专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005084137A2 CD25 DNA VACCINES FOR TREATING AND PREVENTING T-CELL MEDIATED DISEASES 审中-公开
标题翻译：用于治疗和预防T细胞介导性疾病的CD25 DNA疫苗
公开(公告)号：WO2005084137A2
公开(公告)日：2005-09-15
申请号：PCT/IL2005/000273
申请日：2005-03-08
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE , COHEN, Irun, R. , MIMRAN, Avishai , QUINTANA, Francisco , MOR, Felix , CARMI, Pnina
发明人： COHEN, Irun, R. , MIMRAN, Avishai , QUINTANA, Francisco , MOR, Felix , CARMI, Pnina
CPC分类号： A61K39/0008 , A61K2039/53
摘要： The present invention relates to compositions comprising nucleic acids encoding the α chain of IL-2 receptor (IL-2Ra, CD25), homologs and fragment thereof, effective in the treatment and prevention of T cell mediated pathologies. The invention further provides methods for enhancing anti-ergotypic T cell activity in a subject in need thereof, and for treating or preventing T cell mediated pathologies, such as autoimmune diseases, inflammatory diseases and graft rejection.
摘要翻译：本发明涉及包含编码IL-2受体（IL-2Rα，CD25）的α链的核酸的组合物，其同系物及其片段，其有效治疗和预防T细胞介导的病理学。本发明进一步提供了在有需要的受试者中增强抗细胞型T细胞活性，以及用于治疗或预防T细胞介导的病症如自身免疫性疾病，炎性疾病和移植排斥的方法。

2. 发明申请

WO2003096967A2 DNA VACCINES ENCODING HEAT SHOCK PROTEINS 审中-公开
标题翻译： DNA疫苗编码热休克蛋白
公开(公告)号：WO2003096967A2
公开(公告)日：2003-11-27
申请号：PCT/IL2003/000417
申请日：2003-05-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , COHEN, Irun, R. , QUINTANA, Francisco, J. , CARMI, Pnina , MOR, Felix
发明人： COHEN, Irun, R. , QUINTANA, Francisco, J. , CARMI, Pnina , MOR, Felix
IPC分类号： A61K
CPC分类号： A61K39/0008 , A61K31/7088 , A61K38/1709 , A61K39/00 , A61K48/00 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57
摘要： The present invention is related to recombinant constructs encoding heat shock proteins or active fragments thereof, effective in treating T cell mediated inflammatory autoimmune diseases by DNA vaccines. The treatment with the recombinant constructs of the present invention provides long-term expression of specific heat shock proteins for fragments thereof. In one embodiment, the present invention is related to a recombinant construct comprising a nucleic acid sequence encoding HSP60, HSP70 or HSP90. In various preferred embodiments, the present invention is related to a recombinant construct comprising a nucleic acid sequence selected from amino acids 1-140 of HSP60, amino acids 130-260 of HSP60 and amino acids 31-50 of HSP60. Another aspect of the present invention is related to an active fragment of HSP60 corresponding to amino acids 31-50 of HSP60 effective in treating arthritis.
摘要翻译：本发明涉及编码热休克蛋白或其活性片段的重组构建体，其通过DNA疫苗有效治疗T细胞介导的炎性自身免疫性疾病。用本发明的重组构建体进行的治疗提供了对其片段的特异性热休克蛋白的长期表达。在一个实施方案中，本发明涉及包含编码HSP60，HSP70或HSP90的核酸序列的重组构建体。在各种优选实施方案中，本发明涉及包含选自HSP60的氨基酸1-140，HSP60的氨基酸130-260和HSP60的氨基酸31-50的核酸序列的重组构建体。本发明的另一方面涉及对应于有效治疗关节炎的HSP60的氨基酸31-50的HSP60的活性片段。

3. 发明申请

WO2007034490A3 DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY 审中-公开
标题翻译：用于调节细胞免疫的二酯类抗生素
公开(公告)号：WO2007034490A3
公开(公告)日：2011-05-19
申请号：PCT/IL2006001113
申请日：2006-09-21
申请人： YEDA RES & DEV , SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO , GERBER DORON
发明人： SHAI YECHIEL , COHEN IRUN R , QUINTANA FRANCISCO , GERBER DORON
IPC分类号： C07K7/06
CPC分类号： A61K38/1774
摘要： The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in preventing or treating T cell mediated inflammatory diseases. The invention provides pharmaceutical compositions comprising these diastereomeric peptides and conjugates, and uses thereof for therapy of inflammatory diseases, autoimmunity and graft rejection.
摘要翻译：本发明提供了衍生自T细胞受体α跨膜结构域的非对映异构肽及其亲脂性缀合物，该肽和缀合物可有效预防或治疗T细胞介导的炎性疾病。本发明提供包含这些非对映体肽和缀合物的药物组合物及其用于治疗炎性疾病，自身免疫和移植物排斥反应的用途。

