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2. 发明申请

WO2008008608A2 METHOD OF TREATING AND PREVENTING SECONDARY HYPERPARATHYROIDISM 审中-公开
标题翻译：治疗和预防继发性高血压病的方法
公开(公告)号：WO2008008608A2
公开(公告)日：2008-01-17
申请号：PCT/US2007071791
申请日：2007-06-21
申请人： PROVENTIV THERAPEUTICS LLC , CYTOCHROMA INC , BISHOP CHARLES W , CRAWFORD KEITH H , MESSNER ERIC J , PETKOVICH MARTIN P , HELVIG CHRISTIAN F
发明人： BISHOP CHARLES W , CRAWFORD KEITH H , MESSNER ERIC J , PETKOVICH MARTIN P , HELVIG CHRISTIAN F
CPC分类号： A61K31/593 , A61K9/48 , A61K31/59 , A61K31/592
摘要： The a method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25 -hydroxy vitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25 -hydroxy vitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25- hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25- hydroxyvitamin D during treatment comprises predominantly 25 -hydroxy vitamin D3, and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D3 for 25 -hydroxy vitamin D repletion and/or maintenance
摘要翻译：通过根据需要施用维生素D补充剂和维生素D激素替代疗法，通过增加或维持患者的25-羟基维生素D和1,25-二羟基维生素D的血液浓度来治疗iPTH的血液水平升高的方法，被披露。 25-羟基维生素D的血液浓度增加并保持在30ng / mL以上，1,25-二羟基维生素D的血液浓度增加至维持在患者正常的历史生理范围内1,25-二羟基维生素 D，而不会导致患者高钙血症，高磷酸血症或过度抑制血浆iPTH的风险显着增加。 25-羟基维生素D的血液水平在维生素D补充疗法剂量之间维持在或高于30ng / mL，1,25-二羟维生素D的血液水平维持在患者维生素D剂量之间的正常历史生理范围内激素替代疗法。在一个方面，本公开包括其中治疗期间25-羟基维生素D的血液浓度主要包含25-羟基维生素D3和/或其中所述方法包括主要或仅仅使用25-羟基维生素D补充的25-羟基维生素D3的方法， /或维护

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