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1. 发明申请

WO2015120291A1 COMPOSITIONS AND METHODS FOR MEASURING AND EXPANDING BLOOD VOLUME 审中-公开
标题翻译：用于测量和扩大血液体积的组合物和方法
公开(公告)号：WO2015120291A1
公开(公告)日：2015-08-13
申请号：PCT/US2015/014845
申请日：2015-02-06
申请人： PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL , SANDOVAL, JR., Ruben , REILLY, Erinn, Sheridan , MEIER, Daniel
发明人： SANDOVAL, JR., Ruben , REILLY, Erinn, Sheridan , MEIER, Daniel
IPC分类号： A61K35/14
CPC分类号： A61K49/0043 , A61K9/0026 , A61K31/00 , A61K31/721 , A61K38/38 , A61K49/0041 , A61K49/0054 , A61K49/0056 , G01N33/49
摘要： A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard unmodified protein, colloid or crystalloid and a fluorescently-labeled protein, colloid or crystalloid of approximately the same molecular weight. The use of blood volume expanders to measure, adjust and maintain the level of blood volume in a patient also is described.
摘要翻译：描述了用于测量，调节和维持患者体内血容量的方法。血容积扩张剂组合物包括标准未修饰的蛋白质，胶体或晶体蛋白和具有大致相同分子量的荧光标记蛋白，胶体或晶体。还描述了使用血容量扩张器来测量，调节和维持患者血容量的水平。

2. 发明申请

WO2015061680A1 COMPOSITIONS AND METHODS FOR OPTIMIZING THE DETECTION OF FLUORESCENT SIGNALS FROM BIOMARKERS 审中-公开
标题翻译：用于优化从生物标志物检测荧光信号的组合物和方法
公开(公告)号：WO2015061680A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/062170
申请日：2014-10-24
申请人： PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL , SANDOVAL, JR., Ruben , SHERIDAN, Erinn , MEIER, Daniel
发明人： SANDOVAL, JR., Ruben , SHERIDAN, Erinn , MEIER, Daniel
IPC分类号： A61B5/145 , A61K49/00 , A61B5/20 , G01N21/64
CPC分类号： G01N21/6428 , A61K49/0041 , A61K49/0054 , A61M5/007 , G01N2021/6417 , G01N2021/6439 , G01N2201/13
摘要： Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.
摘要翻译：描述了用于增加由生物标志物产生的荧光信号的组合物和方法。这用于当生物标志物用于检测和诊断生理条件（例如器官功能和血浆体积）时提高结果的准确性。

3. 发明申请

WO2010127136A3 MEASUREMENT OF BODY FLUID VOLUMES 审中-公开
公开(公告)号：WO2010127136A3
公开(公告)日：2010-11-04
申请号：PCT/US2010/032997
申请日：2010-04-29
申请人： PHARMACOPHOTONICS, INC. , MOLITORIS, Bruce A. , WANG, Exing , SANDOVAL, Ruben M., Jr.
发明人： MOLITORIS, Bruce A. , WANG, Exing , SANDOVAL, Ruben M., Jr.
IPC分类号： A61B5/00
摘要： The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV = ECFV - TVPV.

4. 发明申请

WO2013123285A1 COMPOSITIONS AND METHODS FOR MONITORING BIOMETRIC INDICATORS 审中-公开
标题翻译：用于监测生物指示剂的组合物和方法
公开(公告)号：WO2013123285A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/026277
申请日：2013-02-15
申请人： PHARMACOPHOTONICS, INC.
发明人： MEIER, Daniel , MOLITORIS, Bruce , SHERIDAN, Erinn , SANDOVAL, Ruben
IPC分类号： A61B6/00
CPC分类号： A61K49/0017 , A61B5/0071 , A61B5/0088 , A61B5/14535 , A61B5/1455 , A61B5/201 , A61B5/682 , A61K49/0004
摘要： Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.
摘要翻译：描述了哺乳动物受试者中生物特征指示物的测量方法。感兴趣的生物特征指标包括血细胞比容，血浆体积，分布体积和肾小球滤过率。该方法特别适用于快速失血的受试者和具有不稳定血细胞比容的受试者。可以通过将具有动态荧光标记物和静态荧光标记物的注射剂或具有两个荧光标签的单个静态标记物注射到受试者的血管系统中来测量血细胞比容，并且通过对受试者的血管系统监测标记物或荧光标签的发射强度一段的时间。然后可以使用校准的光谱分析仪通过确定T0处的标记物的原始比率，计算明显的血细胞比容和应用校正因子来计算血细胞比容。