4. 发明申请

WO2010055510A2 DIAGNOSIS OF MULTIPLE SCLEROSIS 审中-公开
标题翻译：多发性硬化症的诊断
公开(公告)号：WO2010055510A2
公开(公告)日：2010-05-20
申请号：PCT/IL2009/001066
申请日：2009-11-12
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , WEINER, Howard, L. , COHEN, Irun, R. , QUINTANA, Francisco, J.
发明人： WEINER, Howard, L. , COHEN, Irun, R. , QUINTANA, Francisco, J.
IPC分类号： G01N33/53
CPC分类号： G01N33/564 , G01N2800/285
摘要： The present invention relates to methods and kits for diagnosing multiple sclerosis (MS) in a subject. Particularly, the present invention relates to methods and kits for diagnosing a subtype of MS in a subject, the subtype selected from relapsing-remitting MS (RRMS), secondary progressive MS (SPMS), primary progressive MS (PPMS) and a pathologic sub-type of MS lesions selected from Pattern I and Pattern II MS lesion.
摘要翻译：本发明涉及用于诊断受试者中的多发性硬化症（MS）的方法和试剂盒。特别地，本发明涉及用于诊断受试者中MS的亚型的方法和试剂盒，所述亚型选自复发缓解型MS（RRMS），继发进展型MS（SPMS），原发进行型MS（PPMS）和病理亚型，类型的MS病变选自模式I和模式II MS病变。

5. 发明申请

WO2006077601A3 HIV-1 gp41 FUSION PEPTIDES FOR IMMUNOMODULATION 审中-公开
公开(公告)号：WO2006077601A3
公开(公告)日：2006-07-27
申请号：PCT/IL2006/000096
申请日：2006-01-24
申请人： YEDA RESEARCH & DEVELOPMENT CO. LTD. , SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco, J. , GERBER, Doron
发明人： SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco, J. , GERBER, Doron
IPC分类号： A61K38/00
摘要： The present invention provides pharmaceutical compositions and methods for prevention or treatment of autoimmune diseases and other T cell mediated inflammatory diseases and conditions, which comprise as an active ingredient an effective quantity of a peptide derived from HIV gp41 fusion peptide domain or fragments, analogs, homologs and derivatives thereof. The invention further provides novel peptides derived from HIV gp41 fusion peptide domain, useful in the treatment of T cell mediated pathologies.

6. 发明申请

WO2005053603A2 ANTIGEN RECEPTOR VARIABLE REGION TYPING 审中-公开
标题翻译：抗原可变区域类型
公开(公告)号：WO2005053603A2
公开(公告)日：2005-06-16
申请号：PCT/IL2004/000972
申请日：2004-10-25
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , COHEN, Irun, R. , DOUEK, Daniel , MIMRAN, Avishai , CARMI, Pnina , QUINTANA, Francisco, Javier
发明人： COHEN, Irun, R. , DOUEK, Daniel , MIMRAN, Avishai , CARMI, Pnina , QUINTANA, Francisco, Javier
IPC分类号： A61K
CPC分类号： C12Q1/6883 , C07K14/7051 , C12Q1/6876 , C12Q2600/156
摘要： A method of typing a variable region of a specific variant of an antigen receptor chain is disclosed. The method comprises: (a) exposing a probe set to a sense or antisense strand of a polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, wherein the probe set includes a plurality of probe molecules, wherein each probe molecule of the plurality of probe molecules is substantially complementary to a sense or antisense strand of a nucleic acid sequence region of a specific polynucleotide encoding a variant of the antigen receptor chain, the nucleic acid sequence region encoding a specific combination of at least two variable region segments of the antigen receptor chain; and (b) measuring a hybridization of each probe molecule of the plurality of probe molecules with the sense or antisense strand of the nucleic acid sequence region of the polynucleotide encoding at least a portion of the variable region of the specific variant of the antigen receptor chain, thereby typing the variable region of the specific variant of the antigen receptor chain.
摘要翻译：公开了一种对抗原受体链的特定变体的可变区进行分型的方法。该方法包括：（a）将探针组暴露于编码抗原受体链特异性变体的至少一部分可变区的多核苷酸的有义或反义链，其中探针组包括多个探针分子，其中所述多个探针分子中的每个探针分子基本上与编码抗原受体链变体的特异性多核苷酸的核酸序列区域的有义链或反义链互补，所述核酸序列区编码至少抗原受体链的两个可变区片段; 和（b）测量多个探针分子的每个探针分子与编码抗原受体链特异变体的可变区的至少一部分的核酸序列区的有义链或反义链的杂交，从而键入抗原受体链的特定变体的可变区。

7. 发明申请

WO2009067349A8 MODULATION OF THE IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2009067349A8
公开(公告)日：2009-05-28
申请号：PCT/US2008/083016
申请日：2008-11-10
申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , WEINER, Howard , QUINTANA, Francisco, J.
发明人： WEINER, Howard , QUINTANA, Francisco, J.
IPC分类号： A61K31/403 , A61K31/405
摘要： Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease expression of Foxp3.

