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1. 发明申请

WO2007076085A3 FUSED PYRIMIDONES AND THIOPYRIMIDONES, AND USES THEREOF 审中-公开
公开(公告)号：WO2007076085A3
公开(公告)日：2007-07-05
申请号：PCT/US2006/049168
申请日：2006-12-22
申请人： PROLEXYS PHARMACEUTICALS, INC . , VENKAT, Raj, Gopal , QI, Longwu , PIERCE, Michael , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert
发明人： VENKAT, Raj, Gopal , QI, Longwu , PIERCE, Michael , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert
IPC分类号： C07D487/04 , C07D495/04 , A61K31/519 , A61P35/00
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.

2. 发明申请

WO2008013987A2 N-ALKYL SUBSTITUTED PIPERAZINYLMETHYLQUINAZOLINONES AND AZEPANYLMETHYLQUINAZOLINONES 审中-公开
标题翻译： N-烷基取代的哌嗪基甲基喹唑啉酮和间苯二甲基甲基喹唑啉酮
公开(公告)号：WO2008013987A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016996
申请日：2007-07-27
申请人： PROLEXYS PHARMACEUTICALS, INC. , PIERCE, Michael , QI, Longwu , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert , VENKAT, Raj, Gopal
发明人： PIERCE, Michael , QI, Longwu , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert , VENKAT, Raj, Gopal
CPC分类号： C07D403/04
摘要： Compounds represented by Structural Formula (I) : are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译：由结构式（I）表示的化合物例如可用于有效杀死或降低癌细胞（例如患有癌症的患者）的增殖速率。除了化合物本身之外，本发明提供了这些化合物的药物组合物和使用这些化合物的治疗方法。

3. 发明申请

WO2005082341A3 NON-PEPTIDYL AGENTS WITH pHSP20-LIKE ACTIVITY, AND USES THEREOF 审中-公开
公开(公告)号：WO2005082341A3
公开(公告)日：2005-09-09
申请号：PCT/US2005/006126
申请日：2005-02-23
申请人： PROLEXYS PHARMACEUTICALS INC. , VON RECHENBERG, Moritz , PELTIER, John, M. , SAHASRABUDHE, Sudhir, R. , ASKOVIC, Srdjan , SELLIAH, Robert , ZAREMBINSKI, Thomas
发明人： VON RECHENBERG, Moritz , PELTIER, John, M. , SAHASRABUDHE, Sudhir, R. , ASKOVIC, Srdjan , SELLIAH, Robert , ZAREMBINSKI, Thomas
IPC分类号： A61K31/00
摘要： The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.

4. 发明申请

WO2007076085A2 FUSED PYRIMIDONES AND THIOPYRIMIDONES, AND USES THEREOF 审中-公开
标题翻译：熔融吡咯烷酮和三氟乙烯，及其用途
公开(公告)号：WO2007076085A2
公开(公告)日：2007-07-05
申请号：PCT/US2006049168
申请日：2006-12-22
申请人： PROLEXYS PHARMACEUTICALS INC , VENKAT RAJ GOPAL , QI LONGWU , PIERCE MICHAEL , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT
发明人： VENKAT RAJ GOPAL , QI LONGWU , PIERCE MICHAEL , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , C07D495/04
CPC分类号： C07D487/04 , C07D495/04
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译：由结构式（I）表示的化合物：例如可有效地杀死或降低癌细胞增殖的速率，例如癌症患者。除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。

5. 发明申请

WO2005057208A1 METHODS OF IDENTIFYING PEPTIDES AND PROTEINS 审中-公开
标题翻译：鉴定蛋白和蛋白质的方法
公开(公告)号：WO2005057208A1
公开(公告)日：2005-06-23
申请号：PCT/US2004/040225
申请日：2004-12-02
申请人： PROLEXYS PHARMACEUTICALS, INC. , ASKOVIC, Srdjan , PELTIER, John , PHANSALKAR, Amit , ECCLESTON, Joseph, Patrick
发明人： ASKOVIC, Srdjan , PELTIER, John , PHANSALKAR, Amit , ECCLESTON, Joseph, Patrick
IPC分类号： G01N33/48
CPC分类号： G01N33/6848
摘要： The present invention provides methods for identifying biological molecules by mass spectrometry, particularly peptides and proteins. In one aspect, the present invention includes methods of identifying proteins by analizing fragmentation spectra of peptides derived from proteins. In another aspect, the present invention provides methods of quantifying the confidence of a putative peptide sequence assignment generated by a de novo peptide-sequencing algorithm, or a peptide identification algorithm employing one or more protein sequence databases. The present invention includes methods for identifying amino acid sequence of peptides wherein peptide sequence annotators are used to independently verify assigned peptide sequence identities. The present invention also includes methods wherein a parallel confidence assessment algorithm of the present invention calculates the sum of selected peptide sequence annotators multiplied by weighting factors, each selected to achieve an accurate assessment of the confidence of each putative peptide sequence assignment.
摘要翻译：本发明提供了通过质谱鉴定生物分子的方法，特别是肽和蛋白质。一方面，本发明包括通过分析衍生自蛋白质的肽的片段化谱来鉴定蛋白质的方法。在另一方面，本发明提供了定量由通过肽肽测序算法产生的假定肽序列指定的置信度的方法或使用一个或多个蛋白质序列数据库的肽识别算法。本发明包括用于鉴定肽的氨基酸序列的方法，其中肽序列注释者用于独立地验证分配的肽序列同一性。本发明还包括其中本发明的并行置信度评估算法计算所选择的肽序列注释器的总和乘以加权因子的方法，每个加权因子被选择以实现每个推定的肽序列分配的置信度的准确评估。

