专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004091384A2 ERBB SURFACE RECEPTOR COMPLEXES AS BIOMARKERS 审中-公开
标题翻译： ERBB表面受体复合物作为生物标志物
公开(公告)号：WO2004091384A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/009715
申请日：2004-03-30
申请人： ACLARA BIOSCIENCES, INC. , CHAN-HUI, Po-Ying , SALIMI-MOOSAVI, Hossein , SHI, Yining , SINGH, Sharat , DUA, Rajiv , MUKHERJEE, Ali , PIDAPARTHI, Sailaja
发明人： CHAN-HUI, Po-Ying , SALIMI-MOOSAVI, Hossein , SHI, Yining , SINGH, Sharat , DUA, Rajiv , MUKHERJEE, Ali , PIDAPARTHI, Sailaja
IPC分类号： A61B
CPC分类号： G01N33/57492 , C07K16/2863 , G01N33/542 , G01N2333/485 , G01N2800/52
摘要： The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are released and separated from the assay mixture for analysis.
摘要翻译：本发明涉及包含ErbB细胞表面膜受体的二聚体的患者样品中的新一类生物标志物。在一个方面，本发明包括通过将这样的病症与在患者样品，特别是固定组织样品中直接测量的一种或多种ErbB细胞表面膜受体的二聚体的量相关联来确定疾病或健康状况的状态的方法。另一方面，本发明包括通过将样本细胞中的ErbB细胞表面膜受体的一种或多种二聚体的量的测量值与这样的状态相关联来确定来自个体的样品中癌症状态的方法，包括存在或不存在癌前状态，存在或不存在癌症状态，癌症预后或对治疗的反应性。优选地，本发明的方法通过使用具有可释放分子标签的结合化合物来实现，所述组合化合物对于一种或多种类型的受体二聚体的多种组分是特异性的。结合后，分离标签被释放并与测定混合物分离，用于分析。

2. 发明申请

WO2004091384A3 ERBB SURFACE RECEPTOR COMPLEXES AS BIOMARKERS 审中-公开
标题翻译： ERBB表面受体复合物作为生物标志物
公开(公告)号：WO2004091384A3
公开(公告)日：2005-12-29
申请号：PCT/US2004009715
申请日：2004-03-30
申请人： ACLARA BIOSCIENCES INC , CHAN-HUI PO-YING , SALIMI-MOOSAVI HOSSEIN , SHI YINING , SINGH SHARAT , DUA RAJIV , MUKHERJEE ALI , PIDAPARTHI SAILAJA
发明人： CHAN-HUI PO-YING , SALIMI-MOOSAVI HOSSEIN , SHI YINING , SINGH SHARAT , DUA RAJIV , MUKHERJEE ALI , PIDAPARTHI SAILAJA
IPC分类号： A61B20060101 , C07K16/28 , C12N20060101 , C12Q3/00 , G01N33/542 , G01N33/543 , G01N33/574
CPC分类号： G01N33/57492 , C07K16/2863 , G01N33/542 , G01N2333/485 , G01N2800/52
摘要： The invention is directed to a new class of biomarker in patient samples comprising dimers of ErbB cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of ErbB cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of ErbB cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are released and separated from the assay mixture for analysis.
摘要翻译：本发明涉及包含ErbB细胞表面膜受体的二聚体的患者样品中的新一类生物标志物。在一个方面，本发明包括通过将这样的病症与在患者样品，特别是固定组织样品中直接测量的一种或多种ErbB细胞表面膜受体的二聚体的量相关联来确定疾病或健康状况的状态的方法。另一方面，本发明包括通过将样本细胞中的ErbB细胞表面膜受体的一种或多种二聚体的量的测量值与这样的状态相关联来确定来自个体的样品中癌症状态的方法，包括存在或不存在癌前状态，存在或不存在癌症状态，癌症预后或对治疗的反应性。优选地，本发明的方法通过使用具有可释放分子标签的结合化合物来实现，所述组合化合物对于一种或多种类型的受体二聚体的多种组分是特异性的。结合后，分离标签被释放并与测定混合物分离，用于分析。