5. 发明申请

WO2010127089A1 SELF-PUNCTURING PERCUTANEOUS OPTICAL SENSOR FOR OPTICAL SENSING OF INTRAVASCULAR FLUID 审中-公开
标题翻译：自我激光光学传感器，用于光学感应血管内流体
公开(公告)号：WO2010127089A1
公开(公告)日：2010-11-04
申请号：PCT/US2010/032934
申请日：2010-04-29
申请人： PHARMACOPHOTONICS, INC. , RUBIN, Matthew , MEIER, Daniel J.
发明人： RUBIN, Matthew , MEIER, Daniel J.
IPC分类号： A61B5/00
CPC分类号： A61B5/1459 , A61B5/14546 , A61B5/1473 , A61B5/6848
摘要： The present invention is directed to a self-penetrating percutaneous optical sensing device for obtaining and transmitting optical signal from intravascular fluid in a blood vessel, the device comprising: (a) an elongated hollow rigid sensor sheath 20 having a proximal end 21, a distal end 22 and a central channel extending along the sensor sheath, wherein the distal end 22 of the sensor sheath 20 is sufficiently sharpened to puncture a cutaneous barrier and the sensor sheath 20 has a sufficient length to allow the sensor sheath 20 to penetrate into intravascular space of a blood vessel; (b) a flexible optical fiber 30 having a proximal end and a distal end situated coherently within the central channel of the sensor sheath 20 wherein the sensor sheath 20 covers a portion of the distal end of the flexible optical fiber 30 and wherein the distal end of the flexible optical fiber 30 aligns with the distal end 22 of the sensor sheath 20; and (c) an optical sensor 40 connected to the distal end of the flexible optical fiber 30 wherein optical signal generated at the optical sensor 40 can be transmitted from the optical sensor 40 to the proximal end of the flexible optical fiber 30 via the flexible optical fiber 30 and wherein the optical sensor 40 has direct access to the intravascular fluid of the blood vessel.
摘要翻译：本发明涉及一种用于从血管中的血管内流体获得和传输光信号的自穿透经皮光学感测装置，该装置包括：（a）细长的中空刚性传感器护套20，其具有近端21，远端端部22和沿着传感器护套延伸的中心通道，其中传感器护套20的远端22被充分地锐化以刺穿皮肤屏障，并且传感器护套20具有足够的长度以允许传感器护套20穿透入血管内空间的血管（b）柔性光纤30，其具有相邻地位于传感器护套20的中心通道内的近端和远端，其中传感器护套20覆盖柔性光纤30的远端的一部分，并且其中远端柔性光纤30与传感器护套20的远端22对准; 以及（c）连接到柔性光纤30的远端的光学传感器40，其中在光学传感器40处产生的光信号可以经由柔性光学器件从光学传感器40传输到柔性光纤30的近端光纤30，并且其中光学传感器40可以直接进入血管的血管内流体。

6. 发明申请

WO2023039129A1 METHOD AND APPARATUS FOR MONITORING PLASMA VOLUME 审中-公开
公开(公告)号：WO2023039129A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/042998
申请日：2022-09-09
申请人： PHARMACOPHOTONICS, INC. , STRICKLAND, James, S. , MEIER, Daniel, J.
发明人： STRICKLAND, James, S. , MEIER, Daniel, J.
IPC分类号： A61B5/0275 , A61B5/1455 , A61B5/1459 , A61B5/145 , G01N33/49 , G01N33/50
摘要： Disclosed are methods for determining plasma volume in patients undergoing treatment for hypervolemia or hypovolemia. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of more than one dose of an inj ectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample.

