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1. 发明申请

WO1997002817A1 COMPOUNDS USEFUL IN THE TREATMENT OF NEUROFIBROMATOSIS 审中-公开
标题翻译：用于治疗神经病变的化合物
公开(公告)号：WO1997002817A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011577
申请日：1996-07-11
申请人： UNIVERSITY OF CINCINNATI , RATNER, Nancy
发明人： UNIVERSITY OF CINCINNATI
IPC分类号： A61K31/235
CPC分类号： A61K31/223 , A61K31/222
摘要： The present invention relates to compositions useful in the treatment of benign proliferative disorder neurofibromatosis comprising a farnesyl protein transferase inhibitor. Further contained in this invention are methods of treating benign proliferative disorder neurofibromatosis in a mammal, which methods comprise administering to said mammal, a farnesyl proteine transferase inhibitor.
摘要翻译：本发明涉及可用于治疗包括法呢基蛋白转移酶抑制剂的良性增殖性病症神经纤维瘤病的组合物。本发明还包括治疗哺乳动物中良性增生性疾病神经纤维瘤病的方法，该方法包括向所述哺乳动物施用法呢基蛋白转移酶抑制剂。

2. 发明申请

WO2009149166A3 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：WO2009149166A3
公开(公告)日：2009-12-10
申请号：PCT/US2009/046103
申请日：2009-06-03
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , RATNER, Nancy , MILLER, Shyra, J.
发明人： RATNER, Nancy , MILLER, Shyra, J.
IPC分类号： C12Q1/68
摘要： The present invention identifies expression markers associated with neurofibromatosis 1 (NF1) by examining gene expression in tissue from lesions from neurofibromas, plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNST). The present invention also provides for diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism. The present invention relates to novel, rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that act as a therapeutic agent for the treatment of a proliferative disorder. In another aspect, the present invention provides a method of treating a patient with neurofibromatosis and/or MPNST, comprising administering to the patient a pharmaceutical composition, wherein the composition alters the expression of at least one gene related to the NF1-Ras pathway.

3. 发明申请

WO2010094009A3 METHODS AND COMPOSITIONS FOR THE TREATMENT OF RAS ASSOCIATED DISORDERS 审中-公开
标题翻译：治疗RAS相关疾病的方法和组合
公开(公告)号：WO2010094009A3
公开(公告)日：2010-10-07
申请号：PCT/US2010024237
申请日：2010-02-15
申请人： CHILDRENS HOSP MEDICAL CENTER , RATNER NANCY , SANCHEZ YOLANDA , JOHANSSON GUNNAR , SEIBEL WILLIAM
发明人： RATNER NANCY , SANCHEZ YOLANDA , JOHANSSON GUNNAR , SEIBEL WILLIAM
IPC分类号： A61K31/382 , A61K31/4015 , A61K31/415 , A61K31/435 , A61P35/00
CPC分类号： A61K31/382 , A61K31/4015 , A61K31/415 , A61K31/435
摘要： The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NFl gene such as neurofibromatosis type I and/or fungal infections such as those caused by Candida albicans.
摘要翻译：本公开涉及可用作治疗与Ras失调或调节紊乱相关或引起的疾病的治疗剂的组合物，例如与NF1基因改变相关的病症，例如I型神经纤维瘤病和/或真菌感染，例如那些由白色念珠菌引起的。

4. 发明申请

WO2010094009A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF RAS ASSOCIATED DISORDERS 审中-公开
标题翻译：用于治疗相关病症的方法和组合物
公开(公告)号：WO2010094009A2
公开(公告)日：2010-08-19
申请号：PCT/US2010/024237
申请日：2010-02-15
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , RATNER, Nancy , SANCHEZ, Yolanda , JOHANSSON, Gunnar , SEIBEL, William
发明人： RATNER, Nancy , SANCHEZ, Yolanda , JOHANSSON, Gunnar , SEIBEL, William
IPC分类号： A61K31/382 , A61K31/4015 , A61K31/415 , A61K31/435 , A61P35/00
CPC分类号： A61K31/382 , A61K31/4015 , A61K31/415 , A61K31/435
摘要： The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the NFl gene such as neurofibromatosis type I and/or fungal infections such as those caused by Candida albicans .
摘要翻译：本公开涉及可用作治疗剂以治疗与Ras失调或失调相关或由其导致的失调的组合物，例如与NF1基因改变相关的失调如神经纤维瘤病类型我和/或真菌感染，例如由白色念珠菌引起的感染。

5. 发明申请

WO2009149166A2 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于诊断和治疗增生性疾病的方法和组合物
公开(公告)号：WO2009149166A2
公开(公告)日：2009-12-10
申请号：PCT/US2009046103
申请日：2009-06-03
申请人： CHILDRENS HOSP MEDICAL CENTER , RATNER NANCY , MILLER SHYRA J
发明人： RATNER NANCY , MILLER SHYRA J
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/158 , G01N2500/04 , G01N2800/52
摘要： The present invention identifies expression markers associated with neurofibromatosis 1 (NF1) by examining gene expression in tissue from lesions from neurofibromas, plexiform neurofibromas and malignant peripheral nerve sheath tumors (MPNST). The present invention also provides for diagnostic markers as well as markers that can be used to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism. The present invention relates to novel, rapid, reliable and effective assays for screening and identifying pharmaceutically effective compounds that act as a therapeutic agent for the treatment of a proliferative disorder. In another aspect, the present invention provides a method of treating a patient with neurofibromatosis and/or MPNST, comprising administering to the patient a pharmaceutical composition, wherein the composition alters the expression of at least one gene related to the NF1-Ras pathway.
摘要翻译：本发明通过检查来自神经纤维瘤，丛状神经纤维瘤和恶性周围神经鞘瘤（MPNST）病变的组织中的基因表达来鉴定与神经纤维瘤病1（NF1）相关的表达标志物。本发明还提供诊断标志物以及可用于监测疾病状态，疾病进展，药物毒性，药物功效和药物代谢的标志物。本发明涉及用于筛选和鉴定用作治疗增殖性疾病的治疗剂的药学有效化合物的新型，快速，可靠和有效的测定。在另一方面，本发明提供了治疗患有神经纤维瘤病和/或MPNST的患者的方法，包括向患者施用药物组合物，其中所述组合物改变与NF1-Ras途径相关的至少一种基因的表达。

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