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1. 发明申请

WO2012082821A3 MELANOMA TREATMENTS 审中-公开
标题翻译： MELANOMA治疗
公开(公告)号：WO2012082821A3
公开(公告)日：2012-09-13
申请号：PCT/US2011064778
申请日：2011-12-14
申请人： MEDIMMUNE LLC , YAO YIHONG , STREICHER KATIE , GEORGANTAS ROBERT WILLIAM , ZHU WEI , RANADE KOUSTUBH
发明人： YAO YIHONG , STREICHER KATIE , GEORGANTAS ROBERT WILLIAM , ZHU WEI , RANADE KOUSTUBH
IPC分类号： C12N15/11 , A61K31/41 , A61K38/00 , C12Q1/68
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The disclosure provides methods for treating melanoma with an improving therapeutic effectiveness of drugs and reducing drug toxicity. Specifically, the disclosure provides personalized treatments of melanoma that optimize the therapeutic effect of a drug based on identifying the presence, absence or amount of a biomarker in a subject having the melanoma to whom an anti-cancer drug has been administered. Further disclosed are microRNA biomarkers that can be used for optimizing therapeutic efficacy of treating melanoma in a subject.
摘要翻译：本公开提供了治疗黑色素瘤的方法，其具有改善药物的治疗有效性并降低药物毒性。具体地，本公开提供了黑色素瘤的个性化治疗，其基于鉴定已经给予抗癌药物的黑素瘤的受试者中存在，不存在或数量的生物标志物来优化药物的治疗效果。进一步公开的是可用于优化治疗受试者黑素瘤的治疗功效的微小RNA生物标志物。

2. 发明申请

WO2012082821A2 MELANOMA TREATMENTS 审中-公开
标题翻译： MELANOMA治疗
公开(公告)号：WO2012082821A2
公开(公告)日：2012-06-21
申请号：PCT/US2011/064778
申请日：2011-12-14
申请人： MEDIMMUNE, LLC , YAO, Yihong , STREICHER, Katie , GEORGANTAS, Robert, William , ZHU, Wei , RANADE, Koustubh
发明人： YAO, Yihong , STREICHER, Katie , GEORGANTAS, Robert, William , ZHU, Wei , RANADE, Koustubh
CPC分类号： C12N15/1135 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： Provided herein, in some embodiments, are methods for treating melanoma, improving therapeutic effectiveness of drugs and reducing drug toxicity.
摘要翻译：在本文中，在一些实施方案中，是治疗黑素瘤的方法，提高药物的治疗有效性并降低药物毒性。

3. 发明申请

WO2009140685A3 METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS 审中-公开
标题翻译：用DPP-IV抑制剂对增加的病原体鉴别物种的方法
公开(公告)号：WO2009140685A3
公开(公告)日：2010-04-01
申请号：PCT/US2009044376
申请日：2009-05-18
申请人： SQUIBB BRISTOL MYERS CO , ASTRAZENECA UK LTD , EMISON EILEEN , DELMONTE TERRYE AIGELDINGER , RANADE KOUSTUBH , RODRIGUEZ LISA RENEE , SIMONSEN KATY LYNN MOORE
发明人： EMISON EILEEN , DELMONTE TERRYE AIGELDINGER , RANADE KOUSTUBH , RODRIGUEZ LISA RENEE , SIMONSEN KATY LYNN MOORE
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/37 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N2800/042 , G01N2800/52
摘要： The invention provides novel in vitro diagnostic methods for identifying subjects or patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments which comprise at least one polymorphic locus, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the invention are useful in phenotype correlations, medicine, and genetic analysis.
摘要翻译：本发明提供用于鉴定可能具有增加的DPP-IV抑制剂治疗应答可能性的受试者或患者的新型体外诊断方法。本发明还提供与患者对DPP-IV抑制的增加的反应性相关的新型多核苷酸。还提供了包含至少一个多态性位点的多核苷酸片段。还提供了与这些多态性区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性基因座。本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。

