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1. 发明申请

WO2005095579A1 PROCESS 审中-公开
标题翻译：处理
公开(公告)号：WO2005095579A1
公开(公告)日：2005-10-13
申请号：PCT/IB2005/001042
申请日：2005-03-30
申请人： DANISCO A/S , PEDERSEN, Hans, Christian , WEIERGANG, Inge
发明人： PEDERSEN, Hans, Christian , WEIERGANG, Inge
IPC分类号： C12N1/04
CPC分类号： A23L3/32 , A23L3/3571 , A23L29/065 , C02F3/348
摘要： A process for preparing a composition comprising dried microorganisms, comprising culturing one or more species of a microorganism; admixing the cultured microorganism with one or more carriers; treating the microorganism with pulsed electromagnetic fields; incubating the culture: carrier mixture for at least about 6 hours; and drying the microorganism so as to reduce the moisture level to between about 1 wt % to about 6 wt %. The combination of admixing the cultured microorganism with one or more carriers and treating the microorganisms in the composition have significantly enhanced initial survival rate and/or shelf-life.
摘要翻译：一种制备包含干燥微生物的组合物的方法，包括培养一种或多种微生物; 将培养的微生物与一种或多种载体混合; 用脉冲电磁场处理微生物; 将培养物：载体混合物孵育至少约6小时; 并干燥微生物以将水分含量降低至约1重量％至约6重量％之间。将培养的微生物与一种或多种载体混合并且处理组合物中的微生物的组合具有显着提高的初始存活率和/或保质期。

2. 发明申请

WO2004039993A1 POLYNUCLEOTIDE ENCODING A PYRANOSONE DEHYDRATASE 审中-公开
标题翻译：多核苷酸编码吡咯烷酮脱氢酶
公开(公告)号：WO2004039993A1
公开(公告)日：2004-05-13
申请号：PCT/GB2003/004594
申请日：2003-10-24
申请人： DANISCO A/S , YU, Shukun , HANSEN, Egon, Bech , PEDERSEN, Hans, Christian , TURNER, Mark , WEIERGANG, Inge
发明人： YU, Shukun , HANSEN, Egon, Bech , PEDERSEN, Hans, Christian , TURNER, Mark , WEIERGANG, Inge
IPC分类号： C12P17/06
CPC分类号： C07H3/08 , A01N43/16 , C12N9/88 , C12P17/06 , A01N2300/00
摘要： The present invention relates to a polynucleotide sequence encoding a pyranosone dehydratase. The present invention further relates to a method for producing transgenic plants which are resistant to pathogens, particularly fungal pathogens, comprising transforming the plants or part thereof with at least a polynucleotide sequence encoding a pyranosone dehydratase. Further aspects relate to transgenic plants comprising at least a heterologous polynucleotide sequence encoding pyranosone dehydratase, which plants are resistant to pathogens, particularly fungal pathogens. The present invention further relates to the in situ production of one or more antimicrobial compounds, such as microthecin, cortalcerone and/or ascopyrone P (APP) in a host organism, such as a plant.
摘要翻译：本发明涉及编码吡喃龙素脱水酶的多核苷酸序列。本发明还涉及一种用于产生对病原体特别是真菌病原体具有抗性的转基因植物的方法，包括用至少一种编码吡喃松香脱水酶的多核苷酸序列转化植物或其部分。另外的方面涉及至少包含编码吡喃松香脱水酶的异源多核苷酸序列的转基因植物，该植物对病原体特别是真菌病原体具有抗性。本发明还涉及一种或多种抗微生物化合物如主要生物体如植物中的微阵列，皮质酮和/或异黄酮P（APP）的原位生产。

