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1. 发明申请

WO2005075489A1 A PROCESS FOR THE PERPARATION OF AN ANTI-TUMOR PLATINUM (II) - COMPLEX 审中-公开
标题翻译：一种抗肿瘤白蛋白（II） - 复合物的表征方法
公开(公告)号：WO2005075489A1
公开(公告)日：2005-08-18
申请号：PCT/IN2004/000035
申请日：2004-02-05
申请人： DABUR RESEARCH FOUNDATION , MAIKAP, Golak, Chandra , RAJ, Bhagat , KUMAR, Pradipta , VIVEKANANDAN, Kannan , BELWAL, Chandrakant
发明人： MAIKAP, Golak, Chandra , RAJ, Bhagat , KUMAR, Pradipta , VIVEKANANDAN, Kannan , BELWAL, Chandrakant
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： We disclose here processes for making Platinum complex of general formula (I) where in , the conformation of 1,2-diaminocyclohexane is cis, trans-l or trans-d isomer and R 1 and R 2 combinedly make dicarboxylic acid having formulae (II),(III) and (IV), here in, the two carboxylic acid groups are on the same or on vicinal carbon atoms, n is zero or an integer ranging from 1 to 5 and R 3 is either hydrogen or a substituent with electron withdrawing or electron releasing effects exemplified by alkoxy, halo, and nitro groups by reacting a compound of formula M 2 PtX 4 wherein X represents halogen atom such as Cl or Br or thiocyanate with (i) 1,2-diaminocyclohexane (ii) source of silver ion selected from a silver compound containing divalent anion in presence of a corresponding carboxylic acid of formula (II) or (III) or (IV) to get the compound of formula (I), purifying the said compound by treating with alkali metal iodide and isolating the title compound by any conventional methods. The preparation of the said compound involves, for the first time, the intermediate formation of cis-Diiodo-trans-l-1,2-diaminocyclohexane platinum(II) and biscarboylato-trans-l-1,2-diaminocyclohexane platinum(II).
摘要翻译：我们在这里公开了制备通式（I）的铂络合物的方法，其中1,2-二氨基环己烷的构型是顺式，反式-1或反式异构体，并且R 1和R 2'组合地制备具有式（II）的二羧酸），（III）和（IV）中，在这里，两个羧酸基团在相同或相邻的碳原子上，n为0或1至5的整数，R 3为氢或具有吸电子的取代基或通过使式M2PtX4的化合物（其中X表示卤素原子例如Cl或Br或硫氰酸酯）与（i）1,2-二氨基环己烷（ii）的银离子源反应，例如烷氧基，卤素和硝基，在相应的式（II）或（III）或（IV）的羧酸的存在下含有二价阴离子的银化合物，得到式（I）化合物，用碱金属碘化物处理纯化所述化合物，并分离标题通过任何常规方法复合。所述化合物的制备首次涉及中间体形成顺式 - 二碘 - 反式-1,2-二氨基环己烷铂（II）和双羰基 - 反式-1,2-二氨基环己烷铂（II）。

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