专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

WO2012136553A1 SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE SALTS 审中-公开
标题翻译：取代的2,3-二氢吲哚并[1,2-C]喹唑啉盐
公开(公告)号：WO2012136553A1
公开(公告)日：2012-10-11
申请号：PCT/EP2012/055600
申请日：2012-03-29
申请人： Bayer Pharma Aktiengesellschaft , PETERS, Jan, Georg , MILITZER, Hans-Christian , MÜLLER, Hartwig
发明人： PETERS, Jan, Georg , MILITZER, Hans-Christian , MÜLLER, Hartwig
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： A61K31/5377 , A61K45/06 , C07D487/04
摘要： The present invention relates : - to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) : or a tautomer, solvate or hydrate thereof; - to methods of preparing said dihydrochloride salt; - to said dihydrochloride salt for the treatment and/or prophylaxis of a disease; - to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer; - to a pharmaceutical composition comprising said dihydrochloride salt; and - to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.
摘要翻译：本发明涉及：2-氨基-N- [7-甲氧基-8-（3-吗啉-4-基丙氧基）-2,3-二氢咪唑并[1,2-c]喹唑啉-5-基]嘧啶（II）的5-甲酰胺二盐酸盐：或其互变异构体，溶剂合物或水合物; - 制备所述二盐酸盐的方法; - 所述二盐酸盐用于治疗和/或预防疾病; - 使用所述二盐酸盐来制备用于治疗和/或预防疾病，特别是高增殖和/或血管生成障碍的药物，更特别是用于治疗或预防癌症，尤其是肺癌，特别是非小细胞肺癌，结肠直肠癌，黑素瘤，胰腺癌，肝细胞癌，胰腺癌，肝细胞癌或乳腺癌; - 包含所述二盐酸盐的药物组合物; 以及 - 包含所述二盐酸盐与一种或多种其它药剂组合的药物组合。

IPRDB

热门服务

关于我们

友情链接

联系方式