专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0206834A9 COLLECTIONS OF BINDING PROTEINS AND TAGS AND USES THEREOF FOR NESTED SORTING AND HIGH THROUGHPUT SCREENING 审中-公开
标题翻译：用于巢式分选和高通量筛选的结合蛋白和标签及其用途的集合
公开(公告)号：WO0206834A9
公开(公告)日：2002-07-18
申请号：PCT/US0122821
申请日：2001-07-18
申请人： POINTILLISTE INC , AULT-RICHE DANA , KASSNER PAUL D
发明人： AULT-RICHE DANA , KASSNER PAUL D
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C40B30/04 , G01N33/68 , G01N37/00
CPC分类号： C40B30/04 , G01N33/6845
摘要： Provided herein are addressable collections of anti-tag capture agents, such as antibodies, that are used as tools for sorting proteins containg polypeptide tags for which the capture agents are specific . Also provided are methods of nested sorting using the collections. The methods includes the steps of creating tagged collections of molecules by introducing a set of nucleic acid molecules that encode unique preselected polypeptides to create a library of tagged molecules; either before or after introducing the tags, dividing the library into N divisions; translating each division and reacting each with one of N capture agent collections, identifying the capture agents bound to the polypetide tags linked to molecules on interest, and thereby identifying the one of the divided collections that contains the molecules of interest. The method can further include adding a new set of tags and repeating the sorting process with the same or a different collection capture agents and thereby identifying a protein or molecule of interest.
摘要翻译：本文提供了可标记的抗标签捕获剂例如抗体的集合，其被用作用于分选含有捕获剂特异性的多肽标签的蛋白质的工具。还提供了使用集合进行嵌套排序的方法。该方法包括以下步骤：通过引入一组编码独特预选多肽的核酸分子来创建标记分子库; 在引入标签之前或之后，将库分成N个部分; 翻译每个分区并且使每个分区与N个捕获剂集合中的一个反应，识别结合到与感兴趣的分子连接的多肽标签的捕获剂，并且由此识别包含感兴趣的分子的分开的集合中的一个。该方法可以进一步包括添加一组新的标签，并用相同或不同的收集捕获剂重复分类过程，从而鉴定感兴趣的蛋白质或分子。

2. 发明申请

WO2004039962A3 METHODS FOR PRODUCING POLYPEPTIDE-TAGGED COLLECTIONS AND CAPTURE SYSTEMS CONTAINING THE TAGGED POLYPEPTIDES 审中-公开
标题翻译：生产多肽标签收集方法和包含标签多糖的捕获系统
公开(公告)号：WO2004039962A3
公开(公告)日：2009-06-18
申请号：PCT/US0334821
申请日：2003-10-30
申请人： POINTILLISTE INC , AULT-RICHE DANA , ATKINSON BRUCE , GEYSEN MARIO H
发明人： AULT-RICHE DANA , ATKINSON BRUCE , GEYSEN MARIO H
IPC分类号： G01N33/53 , C07K1/04 , C07K1/107 , C07K1/13 , C07K7/06 , C12Q1/68 , G01N33/50 , G01N33/543 , G01N33/573
CPC分类号： C07K7/06 , C07K1/047 , C07K1/1077 , C07K1/13 , C40B30/04 , C40B40/10 , G01N33/5005
摘要： Cell based methods designed to assess intracellular and extracellular activities and interactions and to identify compounds and conditions that modulate such activities and interactions are provided. The cell based methods employ capture systems that display collections of tagged molecules specifically linked to capture agents.
摘要翻译：提供了基于细胞的方法，旨在评估细胞内和细胞外的活性和相互作用，并确定调节这些活性和相互作用的化合物和条件。基于细胞的方法使用捕获系统，其显示与捕获剂特异性连接的标记分子的集合。

3. 发明申请

WO2003062402A2 USE OF COLLECTIONS OF BINDING SITES FOR SAMPLE PROFILING AND OTHER APPLICATIONS 审中-公开
标题翻译：用于样品分析和其他应用的绑定站点集合的使用
公开(公告)号：WO2003062402A2
公开(公告)日：2003-07-31
申请号：PCT/US2003/002397
申请日：2003-01-24
申请人： POINTILLISTE, INC. , AULT-RICHE, Dana , KASSNER, Paul, D.
发明人： AULT-RICHE, Dana , KASSNER, Paul, D.
IPC分类号： C12N
CPC分类号： C40B30/04 , C12Q1/6837 , G01N33/54306 , G01N33/58 , G01N33/6803 , G01N2458/10 , C12Q2563/131 , C12Q2525/149 , C12Q2563/149
摘要： Provided are the use of collections of binding proteins, called capture agents, and their cognate binding partners, called tagged protein libraries, herein for profiling samples. Methods for generating the capture agents, tagged protein libraries and samples are also provided.
摘要翻译：提供了用于分析样品的结合蛋白（称为捕获剂）及其同源结合配偶体（称为标记蛋白质文库）的集合的使用。还提供了生成捕获剂，标记蛋白质文库和样品的方法。

