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1. 发明申请

WO2006129168A2 BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH 审中-公开
标题翻译：用于治疗异常细胞生长的双相衍生物
公开(公告)号：WO2006129168A2
公开(公告)日：2006-12-07
申请号：PCT/IB2006/001408
申请日：2006-05-22
申请人： PFIZER PRODUCTS INC. , BHATTACHARYA, Samit, Kumar , PRAKASH, Chandra, Aggarwal
发明人： BHATTACHARYA, Samit, Kumar , PRAKASH, Chandra, Aggarwal
IPC分类号： C07D401/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/94 , C07D401/12
摘要： The invention relates to substantially pure compounds of the formula (1): and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 , R 5 , and X are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N->O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
摘要翻译：本发明涉及基本上纯的式（1）化合物：及其药学上可接受的盐，前药和溶剂化物，其中R 1，R 2，R 2， 3，R 5和X如本文所定义，并且其中式（1）的化合物任选地还包含羟基取代基，O-葡萄糖醛酸或N-> O（N-氧化物）部分。本发明还涉及通过施用式（1）化合物和用于治疗含有式（1）化合物的病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式（1）化合物的方法。

2. 发明申请

WO0191756A3 S-METHYL-DIHYDRO-ZIPRASIDONE FOR TREATMENT OF PSYCHIATRIC AND OCULAR DISORDERS 审中-公开
标题翻译：用于治疗心理障碍和眼病的S-甲基二氢萘
公开(公告)号：WO0191756A3
公开(公告)日：2002-09-26
申请号：PCT/IB0100933
申请日：2001-05-28
申请人： PFIZER PROD INC , PRAKASH CHANDRA AGGARWAL , SMOLAREK TERESA ANNETTE
发明人： PRAKASH CHANDRA AGGARWAL , SMOLAREK TERESA ANNETTE
IPC分类号： A61K20060101 , A61K31/22 , A61K31/496 , A61P20060101 , A61P25/00 , A61P25/06 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/00 , A61P27/02 , A61P27/06 , C07D20060101 , C07D209/34
CPC分类号： A61K31/22 , A61K31/496
摘要： This invention relates to pharmaceutical compositions containing S-methyl-dihydro-ziprasidone and to the use of such compound and its pharmaceutically acceptable salts for the treatment of psychiatric and ocular disorders. More specifically, it relates to the use of such compound and its pharmaceutically acceptable salts for the treatment of a disorder or condition selected from: schizophrenia, anxiety disorders such as generalized anxiety disorder, panic disorder, posttraumatic stress disorder and phobias ( e.g. , social phobia, agoraphobia etc.); psychotic episodes of anxiety: anxiety, agitation, excessive aggression, tension, or social or emotional withdrawal associated with psychosis; psychotic mood disorders such as severe major depressive disorder; mood disorders associated with psychotic disorders such as acute mania and depression associated with bipolar disorder, and mood disorders associated with schizophrenia; behavioral disturbances associated with mental retardation, autistic disorder, and conduct disorder; dementias such as dementias associated with Alzheimer's disease; drug-induced and neurodegeneration based dyskinesias; obsessive compulsive disorder; Tourette's syndrome; glaucoma; and ischemic retinopathy.
摘要翻译：本发明涉及含有S-甲基 - 二氢 - 齐拉西酮的药物组合物以及这种化合物及其药学上可接受的盐在治疗精神病和眼部疾病中的用途。更具体地，本发明涉及这种化合物及其药学上可接受的盐在治疗选自以下的病症或病症中的用途：精神分裂症，焦虑症例如广泛性焦虑症，惊恐障碍，创伤后应激障碍和恐惧症（例如，，社交恐惧症，广场恐惧症等）; 焦虑的精神病发作：与精神病有关的焦虑，激动，过度侵略，紧张或社会或情绪退缩; 精神病心理障碍如重度抑郁障碍; 与精神病性疾病相关的情绪障碍，例如与双相障碍相关的急性躁狂症和抑郁症，以及与精神分裂症相关的情绪障碍; 与精神发育迟滞，自闭症和行为障碍相关的行为障碍; 痴呆症如与阿尔茨海默病相关的痴呆; 药物诱导和神经退行性运动障碍; 强迫症图雷特综合征青光眼; 和缺血性视网膜病变。

