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1. 发明申请

WO2010051227A1 GALACTOSE ALPHA (1-3) GALACTOSE COMPOSITIONS 审中-公开
标题翻译： GALACTOSE ALPHA（1-3）胶体组合物
公开(公告)号：WO2010051227A1
公开(公告)日：2010-05-06
申请号：PCT/US2009/061810
申请日：2009-10-23
申请人： CENTOCOR ORTHO BIOTECH INC. , RAJU, T., Shantha , SCALLON, Bernard, J.
发明人： RAJU, T., Shantha , SCALLON, Bernard, J.
IPC分类号： C12P19/18 , C12N9/24 , C07G3/00 , C07H1/00
CPC分类号： C07H3/06 , C07H13/04 , C07K16/00 , C07K2317/41 , C08B37/0036 , C08B37/006 , C12P21/005
摘要： An enzymatic method for synthesizing oligosaccharides comprising a terminal Gal-alpha(1,3)-Gal-beta(1-4)GlcNac is used to produce Fc-containing molecules with certain properties. The methods modify glycoproteins that interact with receptors or are processed in vivo and recognized as unique epitopes. In particular, the glycan groups on a therapeutic antibody capable of interaction with Fc-receptors are modified.
摘要翻译：用于合成包含末端Gal-α（1,3）-Gal-β（1-4）GlcNac的寡糖的酶法用于产生具有某些性质的含Fc分子。该方法修饰与受体相互作用或在体内加工并识别为独特表位的糖蛋白。特别地，能够与Fc受体相互作用的治疗性抗体上的聚糖基团被修饰。

2. 发明申请

WO2007005786A3 METHODS AND COMPOSITIONS WITH ENHANCED THERAPEUTIC ACTIVITY 审中-公开
标题翻译：具有增强治疗活性的方法和组合物
公开(公告)号：WO2007005786A3
公开(公告)日：2009-04-23
申请号：PCT/US2006025906
申请日：2006-06-30
申请人： CENTOCOR INC , CAI ANN , NGO CAM , RAJU T SHANTHA , SCALLON BERNARD
发明人： CAI ANN , NGO CAM , RAJU T SHANTHA , SCALLON BERNARD
IPC分类号： C07K16/46 , A61K38/16 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/92
摘要： The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the FcgRI, FcgRIIA, and FcgRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.
摘要翻译：通过改变Fc区中寡糖的唾液酸化来控制含Fc的蛋白质，例如抗体的性质。经修饰的含Fc蛋白质具有治疗效用，其中希望控制对FcgRI，FcgRIIA和FcgRIIIA受体的一种或多种的亲和力，ADCC活性，巨噬细胞或单核细胞活化，血清半衰期和亲和力。

3. 发明申请

WO2011059684A1 ANTIBODY GLYCOSYLATION VARIANTS 审中-公开
标题翻译：抗体糖蛋白变体
公开(公告)号：WO2011059684A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/053948
申请日：2010-10-25
申请人： CENTOCOR ORTHO BIOTECH INC. , LUO, Jinquan , MCCARTHY, Stephen , RAJU, T., Shantha , SCALLON, Bernard , SPINKA-DOMS, Tracy
发明人： LUO, Jinquan , MCCARTHY, Stephen , RAJU, T., Shantha , SCALLON, Bernard , SPINKA-DOMS, Tracy
IPC分类号： C12P21/06 , A61K39/00
CPC分类号： C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/94
摘要： Antibody and other Fc-containing molecules with glycosylation variations in the Fc region show increased resistance to proteases, such as pepsin, plasmin, trypsin, chymotrypsin, a matrix metalloproteinase, a serine endopeptidase, and a cysteine protease. The Fc-containing molecules are useful in the treatment of various diseases and disorders.
摘要翻译： Fc区域中具有糖基化变异的抗体和其它含Fc分子表现出对蛋白酶，如胃蛋白酶，纤溶酶，胰蛋白酶，胰凝乳蛋白酶，基质金属蛋白酶，丝氨酸内肽酶和半胱氨酸蛋白酶的增加的抗性。含Fc的分子可用于治疗各种疾病和病症。

