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1. 发明申请

WO2012145088A1 SELF-SEALED FLUIDIC CHANNELS FOR A NANOPORE ARRAY 审中-公开
标题翻译：自封式流体通道用于NANOPORE ARRAY
公开(公告)号：WO2012145088A1
公开(公告)日：2012-10-26
申请号：PCT/US2012/028231
申请日：2012-03-08
申请人： INTERNATIONAL BUSINESS MACHINES CORP. , DANG, Bing , PENG, Hongbo
发明人： DANG, Bing , PENG, Hongbo
IPC分类号： H01L51/10
CPC分类号： B82Y15/00 , G01N33/48721 , Y10S977/70 , Y10S977/704 , Y10S977/712 , Y10S977/84 , Y10S977/856
摘要： A method of forming a nanopore array includes patterning a front layer of a substrate to form front trenches, the substrate including a buried layer disposed between the front layer and a back layer; depositing a membrane layer over the patterned front layer and in the front trenches; patterning the back layer and the buried layer to form back trenches, the back trenches being aligned with the front trenches; forming a plurality of nanopores through the membrane layer; depositing a sacrificial material in the front trenches and the back trenches; depositing front and back insulating layers over the sacrificial material; and heating the sacrificial material to a decomposition temperature of the sacrificial material to remove the sacrificial material and form pairs of front and back channels, wherein the front channel of each channel pair is connected to the back channel of its respective channel pair by an individual nanopore.
摘要翻译：形成纳米孔阵列的方法包括使衬底的前层图形化以形成前沟槽，所述衬底包括设置在前层和背层之间的掩埋层; 在图案化的前层和前沟槽上沉积膜层; 图案化背层和掩埋层以形成背沟，后沟与前沟槽对齐; 通过膜层形成多个纳米孔; 在前沟槽和后沟槽中沉积牺牲材料; 在所述牺牲材料上沉积前后绝缘层; 并且将所述牺牲材料加热至所述牺牲材料的分解温度以去除所述牺牲材料并形成一对前和后通道，其中每个通道对的前通道通过单独的纳米孔连接到其相应通道对的后通道。

2. 发明申请

WO2011115709A1 NANOPORE BASED DEVICE FOR CUTTING LONG DNA MOLECULES INTO FRAGMENTS 审中-公开
标题翻译：用于将长DNA分子切割成片段的基于纳米层的设备
公开(公告)号：WO2011115709A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/023872
申请日：2011-02-07
申请人： INTERNATIONAL BUSINESS MACHINES CORP. , LUAN, Binquan , MARTYNA, Glenn, J. , PENG, Hongbo , STOLOVITSKY, Gustavo A.
发明人： LUAN, Binquan , MARTYNA, Glenn, J. , PENG, Hongbo , STOLOVITSKY, Gustavo A.
IPC分类号： C12Q1/68
CPC分类号： B82Y15/00 , C12Q1/6806 , C12Q2523/303 , C12Q2565/631
摘要： Apparatus, system, and method are provided for cutting a linear charged polymer inside a nanopore. A first voltage is applied to create an electric field in a first direction. A second voltage is applied to create an electric field in a second direction, and the first direction is opposite to the second direction. When the electric field in the first direction and the electric field in the second direction are applied to a linear charged polymer inside a nanopore, the linear charged polymer is cut at a location with predetermined accuracy.
摘要翻译：提供了用于在纳米孔内切割线性带电聚合物的装置，系统和方法。施加第一电压以在第一方向上产生电场。施加第二电压以在第二方向上产生电场，并且第一方向与第二方向相反。当将第一方向的电场和第二方向的电场施加到纳米孔内的线性带电聚合物时，线性带电聚合物在预定精度的位置被切割。

3. 发明申请

WO2013037240A1 CHARGED ENTITIES AS LOCOMOTIVE TO CONTROL MOTION OF POLYMERS THROUGH A NANOCHANNEL 审中-公开
标题翻译：充电实体通过纳米通道控制聚合物的运动
公开(公告)号：WO2013037240A1
公开(公告)日：2013-03-21
申请号：PCT/CN2012/078585
申请日：2012-07-13
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , HARRER, Stefan , LUAN, Binquan , MARTYNA, Glenn J. , PENG, Hongbo , POLONSKY, Stanislav , ROSSNAGEL, Stephen M. , ROYYURU, Ajay K. , STOLOVITZKY, Gustavo A. , WALKER, George F.
发明人： HARRER, Stefan , LUAN, Binquan , MARTYNA, Glenn J. , PENG, Hongbo , POLONSKY, Stanislav , ROSSNAGEL, Stephen M. , ROYYURU, Ajay K. , STOLOVITZKY, Gustavo A. , WALKER, George F.
IPC分类号： G01N27/30
CPC分类号： B82Y15/00 , C12Q1/6869 , C12Q2565/631
摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.
摘要翻译：提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。第一储存器和第二储存器通过纳米通道连接。电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。第一电极在第一储存器中，第二电极位于第二储存器中。第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。