3. 发明申请

WO2005110406A2 PHENYL DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH 审中-公开
标题翻译：用于治疗异常细胞生长的苯乙烯衍生物
公开(公告)号：WO2005110406A2
公开(公告)日：2005-11-24
申请号：PCT/US2005016985
申请日：2005-05-13
申请人： PFIZER PROD INC , MARX MATTHEW A , MIAO ZHUANG , PRAKASH CHANDRA AGGARWAL
发明人： MARX MATTHEW A , MIAO ZHUANG , PRAKASH CHANDRA AGGARWAL
IPC分类号： A61K31/425 , C07D275/02 , C07D275/03 , C07D417/02
CPC分类号： C07D275/03
摘要： The invention relates to compounds of the formula (1) wherein X , X and X independently is a halogen; p is an integer from 1 to 3; and R is -COOH, OR wherein R is a substituted isothiazole ring, or SR wherein R is (CH2)qC(COOH)(NHC(0)R ) wherein q is an integer from 0 to 3, and R is (C1-C4)alkyl; and to pharmaceutically acceptable salts, prodrugs and solvates thereof. The invention also relates to methods of treating a hyperproliferative disorder in a mammal by administering the compounds of formula (1) and to pharmaceutical compositions containing the compounds of formula (1).
摘要翻译：本发明涉及式（1）的化合物，其中X 1，X 2和X 3独立地是卤素; p是1至3的整数; 并且R是-COOH，OR 1其中R 1是取代的异噻唑环，或SR 2，其中R 2是（CH 2）q C（COOH）（NHC（O）R 3）），其中 q为0〜3的整数，R 3为（C 1〜C 4）烷基; 以及其药学上可接受的盐，前药和溶剂化物。本发明还涉及通过施用式（1）化合物和含有式（1）化合物的药物组合物来治疗哺乳动物中过度增殖性疾病的方法。

4. 发明申请

WO2006129168A3 BICYCLIC DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH 审中-公开
标题翻译：用于治疗异常细胞生长的双相衍生物
公开(公告)号：WO2006129168A3
公开(公告)日：2007-02-08
申请号：PCT/IB2006001408
申请日：2006-05-22
申请人： PFIZER PROD INC , BHATTACHARYA SAMIT KUMAR , PRAKASH CHANDRA AGGARWAL
发明人： BHATTACHARYA SAMIT KUMAR , PRAKASH CHANDRA AGGARWAL
IPC分类号： C07D401/12 , A61K31/517 , A61P35/00
CPC分类号： C07D239/94 , C07D401/12
摘要： The invention relates to substantially pure compounds of the formula (1): and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 , R 5 , and X are as defined herein, and wherein the compound of formula (1) optionally further comprises a hydroxy substituent, an O-glucuronic acid, or an N->O (N-oxide) moiety. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula (1) and to pharmaceutical compositions for treating such disorders that contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).
摘要翻译：本发明涉及基本上纯的式（1）化合物：及其药学上可接受的盐，前药和溶剂化物，其中R 1，R 2，R 2， 3，R 5和X如本文所定义，并且其中式（1）的化合物任选进一步包含羟基取代基，O-葡萄糖醛酸或N-> O（N-氧化物）部分。本发明还涉及通过施用式（1）化合物和用于治疗含有式（1）化合物的病症的药物组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备式（1）化合物的方法。

5. 发明申请

WO2005110406A3 PHENYL DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH 审中-公开
公开(公告)号：WO2005110406A3
公开(公告)日：2005-11-24
申请号：PCT/US2005/016985
申请日：2005-05-13
申请人： PFIZER PRODUCTS INC. , MARX, Matthew A. , MIAO, Zhuang , PRAKASH, Chandra Aggarwal
发明人： MARX, Matthew A. , MIAO, Zhuang , PRAKASH, Chandra Aggarwal
IPC分类号： A61K31/425 , C07D275/02
摘要： The invention relates to compounds of the formula ( 1 ) wherein X 1 , X 2 and X 3 independently is a halogen; p is an integer from 1 to 3; and R is -COOH, OR 1 wherein R 1 is a substituted isothiazole ring, or SR 2 wherein R 2 is (CH 2 ) q C(COOH)(NHC(0)R 3 ) wherein q is an integer from 0 to 3, and R 3 is (C 1 -C 4 )alkyl; and to pharmaceutically acceptable salts, prodrugs and solvates thereof. The invention also relates to methods of treating a hyperproliferative disorder in a mammal by administering the compounds of formula ( 1) and to pharmaceutical compositions containing the compounds of formula (1).

6. 发明申请

WO2003064391A1 METABOLITES OF (3-{[4-TERT-BUTYL-BENZYL)-(PYRIDINE-3-SULFONYL)-AMINO]-METHYL}-PHENOXY)-ACETIC ACID 审中-公开
标题翻译：（3 - {[4-叔丁基苯基） - （吡啶-3-磺酰） - 氨基] - 甲基} - 苯氧基） - 甲酸的代谢物
公开(公告)号：WO2003064391A1
公开(公告)日：2003-08-07
申请号：PCT/IB2003/000121
申请日：2003-01-20
申请人： PFIZER PRODUCTS INC. , CAMERON, Kimberly, O'Keefe , JOHNSON, Kim, Anne , LEFKER, Bruce, Allen , PRAKASH, Chandra, Aggarwal
发明人： CAMERON, Kimberly, O'Keefe , JOHNSON, Kim, Anne , LEFKER, Bruce, Allen , PRAKASH, Chandra, Aggarwal
IPC分类号： C07D213/71
CPC分类号： C07D213/89 , C07D213/71
摘要： The present invention relates to metabolites of (3-{[4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetic acid.
摘要翻译：本发明涉及（3 - {[4-叔丁基 - 苄基） - （吡啶-3-磺酰基） - 氨基] - 甲基} - 苯氧基） - 乙酸的代谢物。

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