4. 发明申请

WO2008083150A3 METHODS AND VECTORS FOR GENERATING ASIALYLATED IMMUNOGLOBULINS 审中-公开
标题翻译：用于产生异构体免疫球蛋白的方法和方法
公开(公告)号：WO2008083150A3
公开(公告)日：2009-04-30
申请号：PCT/US2007088809
申请日：2007-12-26
申请人： CENTOCOR INC , TAM SUSAN , NASO MICHAEL , RAJU T SHANTHA , SCALLON BERNARD
发明人： NASO MICHAEL , RAJU T SHANTHA , SCALLON BERNARD
IPC分类号： C12P1/00 , C07H21/04 , C07K1/00 , C07K16/00 , C12N1/20 , C12N9/00 , C12N9/24
CPC分类号： C12N9/2402 , C07K16/00 , C07K16/241 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C12N15/85 , C12P21/005 , C12Y302/01018
摘要： The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region by transfecting the cell line expressing the Fc-containing protein with a vector sequence encoding a sialidase. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the Fc?RI, Fc?RIIA, and Fc?RIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.
摘要翻译：通过用编码唾液酸酶的载体序列转染表达含Fc的蛋白质的细胞系，通过改变Fc区中的寡糖的唾液酸化来控制含Fc的蛋白质，例如抗体的性质。所述经修饰的含Fc蛋白质具有治疗效用，其中希望控制对FcγRI，FcγRIIA和FcγRIIIA受体，ADCC活性，巨噬细胞或单核细胞活化中的一种或多种的亲和力的疾病或病症，血清半衰期和亲合力。

5. 发明申请

WO2007024743A3 PROTEOLYSIS RESISTANT ANTIBODY PREPARATIONS 审中-公开
标题翻译：抗粘蛋白抗体制剂
公开(公告)号：WO2007024743A3
公开(公告)日：2009-06-25
申请号：PCT/US2006032458
申请日：2006-08-18
申请人： CENTOCOR INC , RAJU T SHANTHA , SCALLON BERNARD
发明人： RAJU T SHANTHA , SCALLON BERNARD
IPC分类号： A61K39/395 , C12Q1/37
CPC分类号： C07K16/00 , C07K2317/41 , C07K2317/50
摘要： Antibody preparations with substantially homogeneous and unsialylated glycoforms, such as G0 and G2, are prepared by enzymatic treatment, expression under certain conditions, use of particular host cells, and contact with serum. These antibody preparations resist cleavage by proteases, such as papain, ficin, bromolein, pepsin, a matrix metalloproteinase, such as MMP-7, neutrophil elastase (HNE), stromelysin (MMP-3) and macrophage elastase (MMP-12), and glycosylation modification enzymes. The antibody preparations with substantially homogeneous and unsialylated glycoforms and methods of testing for glycosylation in an antibody are useful in connection with characterization of antibody properties and/or in diseases or conditions characterized by an increase in protease activity.
摘要翻译：通过酶处理，在某些条件下表达，使用特定的宿主细胞和与血清接触来制备具有基本上均相和非唾液酸化的糖形式的抗体制剂，例如G0和G2。这些抗体制剂抵抗蛋白酶如木瓜蛋白酶，蓖麻毒素，溴林灵，胃蛋白酶，基质金属蛋白酶如MMP-7，嗜中性粒细胞弹性蛋白酶（HNE），溶基质溶解素（MMP-3）和巨噬细胞弹性蛋白酶（MMP-12）的切割，以及糖基化修饰酶。具有基本上均相和非唾液酸化的糖型的抗体制剂和在抗体中测试糖基化的方法可用于抗体特性表征和/或以蛋白酶活性增加为特征的疾病或病症中。

6. 发明申请

WO2008083150A2 METHODS AND VECTORS FOR GENERATING ASIALYLATED IMMUNOGLOBULINS 审中-公开
标题翻译：用于产生异构体免疫球蛋白的方法和方法
公开(公告)号：WO2008083150A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/088809
申请日：2007-12-26
申请人： CENTOCOR, INC. , TAM, Susan , NASO, Michael , RAJU, T., Shantha , SCALLON, Bernard
发明人： NASO, Michael , RAJU, T., Shantha , SCALLON, Bernard
IPC分类号： A61K39/395
CPC分类号： C12N9/2402 , C07K16/00 , C07K16/241 , C07K2317/41 , C07K2317/72 , C07K2317/732 , C12N15/85 , C12P21/005 , C12Y302/01018
摘要： The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region by transfecting the cell line expressing the Fc-containing protein with a vector sequence encoding a sialidase. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the FcγRI, FcγRIIA, and FcγRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.
摘要翻译：通过用编码唾液酸酶的载体序列转染表达含Fc的蛋白质的细胞系，通过改变Fc区中的寡糖的唾液酸化来控制含Fc的蛋白质，例如抗体的性质。所述经修饰的含Fc蛋白质具有治疗效用，其中希望控制对FcγRI，FcγRIIA和FcγRIIIA受体，ADCC活性，巨噬细胞或单核细胞活化中的一种或多种的亲和力的疾病或病症，血清半衰期和亲合力。

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