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2. 发明申请

WO1997000960A1 NOVEL HUMAN CHEMOTACTIC CYTOKINE 审中-公开
标题翻译：新型人类化学细胞因子
公开(公告)号：WO1997000960A1
公开(公告)日：1997-01-09
申请号：PCT/US1996010723
申请日：1996-06-21
申请人： LEUKOSITE, INC. , PONATH, Paul, D. , QIN, Shixin , RINGLER, Douglas, J. , NEWMAN, Walter , MACKAY, Charles
发明人： LEUKOSITE, INC.
IPC分类号： C12N15/19
CPC分类号： C07K16/24 , A61K38/00 , A61K47/642 , C07K14/523 , C07K14/7158 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to isolated and/or recombinant nucleic acids which encode a human chemotactic cytokine designated human eotaxin, and to proteins or polypeptides referred to herein as isolated and/or recombinant human eotaxin, including synthetic polypeptides. The invention further relates to recombinant nucleic acid constructs, comprising a nucleic acid which encodes a human eotaxin of the present invention, a portion thereof, or a variant; to host cells comprising such constructs, useful for the production of recombinant human eotaxin; and to antibodies reactive with human eotaxin, which are useful in in vitro methods, diagnostic and/or therapeutic applications. Also provided are methods of use of the proteins of the present invention, for example in the recruitment of eosinophils to a particular site or in the treatment of allergic conditions. Human eotaxins can be used in assays to identify inhibitors (e.g., antagonists) or promoters (agonists) of human eotaxin function. Agents which inhibit or promote eotaxin function can be administered to an individual, providing a new approach to selective modulation of leukocyte function, which is useful in a variety of inflammatory and autoimmune diseases, or in the treatment of infections.
摘要翻译：本发明涉及编码人类趋化性细胞因子（命名为人类嗜酸细胞活化趋化因子）的分离和/或重组核酸，以及本文称为分离和/或重组人类嗜酸细胞活化趋化因子（包括合成多肽）的蛋白质或多肽。本发明还涉及重组核酸构建体，其包含编码本发明的人类嗜酸细胞活化趋化因子的核酸，其一部分或变体; 包含可用于生产重组人类嗜酸性粒细胞趋化因子的这种构建体的宿主细胞; 以及可用于体外方法，诊断和/或治疗应用的与人类嗜酸细胞活化趋化因子反应的抗体。还提供了使用本发明的蛋白质的方法，例如将嗜酸性粒细胞募集到特定部位或用于治疗过敏性病症。人类嗜酸性粒细胞趋化因子可用于测定人类嗜酸细胞活化趋化因子功能的抑制剂（例如拮抗剂）或启动子（激动剂）。抑制或促进嗜酸细胞活化趋化因子功能的药物可以给予个体，提供了选择性调节白细胞功能的新方法，其可用于各种炎性和自身免疫性疾病，或用于治疗感染。

3. 发明申请

WO9622371A2 C-C CHEMOKINE RECEPTOR 3: CKP-3 OR Eos-L2 审中-公开
标题翻译： C-C化合物受体3：CKP-3或Eos-L2
公开(公告)号：WO9622371A2
公开(公告)日：1996-07-25
申请号：PCT/US9600608
申请日：1996-01-19
申请人： LEUKOSITE INC , BRIGHAM & WOMENS HOSPITAL , CHILDRENS MEDICAL CENTER , GERARD CRAIG J , GERARD NORMA P , MACKAY CHARLES R , PONATH PAUL D , POST THEODORE W , QIN SHIXIN
发明人： GERARD CRAIG J , GERARD NORMA P , MACKAY CHARLES R , PONATH PAUL D , POST THEODORE W , QIN SHIXIN
IPC分类号： G01N33/566 , A61K38/00 , A61K47/48 , A61P29/00 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/02 , C12R1/91 , G01N33/68 , A61K38/17 , C12N15/62
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , A61K47/642 , C07K14/7158 , C07K2317/76 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to isolated and/or recombinant nucleic acids which encode a mammalian (e.g., human) receptor protein designated C-C Chemokine Receptor 3 (CKR-3) or Eos L2, and to proteins or polypeptides, referred to herein as isolated, recombinant mammalian CKR-3 receptors. The invention further relates to recombinant nucleic acid constructs comprising a nucleic acid which encodes a receptor protein of the present invention or a portion thereof; to host cells comprising such constructs, useful for the production of recombinant CKR-3 receptors or polypeptides; and to antibodies reactive with the receptors, which are useful in research and diagnostic applications. Also provided are methods of use of the nucleic acids, proteins, and host cells to identify ligands, inhibitors (e.g., antagonists) or promoters (agonists) of receptor function. Administration of a compound which inhibits or promotes receptor function to an individual in need of therapy provides a new approach to selective modulation of leukocyte function, which is useful in a variety of inflammatory and autoimmune diseases, or in the treatment of infections. As a major leukocyte chemokine receptor present in leukocytes such as eosinophils and lymphocytes, the receptor provides a key target for drug screening and design.
摘要翻译：本发明涉及编码称为CC趋化因子受体3（CKR-3）或Eos L2的哺乳动物（例如，人）受体蛋白以及本文称为分离的重组体的蛋白质或多肽的分离和/或重组核酸哺乳动物CKR-3受体。本发明还涉及包含编码本发明的受体蛋白或其部分的核酸的重组核酸构建体; 包含可用于产生重组CKR-3受体或多肽的包含此类构建体的宿主细胞; 以及与受体反应的抗体，其可用于研究和诊断应用。还提供了使用核酸，蛋白质和宿主细胞来鉴定受体功能的配体，抑制剂（例如拮抗剂）或启动子（激动剂）的方法。对需要治疗的个体抑制或促进受体功能的化合物的给药提供了一种选择性调节白细胞功能的新方法，其可用于各种炎性和自身免疫疾病或用于治疗感染。作为白细胞如嗜酸性粒细胞和淋巴细胞中存在的主要白细胞趋化因子受体，该受体是药物筛选和设计的关键目标。

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