4. 发明申请

WO2013035064A1 EMBEDDING NANOTUBE INSIDE NANOPORE FOR DNA TRANSLOCATION 审中-公开
标题翻译：嵌入纳米粒子纳米粒子进行DNA转录
公开(公告)号：WO2013035064A1
公开(公告)日：2013-03-14
申请号：PCT/IB2012/054614
申请日：2012-09-06
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , IBM (CHINA) INVESTMENT COMPANY LIMITED , PENG, Hongbo , LUAN, Binquan , AFZALI-ARDAKANI, Ali
发明人： PENG, Hongbo , LUAN, Binquan , AFZALI-ARDAKANI, Ali
IPC分类号： B82Y40/00
CPC分类号： B82Y30/00 , B82Y40/00 , C12Q1/6869 , C25D3/665 , C25D5/028 , C25D13/04 , G01N33/48721
摘要： A technique for embedding a nanotube in a nanopore is provided. A membrane separates a reservoir into a first reservoir part and a second reservoir part, and the nanopore is formed through the membrane for connecting the first and second reservoir parts. An ionic fluid fills the nanopore, the first reservoir part, and the second reservoir part. A first electrode is dipped in the first reservoir part, and a second electrode is dipped in the second reservoir part. Driving the nanotube into the nanopore causes an inner surface of the nanopore to form a covalent bond to an outer surface of the nanotube via an organic coating so that the inner surface of the nanotube will be the new nanopore with a super smooth surface for studying bio-molecules while they translocate through the nanotube.
摘要翻译：提供了一种在纳米孔中嵌入纳米管的技术。膜将储存器分离成第一储存部分和第二储存部分，并且纳米孔通过膜形成，用于连接第一和第二储存部分。离子流体填充纳米孔，第一储存部分和第二储存部分。将第一电极浸入第一储存部分中，将第二电极浸入第二储存部分。将纳米管驱动到纳米孔中导致纳米孔的内表面通过有机涂层与纳米管的外表面形成共价键，使得纳米管的内表面将成为具有超光滑表面的新纳米孔，用于研究生物分子，同时它们转移通过纳米管。

5. 发明申请

WO2011160989A1 NANO-FLUIDIC FIELD EFFECTIVE DEVICE TO CONTROL DNA TRANSPORT THROUGH A NANO CHANNEL COMPRISING A SET OF ELECTRODES 审中-公开
标题翻译：纳米流体场效应装置，通过包含一组电极的纳米通道来控制DNA的运输
公开(公告)号：WO2011160989A1
公开(公告)日：2011-12-29
申请号：PCT/EP2011/059937
申请日：2011-06-15
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , LUAN, Binquan , MARTYNA, Glenn, John , NEWNS, Dennis , POLONSKY, Stanislav , STOLOVITZKY, Gustavo, Alejandro , PENG, Hongbo , ROSSNAGEL, Stephen , HARRER, Stefan , AFZALI-ARDAKANI, Ali
发明人： LUAN, Binquan , MARTYNA, Glenn, John , NEWNS, Dennis , POLONSKY, Stanislav , STOLOVITZKY, Gustavo, Alejandro , PENG, Hongbo , ROSSNAGEL, Stephen , HARRER, Stefan , AFZALI-ARDAKANI, Ali
IPC分类号： B01L3/00 , B03C5/02 , C12Q1/68 , G01N33/487 , B82Y15/00 , B82Y30/00
CPC分类号： G01N27/44756 , B01L3/502761 , B01L2200/0663 , B01L2300/0645 , B01L2300/0816 , B01L2300/0896 , B01L2400/0421 , B01L2400/0424 , B82Y15/00 , G01N27/447 , G01N27/44791 , G01N33/48721
摘要： Nano-fluidic field effective device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.
摘要翻译：纳米流体场有效装置包括具有第一侧和第二侧的通道，与第一侧相邻的第一组电极，与第二侧相邻的第二组电极，用于将电位施加到电极的控制单元和在通道内的含有电荷分子的流体。第一组电极被布置成使得施加电势产生空间变化的电场，该电场将带电分子限制在所述通道的预定区域内。第二组电极被布置成使得施加相对于施加到第一组电极的电位的电位产生将电荷分子限制在远离通道的第二侧的区域的电场。

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