7. 发明申请

WO2016210311A1 METHOD AND APPARATUS FOR DETERMINING BIOMETRIC INDICATORS USING MULTIPLE FLUORESCENT MARKERS 审中-公开
标题翻译：使用多个荧光标记物确定生物指标的方法和装置
公开(公告)号：WO2016210311A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039334
申请日：2016-06-24
申请人： PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL
发明人： MEIER, Daniel, J. , SANDOVAL, Ruben, M., Jr. , REILLY, Erinn
IPC分类号： A61B5/1455 , A61B5/1495 , A61K49/00
CPC分类号： G01N33/582 , A61B5/0071 , A61B5/02028 , A61B5/14535 , A61B2560/0233
摘要： Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.
摘要翻译：公开了用于确定哺乳动物受试者例如人类的生物特征指标如血浆体积，血细胞比容和肾小球滤过率的方法。该方法利用具有不同荧光特性的多个荧光标记，其可以与单个静态分子相关联，或者其中静态分子用荧光标记物标记，动态分子用另一个荧光标记进行标记。在引入含有荧光标签的注射剂之后，可采用荧光发射强度的一个或多个测量，其可以使用探针或通过血液或血浆样品进行。还公开了用于实施该方法的组合物和装置。

8. 发明申请

WO2015138702A1 IMPROVED MEASUREMENT OF BODY FLUID VOLUMES 审中-公开
标题翻译：改善身体体液量的测量
公开(公告)号：WO2015138702A1
公开(公告)日：2015-09-17
申请号：PCT/US2015/020140
申请日：2015-03-12
申请人： PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICAL , MOLITORIS, Bruce, A. , WANG, Exing , SANDOVAL, Ruben, M.
发明人： MOLITORIS, Bruce, A. , WANG, Exing , SANDOVAL, Ruben, M.
IPC分类号： G01N33/49 , A61K49/10 , A61B5/145 , A61B5/1455
CPC分类号： A61K49/0054 , A61B5/1451 , A61B5/14546 , A61B5/201 , A61B5/4875 , A61B5/4881 , A61K49/0041
摘要： The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV-TVPV.
摘要翻译：本发明一般涉及动物受试者体液体积的测量。感兴趣的体液体积包括细胞外液体积（ECFV），总血管血浆体积（TVPV）和间质液体体积（IFV）。这些方法对于患有肾功能衰竭的受试者尤其是肾透析患者特别有益。可以通过施用第一分子来测量ECFV，所述第一分子是血管系统的血管壁的非代谢和可渗透的，其中第一分子分布在总血管空间以及间质空间内。 TVPV可以通过施用第二分子来测量，所述第二分子是非代谢的并且不渗透血管系统的血管壁，其中第二分子仅分布在血管空间内。然后可以使用IFV = ECFV-TVPV等式计算IFV。

9. 发明申请

WO2020073042A1 METHOD AND APPARATUS FOR DETERMINING INTERSTITIAL VOLUME 审中-公开
公开(公告)号：WO2020073042A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/054985
申请日：2019-10-07
申请人： PHARMACOPHOTONICS, INC., D/B/A FAST BIOMEDICAL
发明人： MEIER, Daniel J.
IPC分类号： A61B5/145 , A61B5/20
摘要： A method and system for selecting a treatment for a subject based on a value for the interstitial space volume of the subject utilizes plurality of sample data values representing concentrations of small and large markers in plurality of blood samples over time. The sample concentrations are utilized to predict a hypothetical peak concentration of the small marker prior to the dissipation of the markers during the test period. This hypothetical peak concentration and other sample values are utilized with either a bi-exponential or tri-exponential decay curve fitting algorithm to define a decay curve, the curve characteristics of which are then utilized to calculate values for glomerular filtration rate, a leakage rate of the small marker into interstitial space, and finally a value for the interstitial volume. The determined value for the interstitial volume can then be compared with number thresholds and decisions made for recommended therapy for the subject, if desired.

10. 发明申请

WO2011123820A3 SINGLE ISOMERIC CONJUGATES OF RHODAMINE DYES 审中-公开
公开(公告)号：WO2011123820A3
公开(公告)日：2011-10-06
申请号：PCT/US2011/030999
申请日：2011-04-01
申请人： PHARMACOPHOTONICS, INC. , BREMBERG, Ulf , RINGBERG, Erik , BERTS, Wei , DE BELDER, Anthony , STRICKLAND, James S.
发明人： BREMBERG, Ulf , RINGBERG, Erik , BERTS, Wei , DE BELDER, Anthony , STRICKLAND, James S.
IPC分类号： A61K49/00 , C09B11/24
摘要： The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.

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