4. 发明申请

WO2004071641A3 SELF-ASSEMBLING ARRAYS AND USES THEREOF 审中-公开
标题翻译：自组装阵列及其用途
公开(公告)号：WO2004071641A3
公开(公告)日：2005-02-24
申请号：PCT/US0334747
申请日：2003-10-30
申请人： POINTILLISTE INC , AULT-RICHE DANA , KUMBLE KRISHNANAND D , SCHULZ RAINER , SCHULZ KENNETH
发明人： AULT-RICHE DANA , KUMBLE KRISHNANAND D , SCHULZ RAINER , SCHULZ KENNETH
IPC分类号： B01J20060101 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54353
摘要： Provided herein are methods, combinations, kits and systems for self-assembly of a self-assembling array to produce self-assembled arrays. The self-assembling arrays contain addressed collections of capture agents and are used with binding partners and reagents for conjugation of binding partners or molecules and/or biological particles for display in self-assembled arrays. The capture agents at each locus in a self-assembling array are specific to one of a set of binding partner molecules. The binding partners are conjugated to molecules and/or biological particles for display. Following conjugation, the resulting conjugates are sorted on the array based on the specific interaction of the binding partner and the capture agent to produce a self-assembled array.
摘要翻译：本文提供了用于自组装阵列自组装以产生自组装阵列的方法，组合，套件和系统。自组装阵列包含寻址的捕获剂的集合，并且与结合配偶体和试剂一起使用，用于结合配偶体或分子和/或生物颗粒的缀合以在自组装阵列中显示。自组装阵列中每个位点的捕获剂对一组结合配偶体分子之一是特异性的。结合配偶体与分子和/或生物颗粒缀合以进行显示。在共轭之后，基于结合配偶体和捕获剂的特异性相互作用，将所得到的缀合物在阵列上进行分选以产生自组装阵列。

5. 发明申请

WO2004039962A2 METHODS FOR PRODUCING POLYPEPTIDE-TAGGED COLLECTIONS AND CAPTURE SYSTEMS CONTAINING THE TAGGED POLYPEPTIDES 审中-公开
标题翻译：生产多肽标签收集方法和包含标签多糖的捕获系统
公开(公告)号：WO2004039962A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/034821
申请日：2003-10-30
申请人： POINTILLISTE, INC. , AULT-RICHE, Dana , ATKINSON, Bruce , GEYSEN, Mario, H.
发明人： AULT-RICHE, Dana , ATKINSON, Bruce , GEYSEN, Mario, H.
IPC分类号： C12N
CPC分类号： C07K7/06 , C07K1/047 , C07K1/1077 , C07K1/13 , C40B30/04 , C40B40/10 , G01N33/5005
摘要： Cell based methods designed to assess intracellular and extracellular activities and interactions and to identify compounds and conditions that modulate such activities and interactions are provided. The cell based methods employ capture systems that display collections of tagged molecules specifically linked to capture agents.
摘要翻译：提供了基于细胞的方法，旨在评估细胞内和细胞外的活性和相互作用，并确定调节这些活性和相互作用的化合物和条件。基于细胞的方法使用捕获系统，其显示与捕获剂特异性连接的标记分子的集合。

6. 发明申请

WO2003062402A3 USE OF COLLECTIONS OF BINDING SITES FOR SAMPLE PROFILING AND OTHER APPLICATIONS 审中-公开
公开(公告)号：WO2003062402A3
公开(公告)日：2003-07-31
申请号：PCT/US2003/002397
申请日：2003-01-24
申请人： POINTILLISTE, INC. , AULT-RICHE, Dana , KASSNER, Paul, D.
发明人： AULT-RICHE, Dana , KASSNER, Paul, D.
IPC分类号： C12M1/34
摘要： Provided are the use of collections of binding proteins, called capture agents, and their cognate binding partners, called tagged protein libraries, herein for profiling samples. Methods for generating the capture agents, tagged protein libraries and samples are also provided.

7. 发明申请

WO2004042019A3 SYSTEMS FOR CAPTURE AND ANALYSIS OF BIOLOGICAL PARTICLES AND METHODS USING THE SYSTEMS 审中-公开
标题翻译：用于捕获和分析生物颗粒的系统和使用该系统的方法
公开(公告)号：WO2004042019A3
公开(公告)日：2005-09-01
申请号：PCT/US0334693
申请日：2003-10-30
申请人： POINTILLISTE INC , AULT-RICHE DANA , ATKINSON BRUCE , JESAITIS LYNNE , KUMBLE KRISHNANAND D , SPERINDE GIZETTE
发明人： AULT-RICHE DANA , ATKINSON BRUCE , JESAITIS LYNNE , KUMBLE KRISHNANAND D , SPERINDE GIZETTE
IPC分类号： C07K1/04 , C07K1/107 , C07K1/13 , C07K7/06 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/543
CPC分类号： C07K7/06 , C07K1/047 , C07K1/1077 , C07K1/13 , C40B30/04 , C40B40/10 , G01N33/5005
摘要： Cell based methods designed to assess intracellular and extracellular activities and intenactimna and to identify compounds and conditions that modulate such activities and interactions are provided. The cell based methods employ capture systems that display collections of tagged molecules specifically linked to capture agents.
摘要翻译：提供了基于细胞的方法，旨在评估细胞内和细胞外活性和内含子活性，并确定调节这些活性和相互作用的化合物和条件。基于细胞的方法使用捕获系统，其显示与捕获剂特异性连接的标记分子的集合。

