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2. 发明申请

WO1994007887A1 OPTICALLY ACTIVE LACTONES 审中-公开
标题翻译：光学活性乳杆菌
公开(公告)号：WO1994007887A1
公开(公告)日：1994-04-14
申请号：PCT/EP1993002554
申请日：1993-09-21
申请人： GIVAUDAN-ROURE (INTERNATIONAL) S.A. , BOURDINEAUD, Jean-Paul , EHRET, Charles , PETRZILKA, Martin
发明人： GIVAUDAN-ROURE (INTERNATIONAL) S.A.
IPC分类号： C07D309/30
CPC分类号： C07D315/00 , A23L27/24 , C07D309/30 , C07D309/32 , C11B9/008 , C12P17/06 , C12P41/003 , C12Y301/01003
摘要： The present invention relates primarily to the field of optically active lactones of formula (I) as defined below. The invention relates also to the utilisation of compounds of formula (I) so obtained as perfuming or flavoring ingredients. The process for producing the individual optically active lactones of formula (I), wherein the asterisk indicates a chirality center, n stands for zero or 1, R represents a C5- or C6-alkyl radical, which optionally may contain an additional double bond of either Z- or E-configuration, such additional bond being compulsory in case of n = 0, comprises the stereoselective enzymatic hydrolysis of the ester bond of the corresponding racemates in the presence of an esterase, recovering the enzyme-spared isomer, and, if desired, subjecting the hydrolysed isomer to lactonisation, provided the enzymatic hydrolysis is carried out in the presence of potassium ions in case of n = 1.
摘要翻译：本发明主要涉及如下定义的式（I）的光学活性内酯的领域。本发明还涉及如此获得的式（I）化合物作为加香或调味成分的用途。制备式（I）的各种光学活性内酯的方法，其中星号表示手性中心，n表示0或1，R表示C5-或C6-烷基，其任选地可以含有另外的双键 Z-或E-构型，在n = 0的情况下这样的附加键是强制性的，包括在酯酶存在下相应的外消旋体的酯键的立体选择性酶水解，回收酶保留的异构体，如果所需的，使水解的异构体进行内酯化，条件是在n = 1的情况下，在钾离子存在下进行酶促水解。

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