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1. 发明申请

WO2003020220A2 MITOCHONDRIAL BIOLOGY EXPRESSION ARRAYS 审中-公开
标题翻译：微生物生物表达阵列
公开(公告)号：WO2003020220A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/027886
申请日：2002-08-30
申请人： EMORY UNIVERSITY , WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
发明人： WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
IPC分类号： A61K
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/158
摘要： This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of physiological conditions; diagnosing physiological conditions; identifying biochemical pathways, genes, and mutations involved in physiological conditions; identifying therapeutic agents useful for preventing and/or treating such physiological conditions; evaluating and/or monitoring the efficacy of such therapies, and creating and identifying animal models of human physiologic conditions. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes.
摘要翻译：本发明提供了涉及线粒体生物学的基因文库，包含涉及线粒体生物学基因的探针的阵列，以及制备这种阵列的方法，以及使用这种阵列的方法。提供了涉及人和小鼠线粒体生物学的基因和探针序列。本发明的阵列可用于测定线粒体生物学基因表达谱。线粒体生物学基因表达谱可用于确定生理条件诊断的表达谱; 诊断生理条件; 识别涉及生理条件的生物化学途径，基因和突变; 鉴定可用于预防和/或治疗这种生理条件的治疗剂; 评估和/或监测这些疗法的功效，以及创建和鉴定人类生理状况的动物模型。提供了包含已知参与线粒体生物学的所有基因的探针的阵列，以及包含这种探针子集的阵列。

2. 发明申请

WO2005058142A2 DIABETES DIAGNOSTIC 审中-公开
标题翻译：糖尿病诊断
公开(公告)号：WO2005058142A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/042110
申请日：2004-12-16
申请人： EMORY UNIVERSITY , WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
发明人： WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
IPC分类号： A61B
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/042
摘要： A method for identifying a patient likely to have, or at risk of developing, Type II diabetes or insulin resistance is provided. The method is performed by identifying an expression profile typical of Type II diabetes in which selected genes are upregulated and/or selected genes are downregulated. This expression profile correlates with an A3243G mutation level of 10% to 55%.
摘要翻译：提供了用于鉴定可能具有或具有发展为II型糖尿病或胰岛素抵抗的风险的患者的方法。该方法通过鉴定典型的II型糖尿病的表达谱来进行，其中选择的基因被上调和/或选择的基因被下调。该表达谱与A3243G突变水平相关，为10％至55％。

3. 发明申请

WO2005058142A3 DIABETES DIAGNOSTIC 审中-公开
标题翻译：糖尿病诊断
公开(公告)号：WO2005058142A3
公开(公告)日：2006-03-02
申请号：PCT/US2004042110
申请日：2004-12-16
申请人： UNIV EMORY , WALLACE DOUGLAS C , LEVY SHAWN , KERSTANN KEITH , PROCACCIO VINCENT
发明人： WALLACE DOUGLAS C , LEVY SHAWN , KERSTANN KEITH , PROCACCIO VINCENT
IPC分类号： A61B20060101 , G01N33/68 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N2800/042
摘要： A method for identifying a patient likely to have, or at risk of developing, Type II diabetes or insulin resistance is provided. The method is performed by identifying an expression profile typical of Type II diabetes in which selected genes are upregulated and/or selected genes are downregulated. This expression profile correlates with an A3243G mutation level of 10% to 55%.
摘要翻译：提供了用于鉴定可能具有或具有发展为II型糖尿病或胰岛素抵抗的风险的患者的方法。该方法通过鉴定典型的II型糖尿病的表达谱来进行，其中选择的基因被上调和/或选择的基因被下调。该表达谱与A3243G突变水平相关，为10％至55％。

4. 发明申请

WO2003020220A3 MITOCHONDRIAL BIOLOGY EXPRESSION ARRAYS 审中-公开
公开(公告)号：WO2003020220A3
公开(公告)日：2003-03-13
申请号：PCT/US2002/027886
申请日：2002-08-30
申请人： EMORY UNIVERSITY , WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
发明人： WALLACE, Douglas, C. , LEVY, Shawn , KERSTANN, Keith , PROCACCIO, Vincent
IPC分类号： C12Q1/68
摘要： This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of using such arrays. Genes and probe sequences involved in mitochondrial biology in humans and mice are provided. The arrays of this invention are useful for determining mitochondrial biology gene expression profiles. Mitochondrial biology gene expression profiles are useful for determining expression profiles diagnostic of physiological conditions; diagnosing physiological conditions; identifying biochemical pathways, genes, and mutations involved in physiological conditions; identifying therapeutic agents useful for preventing and/or treating such physiological conditions; evaluating and/or monitoring the efficacy of such therapies, and creating and identifying animal models of human physiologic conditions. Arrays containing probes for all genes known to be involved in mitochondrial biology are provided, as well as arrays containing subsets of such probes.

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