6. 发明申请

WO2009002553A1 METHODS OF TREATING MULTIPLE MYELOMA AND RESISTANT CANCERS 审中-公开
标题翻译：治疗多发性骨髓瘤和耐药性癌症的方法
公开(公告)号：WO2009002553A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/008041
申请日：2008-06-25
申请人： PROLEXYS PHARMACEUTICALS, INC. , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R.
发明人： ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R.
IPC分类号： A61K31/495 , A61P35/00
CPC分类号： A61K31/517 , A61K31/454 , A61K31/495 , A61K31/551 , A61K31/704 , A61K38/05 , A61K45/06 , C07D239/90
摘要： Erastin analogs are useful in treating various cancers, particularly multiple multiple myeloma. Erastin analogs are also useful in treating cancers that are resistant to other anticancer agents.
摘要翻译：埃拉斯汀类似物可用于治疗各种癌症，特别是多发性骨髓瘤。埃拉斯汀类似物也可用于治疗对其它抗癌剂具有抗性的癌症。

7. 发明申请

WO2008013987A3 N-ALKYL SUBSTITUTED PIPERAZINYLMETHYLQUINAZOLINONES AND AZEPANYLMETHYLQUINAZOLINONES 审中-公开
标题翻译： N-烷基取代的哌嗪基亚甲基四氢吡喃酮和阿魏酸二甲酯
公开(公告)号：WO2008013987A3
公开(公告)日：2008-10-30
申请号：PCT/US2007016996
申请日：2007-07-27
申请人： PROLEXYS PHARMACEUTICALS INC , PIERCE MICHAEL , QI LONGWU , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT , VENKAT RAJ GOPAL
发明人： PIERCE MICHAEL , QI LONGWU , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT , VENKAT RAJ GOPAL
IPC分类号： A61K31/517 , A61P35/00 , C07D239/90
CPC分类号： C07D403/04
摘要： Compounds represented by Structural Formula (I) : are useful, for example, in the effective killing or reduction in rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译：由结构式（I）表示的化合物：例如可有效地杀死或降低癌细胞增殖的速率，例如癌症患者。除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。

8. 发明申请

WO2007076087A2 ARYL-SUBSTITUTED QUINAZOLONES, AND USES THEREOF 审中-公开
标题翻译： ARYL取代的喹唑啉酮及其用途
公开(公告)号：WO2007076087A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/049172
申请日：2006-12-22
申请人： PROLEXYS PHARMACEUTICALS, INC. , QI, Longwu , VENKAT, Raj, Gopal , PIERCE, Michael , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert
发明人： QI, Longwu , VENKAT, Raj, Gopal , PIERCE, Michael , ROBBINS, Paul, B. , SAHASRABUDHE, Sudhir, R. , SELLIAH, Robert
CPC分类号： C07D239/91
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译：由结构式（I）表示的化合物可用于例如有效杀死或降低癌细胞增殖的速率，例如患有癌症的患者。除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。

9. 发明申请

WO2003095619A3 PROTEIN COMPLEX PURIFICATION 审中-公开
公开(公告)号：WO2003095619A3
公开(公告)日：2003-11-20
申请号：PCT/US2003/014511
申请日：2003-05-09
申请人： PROLEXYS PHARMACEUTICALS, INC. , BONIFACE, John, J. , KERY, Vladimir , PELTIER, John, M. , WEIR, Lawrence , ROBBINS, Paul, B. , RODRIGUEZ, Manuel, M.
发明人： BONIFACE, John, J. , KERY, Vladimir , PELTIER, John, M. , WEIR, Lawrence , ROBBINS, Paul, B. , RODRIGUEZ, Manuel, M.
IPC分类号： C07K1/14
摘要： The present invention provides a method for isolating protein complexes from a cell, a cell or tissue lysate or an whole organism by employing a combined set of affinity tags of high affinity, specificity and ease of elution. The method involves using a known protein modified to contain more than one affinity tag separated by one or more specific protease cleavage sites, as bait, to isolate any interacting proteins or fragments thereof. The proteins or fragments thereof contained in the isolated complex can then be identified and the interacting partners can be used as new targets for diagnostic tools or the basis for the development of new compounds for therapeutic drug intervention.

10. 发明申请

WO2007076087A3 3-ARYL-SUBSTITUTED QUINAZOLONES, AND USES THEREOF 审中-公开
标题翻译： 3-ARYL取代的喹唑啉酮及其用途
公开(公告)号：WO2007076087A3
公开(公告)日：2007-11-08
申请号：PCT/US2006049172
申请日：2006-12-22
申请人： PROLEXYS PHARMACEUTICALS INC , QI LONGWU , VENKAT RAJ GOPAL , PIERCE MICHAEL , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT
发明人： QI LONGWU , VENKAT RAJ GOPAL , PIERCE MICHAEL , ROBBINS PAUL B , SAHASRABUDHE SUDHIR R , SELLIAH ROBERT
IPC分类号： C07D239/91 , A61K31/517 , A61P35/00
CPC分类号： C07D239/91
摘要： Compounds represented by Structural Formula (I): are useful, for example, in the effective killing or reducing the rate of proliferation of cancer cells, such as in patients suffering from cancer. In addition to the compounds themselves, the invention provides pharmaceutical compositions of the compounds and method of treatment using the compounds.
摘要翻译：由结构式（I）表示的化合物可用于例如有效杀死或降低癌细胞增殖的速率，例如患有癌症的患者。除了化合物本身，本发明提供了化合物的药物组合物和使用该化合物的治疗方法。

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