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1. 发明申请

WO2009021287A1 PHOTOACTIVATED CROSSLINKING OF A PROTEIN OR PEPTIDE 审中-公开
标题翻译：蛋白质或肽的光合交联
公开(公告)号：WO2009021287A1
公开(公告)日：2009-02-19
申请号：PCT/AU2008/001178
申请日：2008-08-14
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , BROWNLEE, Alan, George , ELVIN, Christopher, Malcolm , WERKMEISTER, Jerome, Anthony , RAMSHAW, John, Alan, Maurice , LINDALL, Charles, Mark
发明人： BROWNLEE, Alan, George , ELVIN, Christopher, Malcolm , WERKMEISTER, Jerome, Anthony , RAMSHAW, John, Alan, Maurice , LINDALL, Charles, Mark
IPC分类号： C08H1/00 , A61L24/10 , A61L15/32 , A61L15/58 , A61L27/44 , C09J189/00
CPC分类号： A61L24/10 , A61L24/001 , A61L24/0026 , A61L24/102 , A61L24/106 , A61L24/108 , A61L26/0028 , A61L26/0061 , A61L26/0076 , A61L27/22 , A61L27/50 , C08H1/00 , C09J189/00
摘要： A method of crosslinking a protein or peptide for use as a biomaterial, the method comprising the step of irradiating a photoactivatable metal-ligand complex and an electron acceptor in the presence of the protein or peptide, thereby initiating a cross-linking reaction to form a 3-dimensional matrix of the biomaterial.
摘要翻译：交联用作生物材料的蛋白质或肽的方法，所述方法包括在蛋白质或肽存在下照射可光活化的金属 - 配体复合物和电子受体的步骤，由此引发交联反应以形成生物材料的3维矩阵。

2. 发明申请

WO1998018918A1 STABLE EXPRESSION OF TRIPLE HELICAL PROTEINS 审中-公开
标题翻译：三维螺旋蛋白稳定表达
公开(公告)号：WO1998018918A1
公开(公告)日：1998-05-07
申请号：PCT/AU1997000721
申请日：1997-10-29
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , VAUGHAN, Paul, Richard , GALANIS, Maria , RAMSHAW, John, Alan, Maurice , WERKMEISTER, Jerome, Anthony
发明人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
IPC分类号： C12N15/12
CPC分类号： C12N9/0071 , A61K38/00 , C07K14/78 , C12P21/02
摘要： The invention relates to a method of producing a hydroxylated triple helical protein in yeast comprising the steps of: introducing to a suitable yeast host cell a first nucleotide sequence encoding P4H alpha subunit, a second nucleotide sequence encoding P4H beta subunit and one or more product-encoding nucleotide sequences which encode(s) a polypeptide(s) or peptide(s) which, when hydroxylated, form the said hydroxylated triple helical protein, each of said first, second and product-encoding nucleotide sequences being operably linked to promoter sequences; and culturing said yeast host cell under conditions suitable to achieve expression of said first, second and product-encoding nucleotide sequences to thereby produce said hydroxylated triple helical protein; wherein said method is characterised in that the step of introducing the first, second and product-encoding nucleotide sequences results in the said first, second and product-encoding nucleotide sequences, together with their respective operably linked promoter sequences, being borne on one or more replicable DNA molecules that are stably retained and segregated by said yeast host cell during said step of culturing. Transformed yeast host cells and triple helical proteins produced in accordance with the method of the invention are also claimed.
摘要翻译：本发明涉及在酵母中生产羟基化三螺旋蛋白的方法，其包括以下步骤：向合适的酵母宿主细胞导入编码P4Hα亚基的第一核苷酸序列，编码P4Hβ亚基的第二核苷酸序列和一个或多个产物 - 编码编码多肽或多肽的核苷酸序列，所述多肽或多肽当羟基化形成所述羟基化三螺旋蛋白时，所述第一，第二和产物编码核苷酸序列中的每一个可操作地连接于启动子序列; 并在适于实现所述第一，第二和产物编码核苷酸序列的表达的条件下培养所述酵母宿主细胞从而产生所述羟基化三螺旋蛋白; 其中所述方法的特征在于引入第一，第二和产物编码核苷酸序列的步骤导致所述第一，第二和产物编码的核苷酸序列连同它们各自可操作地连接的启动子序列一起承载在一个或多个在所述培养步骤期间由所述酵母宿主细胞稳定保留和分离的可复制DNA分子。还要求保护根据本发明方法生产的转化的酵母宿主细胞和三螺旋蛋白。

3. 发明申请

WO2008014561A1 BIOCOMPATIBLE POLYMER COMPOSITIONS 审中-公开
标题翻译：生物成分聚合物组合物
公开(公告)号：WO2008014561A1
公开(公告)日：2008-02-07
申请号：PCT/AU2007/001085
申请日：2007-08-02
申请人： POLYNOVO BIOMATERIALS PTY LTD , GUNATILLAKE, Pathiraja, Arachchillage , MAYADUNNE, Roshan, Tyrrel, Anton , ADHIKARI, Raju , TAING, Heng, Chy , LE, Tam, Phuong, Thi , WERKMEISTER, Jerome, Anthony , RAMSHAW, John, Alan, Maurice , WHITE, Jacinta, Frances , TEBB, Tracy, Ann
发明人： GUNATILLAKE, Pathiraja, Arachchillage , MAYADUNNE, Roshan, Tyrrel, Anton , ADHIKARI, Raju , TAING, Heng, Chy , LE, Tam, Phuong, Thi , WERKMEISTER, Jerome, Anthony , RAMSHAW, John, Alan, Maurice , WHITE, Jacinta, Frances , TEBB, Tracy, Ann
IPC分类号： C08L33/04 , C08F290/02 , C08G63/08 , A61L27/14 , C08F299/00
CPC分类号： C08G18/4277 , A61L27/16 , C08F290/00 , C08F290/02 , C08F299/00 , C08G18/10 , C08G18/4833 , C08G18/771 , C08G18/8116 , C08G63/08 , C08G63/664 , C08G2230/00 , C08L53/00 , C08L53/005 , C08L53/02 , C08L2666/02
摘要： The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
摘要翻译：本发明提供了包含亲水和疏水链段的生物相容性预聚物，其中疏水链段具有至少一个烯键式不饱和官能团，并且至少5％的链段具有两个或多个烯键式不饱和官能团和水。本发明还提供了包含亲水和疏水预聚物的生物相容性预聚物组合物，其中至少一种疏水性预聚物具有至少一个烯键式不饱和官能团，并且至少5％的预聚物具有两个或更多个烯属不饱和官能团和水。本发明进一步提供了本发明的预聚物或预聚物组合物在生物医学应用如组织工程，骨替代物或支架中以及在伤口治疗中的用途。

