
申请号：PCT/US2006012469
申请日：2006-04-04
申请人： RECEPTOMON LLC , NORFRAY JOSEPH F
发明人： NORFRAY JOSEPH F
IPC分类号： A61B5/055
CPC分类号： A61B5/055
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the endomembranes of the cancerous tissue before and after treatment; the treatment comprises administration of a cytotoxic therapy, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cytotoxic treatment of cancer. In addition, a method for monitoring protein translation related to the cytotoxic treatment of cancer is disclosed.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括通过磁共振光谱法（MRS）测量例如质子MRS，治疗前后癌组织内膜中存在的胆碱的量; 治疗包括施用细胞毒性治疗，由此治疗后胆碱量的减少表明阳性反应。由于细胞器及其分泌颗粒及其运输囊泡的下调，胆碱的量的减少代表内细胞膜的减少。还公开了一种确定癌症细胞毒性治疗有效性的方法。此外，公开了一种用于监测与细胞毒性治疗癌症有关的蛋白质翻译的方法。

3. 发明申请

WO2006036288A2 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：用于监测早期治疗反应的方法
公开(公告)号：WO2006036288A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/027060
申请日：2005-07-29
申请人： RECEPTOMON, LLC , NORFRAY, Joseph F
发明人： NORFRAY, Joseph F
IPC分类号： A61B5/05
CPC分类号： A61B5/055 , A61B5/4833 , G01N24/08 , G01R33/465 , G06F19/00 , G06F19/3456 , G06F19/3481
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the cancerous tissue before and after treatment; the treatment comprises administration of a cell surface receptor inhibitor, for example, an EGFR inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cell surface receptor inhibitor in the treatment of cancer. Further, the present invention provides for a method for monitoring protein translation in an animal having a cancerous tissue by MRS.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括通过磁共振光谱（MRS）测量例如质子MRS，治疗前后癌组织中存在的胆碱的量; 治疗包括施用细胞表面受体抑制剂例如EGFR抑制剂，由此治疗后胆碱量的减少表示阳性反应。由于细胞器及其分泌颗粒及其运输囊泡的下调，胆碱的量的减少代表内细胞膜的减少。还公开了一种确定细胞表面受体抑制剂治疗癌症的有效性的方法。此外，本发明提供了通过MRS具有癌组织的动物监测蛋白质翻译的方法。

4. 发明申请

WO2006086159A3 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：监测早期治疗反应的方法
公开(公告)号：WO2006086159A3
公开(公告)日：2006-12-07
申请号：PCT/US2006002675
申请日：2006-01-26
申请人： RECEPTOMON LLC , NORFRAY JOSEPH F
发明人： NORFRAY JOSEPH F
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61K49/0004 , A61K49/0008 , A61K49/06
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), before and after treatment; the treatment comprises administration of an angiogenesis inhibitor, for example, a VEGF inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. Disclosed also is a method for determining effectiveness of an angiogenesis inhibitor in the treatment of cancer. Also disclosed are methods of monitoring early treatment response in diseases where an angiogenesis effector, i.e., an inhibitor or promoter of angiogenesis, is employed.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括在治疗之前和之后通过磁共振波谱学（MRS）测量; 治疗包括施用血管生成抑制剂，例如VEGF抑制剂，由此治疗后胆碱量的减少指示阳性应答。还公开了用于确定血管生成抑制剂在癌症治疗中的有效性的方法。还公开了监测血管生成效应物（即血管生成的抑制剂或启动子）在疾病中的早期治疗反应的方法。

5. 发明申请

WO2006107950A2 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：用于监测早期治疗反应的方法
公开(公告)号：WO2006107950A2
公开(公告)日：2006-10-12
申请号：PCT/US2006/012469
申请日：2006-04-04
申请人： RECEPTOMON, LLC. , NORFRAY, Joseph, F.
发明人： NORFRAY, Joseph, F.
IPC分类号： A61K49/10
CPC分类号： A61B5/055
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the endomembranes of the cancerous tissue before and after treatment; the treatment comprises administration of a cytotoxic therapy, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cytotoxic treatment of cancer. In addition, a method for monitoring protein translation related to the cytotoxic treatment of cancer is disclosed.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括通过磁共振光谱法（MRS）测量例如质子MRS，治疗前后癌组织内膜中存在的胆碱的量; 治疗包括施用细胞毒性治疗，由此治疗后胆碱量的减少表明阳性反应。由于细胞器及其分泌颗粒及其运输囊泡的下调，胆碱的量的减少代表内细胞膜的减少。还公开了一种确定癌症细胞毒性治疗有效性的方法。此外，公开了一种用于监测与细胞毒性治疗癌症有关的蛋白质翻译的方法。

6. 发明申请

WO2006086159A2 METHOD FOR MONITORING EARLY TREATMENT RESPONSE 审中-公开
标题翻译：用于监测早期治疗反应的方法
公开(公告)号：WO2006086159A2
公开(公告)日：2006-08-17
申请号：PCT/US2006/002675
申请日：2006-01-26
申请人： RECEPTOMON, LLC , NORFRAY, Joseph F.
发明人： NORFRAY, Joseph F.
IPC分类号： A61K49/10 , A61B5/055 , A61B5/05
CPC分类号： A61B5/055 , A61K49/0004 , A61K49/0008 , A61K49/06
摘要： Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), before and after treatment; the treatment comprises administration of an angiogenesis inhibitor, for example, a VEGF inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. Disclosed also is a method for determining effectiveness of an angiogenesis inhibitor in the treatment of cancer. Also disclosed are methods of monitoring early treatment response in diseases where an angiogenesis effector, i.e., an inhibitor or promoter of angiogenesis, is employed.
摘要翻译：公开了一种用于监测癌症治疗的早期治疗反应的方法，包括在治疗前后通过磁共振光谱（MRS）测量; 治疗包括施用血管生成抑制剂，例如VEGF抑制剂，由此治疗后胆碱量的减少表示阳性反应。还公开了一种用于确定血管生成抑制剂在治疗癌症中的有效性的方法。还公开了监测血管生成效应物（即血管生成抑制剂或启动子）的疾病中的早期治疗反应的方法。

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