4. 发明申请

WO2009140685A2 METHODS FOR IDENTIFYING SUBJECTS WITH AN INCREASED LIKELIHOOD OF RESPONDING TO DPP-IV INHIBITORS 审中-公开
标题翻译：用DPP-IV抑制剂对增加的病原体鉴别物种的方法
公开(公告)号：WO2009140685A2
公开(公告)日：2009-11-19
申请号：PCT/US2009/044376
申请日：2009-05-18
申请人： BRISTOL-MYERS SQUIBB COMPANY , ASTRAZENECA UK LIMITED , EMISON, Eileen , DELMONTE, Terrye, Aigeldinger , RANADE, Koustubh , RODRIGUEZ, Lisa, Renee , SIMONSEN, Katy, Lynn Moore
发明人： EMISON, Eileen , DELMONTE, Terrye, Aigeldinger , RANADE, Koustubh , RODRIGUEZ, Lisa, Renee , SIMONSEN, Katy, Lynn Moore
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , C12Q1/37 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , G01N2800/042 , G01N2800/52
摘要： The invention provides novel in vitro diagnostic methods for identifying subjects or patients who may have an increased likelihood of responding to DPP-IV inhibitor therapy. The invention also provides novel polynucleotides associated with increased responsiveness of a patient to DPP-IV inhibition. Polynucleotide fragments which comprise at least one polymorphic locus, are also provided. Allele-specific primers and probes which hybridize to these polymorphic regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the invention are useful in phenotype correlations, medicine, and genetic analysis.
摘要翻译：本发明提供用于鉴定可能具有增加的DPP-IV抑制剂治疗应答可能性的受试者或患者的新型体外诊断方法。本发明还提供与患者对DPP-IV抑制的增加的反应性相关的新型多核苷酸。还提供了包含至少一个多态性位点的多核苷酸片段。还提供了与这些多态性区域杂交的等位基因特异性引物和探针，和/或包含至少一个多态性基因座。本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。

5. 发明申请

WO2007008604A3 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DOSE-DEPENDENT EDEMA AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2007008604A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026353
申请日：2006-07-07
申请人： BRISTOL-MYERS SQUIBB COMPANY , RANADE, Koustubh , DELMONTE, Terrye, A. , GEESE, William, J.
发明人： RANADE, Koustubh , DELMONTE, Terrye, A. , GEESE, William, J.
IPC分类号： C12Q1/68 , C12N9/64 , C07K14/575 , C07K14/705
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polynucleotides and polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly PPAR-agonist induced edema or related indications. The invention further relates to screening methods for identifying agonists of PPAR proteins with decreased risk of inducing periphereal edema in patients.

6. 发明申请

WO2007008604A2 SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED WITH DOSE-DEPENDENT EDEMA AND METHODS OF USE THEREOF 审中-公开
标题翻译：与剂量依赖性EDEMA相关的单核苷酸多态性及其使用方法
公开(公告)号：WO2007008604A2
公开(公告)日：2007-01-18
申请号：PCT/US2006026353
申请日：2006-07-07
申请人： SQUIBB BRISTOL MYERS CO , RANADE KOUSTUBH , DELMONTE TERRYE A , GEESE WILLIAM J
发明人： RANADE KOUSTUBH , DELMONTE TERRYE A , GEESE WILLIAM J
CPC分类号： G01N33/5023 , C07K14/57536 , C07K14/70571 , C12N9/6486 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , C12Y304/23015 , G01N2333/70567 , G01N2500/10
摘要： The invention provides novel polynucleotides and polypeptides associated with the incidence of PPAR-agonist induced edema. The invention also provides polynucleotide fragments corresponding to the genomic and/or coding regions of these polynucleotides which comprise at least one polymorphic locus per fragment. Allele-specific primers and probes which hybridize to these regions, and/or which comprise at least one polymorphic locus are also provided. The polynucleotides, primers, and probes of the present invention are useful in phenotype correlations, medicine, and genetic analysis. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel polynucleotides and polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders, particularly PPAR-agonist induced edema or related indications. The invention further relates to screening methods for identifying agonists of PPAR proteins with decreased risk of inducing periphereal edema in patients.
摘要翻译：本发明提供了与PPAR-激动剂诱导的水肿发生率相关的新型多核苷酸和多肽。本发明还提供了对应于这些多核苷酸的基因组和/或编码区的多核苷酸片段，每个片段包含至少一个多态性基因座。还提供了与这些区域杂交和/或包含至少一个多态性基因座的等位基因特异性引物和探针。本发明的多核苷酸，引物和探针可用于表型相关性，药物和遗传分析。还提供了载体，宿主细胞，抗体以及用于产生所述多核苷酸和/或多肽的重组和合成方法。本发明进一步涉及将这些新多核苷酸和多肽用于诊断，治疗和/或预防各种疾病和/或病症，特别是PPAR-激动剂诱导的水肿或相关适应症的诊断和治疗方法。本发明进一步涉及用于鉴定PPAR蛋白激动剂的筛选方法，其具有降低诱导患者的周边水肿的风险。

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