8. 发明申请

WO2005067980A2 DESIGN OF THERAPEUTICS AND THERAPEUTICS 审中-公开
标题翻译：治疗与治疗的设计
公开(公告)号：WO2005067980A2
公开(公告)日：2005-07-28
申请号：PCT/US2005/000816
申请日：2005-01-10
申请人： POINTILLISTE, INC. , AULT-RICHE, Dana , LEVY, Ronald
发明人： AULT-RICHE, Dana , LEVY, Ronald
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K39/39566 , A61K47/665 , A61K47/6897 , A61K2039/505 , C07K16/2896 , C07K16/4241 , C07K2317/34 , C07K2317/622 , C07K2319/30 , A61K2300/00
摘要： Therapeutic complexes and components of therapeutic complexes are provided herein. Also provided are methods of preparing therapeutic complexes and methods of administering therapeutic complexes.
摘要翻译：本文提供治疗复合物和治疗复合物的组分。还提供了制备治疗复合物的方法和施用治疗复合物的方法。

9. 发明申请

WO0206834A3 NESTED SORTING AND HIGH THROUGHPUT SCREENING 审中-公开
标题翻译：嵌套分选和高通量筛选
公开(公告)号：WO0206834A3
公开(公告)日：2002-10-10
申请号：PCT/US0122821
申请日：2001-07-18
申请人： POINTILLISTE INC , AULT-RICHE DANA , KASSNER PAUL D
发明人： AULT-RICHE DANA , KASSNER PAUL D
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C40B30/04 , G01N33/68 , G01N37/00 , C07H21/00 , G01N33/543
CPC分类号： C40B30/04 , G01N33/6845
摘要： Provided herein are addressable collections of anti-tag capture agents, such as antibodies, that are used as tools for sorting proteins containg polypeptide tags for which the capture agents are specific . Also provided are methods of nested sorting using the collections. The methods includes the steps of creating tagged collections of molecules by introducing a set of nucleic acid molecules that encode unique preselected polypeptides to create a library of tagged molecules; either before or after introducing the tags, dividing the library into N divisions; translating each division and reacting each with one of N capture agent collections, identifying the capture agents bound to the polypetide tags linked to molecules on interest, and thereby identifying the one of the divided collections that contains the molecules of interest. The method can further include adding a new set of tags and repeating the sorting process with the same or a different collection capture agents and thereby identifying a protein or molecule of interest.
摘要翻译：本文提供了抗标签捕获剂（例如抗体）的可寻址的集合，其被用作用于分选含有捕获剂特异性的多肽标签的蛋白质的工具。还提供了使用集合进行嵌套排序的方法。所述方法包括通过引入编码独特预选多肽的一组核酸分子来产生标记分子文库来产生标记的分子集合的步骤; 在引入标签之前或之后，将图书馆分为N个部门; 翻译每个分区并使其与N个捕获剂收集物中的一个反应，鉴定与感兴趣的分子连接的多肽标签结合的捕获剂，从而鉴定包含感兴趣的分子的分割的收集物之一。该方法可以进一步包括添加一组新标签并用相同或不同的收集捕获剂重复分选过程，从而鉴定感兴趣的蛋白质或分子。

10. 发明申请

WO2005067980A3 DESIGN OF THERAPEUTICS AND THERAPEUTICS 审中-公开
标题翻译：治疗与治疗的设计
公开(公告)号：WO2005067980A3
公开(公告)日：2006-10-26
申请号：PCT/US2005000816
申请日：2005-01-10
申请人： POINTILLISTE INC , AULT-RICHE DANA , LEVY RONALD
发明人： AULT-RICHE DANA , LEVY RONALD
IPC分类号： A61K39/395 , A61K47/48 , C07K16/28 , C07K16/42
CPC分类号： B82Y5/00 , A61K39/39566 , A61K47/665 , A61K47/6897 , A61K2039/505 , C07K16/2896 , C07K16/4241 , C07K2317/34 , C07K2317/622 , C07K2319/30 , A61K2300/00
摘要： Therapeutic complexes and components of therapeutic complexes are provided herein. Also provided are methods of preparing therapeutic complexes and methods of administering therapeutic complexes.
摘要翻译：本文提供治疗复合物和治疗复合物的组分。还提供了制备治疗复合物的方法和施用治疗复合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式