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1. 发明申请

WO2007101913A1 NOVEL ASSAY FOR THE DETECTION OF AN ANTIBODY BOUND TO A CELL MEMBRANE RECEPTOR 审中-公开
标题翻译：用于检测细胞膜受体的抗体的新方法
公开(公告)号：WO2007101913A1
公开(公告)日：2007-09-13
申请号：PCT/FI2007/050120
申请日：2007-03-06
申请人： SCHERING OY , PIIRONEN, Timo
发明人： PIIRONEN, Timo
IPC分类号： G01N33/543 , G01N33/566 , G01N33/68 , G01N33/577 , G01N33/574
CPC分类号： G01N33/6854 , G01N2333/705
摘要： This invention relates to the design of a novel immunoassay specific for the measurement of humanized antibody, Campath-1H, bound to the CD52 cell membrane receptor. The method can be used for pharmacokinetic studies and for monitoring purposes. The invention reveals improvements in higher specificities and sensitivities that can be obtained in relation to the conventionally used methods.
摘要翻译：本发明涉及特异性测量与CD52细胞膜受体结合的人源化抗体Campath-1H的新型免疫测定的设计。该方法可用于药代动力学研究和监测目的。本发明揭示了相对于常规使用的方法可获得的较高特异性和敏感性的改进。

2. 发明申请

WO2004099780A1 IMMUNOASSAYS FOR THE DETECTION OF UROKINASE RECEPTOR FORMS 审中-公开
标题翻译：用于检测尿激酶受体形式的免疫测定
公开(公告)号：WO2004099780A1
公开(公告)日：2004-11-18
申请号：PCT/DK2004/000324
申请日：2004-05-06
申请人： RIGSHOSPITALET , PIIRONEN, Timo , HØYER-HANSEN, Gunilla , BRÜNNER, Nils , PLOUG, Michael , LIST, Karin , LAURSEN, Birgitte , DANØ, Keld , LILJAS, Hans , HAESE, Alexander , HARTWIG, Huland , TØRNBLOM, Magnus , GUSTAFSSON, Ove
发明人： PIIRONEN, Timo , HØYER-HANSEN, Gunilla , BRÜNNER, Nils , PLOUG, Michael , LIST, Karin , LAURSEN, Birgitte , DANØ, Keld , LILJAS, Hans , HAESE, Alexander , HARTWIG, Huland , TØRNBLOM, Magnus , GUSTAFSSON, Ove
IPC分类号： G01N33/574
CPC分类号： G01N33/57434 , G01N33/566 , G06F19/18 , G06F19/20
摘要： The present invention relates to the design of three novel monoclonal uPAR sandwich assays for the specific detection of 1) full-length intact uPAR, 2) full-length intact uPAR and domain 2+3 fragment, and 3) domain 1 fragment of uPAR. The invention further relates to a method combining the detected amounts of uPAR forms in a sample with data indicative of the presence of the cancer disease. The method can be used for staging, prognosis or diagnosis of prostate cancer. Two novel monoclonal antibodies and a kit and immunoassays for detecting at least one uPAR form(s) are also described in the present invention.
摘要翻译：本发明涉及用于特异性检测1）全长完整uPAR，2）全长完整uPAR和结构域2 + 3片段以及3）uPAR结构域1片段的三种新型单克隆uPAR夹心测定法的设计。本发明还涉及将检测到的样品中的uPAR形式的量与指示癌症疾病的存在的数据组合的方法。该方法可用于前列腺癌的分期，预后或诊断。两种新型单克隆抗体和用于检测至少一种uPAR形式的试剂盒和免疫测定法也在本发明中描述。

3. 发明申请

WO1992021093A1 FILTER FOR DILATION AND EROSION OF IMAGES 审中-公开
标题翻译：过滤和图像的渗透
公开(公告)号：WO1992021093A1
公开(公告)日：1992-11-26
申请号：PCT/FI1992000147
申请日：1992-05-08
申请人： RAUTARUUKKI OY , VALTION TEKNILLINEN TUTKIMUSKESKUS , SARKKINEN, Timo , PIIRONEN, Timo , TIENSYRJÄ, Kari
发明人： RAUTARUUKKI OY , VALTION TEKNILLINEN TUTKIMUSKESKUS
IPC分类号： G06F15/68
CPC分类号： G06T5/30
摘要： The invention relates to a filter for applying dilation and/or erosion operations of mathematical morphology to a W x H local neighbourhood, the width of which is W and the height H, of a two-dimensional matrix formed by discrete values, the width of which matric is x and the height y. In order to provide an operation in real time by means of a very simple structure, the filter comprises a horizontal portion for applying a dilation/erosion operation to a W x 1 local neighbourhood made to slide over the matrix and a vertical portion for applying a dilation/erosion operation to a 1 x H local neighbourhood made to slide over the matrix, whereby the portions are connected one after another, the output (MINW, MINH) of one portion being connected to the input (IH, IV) of the other portion.
摘要翻译：本发明涉及一种用于将数学形态的扩张和/或侵蚀操作应用于W x H局部邻域的滤波器，其宽度为W和由离散值形成的二维矩阵的高度H，宽度哪个矩阵是x和高度y。为了通过非常简单的结构实时提供操作，滤波器包括用于对W×1局部邻域进行扩张/侵蚀操作的水平部分，该区域在矩阵上滑动，垂直部分用于施加对1×H局部邻域进行扩张/侵蚀操作，使其在矩阵上滑动，由此这些部分依次连接，一部分的输出（MINW，MINH）连接到另一个的输入端（IH，IV）一部分。

4. 发明申请

WO1990007123A1 A METHOD OF OPTICALLY DETERMINING THE SPEED OF A SURFACE 审中-公开
标题翻译：一种光学测定表面速度的方法
公开(公告)号：WO1990007123A1
公开(公告)日：1990-06-28
申请号：PCT/FI1989000231
申请日：1989-12-11
申请人： VALTION TEKNILLINEN TUTKIMUSKESKUS , ELSILÄ, Martti , PIIRONEN, Timo , JOKINEN, Hannu
发明人： VALTION TEKNILLINEN TUTKIMUSKESKUS
IPC分类号： G01P03/68
CPC分类号： G01P3/68
摘要： The invention relates to a method of optically determining the speed of a surface by means of picture rows (3) successive in time, the picture rows being obtained from an array of photodetectors arranged in parallel with the direction of the movement. The method of the invention, applicable within a wide speed range and having a good resolution, comprises digitizing (5) the analog signals from the array of photodetectors (2); storing the digitized picture rows successive in time, whereby the picture rows arranged side by side can be assumed to form a two-dimensional picture in the space-time domain; and determining (8) the slope or a corresponding quantity of a line drawn by each picture element in the picture row in said space-time domain to obtain a value proportional to the speed of the surface (1).
摘要翻译：本发明涉及一种通过在时间上连续的图像行（3）光学地确定表面速度的方法，图像行是从与运动方向平行排列的光电检测器阵列获得的。本发明的方法适用于宽速度范围并具有良好的分辨率，包括数字化（5）来自光电探测器阵列（2）的模拟信号; 在时间上连续地存储数字化图像行，由此可以假设并排布置的图像行在时空域中形成二维图像; 并且确定（8）在所述时空域中的图片行中的每个图像元素绘制的线的斜率或相应量，以获得与表面（1）的速度成比例的值。

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