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    • 5. 发明申请
    • SYSTEMS AND METHODS FOR IMPLODING LEUKEMIA CELLS
    • 用于表达白血病细胞的系统和方法
    • WO2017074509A1
    • 2017-05-04
    • PCT/US2016/031677
    • 2016-05-10
    • PUSKAS, William, L.
    • PUSKAS, William, L.
    • A61M1/36A61N7/00B01J19/10
    • A61M1/36A61M1/3621A61M1/3678A61M2205/3375C12N1/066C12N13/00
    • A system for imploding leukemia cells of a patient includes (a) a first vessel for containing a volume of blood received from the patient, and (b) drive circuitry cooperatively coupled with at least one transducer to produce ultrasound energy that spatially decoheres and disperses throughout the volume, to implode the leukemia cells throughout the volume via absorption of the ultrasound energy by the leukemia cells. The transducer may be an immersible transducer configured to be immersed in the blood. The system may include a second vessel for containing a liquid, within which the ultrasound energy is decohered and dispersed and from which at least a portion of the ultrasound energy is transmitted to the first vessel to implode the leukemia cells.
    • 用于使患者的白血病细胞内爆的系统包括(a)用于容纳从患者接收的大量血液的第一容器,和(b)与至少一个换能器协作地耦合以产生 超声波能量在空间上分散并散布在整个体积中,通过白血病细胞吸收超声能量使白血病细胞在整个体积内部崩解。 换能器可以是被构造成浸入血液中的浸入式换能器。 该系统可以包括用于容纳液体的第二容器,超声能量在该第二容器中被修整和分散,并且超声能量的至少一部分从超声能量被传递到第一容器以使白血病细胞内爆。
    • 8. 发明申请
    • APPARATUS AND METHODS FOR CLEANING DELICATE PARTS
    • 清洁部件的装置和方法
    • WO1998006143A1
    • 1998-02-12
    • PCT/US1997012853
    • 1997-08-01
    • PUSKAS, William, L.
    • H01L41/08
    • B01J19/10B06B1/0276B06B1/0618B06B1/0622B06B2201/71G10K11/004G10K11/006
    • The application of microsonic frequencies to liquid preferably occurs simultaneously with a sweeping of the microsonic frequency within the transducer's (122) harmonic bandwidth to reduce or eliminate (a) standing waves within the liquid, (b) other resonances, (c) high energy cavitation implosion, and (d) non-uniform sound fields, each of which is undesirable for cleaning and/or processing of semiconductor wafers and other delicate parts. The invention can also drive ultrasonic transducers (122) such that the frequency of applied energy has a sweep rate within the ultrasonic bandwidth of the transducers; and that sweep rate is also varied so that the sweep rate is substantially non-constant during operation. An ultrasound generator of the invention sometimes utilizes amplitude modulation (AM), and the AM frequency is swept over time so as to reduce resonances. Two or more transducers are sometimes used by the invention, in combination, to broaden the overall bandwidth of acoustical energy applied to the liquid around the primary frequency or one of the harmonics. The bandwidths of the transducers are made to overlap such that an attached generator can drive the transducers, in combination, to deliver ultrasound to the liquid in a broader bandwidth.
    • 将微声频率应用于液体优选地与在振子(122)谐波带宽内的微声波频率的扫描同时减少或消除(a)液体内的驻波,(b)其它共振,(c)高能空化 内爆和(d)不均匀的声场,每个声场对于半导体晶片和其它微细零件的清洁和/或处理是不期望的。 本发明还可以驱动超声波换能器(122),使得所施加的能量的频率具有在换能器的超声波带宽内的扫描速率; 并且扫描速率也变化,使得扫描速率在操作期间基本上不恒定。 本发明的超声波发生器有时利用振幅调制(AM),并且AM频率随着时间的推移而被扫描,以便减少谐振。 本发明有时使用两个或更多个换能器组合,以扩大施加到主频率周围的液体或谐波之一的声能的总带宽。 使换能器的带宽重叠,使得附接的发生器可以组合地驱动换能器,以在更宽的带宽内将超声波输送到液体。