3. 发明申请

WO2005019470A3 DETECTING AND PROFILING MOLECULAR COMPLEXES 审中-公开
公开(公告)号：WO2005019470A3
公开(公告)日：2005-03-03
申请号：PCT/US2004/025945
申请日：2004-08-10
申请人： ACLARA BIOSCIENCES, INC. , CHAN-HUI, Po-Ying , SINGH, Sharat , SALIMI-MOOSAVI, Hossein , SHI, Uining , MUKHERJEE, Ali , PIDAPARTHI, Sailaja , DUA, Rajiv
发明人： CHAN-HUI, Po-Ying , SINGH, Sharat , SALIMI-MOOSAVI, Hossein , SHI, Uining , MUKHERJEE, Ali , PIDAPARTHI, Sailaja , DUA, Rajiv
IPC分类号： C07K16/46
摘要： Methods are provided for detecting the formation of complexes of molecules, especially proteins, in a sample, such as a cell or tissue lysate. In one aspect, a cleaving probe specific for a first protein in a complex and one or more binding compounds specific for one or more second proteins in a complex are provided. Upon binding, the cleaving probe is induced to generate an active species, such as singlet oxygen, that cleaves molecular tags attached to the binding compounds only in the local region of the cleaving probe. The released molecular tags are separated from the assay mixture and from one another to provide a readout that is related to the number and types of proteins present in the complex.

4. 发明申请

WO2004092353A3 SURFACE RECEPTOR COMPLEXES AS BIOMARKERS 审中-公开
公开(公告)号：WO2004092353A3
公开(公告)日：2004-10-28
申请号：PCT/US2004/009717
申请日：2004-03-30
申请人： ACLARA BIOSCIENCES, INC. , CHAN-HUI, Po-Ying , SALIMI-MOOSAVI, Hossein , SHI, Yining , SINGH, Sharat , DUA, Rajiv , MUKHERJEE, Ali , PIDAPARTHI, Sailaja
发明人： CHAN-HUI, Po-Ying , SALIMI-MOOSAVI, Hossein , SHI, Yining , SINGH, Sharat , DUA, Rajiv , MUKHERJEE, Ali , PIDAPARTHI, Sailaja
IPC分类号： G01N33/543
摘要： The invention is directed to a new class of biomarker in patient samples comprising dimers of cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are release and separated from the assay mixture for analysis.

5. 发明申请

WO2004092353A2 SURFACE RECEPTOR COMPLEXES AS BIOMARKERS 审中-公开
标题翻译：表面受体复合物作为生物标志物
公开(公告)号：WO2004092353A2
公开(公告)日：2004-10-28
申请号：PCT/US2004009717
申请日：2004-03-30
申请人： ACLARA BIOSCIENCES INC , CHAN-HUI PO-YING , SALIMI-MOOSAVI HOSSEIN , SHI YINING , SINGH SHARAT , DUA RAJIV , MUKHERJEE ALI , PIDAPARTHI SAILAJA
发明人： CHAN-HUI PO-YING , SALIMI-MOOSAVI HOSSEIN , SHI YINING , SINGH SHARAT , DUA RAJIV , MUKHERJEE ALI , PIDAPARTHI SAILAJA
IPC分类号： A61B20060101 , C07K16/28 , C12N20060101 , C12Q3/00 , G01N33/542 , G01N33/543 , G01N33/574 , C12N
CPC分类号： G01N33/57492 , C07K16/2863 , G01N33/542 , G01N2333/485 , G01N2800/52
摘要： The invention is directed to a new class of biomarker in patient samples comprising dimers of cell surface membrane receptors. In one aspect, the invention includes a method of determining the status of a disease or healthful condition by correlating such condition to amounts of one or more dimers of cell surface membrane receptors measured directly in a patient sample, in particular a fixed tissue sample. In another aspect, the invention includes a method of determining a status of a cancer in a specimen from an individual by correlating measurements of amounts of one or more dimers of cell surface membrane receptors in cells of the specimen to such status, including presence or absence of a pre-cancerous state, presence or absence of a cancerous state, prognosis of a cancer, or responsiveness to treatment. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more types of receptor dimers. After binding, molecular tags are release and separated from the assay mixture for analysis.
摘要翻译：本发明涉及包含细胞表面膜受体二聚体的患者样品中的新一类生物标志物。在一个方面，本发明包括通过将这样的病症与在患者样品，特别是固定组织样品中直接测量的一种或多种细胞表面膜受体的二聚体的量相关联来确定疾病或健康状况的状态的方法。另一方面，本发明包括通过将样本细胞中的一种或多种细胞表面膜受体的二聚体的量的测量值与这样的状态相关联来确定来自个体的样品中癌症的状态的方法，包括存在或不存在癌前状态，癌症状态的存在或不存在，癌症的预后或对治疗的反应性。优选地，本发明的方法通过使用具有可释放分子标签的结合化合物来实现，所述组合化合物对于一种或多种类型的受体二聚体的多种组分是特异性的。结合后，将分子标签从测定混合物中释放并分离以进行分析。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式