3. 发明申请

WO2004039820A1 MATERIAL 审中-公开
标题翻译：材料
公开(公告)号：WO2004039820A1
公开(公告)日：2004-05-13
申请号：PCT/GB2003/004603
申请日：2003-10-24
申请人： DANISCO A/S , YU, Shukun , BUCHTER-LARSEN, Aksel , MORGAN, Andrew , TURNER, Mark , PEDERSEN, Hans, Christian , WEIERGANG, Inge , BECH-HANSEN, Egon
发明人： YU, Shukun , BUCHTER-LARSEN, Aksel , MORGAN, Andrew , TURNER, Mark , PEDERSEN, Hans, Christian , WEIERGANG, Inge , BECH-HANSEN, Egon
IPC分类号： C07H3/08
CPC分类号： C07H3/08 , A01N43/16 , A01N25/22 , A01N2300/00
摘要： The present invention provides an antimicrobial material comprising (i) an antimicrobial compound in a stabilised form (a "stabilised compound"), or (ii) (a) a first conversion agent capable of converting a precursor of an antimicrobial compound (a "primary precursor") to the antimicrobial compound; and (b) (I) a primary precursor, or (II) a second conversion agent capable of converting a precursor of the primary antimicrobial precursor (a "secondary precursor") to the primary precursor; and a secondary precursor; wherein the antimicrobial compound is selected from microthecin and derivatives thereof, such as compounds having Formula (I), wherein R 1 and R 2 are independently selected from H and C(=O)R 3 wherein R 3 is a hydrocarbyl group, and R 4 is from H and OH.
摘要翻译：本发明提供一种抗微生物材料，其包含（i）稳定化形式的抗微生物化合物（“稳定化合物”），或（ii）（a）能够转化抗微生物化合物前体的第一转化剂前体“）; 和（b）（I）初级前体，或（II）能够将初级抗微生物前体（“次级前体”）的前体转化成初级前体的第二转化剂; 和二级前体; 其中所述抗微生物化合物选自微喜岩石及其衍生物，例如具有式（I）的化合物，其中R 1和R 2独立地选自H和C（= O）R 3，其中R 3是烃基，R 4是H，哦。

4. 发明申请

WO03037918A3 PYRANOSONE DEHYDRATASE FROM PHANEROCHAETE CHRYSOSPORIUM 审中-公开
标题翻译：来自PHANEROCHAETE CHROSOSPORIUM的PYRANOSONE DEHYDRATASE
公开(公告)号：WO03037918A3
公开(公告)日：2003-10-16
申请号：PCT/GB0204916
申请日：2002-10-30
申请人： DANISCO , MORGAN ANDREW JOHN , YU SHUKUN , WEIERGANG INGE , PEDERSEN HANS CHRISTIAN
发明人： MORGAN ANDREW JOHN , YU SHUKUN , WEIERGANG INGE , PEDERSEN HANS CHRISTIAN
IPC分类号： C12N15/09 , A01N63/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/02 , C12N9/88 , C12N15/60 , C12P1/02 , C12P17/06
CPC分类号： C12P17/06 , C12N9/88
摘要： The present invention discloses sequence information relating to pyranosone dehydratase. The invention further relates to the use of pyranosone dehydratase in the conversion of AF to APP and microthecin and the conversion of glucosone to cortalcerone.
摘要翻译：本发明公开了与吡喃酮脱水酶有关的序列信息。本发明还涉及吡喃酮脱水酶在将AF转化为APP和微喜岩石以及将葡萄糖转化为皮质醇时的用途。

5. 发明申请

WO2006114306A1 A DRILLING TOOL 审中-公开
标题翻译：钻井工具
公开(公告)号：WO2006114306A1
公开(公告)日：2006-11-02
申请号：PCT/EP2006/003887
申请日：2006-04-26
申请人： IRWIN INDUSTRIAL TOOL COMPANY A/S , PEDERSEN, Hans, Christian
发明人： PEDERSEN, Hans, Christian
IPC分类号： E21B10/44 , B23B51/02
CPC分类号： B28D1/146 , B23B51/02 , B23B2226/75 , B23B2251/043 , B23B2251/204 , B23B2251/406 , B23B2251/50 , E21B10/445
摘要： A drill, such as a hammer drill, comprises a shank part adapted to be received in a tool-holder, an axially opposite drill head (13), and a conveying part. (11) interconnecting said shank part and said drill head (13). The drill head has a free end surface defining a diametrically extending main cutting edge ( 16) having a tip (17), and a pair of auxiliary cutting edges (18) extending radially in relation to the tip and defining with the main cutting edge a pair of opposite obtuse angles (180° - o) so as to define a pair of opposite sectors (20) of said free end surface. The conveying part (11) defines only two helical flutes (12) opening into the opposite obtuse angled sectors (20). In order to increase the possible drilling speed of the drill, the total cross sectional area of the flutes (12) amounts to 45 - 55 % of the total circular cross-sectional area of the conveying part (11) of the drill. An axially extending inlet portion (22) of each of the flutes (12) has an axial length (I), which is 25 - 35 % of the axial width (w) of each of the helical flutes. The pitch angle of the helical flutes (12) is 30° - 45°, preferably 35° - 40°.
摘要翻译：诸如锤钻的钻头包括适于容纳在工具架中的柄部分，轴向相对的钻头（13）和输送部分。（11），其将所述柄部和所述钻头（13）相互连接。所述钻头具有限定具有尖端（17）的径向延伸的主切削刃（16）的自由端表面，以及一对相对于所述尖端径向延伸并且与所述主切削刃a形成的辅助切削刃（18）一对相对的钝角（180°-o），以便限定所述自由端表面的一对相对的扇形部分（20）。输送部分（11）限定仅有两个螺旋槽（12），该螺旋槽（12）通向相对的钝角部分（20）。为了增加钻头的可能的钻削速度，凹槽（12）的总横截面面积相当于钻头输送部分（11）的总圆形横截面面积的45-55％。每个凹槽（12）的轴向延伸的入口部分（22）具有轴向长度（I），其为每个螺旋槽纹的轴向宽度（w）的25-35％。螺旋槽（12）的桨距角为30°-45°，优选为35°-40°。