8. 发明申请

WO2005084137A3 CD25 DNA VACCINES FOR TREATING AND PREVENTING T-CELL MEDIATED DISEASES 审中-公开
标题翻译：用于治疗和预防T细胞介导性疾病的CD25 DNA疫苗
公开(公告)号：WO2005084137A3
公开(公告)日：2008-01-10
申请号：PCT/IL2005000273
申请日：2005-03-08
申请人： YEDA RES & DEV , COHEN IRUN R , MIMRAN AVISHAI , QUINTANA FRANCISCO , MOR FELIX , CARMI PNINA
发明人： COHEN IRUN R , MIMRAN AVISHAI , QUINTANA FRANCISCO , MOR FELIX , CARMI PNINA
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： A61K39/0008 , A61K2039/53
摘要： The present invention relates to compositions comprising nucleic acids encoding the a chain of IL-2 receptor (IL-2Ra, CD25), homologs and fragment thereof, effective in the treatment and prevention of T cell mediated pathologies. The invention further provides methods for enhancing anti-ergotypic T cell activity in a subject in need thereof, and for treating or preventing T cell mediated pathologies, such as autoimmune diseases, inflammatory diseases and graft rejection.
摘要翻译：本发明涉及包含编码IL-2受体（IL-2Rα，CD25）链的核酸，其同系物和片段的组合物，其有效治疗和预防T细胞介导的病理学。本发明还提供了在有需要的受试者中提高抗细胞型T细胞活性的方法，以及用于治疗或预防T细胞介导的病理学，例如自身免疫性疾病，炎性疾病和移植排斥反应的方法。

9. 发明申请

WO2007034490A2 DIASTEREOMERIC PEPTIDES FOR MODULATING T CELL IMMUNITY 审中-公开
标题翻译：用于调节细胞免疫的二酯类抗生素
公开(公告)号：WO2007034490A2
公开(公告)日：2007-03-29
申请号：PCT/IL2006/001113
申请日：2006-09-21
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD., AT THE WEIZMANN INSTITUTE OF SCIENCE , SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco , GERBER, Doron
发明人： SHAI, Yechiel , COHEN, Irun, R. , QUINTANA, Francisco , GERBER, Doron
IPC分类号： C07K14/07
CPC分类号： A61K38/1774
摘要： The present invention provides diastereomeric peptides derived from the T Cell Receptor alpha Transmembrane Domain, and lipophilic conjugates thereof, which peptides and conjugates are effective in preventing or treating T cell mediated inflammatory diseases. The invention provides pharmaceutical compositions comprising these diastereomeric peptides and conjugates, and uses thereof for therapy of inflammatory diseases, autoimmunity and graft rejection.
摘要翻译：本发明提供了衍生自T细胞受体α跨膜结构域的非对映异构肽及其亲脂性缀合物，该肽和缀合物可有效预防或治疗T细胞介导的炎性疾病。本发明提供包含这些非对映体肽和缀合物的药物组合物及其用于治疗炎性疾病，自身免疫和移植物排斥反应的用途。

10. 发明申请

WO0216549A2 METHODS OF TREATMENT OR PREVENTION OF AUTOIMMUNE DISEASES WITH CpG-CONTAINING POLYNUCLEOTIDE 审中-公开
标题翻译：用含CpG的多核苷酸治疗或预防自身免疫性疾病的方法
公开(公告)号：WO0216549A2
公开(公告)日：2002-02-28
申请号：PCT/IL0100790
申请日：2001-08-23
申请人： YEDA RES & DEV , COHEN IRUN R , QUINTANA FRANCISCO J
发明人： COHEN IRUN R , QUINTANA FRANCISCO J
IPC分类号： C12N15/09 , A61K38/17 , A61K39/00 , A61K39/39 , A61K48/00 , A61P3/10 , A61P37/02 , C07K14/47 , C12N15/117 , C12N
CPC分类号： C12N15/117 , A61K38/1709 , A61K39/0008 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/55561 , A61K2300/00
摘要： The present invention relates to DNA vaccines useful for the prevention and treatment of ongoing autoimmune diseases. The compositions and methods of the invention feature the CpG oligonucleotide, preferably in a motif flanked by two 5' purines and two 3' pyrimidines. The vaccine may further comprise DNA encoding a specific antigen, or the peptide antigen itself. The invention is exemplified for IDDM.
摘要翻译：本发明涉及可用于预防和治疗正在进行的自身免疫性疾病的DNA疫苗。本发明的组合物和方法的特征在于CpG寡核苷酸，优选以两个5'嘌呤和两个3'嘧啶侧接的基序。疫苗还可以包含编码特异性抗原的DNA或肽抗原本身。本发明以IDDM为例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式