4. 发明申请

WO2002062357A1 METHODS AND DEVICES FOR TISSUE REPAIR 审中-公开
标题翻译：用于组织修复的方法和装置
公开(公告)号：WO2002062357A1
公开(公告)日：2002-08-15
申请号：PCT/AU2002/000106
申请日：2002-02-04
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE , WERKMEISTER, Jerome, Anthony , TSAI, Wei-Bor , RAMSHAW, John, Alan, Maurice , THISSEN, Helmut, Werner , CHANG, Ken-Yuan
发明人： WERKMEISTER, Jerome, Anthony , TSAI, Wei-Bor , RAMSHAW, John, Alan, Maurice , THISSEN, Helmut, Werner , CHANG, Ken-Yuan
IPC分类号： A61K35/32
CPC分类号： A61L27/3886 , A61K35/12 , A61L27/3608 , A61L27/3804 , A61L27/3817 , A61L27/3852 , A61L27/3895 , A61L27/52 , A61L2400/06 , A61L2430/06 , C12N5/0075 , C12N5/0653 , C12N5/0654 , C12N5/0655 , C12N5/0656 , C12N2533/40 , C12N2533/54
摘要： Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells and/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis. Also disclosed is a device having tissue-like characteristics for treating diseased or damaged tissue in a subject, wherein the device comprises cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance.
摘要翻译：公开了用于治疗受试者中的患病或受损组织的方法，包括在发生病变或损伤的组织的部位施用所述受试者，通常在对应于患病或损伤的组织的健康组织中发现的细胞和/ 或其合适的祖细胞，其与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。当细胞和/或合适的祖细胞是软骨细胞，胚胎干细胞和/或骨髓基质细胞时，本发明的方法适用于治疗例如与原发性骨关节炎相关的关节软骨退化。还公开了一种具有用于治疗受试者中的患病或受损组织的组织样特征的装置，其中该装置包括通常存在于对应于患病或受损组织的健康组织中的类型的细胞和/或合适的祖细胞与生物可再吸收的珠粒或颗粒以及任选的凝胶和/或凝胶形成物质结合。

5. 发明申请

WO2006128216A1 PREPARATION AND USE OF BASEMENT MEMBRANE PARTICLES 审中-公开
标题翻译：基底膜颗粒的制备和使用
公开(公告)号：WO2006128216A1
公开(公告)日：2006-12-07
申请号：PCT/AU2006/000708
申请日：2006-05-29
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , WERKMEISTER, Jerome , GLATTAUER, Veronica , RAMSHAW, John, Alan, Maurice
发明人： WERKMEISTER, Jerome , GLATTAUER, Veronica , RAMSHAW, John, Alan, Maurice
IPC分类号： C12N5/02 , C12N5/06
CPC分类号： C12N5/0068 , C12N2533/90
摘要： A method for supporting the in vitro growth of one or more eukaryotic cell type(s), the method comprising; seeding cells of said cell type(s) onto particles comprising basement membrane or a basement membrane-like substrate, and culturing said seeded cells in vitro under conditions suitable for expansion of said seeded cells, wherein said particles are less than about 500 μm in size.
摘要翻译：一种用于支持一种或多种真核细胞类型的体外生长的方法，所述方法包括：将所述细胞类型的细胞接种到包含基底膜或基底膜样底物的颗粒上，并在适合于扩增所述接种的细胞的条件下体外培养所述接种的细胞，其中所述颗粒的尺寸小于约500μm 。

6. 发明申请

WO1987004078A1 PRECIPITATION OF COLLAGEN IN TACTOID FORM 审中-公开
标题翻译：胶原蛋白形式的降解
公开(公告)号：WO1987004078A1
公开(公告)日：1987-07-16
申请号：PCT/AU1987000001
申请日：1987-01-02
申请人： THE UNIVERSITY OF MELBOURNE , BATEMAN, John, Francis , RAMSHAW, John, Alan, Maurice , PETERS, David, Edward , TULLOCH, Peter, Archibald
发明人： THE UNIVERSITY OF MELBOURNE
IPC分类号： A61L27/00
CPC分类号： A61L27/24 , A61F2310/00365 , C08H1/06 , Y10S530/84 , Y10S530/842
摘要： Collagen in tactoid form obtained by forming an aqueous solution containing dissolved collagen and a water soluble or miscible polymer adapted to precipitate collagen out of solution in the form of tactoids.
摘要翻译：通过形成含有溶解的胶原的水溶液和适于以胶质形式将胶原蛋白从溶液中沉淀出来的水溶性或可混溶的聚合物获得的眼镜状胶原蛋白。

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