6. 发明申请

WO2005097107A8 DIPHENYL - INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：二苯醚 - 吲哚-2-酮化合物及其在治疗癌症中的应用
公开(公告)号：WO2005097107A8
公开(公告)日：2006-02-16
申请号：PCT/DK2005000244
申请日：2005-04-08
申请人： BIOIMAGE AS , FELDING JAKOB , PEDERSEN HANS CHRISTIAN , KROG-JENSEN CHRISTIAN , PRAESTEGAARD MORTEN , BUTCHER STEVEN PETER , LINDE VIGGO , COULTER THOMAS STEPHEN , MONTALBETTI CHRISTIAN , UDDIN MOHAMMED , REIGNIER SERGE
发明人： FELDING JAKOB , PEDERSEN HANS CHRISTIAN , KROG-JENSEN CHRISTIAN , PRAESTEGAARD MORTEN , BUTCHER STEVEN PETER , LINDE VIGGO , COULTER THOMAS STEPHEN , MONTALBETTI CHRISTIAN , UDDIN MOHAMMED , REIGNIER SERGE
IPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K45/06 , A61P35/00 , C07D209/30 , C07D209/34 , C07D209/56 , C07D209/60 , C07D401/04 , C07D409/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
CPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that the compounds inhibit protein synthesis and/or inhibit activation of the mTOR pathway ehich is an effective method for reducing cell growth and the treatment of cancer. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leucemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) wherein at least one of X
摘要翻译：本发明涉及取代的3,3-二苯基-1,3-二氢 - 吲哚-2-酮化合物，以及这些化合物在哺乳动物中制备用于治疗癌症的药物的用途。假定化合物抑制蛋白质合成和/或抑制mTOR途径的活化，这是减少细胞生长和治疗癌症的有效方法。这样的癌症的例子是乳腺癌，肾癌，多发性骨髓瘤，淋巴瘤，胶质母细胞瘤，横纹肌肉瘤，前列腺，软组织肉瘤，结肠直肠肉瘤，胃癌，头颈鳞状细胞癌，子宫颈，宫颈癌，黑素瘤，淋巴瘤和胰腺癌癌症。化合物的特定亚类由式（II）表示，其中X

7. 发明申请

WO2005097107A2 DIPHENYL OX-INDOL-2-ON COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER 审中-公开
标题翻译：二苯氧基吲哚-2-酮化合物及其在治疗癌症中的应用
公开(公告)号：WO2005097107A2
公开(公告)日：2005-10-20
申请号：PCT/DK2005/000244
申请日：2005-04-08
申请人： BIOLMAGE A/S , FELDING, Jakob , PEDERSEN, Hans, Christian , KROG-JENSEN, Christian , PRÆSTEGAARD, Morten , BUTCHER, Steven, Peter , LINDE, Viggo , COULTER, Thomas, Stephen , MONTALBETTI, Christian , UDDIN, Mohammed , REIGNIER, Serge
发明人： FELDING, Jakob , PEDERSEN, Hans, Christian , KROG-JENSEN, Christian , PRÆSTEGAARD, Morten , BUTCHER, Steven, Peter , LINDE, Viggo , COULTER, Thomas, Stephen , MONTALBETTI, Christian , UDDIN, Mohammed , REIGNIER, Serge
IPC分类号： A61K31/404
CPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that treatment of cancers in which inhibition of protein synthesis and/or inhibition of activation of the mTOR pathway is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leucemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) wherein at least one of X 1 and X 2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.
摘要翻译：本发明涉及取代的3,3-二苯基-1,3-二氢 - 吲哚-2-酮化合物，以及这些化合物在哺乳动物中制备用于治疗癌症的药物的用途。假设治疗抑制蛋白质合成和/或抑制mTOR途径活化的癌症是减少细胞生长的有效方法。这样的癌症的例子是乳腺癌，肾癌，多发性骨髓瘤，淋巴瘤，胶质母细胞瘤，横纹肌肉瘤，前列腺，软组织肉瘤，结肠直肠肉瘤，胃癌，头颈鳞状细胞癌，子宫颈，宫颈癌，黑素瘤，淋巴瘤和胰腺癌癌症。化合物的特定亚类由式（II）表示，其中X 1和X 2中的至少一个是杂原子取代基，例如。 6-氯-3,3-双 - （4-羟基 - 苯基）-7-甲基-1,3-二氢 - 吲哚-2-酮。

8. 发明申请

WO2004083226A1 ANTIMICROBIAL FORMULATION COMPRISING MICROTHECIN OR DERIVATIVES THEREOF AND THEIR USES IN PREVENTION AND THERAPY 审中-公开
标题翻译：包含微血管密度或其衍生物的抗微生物制剂及其在预防和治疗中的应用
公开(公告)号：WO2004083226A1
公开(公告)日：2004-09-30
申请号：PCT/GB2004/001148
申请日：2004-03-18
申请人： DANISCO A/S , MORGAN, Andrew, John , TURNER, Mark , YU, Shukun , WEIERGAN, Inge , PEDERSEN, Hans, Christian
发明人： MORGAN, Andrew, John , TURNER, Mark , YU, Shukun , WEIERGAN, Inge , PEDERSEN, Hans, Christian
IPC分类号： C07H3/08
CPC分类号： A01N43/16 , A01N63/00 , C07H3/08 , C12N9/88 , C12Q1/18
摘要： The present invention provides an anti-microbial composition comprising microthecin or a derivative thereof as an active anti-microbial component, and the microorganism is selected from Candida albicans, Aspergillus fumigentus, E. coli, Staphylococcus aureus, Eimeria spp., Cryptosporidium parvum, Cryptosporidium aruem and Plasmodium spp
摘要翻译：本发明提供了一种抗微生物组合物，其包含作为活性抗微生物成分的微喜岩石或其衍生物，微生物选自白色念珠菌，烟曲霉，大肠杆菌，金黄色葡萄球菌，艾美球虫，隐孢子虫，隐孢子虫 aruem和疟原虫

9. 发明申请

WO2005097107A3 Diphenyl-indol-2-on compounds and their use in thetreatment of cancer 审中-公开
标题翻译：二苯基吲哚-2-酮化合物及其在癌症治疗中的应用
公开(公告)号：WO2005097107A3
公开(公告)日：2006-03-30
申请号：PCT/DK2005000244
申请日：2005-04-08
申请人： BIOIMAGE AS , FELDING JAKOB , PEDERSEN HANS CHRISTIAN , KROG-JENSEN CHRISTIAN , PRAESTEGAARD MORTEN , BUTCHER STEVEN PETER , LINDE VIGGO , COULTER THOMAS STEPHEN , MONTABETTI CHRISTIAN , UDDIN MOHAMMED , REIGNIER SERGE
发明人： FELDING JAKOB , PEDERSEN HANS CHRISTIAN , KROG-JENSEN CHRISTIAN , PRAESTEGAARD MORTEN , BUTCHER STEVEN PETER , LINDE VIGGO , COULTER THOMAS STEPHEN , MONTALBETTI CHRISTIAN , UDDIN MOHAMMED , REIGNIER SERGE
IPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D209/30 , C07D209/34 , C07D209/56 , C07D209/60 , C07D401/04 , C07D409/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , A61P35/00
CPC分类号： A61K31/404 , A61K31/407 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4439 , A61K31/4745 , A61K31/496 , A61K31/5025 , A61K31/5377
摘要： The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the preparation of a medicament for the treatment of cancer in a mammal. It is postulated that the compounds inhibit protein synthesis and/or inhibit activation of the mTOR pathway ehich is an effective method for reducing cell growth and the treatment of cancer. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leucemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterine, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds are represented by the formula (II) wherein at least one of X1 and X2 is a heteroatom substituent, e.g. 6-chloro-3,3-bis-(4-hydroxy-phenyl)-7-methyl-1,3-dihydro-indol-2-one.

10. 发明申请

WO2003037918A2 SEQUENCES 审中-公开
标题翻译：序列
公开(公告)号：WO2003037918A2
公开(公告)日：2003-05-08
申请号：PCT/GB2002/004916
申请日：2002-10-30
申请人： DANISCO A/S , MORGAN, Andrew, John , YU, Shukun , WEIERGANG, Inge , PEDERSEN, Hans, Christian
发明人： MORGAN, Andrew, John , YU, Shukun , WEIERGANG, Inge , PEDERSEN, Hans, Christian
IPC分类号： C07K14/00
CPC分类号： C12P17/06 , C12N9/88
摘要： The present invention discloses sequence information relating to pyranosone dehydratase. The invention further relates to the use of pyranosone dehydratase in the conversion of AF to APP and microthecin and the conversion of glucosone to cortalcerone.
摘要翻译：本发明公开了与吡喃酮脱水酶有关的序列信息。本发明还涉及吡喃酮脱水酶在将AF转化为APP和微喜岩石以及将葡萄糖转化为皮质醇时的用途。

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